Aging-related hyperinflammation in endotoxemia is mediated by the α2A-adrenoceptor and CD14/TLR4 pathways

Life Sciences

Volumn 86, Issue 19-20, 2010, Pages 740-746

  Leong, Jennifer ^a,b   Zhou, Mian ^a,b   Jacob, Asha ^a,b   Wang, Ping ^a,b  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

2A adrenoceptor; Aging; CD14; Endotoxemia; Inflammation; Sepsis; TLR4

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CD14 ANTIGEN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IVD; PROTEIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; RECEPTOR, ADRENERGIC, ALPHA 2A; RECEPTOR, ADRENERGIC, ALPHA-2A;

ADRENERGIC SYSTEM; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTOXEMIA; GERIATRICS; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; IN VIVO STUDY; INFLAMMATION; INNATE IMMUNITY; MALE; MORBIDITY; MORTALITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SPLEEN; AGE; ANIMAL; FISCHER 344 RAT; GENETICS; METABOLISM; PATHOPHYSIOLOGY; SEPSIS;

ANIMALIA; RATTUS;

AGE FACTORS; AGING; ANIMALS; ANTIGENS, CD14; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYTOKINES; ENDOTOXEMIA; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; RATS; RATS, INBRED F344; RECEPTORS, ADRENERGIC, ALPHA-2; RNA, MESSENGER; SEPSIS; SPLEEN; TOLL-LIKE RECEPTOR 4;

EID: 77951905087     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.03.009     Document Type: Article

References (39)

