Functional characterization of human cytochrome P450 2E1 allelic variants: In vitro metabolism of benzene and toluene by recombinant enzymes expressed in yeast cells

Archives of Toxicology

Volumn 84, Issue 5, 2010, Pages 363-371

  Hanioka, Nobumitsu ^a   Yamamoto, Maki ^a   Tanaka Kagawa, Toshiko ^b   Jinno, Hideto ^b   Narimatsu, Shizuo ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Benzene; Cytochrome P450 2E1 (CYP2E1); Genetic polymorphism; Metabolism; Toluene

Indexed keywords

6 HYDROXYCHLORZOXAZONE; BENZENE; BENZYL ALCOHOL; CYTOCHROME P450 2E1; PHENOL; RECOMBINANT ENZYME; TOLUENE;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FUNCTIONAL GENOMICS; GENE FUNCTION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HYDROXYLATION; IN VITRO STUDY; METABOLIC ACTIVATION; MICHAELIS CONSTANT; NONHUMAN; POLLUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; VELOCITY; WILD TYPE; YEAST CELL;

BENZENE; CYTOCHROME P-450 CYP2E1; HUMANS; HYDROXYLATION; POLYMORPHISM, GENETIC; RECOMBINANT PROTEINS; TOLUENE; YEASTS;

EID: 77952094473     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-009-0504-1     Document Type: Article

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