메뉴 건너뛰기




Volumn 17, Issue 3, 2010, Pages 211-222

Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: An immunohistochemical approach

Author keywords

Biliary tree; Cholangiocarcinoma; Cytokeratin; Immunohistochemistry; Mucin; Papillary lesion

Indexed keywords

BETA CATENIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYTOKERATIN 20; GELATINASE B; MATRILYSIN; MUCIN; MUCIN 1; MUCIN 2; TRANSCRIPTION FACTOR CDX2; UVOMORULIN; CADHERIN; CDX2 PROTEIN, HUMAN; CYCLIN D1; HOMEODOMAIN PROTEIN; MUC1 PROTEIN, HUMAN; MUC2 PROTEIN, HUMAN;

EID: 77955872759     PISSN: 18686974     EISSN: 18686982     Source Type: Journal    
DOI: 10.1007/s00534-009-0158-7     Document Type: Review
Times cited : (51)

References (56)
  • 1
    • 0022005695 scopus 로고
    • Cystadenoma with mesenchymal stroma (CMS) in the liver and bile ducts. A clinicopathologic study of 17 cases, 4 with malignant change
    • Wheeler DA, Edmondson HA. Cystadenoma with mesenchymal stroma (CMS) in the liver and bile ducts. A clinicopathologic study of 17 cases, 4 with malignant change. Cancer. 1985;56:1434-45.
    • (1985) Cancer , vol.56 , pp. 1434-1445
    • Wheeler, D.A.1    Edmondson, H.A.2
  • 2
    • 0027946303 scopus 로고
    • Hepatobiliary cystadenoma and cystadenocarcinoma: A light microscopic and immunohistochemical study of 70 patients
    • Devaney K, Goodman ZD, Ishak KG. Hepatobiliary cystadenoma and cystadenocarcinoma. A light microscopic and immunohistochemical study of 70 patients. Am J Surg Pathol. 1994;18:1078-91. (Pubitemid 24337615)
    • (1994) American Journal of Surgical Pathology , vol.18 , Issue.11 , pp. 1078-1091
    • Devaney, K.1    Goodman, Z.D.2    Ishak, K.G.3
  • 3
    • 0032873435 scopus 로고    scopus 로고
    • Treatment strategy for mucin-producing intrahepatic cholangiocarcinoma: Value of percutaneous transhepatic biliary drainage and cholangioscopy
    • Sakamoto E, Hayakawa N, Kamiya J, Kondo S, Nagino M, Kanai M, et al. Treatment strategy for mucin-producing intrahepatic cholangiocarcinoma: value of percutaneous transhepatic biliary drainage and cholangioscopy. World J Surg. 1999;23:1038-43.
    • (1999) World J Surg , vol.23 , pp. 1038-1043
    • Sakamoto, E.1    Hayakawa, N.2    Kamiya, J.3    Kondo, S.4    Nagino, M.5    Kanai, M.6
  • 4
    • 23244438317 scopus 로고    scopus 로고
    • Aberrant expression of pyloric gland-type mucin in mucin-producing bile duct carcinomas: A clear difference between the core peptide and the carbohydrate moiety
    • DOI 10.1111/j.1440-1827.2005.01854.x
    • Goto M, Shibahara H, Tamada S, Hamada T, Oda K, Nagino M, et al. Aberrant expression of pyloric gland-type mucin in mucin-producing bile duct carcinomas: a clear difference between the core peptide and the carbohydrate moiety. Pathol Int. 2005;55:464-70. (Pubitemid 41097846)
    • (2005) Pathology International , vol.55 , Issue.8 , pp. 464-470
    • Goto, M.1    Shibahara, H.2    Tamada, S.3    Hamada, T.4    Oda, K.5    Nagino, M.6    Nagasaka, T.7    Imai, K.8    Nimura, Y.9    Yonezawa, S.10
  • 9
    • 0141429117 scopus 로고    scopus 로고
    • Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract
    • DOI 10.1016/S0046-8177(03)00337-X
