Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype

Pharmacogenomics

Volumn 9, Issue 11, 2008, Pages 1605-1616

  Hayashida, Masakazu ^a   Nagashima, Makoto ^a   Satoh, Yasuo ^a   Katoh, Ryoji ^a   Tagami, Megumi ^a   Ide, Soichiro ^a   Kasai, Shinya ^a   Nishizawa, Daisuke ^a   Ogai, Yasukazu ^a   Hasegawa, Junko ^a   Komatsu, Hiroshi ^a   Sora, Ichiro ^a   Fukuda, Kenichi ^a   Koga, Hisashi ^a   Hanaoka, Kazuo ^a   Ikeda, Kazutaka ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

opioid receptor; analgesic; association study; haplotype analysis; OPRM1 gene; pain; SNP

Indexed keywords

BUPRENORPHINE; DICLOFENAC; DNA; FENTANYL; FLURBIPROFEN; MORPHINE; MU OPIATE RECEPTOR; PENTAZOCINE; PETHIDINE; PROTEIN OPRM1; UNCLASSIFIED DRUG; ANALGESIC AGENT; NARCOTIC ANALGESIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OPRM1 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ABDOMINAL SURGERY; ADULT; AGED; ANALGESIA; ARTICLE; BILE DUCT CANCER; COLON CANCER; COLON RESECTION; CONTINUOUS INFUSION; EPIDURAL ANESTHESIA; EXON; FEMALE; GASTRECTOMY; GENE LINKAGE DISEQUILIBRIUM; GENERAL ANESTHESIA; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INTRON; JAPANESE; LIVER CANCER; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PANCREAS CANCER; PANCREATICODUODENECTOMY; POSTOPERATIVE PAIN; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH CANCER; ABDOMEN; CLINICAL TRIAL; DRUG COMBINATION; GENETICS; MIDDLE AGED; TREATMENT OUTCOME;

ABDOMEN; ADULT; AGED; AGED, 80 AND OVER; ANALGESICS; ANALGESICS, OPIOID; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DIGESTIVE SYSTEM SURGICAL PROCEDURES; DRUG THERAPY, COMBINATION; FEMALE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; PAIN, POSTOPERATIVE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OPIOID, MU; TREATMENT OUTCOME;

EID: 61549091551     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/14622416.9.11.1605     Document Type: Article

References (49)

