Association between novel HLA-G genotypes and risk of recurrent miscarriages: A case-control study in a South Indian population

Reproductive Sciences

Volumn 15, Issue 8, 2008, Pages 817-824

  Suryanarayana, Venkata ^a   Rao, Lakshmi ^a   Kanakavalli, Murthy ^a   Padmalatha, Venkata ^a   Raseswari, Turalpati ^a   Deenadayal, Mamata ^b   Singh, Lalji ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^b Research Centre   (India)

Author keywords

Association; HLA G; Polymorphisms; Recurrent miscarriages

Indexed keywords

HLA G ANTIGEN; RNA;

ALLELE; ARTICLE; CONTROLLED STUDY; EXON; FEMALE; GENE DELETION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SPONTANEOUS ABORTION;

ABORTION, HABITUAL; CASE-CONTROL STUDIES; DNA; FEMALE; GENETIC VARIATION; GENOTYPE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; INDIA; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY;

EID: 54349113604     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719107314061     Document Type: Article

References (29)

1. Inflammation and miscarriage. Semin Fetal Neonatal Med. 2006 ; 11 (5). 302-308.
2. Lachapelle MH, Miron P., Hemmings R., Roy DC Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion: altered profile and pregnancy outcome. J Immunol. 1996 ; 156: 4027-4034.
3. Jenkins C., Roberts J., Wilson R., MacLean MA, Shilito J., Walker JJ Evidence of a T(H)1 type response associated with recurrent miscarriage. Fertil Steril. 2000 ; 73 (6). 1206-1208.
4. Kovats S., Main EK, Librach C., Stubblebine M., Fisher SJ, DeMars R. A class I antigen, HLA-G, expressed in human trophoblasts. Science. 1990 ; 248: 220.
5. LeMaoult J., Le Discorde M., Rouas-Freiss N., et al. Biology and functions of human leukocyte antigen-G in health and sickness. Tissue Antigens. 2003 ; 62: 273-284.
6. Le Gal FA, Riteau B., Sedlik C., et al. HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes. Int Immunol. 1999 ; 11: 1351.
7. LeMaoult J., Krawice-Radanne I., Dausset J., Carosella ED HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells. Proc Natl Acad Sci U S A. 2004 ; 101: 7064.
8. Fournel S., Aguerre-Girr M., Huc X., et al. Soluble HLA-G1 triggers CD95/CD95 ligand- mediated apoptosis in activated CD8+ cells by interacting with CD8. J Immunol. 2000 ; 164: 6100-6104.
9. Yie SM, Li LH, Li YM, Librach C. HLA-G protein concentrations in maternal serum and placental tissue are decreased in preeclampsia. Am J Obstet Gynecol. 2004 ; 191: 525-529.
10. Athanassakis I., Paflis M., Ranella A., Vassiliadis S. Detection of soluble HLA-G levels in maternal serum can be predictive for a successful pregnancy. Transplant Proc. 1999 ; 31 (4). 1834-1837.
11. Steinborn A., Rebmann V., Scharf A., Sohn C., Grosse-Wilde H. Placental abruption is associated with decreased maternal plasma levels of soluble HLA-G. J Clin Immunol. 2003 ; 23: 307-314.
12. Tripathi P., Agrawal S. Non-classical HLA-G antigen and its role in cancer progression. Cancer Invest. 2006 ; 24 (2). 178-186.
13. Nicolae D., Cox NJ, Lester LA, et al. Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21. Am J Hum Genet. 2005 ; 76 (2). 349-357.
14. Cosman D., Fanger N., Borges L., et al. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity. 1997 ; 7: 273-282.
15. Hill JA III, Choi BC Immunodystrophism evidence for a novel alloimmune hypothesis for recurrent pregnancy loss involving Th1- type immunity to trophoblast. Semin Reprod Med. 2000 ; 18: 401-405.
16. Yie S.-M., Xiao R., Librach CL Progesterone regulates HLA-G gene expression through a novel progesterone response element. Hum Reprod.Advance Access published 2006 ; 21 (10). 2538-2544.
17. Hviid TV, Hylenius S., Rørbye C., Nielsen LG HLA-G allelic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels. Immunogenetics. 2003 ; 55 (2). 63-79.
18. Rizzo R., Hviid TV, Stignani M., et al. The HLA-G genotype is associated with IL-10 levels in activated PBMCs. Immunogenetics. 2005 ; 57 (3-4). 172-181.
19. Rousseau P., Le Discorde M., Mouillot G., Marcou C., Carosella ED, Moreau P. The 14 bp deletion-insertion polymorphism in the 3′ UT region of the HLA-G gene influences HLA-G mRNA stability. Hum Immunol. 2003 ; 64 (11). 1005-1010.
20. Hviid TV, Hylenius S., LindhardA, Christiansen OB Association between human leukocyte antigen-G genotype and success of in vitro fertilization and pregnancy outcome. Tissue Antigens. 2004 ; 64 (1). 66-69.
21. Hviid TV, Christiansen OB Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G-possible implications for human reproduction and autoimmune disease. Hum Immunol. 2005 ; 66: 688-699.
22. Kruse C., Steffensen R., Varming K., Christiansen OB A study of HLA-DR and -DQ alleles in 588 patients and 562 controls confirms that HLA-DRB103 is associated with recurrent miscarriage. Hum Reprod. 2004 ; 19 (5). 1215-1221.
23. Miller SA, Dykes DD, Polesky HF, A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988 ; 16 (3). 1215.
24. Excoffier L., Laval G., Schneider S. Arlequin ver. 3.0: an integrated software package for population genetics data analysis. Evolutionary Bioinformatics Online. 2005 ; 1: 47-50.
25. Mathews DH MEBDHT: RNAStructure,Version 3.5. Carlsbad, CA: Isis Pharmaceuticals, Inc; 1999.
26. Lalouel J., Rohswasser A. Power and replication in case-control studies. Am J Hypertens. 2002 ; 15: 201-205.
27. Yie S.-M., Taylor RN, Librach C. Low plasma HLA-G protein concentrations in early gestation indicate the development of preeclampsia later in pregnancy. Am J Obstet Gynecol. 2005 ; 193: 204-208.
28. Rebmann V., Pfeiffer M., Ferrone S., Weiss E., Grosse-Wilde H. Detection of soluble HLA-G molecules in plasma and amniotic fluids. Tissue Antigens. 1999 ; 53: 14-19.
29. Vauvert T., Hviid R., Rizzo R., et al. HLA-G and IL-10 in serum in relation to HLA-G genotype and polymorphisms. Immunogenetics. 2004 ; 56: 135-141.