    • Abraham SC, Lee JH, Hruban RH, Argani P, Furth EE, Wu TT. Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract. Hum Pathol. 2003;34:902-10. (Pubitemid 37169620)
    • (2003) Human Pathology , vol.34 , Issue.9 , pp. 902-910
    • Abraham, S.C.1    Lee, J.-H.2    Hruban, R.H.3    Argani, P.4    Furth, E.E.5    Wu, T.-T.6
  • 12
    • 0036050125 scopus 로고    scopus 로고
    • Cholangiocarcinoma: Recent progress. Part 2: Molecular pathology and treatment
    • DOI 10.1046/j.1440-1746.2002.02780.x
    • Okuda K, Nakanuma Y, Miyazaki M. Cholangiocarcinoma: recent progress. Part 2: molecular pathology and treatment. J Gastroenterol Hepatol. 2002;17:1056-63. (Pubitemid 35013959)
    • (2002) Journal of Gastroenterology and Hepatology , vol.17 , Issue.10 , pp. 1056-1063
    • Okuda, K.1    Nakanuma, Y.2    Miyazaki, M.3
  • 13
    • 20944435837 scopus 로고    scopus 로고
    • Papillary phenotype confers improved survival after resection of hilar cholangiocarcinoma
    • Jarnagin WR, Bowne W, Klimstra DS, Ben-Porat L, Roggin K, Cymes K, et al. Papillary phenotype confers improved survival after resection of hilar cholangiocarcinoma. Ann Surg. 2005;241:703-12.
    • (2005) Ann Surg , vol.241 , pp. 703-712
    • Jarnagin, W.R.1    Bowne, W.2    Klimstra, D.S.3    Ben-Porat, L.4    Roggin, K.5    Cymes, K.6
  • 15
    • 0034255521 scopus 로고    scopus 로고
    • Noninvasive and minimally invasive papillary carcinomas of the extrahepatic bile ducts
    • DOI 10.1002/1097-0142(20000801)89:3<508::AID-CNCR5>3.0.CO;2-D
    • Albores-Saavedra J, Murakata L, Krueger JE, Henson DE. Noninvasive and minimally invasive papillary carcinomas of the extrahepatic bile ducts. Cancer. 2000;89:508-15. (Pubitemid 30640097)
    • (2000) Cancer , vol.89 , Issue.3 , pp. 508-515
    • Albores-Saavedra, J.1    Murakata, L.2    Krueger, J.E.3    Henson, D.E.4
  • 16
    • 43049118296 scopus 로고    scopus 로고
    • Electronic clinical challenges and images in GI. Noninvasive and minimally invasive papillary carcinomas of the common bile duct
    • Young TH, Chen TK, Lee HS. Electronic clinical challenges and images in GI. Noninvasive and minimally invasive papillary carcinomas of the common bile duct. Gastroenterology. 2008;134:e1-3.
    • (2008) Gastroenterology , vol.134
    • Young, T.H.1    Chen, T.K.2    Lee, H.S.3
  • 18
    • 0030803187 scopus 로고    scopus 로고
    • Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply
    • DOI 10.1002/(SICI)1097-0029(19970915)38:6<552::AID-JEMT2>3.0.CO;2-H
    • Nakanuma Y, Hoso M, Sanzen T, Sasaki M. Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply. Microsc Res Tech. 1997;38:552-70. (Pubitemid 27426381)
    • (1997) Microscopy Research and Technique , vol.38 , Issue.6 , pp. 552-570
    • Nakanuma, Y.1    Hoso, M.2    Sanzen, T.3    Sasaki, M.4
  • 19
    • 47549104922 scopus 로고    scopus 로고
    • Expression of cell cycle-related molecules in biliary premalignant lesions: Biliary intraepithelial neoplasia and biliary intraductal papillary neoplasm
    • Nakanishi Y, Zen Y, Kondo S, Itoh T, Itatsu K, Nakanuma Y. Expression of cell cycle-related molecules in biliary premalignant lesions: biliary intraepithelial neoplasia and biliary intraductal papillary neoplasm. Hum Pathol. 2008;39:1153-61.
