A novel approach to biliary tract pathology based on similarities to pancreatic counterparts: Is the biliary tract an incomplete pancreas?

Pathology International

Volumn 60, Issue 6, 2010, Pages 419-429

  Nakanuma, Yasuni ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

Author keywords

Biliary tract; Intraductal papillary neoplasm; Intraepithelial neoplasm; Mucinous neoplasm; Pancreas; Peribiliary glands

Indexed keywords

CYTOKERATIN 20; IMMUNOSUPPRESSIVE AGENT; NEUROGENIN 3; NOTCH RECEPTOR; STEROID; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR PDX 1;

AUTOIMMUNE PANCREATITIS; AUTOIMMUNITY; BILE DUCT CARCINOMA; BILIARY TRACT DISEASE; CHRONIC PANCREATITIS; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DRUG RESPONSE; HISTOPATHOLOGY; HUMAN; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; NONHUMAN; PANCREAS CARCINOMA; PANCREAS DISEASE; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; TISSUE DIFFERENTIATION;

ANIMALS; BILE DUCT DISEASES; BILE DUCT NEOPLASMS; BILE DUCTS, EXTRAHEPATIC; BILIARY TRACT; CARCINOMA, PANCREATIC DUCTAL; HUMANS; PANCREAS; PANCREATIC DISEASES; PANCREATIC NEOPLASMS;

EID: 77952214679     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2010.02543.x     Document Type: Review

References (57)

