The 14 bp Deletion-Insertion Polymorphism in the 3′ UT Region of the HLA-G Gene Influences HLA-G mRNA Stability

Human Immunology

Volumn 64, Issue 11, 2003, Pages 1005-1010

  Rousseau, Philippe ^b   Le Discorde, Magali ^b   Mouillot, Gaël ^b   Marcou, Céline ^b   Carosella, Edgardo D ^b   Moreau, Philippe ^a  

^a Inst Univ d'Hématologie   (France)

^b NONE

Author keywords

3 UTR; HLA G; mRNA stability; Polymorphism

Indexed keywords

DACTINOMYCIN; HLA G ANTIGEN; RNA;

ALTERNATIVE RNA SPLICING; CANCER CELL CULTURE; CHORIOCARCINOMA; CONFERENCE PAPER; CONTROLLED STUDY; DNA POLYMORPHISM; EXON; GENE DELETION; GENE FUNCTION; GENE INSERTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MELANOMA CELL; NULL ALLELE; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION REGULATION; UNTRANSLATED REGION;

EID: 0242609928     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2003.08.347     Document Type: Conference Paper

References (21)

1. Carosella ED, Paul P, Moreau P, Rouas-Freiss N: HLA-G and -E: fundamental and physiopathological aspects. Immunol Today 21:532, 2000.
2. O'Brien M, McCarthy T, Jenkins D, Paul P, Dausset J, Carosella ED, Moreau P: Altered HLA-G transcription in pre-eclampsia is associated with allele specific inheritance: possible role of the HLA-G gene in susceptibility to the disease. Cell Mol Life Sci 58:1943, 2001.
3. Hviid TV, Hylenius S, Hoegh AM, Kruse C, Christiansen OB: HLA-G polymorphisms in couples with recurrent spontaneous abortions. Tissue Antigens 60:122, 2002.
4. Arnaiz-Villena A, Martinez-Laso J, Alvarez M, castro MJ, Varela E, Gomez-Casado E, Suarez B, Recio MJ, Vargas-Alarcon G, Morales P: Primates Mhc-E and -G alleles. Immunogenetics 46:251, 1997.
5. Geraghty DE, Koller BH, Orr HT: A human major histocompatibility complex class I gene that encodes a protein with shortened cytoplasmic segment. Proc Natl Acad Sci U S A 84:9145, 1987.
6. van der Ven K, Skrablin S, Engels G, Krebs D: HLA-G polymorphisms and allele frequencies in Caucasians. Hum Immunol 59:302, 1998.
7. Matte C, Lacaille J, Zijenah L, Ward B, Roger M: HLA-G and HLA-E polymorphisms in an indigenous African population. The ZVITAMBO Study Group. Hum Immunol 61:1150, 2000.
8. Matte C, Lacaille J, Zijenah L, Ward B, Roger M: HLA-G exhibits low level of polymorphism in indigenous East Africans. Hum Immunol 63:495, 2002.
9. Moreau P, Dausset J, Carosella ED, Rouas-Freiss N: View-point on the functionality of the human leukocyte antigen-G null allele at the fetal-maternal interface. Biol Reprod 67:1375, 2002.
10. Hviid TV, Sorensen S, Morling N: Polymorphism in the regulatory region located more than 1.1 kilobases 5′ to the start site of transcription, the promoter region, and exon 1 of the HLA-G gene. Hum Immunol 60:1237, 1999.
11. Ober C, Aldrich CL, Chervoneva I, Billstrand C, Rahimov F, Gray HL, Hyslop T: Variation in the HLA-G promoter region influences miscarriage rates. Am J Hum Genet 72:1425, 2003.
12. Harrison GA, Humphrey KE, Jakobsen IB, Cooper DW: A 14 bp deletion polymorphism in the HLA-G gene. Hum Molec Genet 2:2200, 1993.
13. Hiby S, King A, Sharkey A, Loke YW: Molecular studies of trophoblast HLA-G: polymorphism, isoforms, imprinting and expression in preimplantation embryo. Tissue Antigens 53:1, 1999.
14. Hviid TV, Hylenius S, Rorbye C, Nielsen LG: HLA-G allelic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels. Immunogenetics 55:63, 2003.
15. Paul P, Rouas-Freiss N, Moreau P, Adrian Cabestre F, Menier C, Khalil-Daher I, Pangault C, Onno M, Fauchet R, Martinez-Laso J, Morales P, Arnaiz-Villena A, Giacomini P, Natali PG, Frumento G, Ferrara GB, McMaster M, Fisher S, D. S, Ferrone S, Dausset J, Carosella ED: HLA-G, -E, -F preworkshop: tools and protocols for analysis of non classical class I genes transcription and protein expression. Hum Immunol 61:1177, 2000.
16. Yeilding NM, Rehman MT, Lee WM: Identification of sequences in c-myc mRNA that regulate its steady-state levels. Mol Cell Biol 16:3511, 1996.
17. Rueter SM, Dawson TR, Emeson RB: Regulation of alternative splicing by RNA editing. Nature 399:75, 1999.
18. Chu W, Gao J, Murphy WJ, Hunt JS: A candidate interferon-gamma activated site (GAS element) in the HLA-G promoter does not bind nuclear proteins. Hum Immunol 60:1113, 1999.
19. Ross J, Sullivan TD: Half-lives of beta and gamma globin messenger RNAs and of protein synthetic capacity in cultured human reticulocytes. Blood 66:1149, 1985.
20. Grzybowska EA, Wilczynska A, Siedlecki JA: Regulatory functions of 3′UTRs. Biochem Biophys Res Commun 288:291, 2001.
21. Castro MJ, Morales P, Martinez-Laso J, Allende L, Rojo-Amigo R, Gonzalez-Hevilla M, Varela P, Moreno A, Garcia-Berciano M, Arnaiz-Villena A: Evolution of MHC-G in humans and primates based on three new 3′ UT polymorphisms. Hum Immunol 61:1157, 2000.