Periodontal regeneration using an anabolic peptide with two carriers in baboons

Journal of Periodontology

Volumn 81, Issue 5, 2010, Pages 727-736

  Yamashita, Motofumi ^a   Lazarov, Mirella ^b   Jones, Archie A ^c   Mealey, Brian L ^c   Mellonig, James T ^c   Cochran, David L ^c  

^a Funakoshi Research Institute of Clinical Periodontology   (Japan)

^b Acologix Inc   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Cementogenesis; Growth factors; Intercellular signaling peptides and proteins; Periodontal ligament; Pilot study

Indexed keywords

ANABOLIC AGENT; BETA-TRICALCIUM PHOSPHATE; BIOMATERIAL; CALCIUM PHOSPHATE; COLLAGEN; DRUG CARRIER; GLYCOPROTEIN; MEPE PROTEIN, HUMAN; PEPTIDE FRAGMENT; PHOSPHOPROTEIN; SCLEROPROTEIN;

ALVEOLAR BONE LOSS; ANIMAL; ARTICLE; BABOON; BIODEGRADABLE IMPLANT; BONE REGENERATION; CEMENTUM; COMPARATIVE STUDY; DRUG EFFECT; FEMALE; METHODOLOGY; PATHOLOGY; PERIODONTAL DISEASE; PERIODONTAL LIGAMENT; PERIODONTICS; PILOT STUDY; RANDOMIZATION; TIME; TOOTH DEVELOPMENT;

ABSORBABLE IMPLANTS; ALVEOLAR BONE LOSS; ANABOLIC AGENTS; ANIMALS; BIOCOMPATIBLE MATERIALS; BONE REGENERATION; CALCIUM PHOSPHATES; CEMENTOGENESIS; COLLAGEN; DENTAL CEMENTUM; DRUG CARRIERS; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GLYCOPROTEINS; GUIDED TISSUE REGENERATION, PERIODONTAL; PAPIO; PEPTIDE FRAGMENTS; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL DISEASES; PERIODONTAL LIGAMENT; PHOSPHOPROTEINS; PILOT PROJECTS; RANDOM ALLOCATION; TIME FACTORS;

EID: 77952039395     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2010.090224     Document Type: Article

References (40)