    • (2008) Hum Pathol , vol.39 , pp. 1153-1161
    • Nakanishi, Y.1    Zen, Y.2    Kondo, S.3    Itoh, T.4    Itatsu, K.5    Nakanuma, Y.6
  • 20
    • 35148830425 scopus 로고    scopus 로고
    • Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis
    • DOI 10.1111/j.1478-3231.2007.01577.x
    • Itatsu K, Zen Y, Ohira S, Ishikawa A, Sato Y, Harada K, et al. Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis. Liver Int. 2007;27:1174-84. (Pubitemid 47543145)
    • (2007) Liver International , vol.27 , Issue.9 , pp. 1174-1184
    • Itatsu, K.1    Zen, Y.2    Ohira, S.3    Ishikawa, A.4    Sato, Y.5    Harada, K.6    Ikeda, H.7    Sasaki, M.8    Nimura, Y.9    Nakanuma, Y.10
  • 22
    • 0035217513 scopus 로고    scopus 로고
    • Oncocytic biliary cystadenocarcinoma is a form of intraductal oncocytic papillary neoplasm of the liver
    • DOI 10.1038/modpathol.3880479
    • Sudo Y, Harada K, Tsuneyama K, Katayanagi K, Zen Y, Nakanuma Y. Oncocytic biliary cystadenocarcinoma is a form of intraductal oncocytic papillary neoplasm of the liver. Mod Pathol. 2001;14:1304-9. (Pubitemid 33151175)
    • (2001) Modern Pathology , vol.14 , Issue.12 , pp. 1304-1309
    • Sudo, Y.1    Harada, K.2    Tsuneyama, K.3    Katayanagi, K.4    Zen, Y.5    Nakanuma, Y.6
  • 23
    • 47549104922 scopus 로고    scopus 로고
    • Expression of cell cycle-related molecules in biliary premalignant lesions: Biliary intraepithelial neoplasia and biliary intraductal papillary neoplasm
    • Nakanishi Y, Zen Y, Kondo S, Itoh T, Itatsu K, Nakanuma Y. Expression of cell cycle-related molecules in biliary premalignant lesions: biliary intraepithelial neoplasia and biliary intraductal papillary neoplasm. Hum Pathol. 2008;39:1153-61.
    • (2008) Hum Pathol , vol.39 , pp. 1153-1161
    • Nakanishi, Y.1    Zen, Y.2    Kondo, S.3    Itoh, T.4    Itatsu, K.5    Nakanuma, Y.6
  • 24
    • 34347204093 scopus 로고    scopus 로고
    • Expression profiles of MUC mucins and trefoil factor family (TFF) peptides in the intrahepatic biliary system: Physiological distribution and pathological significance
    • DOI 10.1016/j.proghi.2007.02.001, PII S0079633607000034
    • Sasaki M, Ikeda H, Nakanuma Y. Expression profiles of MUC mucins and trefoil factor family (TFF) peptides in the intrahepatic biliary system: physiological distribution and pathological significance. Prog Histochem Cytochem. 2007;42:61-110. (Pubitemid 47007727)
    • (2007) Progress in Histochemistry and Cytochemistry , vol.42 , Issue.2 , pp. 61-110
    • Sasaki, M.1    Ikeda, H.2    Nakanuma, Y.3
  • 25
    • 44649168797 scopus 로고    scopus 로고
    • INK4ain cholangiocarcinogenesis in hepatolithiasis
    • DOI 10.1002/path.2345
    • Sasaki M, Yamaguchi J, Itatsu K, Ikeda H, Nakanuma Y. Overexpression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis. J Pathol. 2008;215:175-83. (Pubitemid 351786036)
    • (2008) Journal of Pathology , vol.215 , Issue.2 , pp. 175-183
    • Sasaki, M.1    Yamaguchi, J.2    Itatsu, K.3    Ikeda, H.4    Nakanuma, Y.5
  • 26
    • 2942538602 scopus 로고    scopus 로고
    • Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis
    • DOI 10.1038/labinvest.3700087
    • Ishikawa A, Sasaki M, Ohira S, Ohta T, Oda K, Nimura Y, et al. Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis. Lab Invest. 2004;84:629-38. (Pubitemid 38858472)
    • (2004) Laboratory Investigation , vol.84 , Issue.5 , pp. 629-638
    • Ishikawa, A.1    Sasaki, M.2    Ohira, S.3    Ohta, T.4    Oda, K.5    Nimura, Y.6    Chen, M.-F.7    Jan, Y.-Y.8    Yeh, T.-S.9    Nakanuma, Y.10
  • 27
    • 1542394981 scopus 로고    scopus 로고
    • Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology
    • Sasaki M, Tsuneyama K, Saito T, Kataoka H, Mollenhauer J, Poustka A, et al. Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology. Liver Int. 2004;24:29-37.
