Review of Statistical Methods for QTL Mapping in Experimental Crosses

Lab Animal

Volumn 30, Issue 7, 2001, Pages 44-52

  Broman, Karl W ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BIOLOGICAL MODEL; BREEDING; CHROMOSOME MAP; CROSS BREEDING; GENETIC MARKER; GENOTYPE; MATHEMATICAL COMPUTING; MOUSE; PHENOTYPE; REVIEW; STATISTICS;

ANIMALS; BREEDING; CHROMOSOME MAPPING; CROSSES, GENETIC; GENETIC MARKERS; GENOTYPE; MATHEMATICAL COMPUTING; MICE; MODELS, GENETIC; PHENOTYPE;

EID: 0035409461     PISSN: 00937355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (29)

1. Doerge, R.W., et al. Statistical issues in the search for genes affecting quantitative traits in experimental populations. Stat. Sci.; 12:195-219, 1997.
2. Lynch, M. and Walsh, B. Genetics and Analysis of Quantitative Traits. Sinauer Associates, Sunderland, MA, pp. 431-89, 1998.
3. Broman, K.W. and Speed, T.P. A review of methods for identifying QTLs in experimental crosses. In: Seillier-Moiseiwitsch, F., ed., Statistics in Molecular Biology and Genetics. Vol. 33 of IMS Lecture Notes - Monograph Series, pp. 114-42, 1999.
4. Soller, M., et al. On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines. Theor. Appl. Genet.; 47:35-9, 1976.
5. rd Edition. Cambridge University Press, 1995.
6. Lander, E.S. and Botstein, D. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics; 121:185-99, 1989.
7. Lincoln, S.E. and Lander, E.S. Systematic detection of errors in genetic linkage data. Genomics; 14:604-10, 1992.
8. Haley, C.S. and Knott, S.A. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity, 69:315-24, 1992.
9. Churchill, G.A. and Doerge, R.W. Empirical threshold values for quantitative trait mapping. Genetics; 138:963-71, 1994.
10. van Ooijen, J.W. Accuracy of mapping quantitative trait loci in autogamous species. Theor. Appl. Genet.; 84:803-11, 1992.
11. Shrimpton, A.E. and Robertson, A. The Isolation of polygenic factors controlling bristle score in Drosophila melanogaster. I. Allocation of third chromosome stemopleural bristle effects to chromosome sections. Genetics; 118:437-43, 1988.
12. Frankel, W.N. and Schork, N.J. Who's afraid of epistasis? Nat. Genet.; 14:371-3, 1996.
13. Mackay, T.F.C. The nature of quantitative genetic variation revisited: Lessons from Drosophila bristles. BioEssays; 18:113-21, 1996.
14. rd Edition. Macmillan, New York, pp.180-8, 1985.
15. Bateson, W. Facts limiting the theory of heredity. Science; 26:649-60, 1907.
16. Cowen, N.M. Multiple linear regression analysis of RFLP data sets used in mapping QTLs. In: Helentjaris, T. and Burr, B., eds. Development and Application of Molecular Markers to Problems in Plant Genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp.113-6, 1989.
17. Miller, A.J. Subset Selection in Regression. Chapman and Hall, New York, 1990.
18. Broman, K.W. Identifying quantitative trait loci in experimental crosses. Ph.D. thesis, Department of Statistics, University of California, Berkeley; 1997.
19. Jansen, R.C. Interval mapping of multiple quantitative trait loci. Genetics; 135:205-11, 1993.
20. Jansen, R.C. and Stam, P. High resolution of quantitative traits into multiple loci via interval mapping. Genetics; 136:1447-55, 1994.
21. Zeng, Z.-B. Theoretical basis for separation of multiple linked gene effects in mapping quantitative trait loci. Proc. Natl. Acad. Sci. USA; 90:10972-6, 1993.
22. Zeng, Z.-B. Precision mapping of quantitative trait loci. Genetics; 136:1457-68, 1994.
23. Kao, C.-H., et al. Multiple interval mapping for quantitative trait loci. Genetics; 152:1203-16, 1999.
24. Zeng, Z.-B., et al. Estimating the genetic architecture of quantitative traits. Genet. Res.; 74:279-89, 1999.
25. Hoeschele, I. and VanRaden, P.M. Bayesian analysis of linkage between genetic markers and quantitative trait loci. I. Prior knowledge. Theor. Appl. Genet.; 85:953-60, 1993.
26. Satagopan, J.M., et al. A Bayesian approach to detect quantitative trait loci using Markov chain Monte Carlo. Genetics; 144:805-16, 1996.
27. Uimari, P. and Hoeschele, I. Mapping-linked quantitative trait loci using Bayesian analysis and Markov chain Monte Carlo algorithms. Genetics; 146:735-43, 1997.
28. Sillanpää, M.J. and Arjas, E. Bayesian mapping of multiple quantitative trait loci from incomplete outbred offspring data. Genetics; 151:1605-19, 1999.
29. Cariborg, O., et al. The use of a genetic algorithm for simultaneous mapping of multiple interacting quantitative trait loci. Genetics; 155:2003-10, 2000.