Insight into the stability of cross-β amyloid fibril from molecular dynamics simulation

Biopolymers

Volumn 93, Issue 6, 2010, Pages 578-586

  Chen, Yue ^a   He, Yong Jie ^a   Wu, Maoying ^a   Yan, Guanwen ^b   Li, Yixue ^c   Zhang, Jian ^d   Chen, Hai Feng ^a,c  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai High School   (China)

^c SHANGHAI CENTER FOR BIOINFORMATION TECHNOLOGY   (China)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Aggregation mechanism; Amyloid like fibril; Mutation; Oligomer; Stability

Indexed keywords

AGGREGATION MECHANISM; ALZHEIMER'S DISEASE; AMYLOID FIBRIL; AMYLOID-LIKE FIBRIL; DEGENERATIVE DISEASE; DIABETES MELLITUS; FIBRIL FORMATION; HEXAMERS; HYDROPHOBIC RESIDUES; INTERMEDIATE STATE; MOLECULAR DYNAMICS SIMULATIONS; OLIGOMER STABILITY; PRION DISEASE; SINGLE POINT; STABILITY RESULTS; STATISTICS ANALYSIS; TETRAMERS; TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES; TYPE II;

DYNAMICS; GLYCOPROTEINS; HYDROPHOBICITY; MOLECULAR DYNAMICS; STABILITY;

PROTEINS;

AMYLOID BETA PROTEIN; GLYCYLGLYCYLVALYLVALYLISOLEUCYLALANINE; LEUCYLTYROSYLGLUTAMYLLEUCYLGLUTAMYLASPARAGINE; METHIONINE; METHIONYLVALYLGLYCYLGLYCYLVALYLVALINE 1; METHIONYLVALYLGLYCYLGLYCYLVALYLVALINE 2; OLIGOMER; PEPTIDE DERIVATIVE; SERYLASPARAGYLGLUTAMYLASPARAGYLASPARAGYLTYROSINE; SERYLSERYLTHREONYLSERYLALANYLALANINE; UNCLASSIFIED DRUG; VALINE; VALYLGLUTAMYLALANYLLEUCYLTYROSYLLEUCINE; VALYLGLUTAMYLISOLEUCYLVALYLTYROSYLLYSINE;

AMINO ACID SEQUENCE; ARTICLE; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN STRUCTURE;

AMYLOID BETA-PROTEIN; COMPUTER SIMULATION; DIMERIZATION; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; MUTATION; NEURODEGENERATIVE DISEASES; PEPTIDES; POLYMERS; PRIONS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; TEMPERATURE; TIME FACTORS;

EID: 77952085334     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.21405     Document Type: Article

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