-
1
-
-
32944454902
-
Genetic variation in the gene for P-glycoprotein: Implications for the clinical efficacy of morphine
-
International Association for the Study of Pain. Program No. 1073-P515;
-
Baar C, Laugsand E, Rakvag TN, Klepstad P, Dale O, Kaasa S, et al. Genetic variation in the gene for P-glycoprotein: implications for the clinical efficacy of morphine. Abstract 11th World Congress of Pain. International Association for the Study of Pain. Program No. 1073-P515; 2005.
-
(2005)
Abstract 11th World Congress of Pain
-
-
Baar, C.1
Laugsand, E.2
Rakvag, T.N.3
Klepstad, P.4
Dale, O.5
Kaasa, S.6
-
2
-
-
25844495344
-
COMT Val108/158Met genotype affects the mu-opioid receptor system in the human brain: Evidence from ligand-binding, G-protein activation and preproenkephalin mRNA expression
-
A. Berthele, S. Platzer, B. Jochim, H. Boecker, A. Buettner, and B. Conrad COMT Val108/158Met genotype affects the mu-opioid receptor system in the human brain: evidence from ligand-binding, G-protein activation and preproenkephalin mRNA expression Neuroimage 28 2005 185 193
-
(2005)
Neuroimage
, vol.28
, pp. 185-193
-
-
Berthele, A.1
Platzer, S.2
Jochim, B.3
Boecker, H.4
Buettner, A.5
Conrad, B.6
-
3
-
-
2042527666
-
Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor
-
A. Beyer, T. Koch, H. Schroder, S. Schulz, and V. Höllt Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor J Neurochem 89 2004 553 560
-
(2004)
J Neurochem
, vol.89
, pp. 553-560
-
-
Beyer, A.1
Koch, T.2
Schroder, H.3
Schulz, S.4
Höllt, V.5
-
4
-
-
13144261678
-
Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction
-
C. Bond, K.S. LaForge, M. Tian, D. Melia, S. Zhang, and L. Borg Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction Proc Natl Acad Sci USA 95 1998 9608 9613
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9608-9613
-
-
Bond, C.1
Laforge, K.S.2
Tian, M.3
Melia, D.4
Zhang, S.5
Borg, L.6
-
5
-
-
14944377768
-
Variability in alfentanil analgesia maybe attributed to polymorphism in the mu-opiod receptor gene
-
Y. Caraco, Y. Maroz, and E. Davidson Variability in alfentanil analgesia maybe attributed to polymorphism in the mu-opiod receptor gene Clin Pharmacol Ther 69 2001 p63
-
(2001)
Clin Pharmacol Ther
, vol.69
, pp. 63
-
-
Caraco, Y.1
Maroz, Y.2
Davidson, E.3
-
6
-
-
0030432381
-
Pharmacogenetic determination of the effects of codeine and prediction of drug interactions
-
Y. Caraco, J. Sheller, and A.J. Wood Pharmacogenetic determination of the effects of codeine and prediction of drug interactions J Pharmacol Exp Ther 278 1996 1165 1174
-
(1996)
J Pharmacol Exp Ther
, vol.278
, pp. 1165-1174
-
-
Caraco, Y.1
Sheller, J.2
Wood, A.J.3
-
8
-
-
0029064096
-
Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis
-
M.L. Dahl, I. Johansson, L. Bertilsson, M. Ingelman-Sundberg, and F. Sjoqvist Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis J Pharmacol Exp Ther 274 1995 516 520
-
(1995)
J Pharmacol Exp Ther
, vol.274
, pp. 516-520
-
-
Dahl, M.L.1
Johansson, I.2
Bertilsson, L.3
Ingelman-Sundberg, M.4
Sjoqvist, F.5
-
9
-
-
0031405796
-
Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine
-
P. Dalen, C. Frengell, M.L. Dahl, and F. Sjoqvist Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine Ther Drug Monit 19 1997 543 544
-
(1997)
Ther Drug Monit
, vol.19
, pp. 543-544
-
-
Dalen, P.1
Frengell, C.2
Dahl, M.L.3
Sjoqvist, F.4
-
10
-
-
0031746749
-
Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation
