Study of the structure and impact of human leukocyte antigen (HLA)-G-A, HLA-G-B, and HLA-G-DRB1 haplotypes in families with recurrent miscarriage

Human Immunology

Volumn 71, Issue 5, 2010, Pages 482-488

  Kolte, Astrid M ^a   Steffensen, Rudi ^b   Nielsen, Henriette S ^a   Hviid, Thomas V ^c   Christiansen, Ole B ^a,b  

^a Rigshospitalet   (Denmark)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

^c ROSKILDE HOSPITAL   (Denmark)

Author keywords

HLA A; HLA G; Linkage disequlibrium; Recurrent miscarriage; Reproduction

Indexed keywords

HLA A ANTIGEN; HLA A1 ANTIGEN; HLA A11 ANTIGEN; HLA A2 ANTIGEN; HLA A24 ANTIGEN; HLA A3 ANTIGEN; HLA A31 ANTIGEN; HLA B ANTIGEN; HLA B8 ANTIGEN; HLA DR ANTIGEN; HLA DR3 ANTIGEN; HLA G ANTIGEN; UNCLASSIFIED DRUG;

ADULT; ANTIGEN STRUCTURE; ARTICLE; CAUCASIAN; CLINICAL ARTICLE; CONTROLLED STUDY; FATHER; FEMALE; GENE DELETION; GENE INSERTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HETEROZYGOSITY; HUMAN; MOTHER; MOTHER FETUS RELATIONSHIP; NUCLEAR FAMILY; PRIORITY JOURNAL; SIBLING; SPONTANEOUS ABORTION;

ABORTION, HABITUAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HLA-A ANTIGENS; HLA-B ANTIGENS; HLA-DR ANTIGENS; HUMANS; LINKAGE DISEQUILIBRIUM; PEDIGREE; PREGNANCY;

EID: 77951939524     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2010.02.001     Document Type: Article

References (35)

