Crystal structure of γ-glutamylcysteine synthetase: Insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 42, 2004, Pages 15052-15057

  Hibi, Takao ^a   Nii, Hiroshi ^a   Nakatsu, Toru ^b   Kimura, Akira ^c   Kato, Hiroaki ^b   Hiratake, Jun ^b   Oda, Jun'ichi ^a  

^a FUKUI PREFECTURAL UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Greenbio Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; GAMMA GLUTAMYLCYSTEINE SYNTHETASE INHIBITOR; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; IMIDE; MAGNESIUM ION; NITROGEN; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING COMPETITION; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME STRUCTURE; ESCHERICHIA COLI; GLUTATHIONE METABOLISM; HOMEOSTASIS; HYDROGEN BOND; NONHUMAN; PHOSPHORYLATION; PREDICTION; PRIORITY JOURNAL; REACTION ANALYSIS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ELECTROSTATICS; ESCHERICHIA COLI; GLUTAMATE-CYSTEINE LIGASE; GLUTAMIC ACID; GLUTATHIONE; HOMEOSTASIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

ESCHERICHIA COLI; EUKARYOTA; MAMMALIA; NEGIBACTERIA;

EID: 6344266863     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0403277101     Document Type: Article

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