1. Bartold PM, Xiao Y, Lyngstaadas SP, Paine ML, Snead ML. Principles and applications of cell delivery systems for periodontal regeneration. Periodontol 2000 2006;41:123-135.
2. Cochran DL, Wozney JM. Biological mediators for periodontal regeneration. Periodontol 2000 1999;19:40-58.
3. Hovey LR, Jones AA, McGuire M, Mellonig JT, Schoolfield J, Cochran DL. Application of periodontal tissue engineering using enamel matrix derivative and a human fibroblast-derived dermal substitute to stimulate periodontal wound healing in Class III furcation defects. J Periodontol 2006;77:790-799.
4. Page RC. Periodontal therapy: Prospects for the future. J Periodontol 1993;64(Suppl. 8):744-753.
5. Mellonig JT. Bone allografts in periodontal therapy. Clin Orthop Relat Res 1996;(324):116-125.
6. Garraway R, Young WG, Daley T, Harbrow D, Bartold PM. An assessment of the osteoinductive potential of commercial demineralized freeze-dried bone in the murine thigh muscle implantation model. J Periodontol 1998;69:1325-1336.
7. Lynch SE, de Castilla GR, Williams RC, et al. The effects of short-term application of a combination of plateletderived and insulin-like growth factors on periodontal wound healing. J Periodontol 1991;62:458-467.
8. Rutherford RB, Ryan ME, Kennedy JE, Tucker MM, Charette MF. Platelet-derived growth factor and dexamethasone combined with a collagen matrix induce regeneration of the periodontium in monkeys. J Clin Periodontol 1993;20:537-544.
9. Urist MR. Bone: Formation by autoinduction. Science 1965;150:893-899.
10. Wang EA, Rosen V, D'Alessandro JS, et al. Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci USA 1990;87: 2220-2224.
11. Hammarström L. Enamel matrix, cementum development and regeneration. J Clin Periodontol 1997;24: 658-668.
12. Tonetti MS, Lang NP, Cortellini P, et al. Enamel matrix proteins in the regenerative therapy of deep intrabony defects. J Clin Periodontol 2002;29:317-325.
13. Camargo PM, Lekovic V, Weinlaender M, Vasilic N, Kenney EB, Madzarevic M. The effectiveness of enamel matrix proteins used in combination with bovine porous bone mineral in the treatment of intrabony defects in humans. J Clin Periodontol 2001;28:1016-1022. (Pubitemid 33757264)
14. BratthallG, Lindberg P, Havemose-PoulsenA, et al.Comparisonof ready-to-useEMDOGAIN-gel andEMDOGAIN in patients with chronic adult periodontitis. J Clin Periodontol 2001;28:923-929.
15. Mellonig JT. Enamel matrix derivative for periodontal reconstructive surgery: Technique and clinical and histologic case report. Int J Periodontics Restorative Dent 1999;19:8-19.
16. Rowe PS, de Zoysa PA, Dong R, et al. MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. Genomics 2000;67:54-68.
17. Argiro L, Desbarats M, Glorieux FH, Ecarot B. Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. Genomics 2001;74:342-351.
18. MacDougall M, Simmons D, Gu TT, Dong J. MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21. Connect Tissue Res 2002;43:320-330.
19. Fisher LW, Fedarko NS. Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins. Connect Tissue Res 2003;44(Suppl. 1):33-40.
20. Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R, Brown TA. Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes. J Biol Chem 2000;275:36172-36180.
21. Nagel DE, Khosla S, Sanyal A, Rosen DM, Kumagai Y, Riggs BL. A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors. J Cell Biochem 2004;93:1107-1114.
22. Hayashibara T, Hiraga T, Yi B, et al. A synthetic peptide fragment of human MEPE stimulates new bone formation in vitro and in vivo. J Bone Miner Res 2004;19:455-462.
23. Lazarov M, Fellman JD, Rosen DM, Denbesten P, Pameijer C. AC-100, Novel biological approach to promoting dentin formation in humans. J Dent Res 2006:85(Spec. Issue B): 0545.
24. Caton J, Mota L, Gandini L, Laskaris B. Non-human primate models for testing the efficacy and safety ofperiodontal regenerationprocedures. J Periodontol1994;65: 1143-1150.
25. Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans. Part III. J Periodontol 1989;60:683-693.
26. King GN, King N, Cruchley AT, Wozney JM, Hughes FJ. Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. J Dent Res 1997;76:1460-1470.
27. Wikesjö UM, Sorensen RG, Kinoshita A, Jian Li X, Wozney JM. Periodontal repair in dogs: Effect of recombinant human bone morphogenetic protein-12 (rhBMP-12) on regeneration of alveolar bone and periodontal attachment. J Clin Periodontol 2004;31:662-670. (Pubitemid 39092230)
28. King GN, Cochran DL. Factors that modulate the effects of bone morphogenetic protein-induced periodontal regeneration: A critical review. J Periodontol 2002;73:925-936.
29. Sigurdsson TJ, Nygaard L, Tatakis DN, et al. Periodontal repair in dogs: Evaluation of rhBMP-2 carriers. Int J Periodontics Restorative Dent 1996;16:524-537.
30. Winn SR, Uludag H, Hollinger JO. Carrier systems for bone morphogenetic proteins. Clin Orthop Relat Res 1999;(Suppl. 367):S95-S106.
31. Friess W, Uludag H, Foskett S, Biron R, Sargeant C. Characterization of absorbable collagen sponges as rhBMP-2 carriers. Int J Pharm 1999;187:91-99.
32. Cochran DL, Jones AA, Lilly LC, Fiorellini JP, Howell H. Evaluation of recombinant human bone morphogenetic protein-2 in oral applications including the use of endosseous implants: 3-year results of a pilot study in humans. J Periodontol 2000;71:1241-1257.
33. Barboza EP, Duarte ME, Geolás L, Sorensen RG, Riedel GE, Wikesjö UM. Ridge augmentation following implantation of recombinant human bone morphogenetic protein-2 in the dog. J Periodontol 2000;71:488-496.
34. Kim CS, Kim JI, Kim J, et al. Ectopic bone formation associated with recombinant human bone morphogenetic proteins-2 using absorbable collagen sponge and beta tricalcium phosphate as carriers. Biomaterials 2005;26:2501-2507.
35. Saffar JL, Colombier ML, Detienville R. Bone formation in tricalcium phosphate-filled periodontal intrabony lesions. Histological observations in humans. J Periodontol 1990;61:209-216.
36. Dragoo MR, Kaldahl WB. Clinical and histological evaluation of alloplasts and allografts in regenerative periodontal surgery in humans. Int J Periodontics Restorative Dent 1983;3(2):8-29.
37. Bowers GM, Vargo JW, Levy B, Emerson JR, Bergquist JJ. Histologic observations following the placement of tricalcium phosphate implants in human intrabony defects. J Periodontol 1986;57:286-287.
38. Urist MR, Lietze A, Dawson E. Beta-tricalcium phosphate delivery system for bone morphogenetic protein. Clin Orthop Relat Res 1984;(187):277-280.
39. Gao TJ, Lindholm TS, Kommonen B, et al. Enhanced healing of segmental tibial defects in sheep by a composite bone substitute composed of tricalcium phosphate cylinder, bone morphogenetic protein, and type IV collagen. J Biomed Mater Res 1996;32:505-512.
40. Wu CH, Hara K, Ozawa H. Enhanced osteoinduction by intramuscular grafting of BMP-beta-TCP compound pellets into murine models. Arch Histol Cytol 1992;55: 97-112.