Inhibition by dietary hydroquinone of acetylaminofluorene induction of initiation of rat liver carcinogenesis

Food and Chemical Toxicology

Volumn 45, Issue 9, 2007, Pages 1620-1625

  Williams, Gary M ^a   Iatropoulos, Michael J ^a   Jeffrey, Alan M ^a   Duan, Jian Dong ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Antioxidants; Cell proliferation; DNA adducts; Hepatocarcinogenesis; Hepatocellular altered foci; Hydroquinone

Indexed keywords

CARBOXYMETHYLCELLULOSE; HYDROQUINONE; N (2 FLUORENYL)ACETAMIDE; PHOSPHORUS 32;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DIETARY INTAKE; DNA ADDUCT; DOSE RESPONSE; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; MALE; NONHUMAN; RAT; WEIGHT GAIN;

2-ACETYLAMINOFLUORENE; ANIMALS; ANTIOXIDANTS; CARCINOGENS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; DNA ADDUCTS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD ADDITIVES; HYDROQUINONES; IMMUNOHISTOCHEMISTRY; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; ORGAN SIZE; PRECANCEROUS CONDITIONS; RANDOM ALLOCATION; RATS; RATS, INBRED F344; WEIGHT GAIN;

RATTUS;

EID: 34547137896     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.02.023     Document Type: Article

References (40)

