Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution

European Journal of Pharmaceutical Sciences

Volumn 28, Issue 1-2, 2006, Pages 59-66

  Evstigneev, M P ^a   Evstigneev, V P ^a   Santiago, A A Hernandez ^b   Davies, D B ^c  

^a SEVASTOPOL STATE UNIVERSITY   (Russian Federation)

^b BENEMÉRITA UNIVERSIDAD AUTÓNOMA DE PUEBLA   (Mexico)

^c UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Caffeine; Hetero association; Nicotinamide; Solubility; Vitamin B2

Indexed keywords

CAFFEINE; CYANOCOBALAMIN; FLAVINE MONONUCLEOTIDE; NICOTINAMIDE;

AQUEOUS SOLUTION; ARTICLE; DRUG EFFECT; DRUG MIXTURE; DRUG SOLUBILITY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SOLUBILIZATION;

ALGORITHMS; CAFFEINE; CHEMISTRY, PHARMACEUTICAL; DRUG COMBINATIONS; MODELS, MOLECULAR; NIACINAMIDE; RIBOFLAVIN; SOLUBILITY; SOLUTIONS; VITAMINS; WATER;

EID: 33644924075     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2005.12.010     Document Type: Article

References (19)

1. R.E. Coffman, and D.O. Kildsig Effect of nicotinamide and urea on the solubility of riboflavin in various solvents J. Pharm. Sci. 85 1996 951 954
2. R.E. Coffman, and D.O. Kildsig Hydrotropic solubilization - mechanistic studies Pharm. Res. 13 1996 1460 1463
3. S. Datta, C. Mukhopadhyay, and S.K. Bose Molecular complex formation between riboflavin and salicylate in an aqueous medium Bull. Chem. Soc. Jpn. 76 2003 1729 1734
4. D.B. Davies, D.A. Veselkov, L.N. Djimant, and A.N. Veselkov Hetero-association of caffeine and aromatic drugs and their competitive binding with a DNA oligomer Eur. Biophys. J. 30 2001 354 366
5. 1H NMR study of the association of caffeine with flavine mononucleotide in aqueous solutions Russ. J. Phys. Chem. 79 2005 573 578
6. M.P. Evstigneev, D.B. Davies, and A.N. Veselkov Stochastic models (cooperative and non-cooperative) for NMR analysis of the hetero-association of aromatic molecules in aqueous solution Chem. Phys. 321 2006 25 33
7. M. Fawzi, E. Davison, and M. Tute Rationalization of drug complexation in aqueous solution by use of Huckel frontier molecular orbital calculations J. Pharm. Sci. 69 1980 104 106
8. M.A. Hussain, R.C. DiLuccio, and M.B. Maurin Complexation of moricizine with nicotinamide and evaluation of the complexation constants by various methods J. Pharm. Sci. 82 1993 77 79
9. N.K. Jain, A.K. Singhai, and S. Jain Hydrotropic solubilization of ketoprofen Pharmazie 51 1996 236 239
10. R.M. Khalil Interaction of ibuprofen and indomethacin with caffeine Pharmazie 51 1996 970 973
11. R.W. Larsen, R. Jasuja, R.K. Hetzler, P.T. Muraoka, V.G. Andrada, and D.M. Jameson Spectroscopic and molecular modelling studies of caffeine complexes with DNA intercalators Biophys. J. 70 1996 443 452
12. L.-Y. Lim, and M.-L. Go Caffeine and nicotinamide enhances the aqueous solubility of the antimalarial agent halofantrine Eur. J. Pharm. Sci. 10 2000 17 28
13. A. Rasool, A. Hussain, and L.W. Dittern Solubility enhancement of some water-insoluble drugs in the presence of nicotinamide and related compounds J. Pharm. Sci. 80 1991 387 393
14. E. Redenti, P. Ventura, G. Fronza, A. Selva, S. Rivara, P.V. Plazzi, and M. Mor Experimental and theoretical analysis of the interaction of (±)-cis-ketoconazole with β-cyclodextrin in the presence of (+)-l-tartaric acid J. Pharm. Sci. 88 1999 599 607
15. L. Ribeiro, R.A. Carvalho, D.C. Ferreira, and F.J.B. Veiga Multicomponent complex formation between vinpocetine, cyclodextrins, tartaric acid and water-soluble polymers monitored by NMR and solubility studies Eur. J. Pharm. Sci. 24 2005 1 13
16. 1H NMR analysis of the self-association of riboflavin-mononucleotide and its complexation with nicotinamide in an aqueous solution Russ. J. Phys. Chem. 76 2002 1350 1356
17. 1H NMR data Russ. J. Phys. Chem. 75 2001 2006 2010
18. A.N. Veselkov, M.P. Evstigneev, D.A. Veselkov, and D.B. Davies A generalized NMR-derived statistical-thermodynamical model of hetero-association of aromatic molecules in aqueous solution J. Chem. Phys. 115 2001 2252 2266
19. 1H NMR structural and thermodynamical analysis of the hetero-association of daunomycin and novatrone in aqueous solution J. Mol. Struct. 701 2004 31 37