1. Portman BC, Nakanuma Y. Diseases of bile ducts. In : Burt AD, Portman BC, Ferrell LD, eds. MacSween's Pathology of the Liver, 5th edn.
2. Roskams T, Desmet VJ, Verslype C. Development, structure and function of the liver. In : Burt AD, Portman BC, Ferrell LD, eds. MacSween's Pathology of the Liver, 5th edn.
3. Sumazaki R, Shiojiri N, Isoyama S et al. Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat Genet 2004 36 : 83 87.
4. Fukuda A, Kawaguchi Y, Furuyama K et al. Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J Clin Invest 2006 11 : 1484 1493.
5. Eberhard D, Tosh D, Slack JM. Origin of pancreatic endocrine cells from biliary duct epithelium. Cell Mol Life Sci 2008 65 : 3467 3480.
6. Zen Y, Harada K, Sasaki M et al. IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis: Do they belong to a spectrum of sclerosing pancreatitis? Am J Surg Pathol 2004 28 : 1193 1203.
7. Nakanuma Y, Zen Y. Pathology and immunopathology of immunoglobulin G4-related sclerosing cholangitis: The latest addition to the sclerosing cholangitis family. Hepatol Res 2007 37 (Suppl. 3 S478 86.
8. Zen Y, Fujii T, Itatsu K et al. Biliary cystic tumors with bile duct communication: A cystic variant of intraductal papillary neoplasm of the bile duct. Mod Pathol 2006 19 : 1243 1254.
9. Zen Y, Sasaki M, Fujii T et al. Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct - An immunohistochemical study of 110 cases of hepatolithiasis. J Hepatol 2006 44 : 350 358.
10. Zamboni G, Longnecker DS, Kloppel G, Adler G, Hruban RH. Mucinous cystic neoplasm of the pancreas. In : Hamilton SR, Aaltonen LA, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System.
11. Nakanuma Y, Hoso M, Sanzen T, Sasaki M. Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply. Microsc Res Tech 1997 38 : 552 570.
12. Nakanuma Y, Zen Y, Harada K et al. Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: An immunohistochemical approach. J Hepatobiliary Pancreat Surg 2009 in press).
13. Terada T, Nakanuma Y, Ohta G. Glandular elements around the intrahepatic bile ducts in man; their morphology and distribution in normal livers. Liver 1987 7 : 1 8.
14. Terada T, Nakanuma Y, Kakita A. Pathologic observations of intrahepatic peribiliary glands in 1000 consecutive autopsy livers. Heterotopic pancreas in the liver. Gastroenterology 1990 98 : 1333 1337. (Pubitemid 20143122)
15. Terada T, Nakanuma Y. Development of human intrahepatic peribiliary glands. Histological, keratin immunohistochemical, and mucus histochemical analyses. Lab Invest 1993 68 : 261 269.
16. Nakanuma Y, Sasaki M, Ikeda H et al. Pathology of peripheral intrahepatic cholangiocarcinoma with reference to tumorigenesis. Hepatol Res 2008 38 : 325 334.
17. Saito K, Nakanuma Y. Lactoferrin and lysozyme in the intrahepatic bile duct of normal livers and hepatolithiasis. An immunohistochemical study. J Hepatol 1992 15 : 147 153.
18. Terada T, Kitamura Y, Nakanuma Y. Normal and abnormal development of the human intrahepatic biliary system: A review. Tohoku J Exp Med 1997 181 : 19 32.
19. Terada T, Kato M, Horie S, Endo K, Kitamura Y. Expression of pancreatic alpha-amylase protein and messenger RNA in hilar primitive bile ducts and hepatocytes during human fetal liver organogenesis: An immunohistochemical and in situ hybridization study. Liver 1998 18 : 313 319.
20. McDonald E, Krishnamurthy M, Goodyer CG, Wang R. The emerging role of SOX transcription factors in pancreatic endocrine cell development and function. Stem Cells Dev 2009 18 : 1379 1388.
21. Kawaguchi K, Koike M, Tsuruta K, Okamoto A, Tabata I, Fujita N. Lymphoplasmacytic sclerosing pancreatitis with cholangitis: A variant of primary sclerosing cholangitis extensively involving pancreas. Hum Pathol 1991 22 : 387 395.
22. Notohara K, Burgart LJ, Yadav D, Chari S, Smyrk TC. Idiopathic chronic pancreatitis with periductal lymphoplasmacytic infiltration: Clinicopathologic features of 35 cases. Am J Surg Pathol 2003 27 : 1119 1127.
23. Zamboni G, Lüttges J, Capelli P et al. Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: A study on 53 resection specimens and 9 biopsy specimens. Virchows Arch 2004 445 : 552 563.
24. Wang WL, Farris AB, Lauwers GY, Deshpande V. Autoimmune pancreatitis-related cholecystitis: A morphologically and immunologically distinctive form of lymphoplasmacytic sclerosing cholecystitis. Histopathology 2009 54 : 829 836.
25. Asada M, Nishio A, Uchida K et al. Identification of a novel autoantibody against pancreatic secretory trypsin inhibitor in patients with autoimmune pancreatitis. Pancreas 2006 33 : 20 26.
26. Nakanuma Y, Harada K, Katayanagi K, Tsuneyama K, Sasaki M. Definition and pathology of primary sclerosing cholangitis. J Hepatobiliary Pancreat Surg 1999 6 : 333 342.
27. Takikawa H, Takamori Y, Tanaka A, Kurihara H, Nakanuma Y. Analysis of 388 cases of primary sclerosing cholangitis in Japan; presence of a subgroup without pancreatic involvement in older patients. Hepatol Res 2004 29 : 153 159.
28. Kloppel G, Adler G, Hruban RH, Kern SE, Longnecker DS, Partanen TJ. Ductal adenocarcinoma of the pancreas. In : Hamilton SR, Aaltonen LA, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System.