-
K. Eckhardt, S. Li, S. Ammon, G. Schanzle, G. Mikus, and M. Eichelbaum Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation Pain 76 1998 27 33
-
(1998)
Pain
, vol.76
, pp. 27-33
-
-
Eckhardt, K.1
Li, S.2
Ammon, S.3
Schanzle, G.4
Mikus, G.5
Eichelbaum, M.6
-
11
-
-
11144221180
-
Codeine intoxication associated with ultrarapid CYP2D6 metabolism
-
Y. Gasche, Y. Daali, M. Fathi, A. Chiappe, S. Cottini, and P. Dayer Codeine intoxication associated with ultrarapid CYP2D6 metabolism N Engl J Med 351 2004 2827 2831
-
(2004)
N Engl J Med
, vol.351
, pp. 2827-2831
-
-
Gasche, Y.1
Daali, Y.2
Fathi, M.3
Chiappe, A.4
Cottini, S.5
Dayer, P.6
-
12
-
-
0034724324
-
Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
-
S. Hoffmeyer, O. Burk, O. von Richter, H.P. Arnold, J. Brockmöller, and A. Johne Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo Proc Natl Acad Sci USA 97 2000 3473 3478
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3473-3478
-
-
Hoffmeyer, S.1
Burk, O.2
Von Richter, O.3
Arnold, H.P.4
Brockmöller, J.5
Johne, A.6
-
13
-
-
8544257029
-
The 118 a > G polymorphism in the human micro-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease
-
P. Klepstad, T.T. Rakvag, S. Kaasa, M. Holthe, O. Dale, and P.C. Borchgrevink The 118 A > G polymorphism in the human micro-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease Acta Anaesthesiol Scand 48 2004 1232 1239
-
(2004)
Acta Anaesthesiol Scand
, vol.48
, pp. 1232-1239
-
-
Klepstad, P.1
Rakvag, T.T.2
Kaasa, S.3
Holthe, M.4
Dale, O.5
Borchgrevink, P.C.6
-
14
-
-
0036152705
-
The polymorphism A118G of the human mu-opioid receptor gene decreases the clinical activity of morphine-6-glucuronide but not that of morphine
-
J. Lötsch, C. Skarke, S. Grösch, J. Darimont, H. Schmidt, and G. Geisslinger The polymorphism A118G of the human mu-opioid receptor gene decreases the clinical activity of morphine-6-glucuronide but not that of morphine Pharmacogenetics 12 2002 3 9
-
(2002)
Pharmacogenetics
, vol.12
, pp. 3-9
-
-
Lötsch, J.1
Skarke, C.2
Grösch, S.3
Darimont, J.4
Schmidt, H.5
Geisslinger, G.6
-
15
-
-
10044297116
-
Genetic predictors of the clinical response to opioid analgesics: Clinical utility and future perspectives
-
J. Lötsch, C. Skarke, J. Liefhold, and G. Geisslinger Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives Clin Pharmacokinet 43 2004 983 1013
-
(2004)
Clin Pharmacokinet
, vol.43
, pp. 983-1013
-
-
Lötsch, J.1
Skarke, C.2
Liefhold, J.3
Geisslinger, G.4
-
16
-
-
30344470208
-
Evidence for morphine-independent central nervous opioid effects after administration of codeine: Contribution of other codeine metabolites
-
J. Lötsch, C. Skarke, H. Schmidt, M. Rohrbacher, U. Hofmann, and M. Schwab Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites Clin Pharmacol Ther 79 2006 35 48
-
(2006)
Clin Pharmacol Ther
, vol.79
, pp. 35-48
-
-
Lötsch, J.1
Skarke, C.2
Schmidt, H.3
Rohrbacher, M.4
Hofmann, U.5
Schwab, M.6
-
17
-
-
30344473318
-
Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action
-
J. Lötsch, C. Skarke, J. Wieting, B. Oertel, H. Schmidt, and J. Brockmöller Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action Clin Pharmacol Ther 79 2006 72 89
-
(2006)
Clin Pharmacol Ther
, vol.79
, pp. 72-89
-
-
Lötsch, J.1
Skarke, C.2
Wieting, J.3
Oertel, B.4
Schmidt, H.5
Brockmöller, J.6
-
18
-
-
0036792226
-
Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?
