Increased intrinsic neuronal vulnerability and decreased beneficial reaction of macrophages on axonal regeneration in aged rats

Neurobiology of Aging

Volumn 31, Issue 6, 2010, Pages 1003-1009

  Luo, Jian Min ^a,b   Geng, Yi Qun ^a   Zhi, Ye ^a,b   Zhang, Ming Zhi ^a   van Rooijen, Nico ^c   Cui, Qi ^a,d  

^a Chinese University of Hongkong   (China)

^b SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Brain aging; Macrophages; Neural damage; Neuronal survival and axonal regeneration

Indexed keywords

ZYMOSAN;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXONAL INJURY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE ACTIVATION; NERVE CELL GROWTH; NERVE CELL LESION; NERVE FIBER REGENERATION; NERVE GRAFT; NONHUMAN; OPTIC NERVE INJURY; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL;

EID: 77951976521     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2008.07.018     Document Type: Article

References (36)

1. Bechmann I., Galea I., Perry V.H. What is the blood-brain barrier (not)?. Trends Immunol. 2007, 28:5-11.
2. Berkelaar M., Clarke D.B., Wang Y.C., Bray G.M., Aguayo A.J. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J. Neurosci. 1994, 14:4368-4374.
3. Bizon J.L., Lasarge C.L., Monthomery K.S., McDermott A.N., Setlow B., Griffith W.H. Spatial reference and working memory across the lifespan of male Fischer 344 rats. Neurobiol. Aging 2008, 10.1016/j.neurobiolaging.2007.08.004.
4. Cen L.P., Luo J.M., Zhang C.W., Fan Y.M., Song Y., So K.F., van Rooijen N., Pang C.P., Lam D.S.C., Cui Q. Chemotactic effect of ciliary neurotrophic factor on macrophages in retinal ganglion cell survival and axonal regeneration. Invest. Ophthalmol. Vis. Sci. 2007, 48:4257-4266.
5. Cui Q., Yip H.K., Zhao R.C., So K.F., Harvey A.R. Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons. Mol. Cell. Neurosci. 2003, 22:49-61.
6. Donnelly D.J., Popovich P.G. Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp. Neurol. 2008, 209:378-388.
7. Edwards D., Berry J.J. The efficiency of simulation-based multiple comparisons. Biometrics 1987, 43:913-928.
8. Filbin M.T. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nat. Rev. Neurosci. 2003, 4:703-713.
9. Fischer D., He Z., Benowitz L.I. Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state. J. Neurosci. 2004, 24:1646-1651.
10. Fischer D., Petkowa V., Thanos S., Benowitz L.I. Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation. J. Neurosci. 2004, 24:8726-8740.
11. Foster K.A., Margraf R.R., Turner D.A. NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia. Neurobiol. Aging 2008, 29:598-613.
12. Garcia-Valenzuela E., Sharma S.C. Laminar restriction of retinal macrophagic response to optic nerve axotomy in the rat. J. Neurobiol. 1999, 40:55-66.
13. Gordon S. Alternative activation of macrophages. Nat. Rev. Immunol. 2003, 3:23-35.
14. Hailer N.P. Immunosuppression after traumatic or ischemic CNS damage: it is neuroprotective and illuminates the role of microglial cells. Prog. Neurobiol. 2008, 84:211-233.
15. Hanisch U.K. Microglia as a source and target of cytokines. Glia 2002, 40:140-155.
16. He Z., Koprivica V. The Nogo signaling pathway for regeneration block. Annu. Rev. Neurosci. 2004, 27:341-368.
17. Hendriks J.J.A., Teunissen C.E., de Vries H.E., Dijkstra C.D. Macrophages and neurodegeneration. Brain Res. Rev. 2005, 48:185-195.
18. Koprivica V., Cho K.S., Park J.B., Yiu G., Atwal J., Gore B., Kim J.A., Lin E., Tessier-Lavigne M., Chen D.F., He Z. EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science 2005, 310:106-110.
19. Longbrake E.E., Lai W., Ankeny D.P., Popovich P.G. Characterization and modeling of monocyte-derived macrophages after spinal cord injury. J. Neurochem. 2007, 102:1083-1094.
20. Lu T., Pan Y., Kao S.Y., Li C., Kohane I., Chan J., Yankner B.A. Gene regulation and DNA damage in the ageing human brain. Nature 2004, 429:883-891.
21. Luo J.M., Cen L.P., Zhang X.M., Chiang S.Y., Huang Y., Lin D., Fan Y., van Rooijen N., Lam D.S.C., Pang C.P., Cui Q. PI3K/akt JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury. Eur. J. Neurosci. 2007, 26:828-842.
22. Luo J.M., Zhi Y., Chen Q., Cen L.P., Zhang C.W., Lam D.S.C., Harvey A.R., Cui Q. Influence of macrophages and lymphocytes on the survival and axon regeneration of injured retinal ganglion cells in rats from different autoimmune backgrounds. Eur. J. Neurosci. 2007, 26:3475-3485.
23. Minghetti L., Ajmone-Cat M.A., De Berardinis M.A., De Simone R. Microglial activation in chronic neurodegenerative diseases: roles of apoptotic neurons and chronic stimulation. Brain Res. Rev. 2005, 48:251-256.
24. Mooradian A.D. Effect of aging on the blood-brain barrier. Neurobiol. Aging 1988, 9:31-39.
25. Moore S., Thanos S. The concept of microglia in relation to central nervous system disease and regeneration. Prog. Neurobiol. 1996, 48:441-460.
26. Park K., Luo J.M., Hisheh S., Harvey A.R., Cui Q. Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells. J. Neurosci. 2004, 24:10806-10815.
27. Pearse D.D., Pereira F.C., Marcillo A.E., Bates M.L., Berrocal Y.A., Filbin M.T., Bunge M.B. cAMP and Schwann cells promote axon growth and functional recovery after spinal cord injury. Nat. Med. 2004, 10:610-616.
28. Sloane J.A., Hollander W., Moss M.B., Rosene D.L., Abraham C.R. Increased microglial activation and protein nitration in white matter of the aging monkey. Neurobiol. Aging 1999, 20:395-405.
29. Sowell E.R., Thompson P.M., Toga A.W. Mapping changes in the human cortex throughout the span of life. Neuroscientist 2004, 10:372-392.
30. Stichel C.C., Luebbert H. Inflammatory processes in the aging mouse brain: participation of dendritic cells and T-cells. Neurobiol. Aging 2007, 28:1507-1521.
31. Streit W.J. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 2002, 40:133-139.
32. Streit W.J., Sammons N.W., Kuhns A.J., Sparks D.L. Dystrophic microglia in the aging human brain. Glia 2004, 45:208-212.
33. van Rooijen N., Sanders A. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J. Immunol. Methods 1994, 174:83-93.
34. Yin Y., Cui Q., Li Y., Irwin N., Fischer D., Harvey A.R., Benowitz L.I. Macrophage-derived factors stimulate optic nerve regeneration. J. Neurosci. 2003, 23:2284-2293.
35. Yin Y., Henzl M.T., Lorber B., Nakazawa T., Thamos T.T., Jiang F., Langer R., Benowitz L.I. Oncomodulin is a macrophage-derived signal for axonal regeneration in retinal ganglion cells. Nat. Neurosci. 2006, 9:843-852.
36. Yu W.H., Go L., Guinn B.A., Fraser P.E., Westaway D., McLaurin J. Phenotypic and functional changes in glial cells as a function of age. Neurobiol. Aging 2002, 23:105-115.