Preparation and investigation of acetyl salicylic acid-caffeine complex for rectal administration

Pharmaceutical Development and Technology

Volumn 15, Issue 3, 2010, Pages 249-257

  Fouad, Ehab A ^a   El Badry, Mahmoud ^a   Alanazi, Fars K ^a   Arafah, Maha M ^b   Al Ashban, Riyadh ^c   Alsarra, Ibrahim A ^a,d  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c MINISTRY OF HEALTH   (Saudi Arabia)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Acetyl salicylic acid; Caffeine; Complex; Rectal administration; Suppository

Indexed keywords

ACETYLSALICYLIC ACID DERIVATIVE; ACETYLSALICYLIC ACID PLUS CAFFEINE; MACROGOL; UNCLASSIFIED DRUG; WITEPSOL H 15;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSION; DRUG FORMULATION; FREEZE DRYING; HISTOPATHOLOGY; HYDROPHILICITY; INFRARED SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RECTUM MUCOSA; SCANNING ELECTRON MICROSCOPY; SUPPOSITORY;

ADMINISTRATION, RECTAL; ANIMALS; ASPIRIN; CAFFEINE; CHEMISTRY, PHARMACEUTICAL; MALE; RATS; RATS, WISTAR; RECTUM; SUPPOSITORIES;

EID: 77952026578     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450903127350     Document Type: Article

References (39)