1. Carlson A.J., and Brewer N.R. Toxicity studies on hydroquinone. Proc. Soc. Exp. Biol. (NY) 84 (1953) 684-688
2. Corley R.A., English J.C., Hill T.S., Fiorica L.A., and Morgott D.A. Development of a physiologically based pharmacokinetic model for hydroquinone. Toxicol. Appl. Pharmacol. 165 (2000) 163-174
3. Deisinger P.J., and English J.C. Bioavailability and metabolism of hydroquinone after intratracheal instillation in male rats. Drug Metab. Disp. 24 (1999) 442-448
4. Deisinger P.J., Hill T.S., and English J.C. Human exposure to naturally occurring hydroquinone. J. Toxicol. Environ. Health 47 (1996) 31-46
5. Dietrich D.R. Toxicological and pathological applications of proliferating cell nuclear antigen (PCNA), a novel endogenous marker for cell proliferation. Crit. Rev. Toxicol. 23 (1993) 77-109
6. 14C] hydroquinone given orally to Sprague-Dawley rats. Toxicology 33 (1984) 9-18
7. 32P-postlabeling in the kidneys of male and female Fischer 344 rats after multiple gavage doses of hydroquinone. Fund. Appl. Toxicol. 23 3 (1994) 391-396
8. English J.C., Perry L.G., Vlaovic M., Moyer C., and O'Donoghue J.L. measurement of cell proliferation in the kidneys of Fischer 344 and Sprague-Dawley rats after gavage administration of hydroquinone. Fundam. Appl. Toxicol. 23 3 (1994) 397-406
9. Iatropoulos M.J., and Williams G.M. Proliferation markers. Exp. Toxicol. Pathol. 48 (1996) 175-181
10. JECFA (Joint FAO/WHO Expert Committee on Food Additives), 1996. Toxicological evaluation of certain food additives and contaminants in food, Series 35, IPCS/WHO, Geneva, CH.
11. Jeffrey, A.M., Williams, G.M., 2005. Risk assessment of DNA-reactive carcinogens in food. In: Proceedings 10th International Congress of Toxicology Toxicol. Appl. Pharmacol. 207, S628-S635.
12. Jeffrey A.M., Jennette K.W., Blobstein S.H., Weinstein I.B., Beland F.A., Harvey R.G., Kasai W., Miura I., and Nakanishi k. Benzo[a]pyrene-nucleic acid derivative found in vivo: Structure of benzo[a]pyrene tetrahydrodiol epoxide-guanosine adduct. J. Am. Chem. Soc. 98 (1976) 5714-5715
13. Jeffrey A.M., Luo F.Q., Amin S., Krzeminski J., Zech K., and Williams G.M. Lack of DNA binding in the rat nasal mucosa and other tissues of the nasal toxicants roflumilast, a phosphodiesterase 4 inhibitor, and a metabolite, 4-amino-3,5-dichloropyridine, in contrast to the nasal carcinogen 2,6-dimethylaniline. Drug Chem. Toxicol. 25 (2002) 93-107
14. Kari F.W., Bucher J., Eustis S.L., Haseman J.K., and Huff J.E. Toxicity and carcinogenicity of hydroquinone in F344/N rats and B6C3F1 mice. Food Chem. Toxicol. 30 (1992) 737-747
15. Lee B.L., Ong H.Y., Shi C.Y., and Ong C.N. Simultaneous determination of hydroquinone, catechol and phenol in urine using high-performance liquid chromatography with fluorimetric detection. J. Chromatogr. 619 (1993) 259-266
16. Leong C.O., Gaskell M., Martin E.A., Heydon R.T., Farmer P.B., Bibby M.C., Cooper P.A., Double J.A., Bradshaw T.D., and Stevens M.F. Antitumour 2-(4-aminophenyl)benzothiasoles generate DNA adducts in sensitive tumour cells in vitro and in vivo. Br. J. Cancer 88 (2003) 470-477
17. National Toxicology Program (NTP), 1989. Toxicology and carcinogenesis studies of hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 mice (Gavage Studies). NTP Technical Report, 366. NIH publication 90-2821. National Toxicology Program, Research Triangle Park, NC.
18. O'Donoghue J., Barber E.D., Hill T., Aebi J., and Fiorica L. Hydroquinone: genotoxicity and prevention of genotoxicity following ingestion. Food Chem. Toxicol. 37 (1999) 931-936
19. Owen R.W., Mier W., Giacosa A., Hull W.E., Spiegelhalder B., and Bartsch H. Phenolic compounds and squalene in olive oils: the concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignans and squalene. Food Chem. Toxicol. 38 (2000) 647-659
20. Phillips D.H., and Castegnaro M. Standardization and validation of DNA adduct postlabeling methods: report of interlaboratory trials and production of recommended protocols. Mutagenesis 14 (1999) 301-315
21. 32P-postlabeling assay for aromatic carcinogen-DNA adducts. Carcinogenesis 12 9 (1991) 1745-1748
22. 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis 7 (1986) 1543-1551
23. Rogers L.K., Moorthy B., and Smith C.V. Acetaminophen binds to mouse hepatic and renal DNA at human therapeutic doses. Chem. Res. Toxicol. 10 (1997) 470-476
24. Sato K. Gluthatione transferases as markers of preneoplasia and neoplasia. Adv. Cancer Res. 52 (1989) 205-225
25. Schmeiser, H.H., Bieler, C.A., Weißler, M., Fried, M., Erdinger, L., 1999. Identifizierung spezifischer DNA-Adduktmuster durch organische Verbindungen in der Außenluft: Biomarker für Luftschadstoffe. http:/bwplus.fzk.de/berichte/ZBer/99/ZBerL96011.pdf.
26. Shibata M.-A., Hirose M., Tanaka H., Asakawa E., Shirai T., and Ito N. Induction of renal cell tumors in rats and mice, and enhancement of hepatocellular tumor development in mice after long-term hydroquinone treatment. Jpn. J. Cancer Res. (Gann) 82 (1991) 1211-1219
27. Trichopoulou A., Katsoyanni K., Stuver S., Tzala L., Gnardellis C., Rimm E., and Trichopoulos D. Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece. J. Natl. Cancer Inst. 87 (1995) 110-116
28. Umemura T., Tokumo K., Gebhardt R., Poirier M., and Williams G.M. Dose-response effects of 2-acetylaminofluorene on DNA damage, cytotoxicity, cell proliferation and neoplastic conversion in rat liver. Cancer Lett. 73 (1993) 1-10
29. 2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal in vivo. Chem. Res. Toxicol. 13 (2000) 1165-1173
30. Whysner J., Verna L., English J.C., and Williams G.M. Analysis of studies related to tumorigenicity induced by hydroquinone. Reg. Toxicol. Pharmacol. 21 (1995) 158-176
31. Williams G.M. Chemically induced preneoplastic lesions in rodents as indicators of carcinogenic activity. In: McGregor D.B., Rice J.M., and Venitt S. (Eds). The Use of Short- and Medium-Term Tests for Carcinogens and Data on Genetic Effects in Carcinogenic Hazard Evaluation (1999), IARC, Lyon, France 185-202
32. 1 in rats by low levels of the phenolic antioxidants butylated hydroxyanisole and butylated hydroxy toluene. Cancer Lett. 104 (1996) 49-53
33. Williams G.M., and Watanabe K. Quantitative kinetics of development of N-2-fluorenylacetamide-induced, altered (hyperplastic) hepatocellular foci resistant to iron accumulation and of their reversion or persistence following removal of carcinogen. J. Natl. Cancer Inst. 61 (1978) 113-121
34. 1 induced hepatocarcinogenesis by the phenolic antioxidants, butylated hydroxyanisole and butylated hydroxytoluene. Carcinogenesis 7 (1986) 1043-1050
35. Williams G.M., Tanaka T., Maruyama H., Maeura Y., Weisburger J.H., and Zang E. Modulation by butylated hydroxytoluene of liver and bladder carcinogenesis induced by chronic low-level exposure to 2-acetylaminofluorene. Cancer Res. 51 (1991) 6224-6230
36. Williams G.M., Iatropoulos M.J., Wang C.X., Jeffrey A.M., Thompson S., Pittman B., Palasch M., and Gebhardt R. Nonlinearities in 2-acetylaminofluorene exposure responses for genotoxic and epigenetic effects leading to initiation of carcinogenesis in rat liver. Toxicol. Sci. 45 (1998) 152-161
37. Williams G.M., Iatropoulos M.J., and Jeffrey A.M. Anticarcinogenicity of monocyclic phenolic compounds. Eur. J. Cancer Prev. 11 Supplement 2 (2002) S101-S107
38. Williams G.M., Iatropoulos M.J., Jeffrey A.M., and Shirai T. Protective effect of acetaminophen against colon cancer initiation effects of 3,2′-dimethyl-4-aminobiphenyl in rats. Eur. J. Cancer Prev. 11 (2002) 1-11
39. Williams, G.M., Iatropoulos, M.J., Jeffrey, A.M., Duan, J.-D., Perrone, C.E., 2007. Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by DNA-reactive hepatocarcinogen N-acetyl-2-amino-fluorene. Eur. J. Cancer Prev. 16, in press.
40. Zhao X., Demary K., Wong L., Vaziri C., McKenzie A.B., Eberlein T.J., and Spanjaard R.A. Retinoic acid receptor-independent mechanism of apoptosis of melanoma cells by the retinoid CD4376 (AHPN). Cell Death Differ. 8 (2001) 878-886