A repurposing strategy identifies novel synergistic inhibitors of plasmodium falciparum heat shock protein 90

Journal of Medicinal Chemistry

Volumn 53, Issue 9, 2010, Pages 3552-3557

  Shahinas, Dea ^a   Liang, Michael ^a   Datti, Alessandro ^b   Pillai, Dylan R ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c PUBLIC HEALTH ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 PHOSPHONOPROPIONIC ACID; ACRISORCIN; ADENOSINE TRIPHOSPHATE; ARTEMISININ; CHLOROQUINE; HARMINE; HEAT SHOCK PROTEIN 90 INHIBITOR; MEFLOQUINE;

AMINO ACID SEQUENCE; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CELL ASSAY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; DRUG SPECIFICITY; HIGH THROUGHPUT SCREENING; IC 50; NONHUMAN; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN DOMAIN; ROBOTICS; VALIDATION STUDY;

ADENOSINE TRIPHOSPHATE; ANTIMALARIALS; BINDING SITES; BINDING, COMPETITIVE; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; HSP90 HEAT-SHOCK PROTEINS; HUMANS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; SMALL MOLECULE LIBRARIES; SUBSTRATE SPECIFICITY;

EID: 77952043055     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901796s     Document Type: Article

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