1. Ammar HO, Ghorab M, El-Nahhas SA, Kamel R. Design of a transdermal delivery system for aspirin as an antithrombotic drug. Int J Pharm 2006;327:81-88.
2. Baigent C, Sudlow C, Collins R, Peto R. Antithrombotic trialists' collaboration: Collaborative meta-analysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction and stroke in high risk patients. BMJ 2002;324:71-86.
3. Barnes CJ, Hamby-Mason RL, Hardman WE, Cameron IL, Speeg KV, Lee M. Effect of aspirin on prostaglandin E2 formation and transforming growth factor an expression in human rectal mucosa from individuals with a history of adenomatous polyps of the colon. Cancer Epidemiol Biomarkers Prev 1999;8:311-315.
4. Choudhury S, Mitra AK. Kinetics of aspirin hydrolysis and stabilization in presence of 2-hydroxypropyl-cyclodextrin. Pharm Res 1993;10:156-159.
5. Kishore AK, Nagwekar JB. Influence of temperature and hydrophobic group associated icebergs on the activation energy of drug decomposition and its implication in drug shelf-life prediction. Pharm Res 1990;7:730-735.
6. Satoh S, Horiguchi Y. Irritative effects of the aspirin suppository on the rectal membrane in rabbit. Arch Pract Pharm 1981;41:82-86.
7. Borg KO, Ekenved G, Elofsson R, Sjogren J, Solvell L. Bioavailability and tolerance studies on acetylsalicylic acid suppositories. Acta Pharm Suec 1975;12:491-498.
8. Lim RKS, Miller DG, Guzman F, Rodgers DW, Wang SK, Chao PY, Shih TY. Pain and analgesia evaluated by the intraperitoneal bradykinin-evoked pain method in man. Clin Pharmacol Ther 1967;8:521-542.
9. Hutton CW. Treatment, pain, and epidemiology of osteoarthritis. Current Opin Rhumatol 1990;2:765-769.
10. Aguejouf O, Belougne-Malfatti E, Doutremepuich F, Belon P, Doutremepuich C. Tromboembolic complications several days after a single-dose administration of aspirin. Tromb Res 1998;89:123-127.
11. Nehlig A, Daval JL, Debry G. Caffeine and the central nervous system: Mechanisms of action, biochemical, metabolic, and psychostimulant effects. Brain Res Rev 1992;17:139-170.
12. Evstigneev MP, Evstigneev VP, Hernandez-Santiago AA, Davies DB. Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution. Eur J Pharm Sci 2006;28:59-66.
13. Ulanowska K, Piosik J, Gwizdek-Wimniewska A, Wegrzyn G. Formation of stacking complexes between caffeine (1,2,3-trimethylxanthine) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine may attenuate biological effects of this Neurotoxin. Bioorg Chem 2005;33:402-413.
14. °. J Phys Chem 1974;78:1922-1928.
15. Fiebich BL, Lieb K, Hüll M, Aicher B, van Ryn J, Pairet M, Engelhardt G. Effects of caffeine and paracetamol alone or in combination with acetylsalicylic acid on prostaglandin e (2) synthesis in rat microglial cells. Neuropharmacology 2000;39:2205-2213.
16. Farcasa A, Jarrouxb N, Farcasc A, Harabagiua V, Gueganb P. Synthesis and characterization of furosemide complex in β-cyclodextrin. Digest J Nanomater Biostruct 2006;1:55-60.
17. Pralhad T, Rajendrakumar K. Study of freeze-dried quercetincyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis. J Pharm Biomed Anal 2004;34:333-339.
18. Uzunkaya G, Bergişadi N. In vitro drug liberation and kinetics of sustained release indomethacin suppository. Int J Pharm 2003;58:509-512.
19. Samy EM, Hassan MA, Tous SS, Rhodes CT. Improvement of availability of allopurinol from pharmaceutical dosage forms I-suppositories. Eur J Pharm Biopharm 2000;49:119-127.
20. Othman S, Muti H. The effect of bases and formulation on the release of indomethacin from suppositories. Drug Dev Ind Pharm 1986;12:1813-1831.
21. Peppas NA. Analysis of Fickian and non-Fickian drug release polymers. Pharm Acta Helv 1985;60:110-111.
22. Choi HG, Jung JH, Yong CS, Rhee JD, Lee MK, Han JH, Park KM, Kim CK. Formulation and in vivo evaluation of omeprazole buccal adhesive tablet. J Control Release 2000;68:405-412.
23. Yong CS, Oh Y, Kim Y, Kim JO, Yoo B, Jong-Dal RJ, Lee KC, Dae-Duk KD, Park Y, Kim C, Choi H. Physicochemical characterization and in vivo evaluation of poloxamer-based solid suppository containing diclofenac sodium in rats. Int J Pharm 2005;301:54-61.
24. Hemmati H, Rezvani A, Djahanguiri B. Prevention of aspirin induced ulceration in rats with alphamethyldopa and disulfiram. Pharmacology 1974;9:374-378.
25. Choi M, Chung S, Shim C. Rectal absorption of omeprazole from suppository in humans. J Pharm Sci 1996;40:893-994.
26. Jambhekar S, Casella R, Maher T. The physicochemical characteristics and bioavailability of indomethacin from beta-cyclodextrin, hydroxyethyl-beta- cyclodextrin, and hydroxypropyl-beta-cyclodextrin complexes. Int J Pharm 2004;270:149-166.
27. Ermi D, Tarlmcl N. Ketoprofen sustained-release suppositories containing hydroxypropylmethylcellulose phthalate in polyethylene glycol bases. Int J Pharm 1995;11:65-71.
28. Watanabe K, Yakou S, Takayama K, Machida Y, Isowa K. Investigation on rectal absorption of indomethacin from sustained-release hydrogel suppositories prepared with water soluble dietary fibers, xanthan gum and locust bean gum. Biol Pharm Bull 1993;16:391-494.
29. Miyazaki S, Nakamura T, Yokouchi C, Tanaka M. Effect of pluronic gels on the rectal absorption of indomethacin in rabbits. Chem Pharm Bull 1987;35:1243-1248.
30. Møller PL, Pærregaard A, Gad M, Kristensen N, Claesson MH. Colitic scid mice fed Lactobacillus spp. show an ameliorated gut histopathology and an altered cytokine profile by local T cells. Inflamm Bowel Dis 2005;11:814-819.
31. Wulff M, Alden M. Solid state studies of drug-cyclodextrin inclusion complexes in PEG 6000 prepared by a new method. Eur J Pharm Sci 1999;8:269-281.
32. Abdala AA, Tonelli AE, Khan SA. Modulation of hydrophobic interactions in associative polymers using inclusion compounds and surfactants. Macromolecules 2003;36:7833-7841.
33. Young CS, Oh Y, Kim Y, Kim JO, Yoo B, Rhee J, Lee KC, Kim D, Park Y, Kim C, Choi H. Physicochemical characterization and in vivo evaluation of poloxamer-based solid suppository containing diclofenac sodium in rats. Int J Pharm 2005;11:65-71.
34. Jainu M, Mohan KV, Devi CS. Gastroprotective effect of Cissus quadrangularis extract in rats with experimentally induced ulcer. Indian J Med Res 2006;123:799-806 (Pubitemid 44269947)
35. Wallace JL, Zamuner SR, McKnight W, Dicay M, Mencarelli A, del Soldato P, Fiorucci S. Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation. Am J Physiol Gastrointest Liver Physiol 2004;286: G76-81.
36. Arima H, Kondo T, Irie T, Uekama K. Enhanced rectal absorption and reduced local irritation of the anti-inflammatory drug ethyl 4-biphenylylacetate in rats by complexation with water-soluble β-cyclodextrin derivatives and formulation as oleaginous suppository. J Pharm Sci 1992;81:1119-1125.
37. Piosik J, Zdunek M, Kapuscinski J. The modulation by xanthine of the DNA-damaging effect of polycyclic aromatic agents Part II. Te stacking complexes of caffeine with doxorubicin and mitoxantrone. Biochem Pharmacol 2002;63:635-646. (Pubitemid 34457697)
38. Dueñas V, Sanchez S, Planas E, Poveda R. Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: Prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat. Eur J Pain 2008;12:157-163.
39. Koyama R, Kataoka H, Tanaka Y, Nakatsugi S, Furukawa M. Effect of caffeine on ibuprofen-induced gastric mucosal damage in rats. J Pharm Pharmacol 1999;51:817-824.