    • (2004) Liver Int , vol.24 , pp. 29-37
    • Sasaki, M.1    Tsuneyama, K.2    Saito, T.3    Kataoka, H.4    Mollenhauer, J.5    Poustka, A.6
  • 29
    • 0025308380 scopus 로고
    • Pathologic observations of intrahepatic peribiliary glands in 1,000 consecutive autopsy livers. Heterotopic pancreas in the liver
    • Terada T, Nakanuma Y, Kakita A. Pathologic observations of intrahepatic peribiliary glands in 1,000 consecutive autopsy livers. Heterotopic pancreas in the liver. Gastroenterology. 1990;98:1333-7.
    • (1990) Gastroenterology , vol.98 , pp. 1333-1337
    • Terada, T.1    Nakanuma, Y.2    Kakita, A.3
  • 30
    • 0027395099 scopus 로고
    • Development of human intrahepatic peribiliary glands. Histological, keratin immunohistochemical, and mucus histochemical analyses
    • Terada T, Nakanuma Y. Development of human intrahepatic peribiliary glands. Histological, keratin immunohistochemical, and mucus histochemical analyses. Lab Invest. 1993;68:261-9.
    • (1993) Lab Invest , vol.68 , pp. 261-269
    • Terada, T.1    Nakanuma, Y.2
  • 31
    • 0028933919 scopus 로고
    • Expression of pancreatic enzymes (alpha-amylase, trypsinogen, and lipase) during human liver development and maturation
    • Terada T, Nakanuma Y. Expression of pancreatic enzymes (alpha-amylase, trypsinogen, and lipase) during human liver development and maturation. Gastroenterology. 1995;108:1236-45.
    • (1995) Gastroenterology , vol.108 , pp. 1236-1245
    • Terada, T.1    Nakanuma, Y.2
  • 34
    • 0026622885 scopus 로고
    • Pathologic observations of intrahepatic peribiliary glands in 1,000 consecutive autopsy livers: IV. Hyperplasia of intramural and extramural glands
    • Terada T, Nakanuma Y. Pathologic observations of intrahepatic peribiliary glands in 1,000 consecutive autopsy livers: IV. Hyperplasia of intramural and extramural glands. Hum Pathol. 1992;23:483-90.