29. Shimonishi T, Sasaki M, Nakanuma Y. Precancerous lesions of intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg 2000 7 : 542 550.
30. Nakanuma Y, Leong ASY, Sripa B, Ponchon T, Vatanasapt V, Ishak KG. Intrahepatic cholangiocarcinoma. In : Hamilton SR, Aaltonen LA, eds. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System.
31. Chen TC, Nakanuma Y, Zen Y et al. Intraductal papillary neoplasia of the liver associated with hepatolithiasis. Hepatology 2001 34 : 651 658.
32. Zen Y, Adsay NV, Bardadin K et al. Biliary intraepithelial neoplasia: An international interobserver agreement study and proposal for diagnostic criteria. Mod Pathol 2007 20 : 701 709.
33. Terada T, Nakanuma Y, Ohta T, Nagakawa T. Histological features and interphase nucleolar organizer regions in hyperplastic, dysplastic and neoplastic epithelium of intrahepatic bile ducts in hepatolithiasis. Histopathology 1992 21 : 233 240.
34. Takaori K, Hruban RH, Maitra A, Tanigawa N. Pancreatic intraepithelial neoplasia. Pancreas 2004 28 : 257 262.
35. Zhu L, Shi G, Schmidt CM, Hruban RH, Konieczny SF. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol 2007 171 : 263 273.
36. Zen Y, Aishima S, Ajioka Y et al. Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: Preliminary report based on interobserver agreement. Pathol Int 2005 55 : 180 188.
37. Brune K, Abe T, Canto M et al. Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer. Am J Surg Pathol 2006 30 : 1067 1076.
38. Klöppel G, Kosmahl M. Is the intraductal papillary mucinous neoplasia of the biliary tract a counterpart of pancreatic papillary mucinous neoplasm? J Hepatol 2006 44 : 249 250.
39. Zen Y, Fujii T, Itatsu K et al. Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas. Hepatology 2006 44 : 1333 1343.
40. Ishida M, Egawa S, Aoki T et al. Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas. Pancreas 2007 35 : 348 352.
41. Kim SC, Park KT, Lee YJ et al. Intraductal papillary mucinous neoplasm of the pancreas: Clinical characteristics and treatment outcomes of 118 consecutive patients from a single center. J Hepatobiliary Pancreat Surg 2008 15 : 183 188.
42. Woo SM, Ryu JK, Lee SH, Yoon WJ, Kim YT, Yoon YB. Branch duct intraductal papillary mucinous neoplasms in a retrospective series of 190 patients. Br J Surg 2009 96 : 405 411.
43. Amaya S, Sasaki M, Watanabe Y et al. Expression of MUC1 and MUC2 and carbohydrate antigen Tn change during malignant transformation of biliary papillomatosis. Histopathology 2001 38 : 550 560.
44. Lee SS, Kim MH, Lee SK et al. Clinicopathologic review of 58 patients with biliary papillomatosis. Cancer 2004 100 : 783 793.
45. Adsay NV, Conlon KC, Zee SY, Brennan MF, Klimstra DS. Intraductal papillary-mucinous neoplasms of the pancreas: An analysis of in situ and invasive carcinomas in 28 patients. Cancer 2002 94 : 62 77.
46. Nakanuma Y, Kurumaya H, Ohta G. Multiple cysts in the hepatic hilum and their pathogenesis. A suggestion of periductal gland origin. Virchows Arch A Pathol Anat Histopathol 1984 404 : 341 350.
47. Kida T, Nakanuma Y, Terada T. Cystic dilatation of peribiliary glands in livers with adult polycystic disease and livers with solitary nonparasitic cysts: An autopsy study. Hepatology 1992 16 : 334 340.
48. Terada T, Nakanuma Y. Pathologic observations of intrahepatic peribiliary glands in 1000 consecutive autopsy livers: IV. Hyperplasia of intramural and extramural glands. Hum Pathol 1992 23 : 483 490.
49. Ishak KG, Willis GW, Cummins SD, Bullock AA. Biliary cystadenoma and cystadenocarcinoma: Report of 14 cases and review of the literature. Cancer 1977 39 : 322 338.
50. Devaney K, Goodman ZD, Ishak KG. Hepatobiliary cystadenoma and cystadenocarcinoma. A light microscopic and immunohistochemical study of 70 patients. Am J Surg Pathol 1994 18 : 1078 1091.
51. Sudo Y, Harada K, Tsuneyama K, Katayanagi K, Zen Y, Nakanuma Y. Oncocytic biliary cystadenocarcinoma is a form of intraductal oncocytic papillary neoplasm of the liver. Mod Pathol 2001 14 : 1304 1309.
52. Shibahara H, Tamada S, Goto M et al. Pathologic features of mucin-producing bile duct tumors: Two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms. Am J Surg Pathol 2004 28 : 327 338.
53. Goto M, Shibahara H, Tamada S et al. Aberrant expression of pyloric gland-type mucin in mucin-producing bile duct carcinomas: A clear difference between the core peptide and the carbohydrate moiety. Pathol Int 2005 55 : 464 470.
54. Aldores-Saavedra J, Sheahan K, O'Riain C, Shukla D. Intraductal tubular adenoma, pyloric type, of the pancreas: Additional observations on a new type of pancreatic neoplasm. Am J Surg Pathol 2004 28 : 233 238.
55. Nakayama Y, Inoue H, Hamada Y et al. Intraductal tubular adenoma of the pancreas, pyloric gland type: A clinicopathologic and immunohistochemical study of 6 cases. Am J Surg Pathol 2005 29 : 607 616.
56. Kozaka K, Sasaki M, Fujii T et al. A subgroup of intrahepatic cholangiocarcinoma with an infiltrating replacement growth pattern and a resemblance to reactive proliferating bile ductules: 'bile ductular carcinoma. Histopathology 2007 51 : 390 400.
57. Komuta M, Spee B, Vander Borght S et al. Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. Hepatology 2008 47 : 1544 1556.