1. Cancer pain relief and palliative care: report of a WHO Expert Committee. World Health Organ. Tech. Rep. Ser. 804, 1-75 (1990).
2. Ikeda K, Ide S, Han W, Hayashida M, Uhl GR, Sora I: How individual sensitivity to opiates can be predicted by gene analyses. Trends Pharmacol. Sci. 26, 311-317 (2005). (Pubitemid 40733524)
3. Loh HH, Liu HC, Cavalli A, Yang W, Chen YF, Wei LN: opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality. Brain Res. Mol. Brain Res. 54, 321-326 (1998). (Pubitemid 28171797)
4. Sora I, Takahashi N, Funada M, et al. Opiate receptor knockout mice define receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc. Natl Acad. Sci. USA 94, 1544-1549 (1997). (Pubitemid 27087888)
5. Sora I, Elmer G, Funada M, et al. opiate receptor gene dose effects on different morphine actions: evidence for differential in vivoreceptor reserve. Neuropsychopharmacology 25, 41-54 (2001). (Pubitemid 32493821)
6. Ide S, Minami M, Satoh M, Uhl GR, Sora I, Ikeda K: Buprenorphine antinociception is abolished, but naloxone-sensitive reward is retained, in α-opioid receptor knockout mice. Neuropsychopharmacology 29, 1656-1663 (2004). (Pubitemid 39150107)
7. Matthes HW, Maldonado R, Simonin F, et al. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the β-opioid-receptor gene. Nature 383, 819-823 (1996). (Pubitemid 26372664)
8. Han W, Ide S, Sora I, Yamamoto H, Ikeda K: A possible genetic mechanism underlying individual and interstrain differences in opioid actions: focus on the α opioid receptor gene. Ann. NY Acad. Sci. 1025, 370-375 (2004). (Pubitemid 39643883)
9. Ikeda K, Ichikawa T, Kobayashi T, Kumanishi T, Oike S, Yano R: Unique behavioural phenotypes of recombinantinbred CXBK mice: partial deficiency of sensitivity to β-and β-agonists. Neurosci. Res. 34, 149-155 (1999). (Pubitemid 29421719)
10. Zhang Y, Wang D, Johnson AD, Papp AC, Sadee W: Allelic expression imbalance of human α opioid receptor (OPRM1) caused by variant A118G. J. Biol. Chem. 280, 32618-32624 (2005). (Pubitemid 41368304)
11. Ide S, Kobayashi H, Tanaka K, et al. Gene polymorphisms of the α opioid receptor in methamphetamine abusers. Ann. NY Acad. Sci. 1025, 316-324 (2004). (Pubitemid 39643877)
12. Ide S, Kobayashi H, Ujike h, et al. Linkage disequilibrium and association with methamphetamine dependence/psychosis of opioid receptor gene polymorphisms. Pharmacogenomics J. 6, 179-188 (2006). (Pubitemid 43811569)
13. Bond C, LaForge KS, Tian M, et al. Single-nucleotide polymorphism in the human α opioid receptor gene alters b-endorphin binding and activity: possible implications for opiate addiction. Proc. Natl. Acad. Sci. USA 95, 9608-9613 (1998). (Pubitemid 28506279)
14. Nishizawa D, Han W, Hasegawa J, et al. Association of α-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population. Neuropsychobiology 53, 137-141 (2006). (Pubitemid 43854172)
15. Kim SG, Kim CM, Kang DH, et al. Association of functional opioid receptor genotypes with alcohol dependence in Koreans. Alcohol. Clin. Exp. Res. 28, 986-990 (2004). (Pubitemid 38955195)
16. Bart G, Heilig M, LaForge KS, et al. Substantial attributable risk related to a functional α-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Mol. Psychiatry 9, 547-549 (2004). (Pubitemid 38850433)
17. Bart G, Kreek MJ, Ott J, et al. Increased attributable risk related to a functional α-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology 30, 417-422 (2005). (Pubitemid 40129493)
18. Shi J, Hui L, Xu Y, Wang F, Huang W, Hu G: Sequence variations in the α-opioid receptor gene (OPRM1) associated with human addiction to heroin. Hum. Mutat. 19, 459-460 (2002).
19. Chou WY, Yang LC, Lu HF, et al. Association of α-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty. Acta Anaesthesiol. Scand. 50, 787-792 (2006). (Pubitemid 44034227)
20. Chou WY, Wang CH, Liu PH, Liu CC, Tseng CC, Jawan B: Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy. Anesthesiology 105, 334-337 (2006). (Pubitemid 44148178)
21. Klepstad P, Rakvag TT, Kaasa S, et al. The 118 AG polymorphism in the human α-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol. Scand. 48, 1232-1239 (2004). (Pubitemid 39490855)
22. Coulbault L, Beaussier M, Verstuyft C, et al. Environmental and genetic factors associated with morphine response in the postoperative period. Clin. Pharmacol. Ther. 79, 316-324 (2006).