    • (1992) Hum Pathol , vol.23 , pp. 483-490
    • Terada, T.1    Nakanuma, Y.2
  • 35
    • 30344434023 scopus 로고    scopus 로고
    • Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct - An immunohistochemical study of 110 cases of hepatolithiasis
    • DOI 10.1016/j.jhep.2005.09.025, PII S0168827805007579
    • Zen Y, Sasaki M, Fujii T, Chen TC, Chen MF, Yeh TS, et al. Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct - an immunohistochemical study of 110 cases of hepatolithiasis. J. Hepatol. 2006;44:350-8. (Pubitemid 43069217)
    • (2006) Journal of Hepatology , vol.44 , Issue.2 , pp. 350-358
    • Zen, Y.1    Sasaki, M.2    Fujii, T.3    Chen, T.-C.4    Chen, M.-F.5    Yeh, T.-S.6    Jan, Y.-Y.7    Huang, S.-F.8    Nimura, Y.9    Nakanuma, Y.10
  • 37
    • 34250215943 scopus 로고    scopus 로고
    • Intraductal papillary cholangiocarcinoma and atypical biliary epithelial lesions confused with intrabiliary extension of metastatic colorectal carcinoma
    • Itatsu K, Fujii T, Sasaki M, Zen Y, Nakanuma Y. Intraductal papillary cholangiocarcinoma and atypical biliary epithelial lesions confused with intrabiliary extension of metastatic colorectal carcinoma. Hepatogastroenterology. 2007;54:677-80. (Pubitemid 46903700)
    • (2007) Hepato-Gastroenterology , vol.54 , Issue.75 , pp. 677-680
    • Itatsu, K.1    Fujii, T.2    Sasaki, M.3    Zen, Y.4    Nakanuma, Y.5
  • 38
    • 10944237188 scopus 로고    scopus 로고
    • ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis
    • DOI 10.1016/j.humpath.2004.08.014, PII S0046817704004691
    • Ishikawa A, Sasaki M, Sato Y, Ohira S, Chen MF, Huang SF, et al. Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis. Hum Pathol. 2004;35:1505-14. (Pubitemid 40017991)
    • (2004) Human Pathology , vol.35 , Issue.12 , pp. 1505-1514
    • Ishikawa, A.1    Sasaki, M.2    Sato, Y.3    Ohira, S.4    Chen, M.-F.5    Huang, S.-F.6    Oda, K.7    Nimura, Y.8    Nakanuma, Y.9
  • 41
    • 33644831221 scopus 로고    scopus 로고
    • Immunohistochemical and mutational analyses of Wnt signaling components and target genes in intrahepatic cholangiocarcinomas
    • Tokumoto N, Ikeda S, Ishizaki Y, Kurihara T, Ozaki S, Iseki M, et al. Immunohistochemical and mutational analyses of Wnt signaling components and target genes in intrahepatic cholangiocarcinomas. Int J Oncol. 2005;27:973-80.
    • (2005) Int J Oncol , vol.27 , pp. 973-980
    • Tokumoto, N.1    Ikeda, S.2    Ishizaki, Y.3    Kurihara, T.4    Ozaki, S.5    Iseki, M.6
  • 42
    • 13244265798 scopus 로고    scopus 로고
    • Changes in the Wnt signalling pathway in gastrointestinal cancers and their prognostic significance
    • DOI 10.1016/j.ejca.2004.11.005, PII S0959804904009219
    • Doucas H, Garcea G, Neal CP, Manson MM, Berry DP. Change in the Wnt signaling pathway in gastrointestinal cancers and their prognostic significance. Eur J Cancer. 2005;41:365-79. (Pubitemid 40187207)
    • (2005) European Journal of Cancer , vol.41 , Issue.3 , pp. 365-379
    • Doucas, H.1    Garcea, G.2    Neal, C.P.3    Manson, M.M.4    Berry, D.P.5
  • 43
    • 33846889537 scopus 로고    scopus 로고
    • An assessment of chromosomal alterations detected by fluorescence in situ hybridization and p16 expression in sporadic and primary sclerosing cholangitis-associated cholangiocarcinomas
    • DOI 10.1016/j.humpath.2006.09.004, PII S0046817706005727