1. Maejima M., Fujii T., Kuzuma S., Okai T., Taketani Y. Presence of HLA-G-expressing cells modulates the ability of peripheral blood mononuclear cells to release cytokines. Am J Reprod Immunol 1997, 38:79-82.
2. Navarro F., Llano M., Bellon T., Colonna M., Geraghty D.E., Lopez-Botet M. The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules coexpressed on target cells. Eur J Immunol 1999, 29:277-283.
3. Kapasi K., Albert S.E., Yie S., Zavazava N., Librach C.L. HLA-G has a concentration-dependent effect on the generation of an allo-CTL response. Immunology 2000, 101:191-200.
4. Riteau B., Rouas-Freiss N., Menier C., Paul P., Dausset J., Carosella D. HLA-G2-G3, and -G4 isoforms expressed as nonmature cell surface glycoproteins inhibit NK and antigen-specific CTL cytolysis. J Immunol 2001, 166:5018-5026.
5. Fuzzi B., Rizzo R., Criscuoli L., Noci I., Melchiorri L., Scarselli B., et al. HLA-G expression in early embryos is a fundamental prerequisite for the obtainment of pregnancy. Eur J Immunol 2002, 32:311-315.
6. Pfeiffer K.A., Rebmann V., Pässler M., van der Ven K., van der Ven H., Krebs D., et al. Soluble HLA levels in early pregnancy after in-vitro fertilization. Hum Immunol 2000, 61:559-564.
7. Hviid T.V., Hylenius S., Lindhard A., Christiansen O.B. Association between human leukocyte antigen-G genotype and success of in-vitro fertilization and pregnancy outcome. Tissue Antigens 2004, 64:66-69.
8. Rebmann V., van der Ven K., Passler M., Pfeiffer K., Krebs D., Grosse-Wilde H. Association of soluble HLA-G plasma levels with HLA-G alleles. Tissue Antigens 2001, 57:15-21.
9. Hviid T.V., Rizzo R., Christiansen O.B., Melchiorri L., Lindhard A., Baricordi O.R. HLA-G and IL-10 in serum in relation to HLA-G genotype and polymorphisms. Immunogenetics 2004, 56:135-141.
10. Rousseau P., Le Discorde M., Mouillot G., Marcou C., Carosella E.D., Moreau P. The 14bp deletion-insertion polymorphism in the 3' UT region of the HLA-G gene influences HLA-G mRNA stability. Hum Immunol 2003, 64:1005-1010.
11. Hviid T.V.F., Hylenius S., Rørbye C., Nielsen L.G. HLA-G alellic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels. Immunogenetics 2003, 55:63-79.
12. Christiansen O.B., Riisom K., Lauritsen J.G., Grunnet N., Jersild C. Association of maternal HLA haplotypes with recurrent spontaneous abortions. Tissue Antigens 1989, 4:190-199.
13. Kruse C., Steffensen R., Varming K., Christiansen O.B. A study of HLA-DR and -DQ alleles in 588 patients and 562 controls confirms that HLA-DRB1*03 is associated with recurrent miscarriage. Hum Reprod 2004, 19:1215-1221.
14. Christiansen O.B., Ulcova-Gallova Z., Mohapeloa H., Krauz V. Studies on associations between human leukocyte antigen class II alleles and antiphospholipid antibodies in Danish and Czech women with recurrent miscarriage. Hum Reprod 1998, 13:3326-3331.
15. Nielsen H.S., Steffensen R., Varming K., van Halteren A.G.S., Spierings E., Ryder L.P., et al. Association between HY-restricting HLA class II alleles with pregnancy outcome in patients with recurrent miscarriage subsequent to a firstborn boy. Hum Mol Genet 2009, 18:1684-1691.
16. Hviid T.V., Christiansen O.B. Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G - possible implications for human reproduction and autoimmune disease. Hum Immunol 2005, 66:688-699.
17. Ober C., Rosinsky B., Grimsley C., van der Ven K., Robertson A., Runge A. Population genetic studies of HLA-G: allele frequencies and linkage disequilibrium with HLA-A. J Reprod Immunol 1996, 32:111-123.
18. van den Ven K., Skrablin S., Krebs D. HLA-G polymorphisms and allele frequencies in Caucasians. Hum Immunol 1998, 59:302-312.
19. Hviid T.V., Hylenius S., Hoegh A.M., Kruse C., Christiansen O.B. HLA-G polymorphisms in couples with recurrent spontaneous abortions. Tissue Antigens 2002, 60:122-132.
20. Smith W.P., Vu Q., Li S.S., Hansen J.A., Zhao L.P., Geraghty D.E. Toward understanding of MHC disease associations: Partial resequencing of 46 distinct HLA haplotypes. Genomics 2006, 87:561-571.
21. Morales P.S.J., Corell A., Martinez-Laso J., Martin-Villa M., Varela M., Paz-Artal E., et al. Three new HLA-G alleles and their linkage disequilibria with HLA-A. Immunogenetics 1993, 38:323-331.
22. Kauhukorpi J., Ikaheimo I., Silvennoinen-Kassinen S., Tiilikainen A. HLA-G polymorphism and allelic association with HLA-A in a Finnish population. Eur J Immunogenet 1996, 23:153-155.
23. Shao W., Yoo Y., Tang J., Zhang K., Allen S., Kaslow R. Tight linkage disequilibrium between HLA-G and HLA-A alleles in native Africans. Hum Immunol 2006, 67:S118.
24. Pirri A., Contieri F., Benvenutti R., da Graca Bicalho M. A study of HLA-G polymorphism and linkage disequilibrium in renal transplant patients and their donors. Transpl Immunol 2009, 20:13-19.
25. Vendetti C.P., Chorney M.J., Gene C.I. Contraction within the HLA-A subregion of the human MHC. Genomics 1992, 14:1003-1009.
26. Gregersen J.W., Kranc K.R., Ke X., Svendsen P., Madsen L.S., Thomsen A.R., et al. Functional epistasis on a common MHC haplotype associated with multiple sclerosis. Nature 2006, 443:574-577.
27. Nejentsev S., Howson J.M., Walker N.M., Szeszko J., Field S.F., Stevens H.E., et al. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007, 450:887-892.
28. Eike M.C., Becker T., Humphreys K., Olsson M., Lie B.A. Conditional analyses on the T1DGC MHC dataset: novel associations with type 1 diabetes around HLA-G and confirmation of HLA-B. Genes Immun 2009, 10:56-67.
29. Voight B.F., Kudaravalli S., Wen X., Pritchard J.K. A map of recent positive selection in the human genome. PLoS Biol 2006, 4:e154.
30. Castro M.J., Morales P., Martinez-Laso J., Allende L., Rojo-Amigo R., Gonzalez-Hevilla M., et al. Evolution of MHC-G in humans and primates based on three new 3' UT polymorphisms. Hum Immunol 2000, 61:1157-1163.
31. Ishitani A., Kishida M., Sageshima N., Yashiki S., Sonoda S., Hayami M., et al. Re-examination of HLA-G polymorphism in African-Americans. Immunogenetics 1999, 49:808-811.
32. Matte C., Lacaille J., Zijenah L., Ward B., Roger M. HLA-G exhibits low level of polymorphism in indigenous east Africans. Hum Immunol 2002, 63:495-501.
33. McEvoy B.P., Montgomery G.W., McRae A.F., Ripatti S., Perola M., Spector T.D., et al. Geographical structure and differential natural selection among North European populations. Genome Res 2009, 19:804-814.
34. Suryanarayana V., Rao L., Kanakavalli M., Padmalatha V., Raseswari T., Deenadayal M., et al. Association between novel HLA-G genotypes and risk of recurrent miscarriages: A case- control study in a South Indian population. Reprod Sci 2008, 15:817-824.
35. Tan Z., Shon A.M., Ober C. Evidence for balancing selection at the HLA-G promoter region. Hum Mol Genet 2005, 14:3619-3628.