-
J. Lötsch, M. Zimmermann, J. Darimont, C. Marx, R. Dudziak, and C. Skarke Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity? Anesthesiology 97 2002 814 819
-
(2002)
Anesthesiology
, vol.97
, pp. 814-819
-
-
Lötsch, J.1
Zimmermann, M.2
Darimont, J.3
Marx, C.4
Dudziak, R.5
Skarke, C.6
-
19
-
-
22244492308
-
Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans
-
J.S. Mogil, J. Ritchie, S.B. Smith, K. Strasburg, L. Kaplan, and M.R. Wallace Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans J Med Genet 42 2005 583 587
-
(2005)
J Med Genet
, vol.42
, pp. 583-587
-
-
Mogil, J.S.1
Ritchie, J.2
Smith, S.B.3
Strasburg, K.4
Kaplan, L.5
Wallace, M.R.6
-
20
-
-
0344341625
-
The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans
-
J.S. Mogil, S.G. Wilson, E.J. Chesler, A.L. Rankin, K.V. Nemmani, and W.R. Lariviere The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans Proc Natl Acad Sci USA 100 2003 4867 4872
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4867-4872
-
-
Mogil, J.S.1
Wilson, S.G.2
Chesler, E.J.3
Rankin, A.L.4
Nemmani, K.V.5
Lariviere, W.R.6
-
22
-
-
20444451123
-
The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients
-
T.T. Rakvag, P. Klepstad, C. Baar, T.M. Kvam, O. Dale, and S. Kaasa The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients Pain 116 2005 73 78
-
(2005)
Pain
, vol.116
, pp. 73-78
-
-
Rakvag, T.T.1
Klepstad, P.2
Baar, C.3
Kvam, T.M.4
Dale, O.5
Kaasa, S.6
-
23
-
-
0347363517
-
Pharmacokinetic-pharmacodynamic modeling of morphine-6-glucuronide- induced analgesia in healthy volunteers: Absence of sex differences
-
R. Romberg, E. Olofsen, E. Sarton, J. den Hartigh, P.E. Taschner, and A. Dahan Pharmacokinetic-pharmacodynamic modeling of morphine-6-glucuronide-induced analgesia in healthy volunteers: absence of sex differences Anesthesiology 100 2004 120 133
-
(2004)
Anesthesiology
, vol.100
, pp. 120-133
-
-
Romberg, R.1
Olofsen, E.2
Sarton, E.3
Den Hartigh, J.4
Taschner, P.E.5
Dahan, A.6
-
24
-
-
14644441712
-
Polymorphism of mu-opioid receptor gene (OPRM1:c.118A > G) does not protect against opioid-induced respiratory depression despite reduced analgesic response
-
R.R. Romberg, E. Olofsen, H. Bijl, P.E. Taschner, L.J. Teppema, and E.Y. Sarton Polymorphism of mu-opioid receptor gene (OPRM1:c.118A > G) does not protect against opioid-induced respiratory depression despite reduced analgesic response Anesthesiology 102 2005 522 530
-
(2005)
Anesthesiology
, vol.102
, pp. 522-530
-
-
Romberg, R.R.1
Olofsen, E.2
Bijl, H.3
Taschner, P.E.4
Teppema, L.J.5
Sarton, E.Y.6
-
25
-
-
0031038038
-
Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
-
C. Sachse, J. Brockmöller, S. Bauer, and I. Roots Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences Am J Hum Genet 60 1997 284 295
-
(1997)
Am J Hum Genet
, vol.60
, pp. 284-295
-
-
Sachse, C.1
Brockmöller, J.2
Bauer, S.3
Roots, I.4
-
26
-
-
0025649038
-
Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine
-
S.H. Sindrup, K. Brosen, P. Bjerring, L. Arendt-Nielsen, U. Larsen, and H.R. Angelo Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine Clin Pharmacol Ther 48 1990 686 693
-
(1990)
Clin Pharmacol Ther
, vol.48
, pp. 686-693
-
-
Sindrup, S.H.1
Brosen, K.2
Bjerring, P.3
Arendt-Nielsen, L.4
Larsen, U.5
Angelo, H.R.6
-
27
-
-
0037261291
-
Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers
-
C. Skarke, J. Darimont, H. Schmidt, G. Geisslinger, and J. Lötsch Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers Clin Pharmacol Ther 73 2003 107 121
-
(2003)
Clin Pharmacol Ther
, vol.73
, pp. 107-121
-
-
Skarke, C.1
Darimont, J.2
Schmidt, H.3
Geisslinger, G.4
Lötsch, J.5
-
28
-
-
0141626841
-
Impact of CYP2D6 genotype on postoperative tramadol analgesia
-
U.M. Stamer, K. Lehnen, F. Hothker, B. Bayerer, S. Wolf, and A. Hoeft Impact of CYP2D6 genotype on postoperative tramadol analgesia Pain 105 2003 231 238
-
(2003)
Pain
, vol.105
, pp. 231-238
-
-
Stamer, U.M.1
Lehnen, K.2
Hothker, F.3
Bayerer, B.4
Wolf, S.5
Hoeft, A.6
-
29
-
-
25444491710
-
Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G
-
Y. Zhang, D. Wang, A.D. Johnson, A.C. Papp, and W. Sadee Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G J Biol Chem 2005
-
(2005)
J Biol Chem
-
-
Zhang, Y.1
Wang, D.2
Johnson, A.D.3
Papp, A.C.4
Sadee, W.5
-
30
-
-
0037458277
-
COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor
-
J.K. Zubieta, M.M. Heitzeg, Y.R. Smith, J.A. Bueller, K. Xu, and Y. Xu COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor Science 299 2003 1240 1243
-
(2003)
Science
, vol.299
, pp. 1240-1243
-
-
Zubieta, J.K.1
Heitzeg, M.M.2
Smith, Y.R.3
Bueller, J.A.4
Xu, K.5
Xu, Y.6
|