    • DeHaan RD, Kipp BR, Smyrk TC, Abraham SC, Roberts LR, Halling KC. An assessment of chromosomal alterations detected by fluorescence in situ hybridization and p16 expression in sporadic and primary sclerosing cholangitis-associated cholangiocarcinomas. Hum Pathol. 2007;38:491-9. (Pubitemid 46227534)
    • (2007) Human Pathology , vol.38 , Issue.3 , pp. 491-499
    • DeHaan, R.D.1    Kipp, B.R.2    Smyrk, T.C.3    Abraham, S.C.4    Roberts, L.R.5    Halling, K.C.6
  • 44
    • 18744414743 scopus 로고    scopus 로고
    • Microsatellite instability in intraductal papillary neoplasms of the biliary tract
    • DOI 10.1097/01.MP.0000038461.80167.34
    • Abraham SC, Lee JH, Boitnott JK, Argani P, Furth EE, Wu TT. Microsatellite instability in intraductal papillary neoplasms of the biliary tract. Mod Pathol. 2002;15:1309-17. (Pubitemid 35462999)
    • (2002) Modern Pathology , vol.15 , Issue.12 , pp. 1309-1317
    • Abraham, S.C.1    Lee, J.-H.2    Boitnott, J.K.3    Argani, P.4    Furth, E.E.5    Wu, T.-T.6
  • 45
    • 0034823869 scopus 로고    scopus 로고
    • Expression of MUC1 and MUC2 and carbohydrate antigen Tn change during malignant transformation of biliary papillomatosis
    • DOI 10.1046/j.1365-2559.2001.01103.x
    • Amaya S, Sasaki M, Watanabe Y, Tsui WM, Tsuneyama K, Harada K, et al. Expression of MUC1 and MUC2 and carbohydrate antigen Tn change during malignant transformation of biliary papillomatosis. Histopathology. 2001;38:550-60. (Pubitemid 32863008)
    • (2001) Histopathology , vol.38 , Issue.6 , pp. 550-560
    • Amaya, S.1    Sasaki, M.2    Watanabe, Y.3    Tsui, W.M.S.4    Tsuneyama, K.5    Harada, K.6    Nakanuma, Y.7
  • 46
    • 0029858362 scopus 로고    scopus 로고
    • Characterization of apomucin expression in intrahepatic cholangiocarcinomas and their precursor lesions: An immunohistochemical study
    • DOI 10.1053/jhep.1996.v24.pm0008903378
    • Sasaki M, Nakanuma Y, Kim YS. Characterization of apomucin expression in intrahepatic cholangiocarcinomas and their precursor lesions: an immunohistochemical study. Hepatology. 1996;24:1074-8. (Pubitemid 26365906)
    • (1996) Hepatology , vol.24 , Issue.5 , pp. 1074-1078
    • Sasaki, M.1    Nakanuma, Y.2    Kim, Y.S.3
  • 47
    • 18644383374 scopus 로고    scopus 로고
    • The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: Differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis
    • Adsay NV, Merati K, Andea A, Sarkar F, Hruban RH, Wilentz RE, et al. The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis. Mod Pathol. 2002;15:1087-95.
    • (2002) Mod Pathol , vol.15 , pp. 1087-1095
    • Adsay, N.V.1    Merati, K.2    Andea, A.3    Sarkar, F.4    Hruban, R.H.5    Wilentz, R.E.6
  • 48
    • 0031948695 scopus 로고    scopus 로고
    • Expression of Ecadherin, alpha-catenin, beta-catenin, and CD44 (standard and variant isoforms) in human cholangiocarcinoma: An immunohistochemical study
    • DOI 10.1002/hep.510270412
    • Ashida K, Terada T, Kitamura Y, Kaibara N. Expression of Ecadherin, alpha-catenin, beta-catenin, and CD44 (standard and variant isoforms) in human cholangiocarcinoma: an immunohistochemical study. Hepatology. 1998;27:974-82. (Pubitemid 28160482)
    • (1998) Hepatology , vol.27 , Issue.4 , pp. 974-982
    • Ashida, K.1    Terada, T.2    Kitamura, Y.3    Kaibara, N.4
  • 49
    • 0032940579 scopus 로고    scopus 로고
    • Downregulation and abnormal expression of e-cadherin and beta-catenin in nasopharyngeal carcinoma: Close association with advanced disease stage and lymph node metastasis
