Role for the proapoptotic factor BIM in mediating imatinib-induced apoptosis in a c-KIT-dependent gastrointestinal stromal tumor cell line

Journal of Biological Chemistry

Volumn 285, Issue 19, 2010, Pages 14109-14114

  Gordon, Peter M ^a,b,c,d   Fisher, David E ^c,d  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL PATHWAY; GASTROINTESTINAL STROMAL TUMORS; IMATINIB; INDUCED APOPTOSIS; MODEL SYSTEM; PRO-APOPTOTIC FACTORS; RECEPTOR TYROSINE KINASE; RNA INTERFERENCE; SELECTIVE INHIBITORS; UP-REGULATION;

AMINO ACIDS; CELL CULTURE; CHEMOTHERAPY; PHOSPHATASES; RNA; TRANSCRIPTION; TRANSCRIPTION FACTORS; TUMORS;

CELL DEATH;

BIM PROTEIN; IMATINIB; MESSENGER RNA; STEM CELL FACTOR RECEPTOR; TRANSCRIPTION FACTOR FKHRL1;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG TARGETING; GASTROINTESTINAL STROMAL TUMOR; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPHOSPHORYLATION; PROTEIN PROCESSING; RNA INTERFERENCE; RNA TRANSCRIPTION; TUMOR CELL LINE; UBIQUITINATION; UPREGULATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; BUTADIENES; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; FORKHEAD TRANSCRIPTION FACTORS; GASTROINTESTINAL STROMAL TUMORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOPRECIPITATION; MEMBRANE PROTEINS; NITRILES; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 77952004119     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.078592     Document Type: Article

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