23. Janicki PK, Schuler G, Francis D, et al. A genetic association study of the functional A118G polymorphism of the human α-opioid receptor gene in patients with acute and chronic pain. Anesth. Analg. 103, 1011-1017 (2006). (Pubitemid 44576714)
24. Hayashida M, Imamura S: Current status of portable disposable infusers. Masui 55, 1118-1127 (2006). (Pubitemid 44433919)
25. Loper KA, Ready LB, Downey M, et al. Epidural and intravenous fentanyl infusions are clinically equivalent after knee surgery. Anesth. Analg. 70, 72-75 (1990). (Pubitemid 20039982)
26. Guinard JP, Carpenter RL, Chassot PG: Epidural and intravenous fentanyl produce equivalent effects during major surgery. Anesthesiology 82, 377-382 (1995).
27. Pathak KS, Brown RH, Nash Jr CL, Cascorbi HF: Continuous opioid infusion for scoliosis fusion surgery. Anesth. Analg. 62, 841-845 (1983).
28. Klinck JR, Lindop MJ: Epidural morphine in the elderly: a controlled trial after upper abdominal surgery. Anaesthesia 37, 907-912 (1982). (Pubitemid 12019488)
29. Hoskin PJ, Hanks GW: Opioid agonistantagonist drugs in acute and chronic pain states. Drugs 41, 326-344 (1991).
30. Bahar M, Rosen M, Vickers MD: Self-administered nalbuphine, morphine and pethidine: comparison, by intravenous route, following cholecystectomy. Anaesthesia 40, 529-532 (1985). (Pubitemid 15034843)
31. Buchanan WW, Kassam YB: European experience with flurbiprofen: a new analgesic/anti-inflammatory agent. Am. J. Med. 80, 145-152 (1986). (Pubitemid 16044390)
32. Sunshine S, Olson NZ: Nonnarcotic analgesics. In: Textbook of Pain. Wall PD, Melzack R (Eds), Churchill Livingstone, Edinburgh, UK, 923-942 (1994).
33. Basar H, Yilmaz E, Ozcan S, et al. Four analgesic techniques for shockwave lithotripsy: eutectic mixture local anesthetic is a good alternative. J. Endourol. 17, 3-6 (2003). (Pubitemid 36286472)
34. Ozcan S, Yilmaz E, Buyukkocak U, Basar H, Apan A: Comparison of three analgesics for extracorporeal shock wave lithotripsy. Scand. J. Urol. Nephrol. 36, 281-285 (2002). (Pubitemid 34921094)
35. Zhang K, Jin L: HaploBlockFinder: haplotype block analyses. Bioinformatics 19, 1300-1301 (2003). (Pubitemid 36850228)
36. Imai K, Ogai Y, Nishizawa D, Kasai S, Ikeda K, Koga H: A novel SNP detection technique utilizing a multiple primer extension (MPEX) on a phospholipid polymer-coated surface. Mol. Biosyst. 3, 547-553 (2007). (Pubitemid 47118864)
37. Li J, Ji L: Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity 95, 221-227 (2005). (Pubitemid 43093236)
38. Nyholt DR: A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am. J. Hum. Genet. 74, 765-769 (2004).
39. Faul F, Erdfelder E, Lang AG, Buchner A: G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav. Res. Methods 39, 175-191 (2007).
40. Zhao LP, Li SS, Khalid N: A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case-control studies. Am. J. Hum. Genet. 72, 1231-1250 (2003). (Pubitemid 36530010)
41. Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Statist. Soc. Ser. B 57, 289-300 (1995).
42. Landau R, Kern C, Columb MO, Smiley RM, Blouin JL: Genetic variability of the α-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women. Pain 139(1), 5-14 (2008).
43. Fillingim RB: Sex, gender, and pain: women and men really are different. Curr. Rev. Pain 4, 24-30 (2000).
44. Tan EC, Tan CH, Karupathivan U, Yap EP: α Opioid receptor gene polymorphisms and heroin dependence in Asian populations. Neuroreport 14, 569-572 (2003). (Pubitemid 36528992)
45. Kroslak T, LaForge KS, Gianotti RJ, Ho A, Nielsen DA, Kreek MJ: The single nucleotide polymorphism A118G alters functional properties of the human α opioid receptor. J. Neurochem. 103, 77-87 (2007). (Pubitemid 47404205)
46. Beyer A, Koch T, Schroder H, Schulz S, Hollt V: Effect of the A118G polymorphism on binding affinity, potency and agonistmediated endocytosis, desensitization, and resensitization of the human α-opioid receptor. J. Neurochem. 89, 553-560 (2004). (Pubitemid 38534141)
47. HaploBlockFinder http://cgi.uc.edu/cgi-bin/kzhang/haploBlockFinder.cgi
48. SNPSpD Web interface program http://genepi.qimr.edu.au/general/daleN/ SNPSpD/
49. The R Foundation for Statistical Computing www.r-project.org/