    • Zheng Z, Pan J, Chu B, Wong YC, Cheung AL, Tsao SW. Downregulation and abnormal expression of E-cadherin and betacatenin in nasopharyngeal carcinoma: close association with advanced disease stage and lymph node metastasis. Hum Pathol. 1999;30:458-66. (Pubitemid 29177827)
    • (1999) Human Pathology , vol.30 , Issue.4 , pp. 458-466
    • Zheng, Z.1    Pan, J.2    Chu, B.3    Wong, Y.-C.4    Cheung, A.L.-M.5    Tsao, S.-W.6
  • 50
    • 0029954681 scopus 로고    scopus 로고
    • Expression of immunoreactive matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human normal livers and primary liver tumors
    • DOI 10.1053/jhep.1996.v23.pm0008675149
    • Terada T, Okada Y, Nakanuma Y. Expression of immunoreactive matrix metalloproteinases in human normal livers and primary liver tumors. Hepatology. 1996;23:1341-4. (Pubitemid 26181214)
    • (1996) Hepatology , vol.23 , Issue.6 , pp. 1341-1344
    • Terada, T.1    Okada, Y.2    Nakanuma, Y.3
  • 51
    • 0037080114 scopus 로고    scopus 로고
    • Matrix metalloproteinase-7 expression and biologic aggressiveness of cholangiocellular carcinoma
    • DOI 10.1002/cncr.10235
    • Miwa S, Miyagawa S, Soeda J, Kawasaki S. Matrix metalloproteinase- 7 expression and biologic aggressiveness of cholangiocellular carcinoma. Cancer. 2002;94:428-34. (Pubitemid 34081373)
    • (2002) Cancer , vol.94 , Issue.2 , pp. 428-434
    • Miwa, S.1    Miyagawa, S.-I.2    Soeda, J.3    Kawasaki, S.4
  • 52
    • 0141763443 scopus 로고    scopus 로고
    • Hepatobiliary cystadenocarcinoma connected to the hepatic duct: A case report and review of the literature
    • Sato M, Watanabe Y, Tokui K, Kohtani T, Nakata Y, Chen Y, et al. Hepatobiliary cystadenocarcinoma connected to the hepatic duct: a case report and review of the literature. Hepatogastroenterology. 2003;50:1621-4. (Pubitemid 37186545)
    • (2003) Hepato-Gastroenterology , vol.50 , Issue.53 , pp. 1621-1624
    • Sato, M.1    Watanabe, Y.2    Tokui, K.3    Kohtani, T.4    Nakata, Y.5    Chen, Y.6    Kawachi, K.7
  • 53
    • 35148897568 scopus 로고    scopus 로고
    • Diseases of bile ducts
    • Burt AD, Portman BC, Ferrell LD, editors 5.th ed. London: Churchill Livingstone
    • Portman BC, Nakanuma Y. Diseases of bile ducts. In: Burt AD, Portman BC, Ferrell LD, editors. MacSween's pathology of the liver. 5.th ed. London: Churchill Livingstone; 2006. p. 517-81.
    • (2006) MacSween's Pathology of the Liver , pp. 517-581
    • Portman, B.C.1    Nakanuma, Y.2
  • 54
    • 0025341618 scopus 로고
    • Pathological observations of intrahepatic peribiliary glands in 1,000 consecutive autopsy livers. II. A possible source of cholangiocarcinoma
    • Terada T, Nakanuma Y. Pathological observations of intrahepatic peribiliary glands in 1,000 consecutive autopsy livers. II. A possible source of cholangiocarcinoma. Hepatology. 1990;12:92-7.
    • (1990) Hepatology , vol.12 , pp. 92-97
    • Terada, T.1    Nakanuma, Y.2
  • 56
    • 18744386147 scopus 로고    scopus 로고
    • Intrahepatic cholangiocarcinoma with multicystic, mucinous appearance and oncocytic change
    • DOI 10.1111/j.1440-1827.2005.01812.x
    • Fujii T, Harada K, Katayanagi K, Kurumaya H, Nakanuma Y. Intrahepatic cholangiocarcinoma with multicystic, mucinous appearance and oncocytic change. Pathol Int. 2005;55:206-9. (Pubitemid 40676930)
    • (2005) Pathology International , vol.55 , Issue.4 , pp. 206-209
    • Fujii, T.1    Harada, K.2    Katayanagi, K.3    Kurumaya, H.4    Nakanuma, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.