Structural basis for feedback and pharmacological inhibition of Saccharomyces cerevisiae glutamate cysteine ligase

Journal of Biological Chemistry

Volumn 285, Issue 19, 2010, Pages 14459-14466

  Biterova, Ekaterina I ^a   Barycki, Joseph J ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP-BINDING SITE; CATALYTIC MECHANISMS; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE BIOSYNTHESIS; GLUTATHIONES; HUMAN ENZYMES; IN-CELL; IN-VIVO; MOLECULAR REGULATION; PHARMACOLOGICAL INHIBITION; RATE-LIMITING STEPS; SACCHAROMYCES CEREVISIAE; SEQUENCE IDENTITY; STRUCTURAL BASIS; STRUCTURAL CHARACTERIZATION; SUBSTRATE RECOGNITION; SULFOXIMINES; TRANSITION STATE STABILIZATION;

ANIMAL CELL CULTURE; BINDING ENERGY; BIOCHEMISTRY; CELL CULTURE; COORDINATION REACTIONS; PHOSPHORYLATION; YEAST;

ENZYMES;

ADENOSINE TRIPHOSPHATE; CYSTEINE; GLUTAMATE CYSTEINE LIGASE; GLUTAMIC ACID; GLUTATHIONE; MAGNESIUM ION;

ARTICLE; BINDING SITE; CATALYSIS; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME STRUCTURE; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE;

ADENOSINE TRIPHOSPHATE; BINDING SITES; BUTHIONINE SULFOXIMINE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 77951984872     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.104802     Document Type: Article

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