1. Angus D.C., Linde-Zwirble W.T., Lidicker J., Clermont G., Carcillo J., Pinsky M.R. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical Care Medicine 2001, 29(7):1303-1310.
2. Ariga M., Neitzert B., Nakae S., Mottin G., Bertrand C., Pruniaux M.P., Jin S.L., Conti M. Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation. Journal of Immunology 2004, 173(12):7531-7538.
3. Ayala A., Deol Z.K., Lehman D.L., Herdon C.D., Chaudry I.H. Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-gamma release while increasing IL-4/IL-10 production. Journal of Surgical Research 1994, 56(6):579-585.
4. Ayala A., Deol Z.K., Lehman D.L., Herdon C.D., Chaudry I.H. Does endotoxin play a major role in inducing the depression of macrophage function during polymicrobial sepsis?. Archives of Surgery 1995, 11:1178-1184. discussion 1184-1175.
5. Ayala A., Song G.Y., Chung C.S., Redmond K.M., Chaudry I.H. Immune depression in polymicrobial sepsis: the role of necrotic (injured) tissue and endotoxin. Critical Care Medicine 2000, 28(8):2949-2955.
6. Bruunsgaard H., Pedersen M., Pedersen B.K. Aging and proinflammatory cytokines. Current Opinions in Hematology 2001, 8(3):131-136.
7. Calverley P.M., Sanchez-Toril F., McIvor A., Teichmann P., Bredenbroeker D., Fabbri L.M. Effect of 1-year treatment with roflumilast in severe chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 2007, 176(2):154-161.
8. Donoso V., Gomez C.R., Orriantia M.A., Perez V., Torres C., Coddou C., Nelson P., Maisey K., Morales B., Fernandez R., Imarai M., Huidobro-Toro J.P., Sierra F., Acuna-Castillo C. The release of sympathetic neurotransmitters is impaired in aged rats after an inflammatory stimulus: a possible link between cytokine production and sympathetic transmission. Mechanism of Ageing and Development 2008, 129(12):728-734.
9. Eigler A., Siegmund B., Emmerich U., Baumann K.H., Hartmann G., Endres S. Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production. Journal of Leukocyte Biology 1998, 63(1):101-107.
10. Giembycz M.A. Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here?. Drugs 2000, 59(2):193-212.
11. Hahn P.Y., Wang P., Tait S.M., Ba Z.F., Reich S.S., Chaudry I.H. Sustained elevation in circulating catecholamine levels during polymicrobial sepsis. Shock 1995, 4(4):269-273.
12. Hebenstreit G.F., Fellerer K., Fichte K., Fischer G., Geyer N., Meya U., Sastre-y-Hernandez M., Schony W., Schratzer M., Soukop W., et al. Rolipram in major depressive disorder: results of a double-blind comparative study with imipramine. Pharmacopsychiatry 1989, 22(4):156-160.
13. Houslay M.D., Sullivan M., Bolger G.B. The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions. Advances in Pharmacology 1998, 44225-44342.
14. Jin S.L., Lan L., Zoudilova M., Conti M. Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages. Journal of Immunology 2005, 175(3):1523-1531.
15. Jin S.L., Conti M. Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses. Proceedings of National Academy of Sciences USA 2002, 99(11):7628-7633.
16. Koo D.J., Chaudry I.H., Wang P. Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis. Journal of Surgical Research 1999, 83(2):151-157.
17. Liopeta K., Boubali S., Virgilio L., Thyphronitis G., Mavrothalassitis G., Dimitracopoulos G., Paliogianni F. cAMP regulates IL-10 production by normal human T lymphocytes at multiple levels: a potential role for MEF2. Molecular Immunology 2009, 46(3):345-354.
18. Lu Y.C., Yeh W.C., Ohashi P.S. LPS/TLR4 signal transduction pathway. Cytokine 2008, 42(2):145-151.
19. Miksa M., Das P., Zhou M., Wu R., Dong W., Ji Y., Goyert S.M., Ravikumar T.S., Wang P. Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis. PLoS ONE 2009, 4(5):e5504.
20. Miksa M., Wu R., Dong W., Komura H., Amin D., Ji Y., Wang Z., Wang H., Ravikumar T.S., Tracey K.J., Wang P. Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor VIII. Journal of Immunology 2009, 183(9):5983-5990.
21. Muise E.S., Chute I.C., Claveau D., Masson P., Boulet L., Tkalec L., Pon D.J., Girard Y., Frenette R., Mancini J.A. Comparison of inhibition of ovalbumin-induced bronchoconstriction in guinea pigs and in vitro inhibition of tumor necrosis factor-alpha formation with phosphodiesterase 4 (PDE4) selective inhibitors. Biochemical Pharmacology 2002, 63(8):1527-1535.
22. Rabe K.F., Bateman E.D., O'Donnell D., Witte S., Bredenbroker D., Bethke T.D. Roflumilast-an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2005, 366(9485):563-571.
23. Renshaw M., Rockwell J., Engleman C., Gewirtz A., Katz J., Sambhara S. Cutting edge: impaired Toll-like receptor expression and function in aging. Journal of Immunology 2002, 169(9):4697-4701.
24. Renshaw M., Rockwell J., Engleman C., Gewirtz A., Katz J., Sambhara S. Cutting edge: impaired Toll-like receptor expression and function in aging. Journal of Immunology 2002, 169(9):4697-4701.
25. Robichaud A., Stamatiou P.B., Jin S.L., Lachance N., MacDonald D., Laliberte F., Liu S., Huang Z., Conti M., Chan C.C. Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. Journal of Clinical Investigation 2002, 110(7):1045-1052.
26. Sinha B., Semmler J., Eisenhut T., Eigler A., Endres S. Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids. European Journal of Immunology 1995, 25(1):147-153.
27. Spengler R.N., Allen R.M., Remick D.G., Strieter R.M., Kunkel S.L. Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor. Journal of Immunology 1990, 145(5):1430-1434.
28. Tateda K., Matsumoto T., Miyazaki S., Yamaguchi K. Lipopolysaccharide-induced lethality and cytokine production in aged mice. Infection and Immunity 1996, 64(3):769-774.
29. Timmer W., Leclerc V., Birraux G., Neuhauser M., Hatzelmann A., Bethke T., Wurst W. The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exercise-induced asthma and leads to suppression of LPS-stimulated TNF-alpha ex vivo. Journal of Clinical Pharmacology 2002, 42(3):297-303.
30. Torphy T.J. Phosphodiesterase isozymes: molecular targets for novel antiasthma agents. American Journal of Respiratory and Critical Care Medicine 1998, 157(2):351-370.
31. Tracey K.J. Reflex control of immunity. Nature Reviews. Immunology 2009, 9(6):418-428.
32. Wang P., Ba Z.F., Chaudry I.H. Mechanism of hepatocellular dysfunction during early sepsis. Key role of increased gene expression and release of proinflammatory cytokines tumor necrosis factor and interleukin-6. Archives of Surgery 1997, 132(4):364-369. discussion 369-370.
33. Wu R., Zhou M., Dong W., Ji Y., Miksa M., Marini C.P., Ravikumar T.S., Wang P. Ghrelin hyporesponsiveness contributes to age-related hyperinflammation in septic shock. Annals of Surgery 2009, 250(1):126-133.
34. Yang S., Koo D.J., Zhou M., Chaudry I.H., Wang P. Gut-derived norepinephrine plays a critical role in producing hepatocellular dysfunction during early sepsis. American Journal of Physiology. Gastrointestinal and Liver Physiology 2000, 279(6):G1274-G1281.
35. Yang S., Zhou M., Chaudry I.H., Wang P. Norepinephrine-induced hepatocellular dysfunction in early sepsis is mediated by activation of alpha2-adrenoceptors. American Journal of Physiology. Gastrointestinal and Liver Physiology 2001, 281(4):G1014-G1021.
36. Yang S., Koo D.J., Zhou M., Chaudry I.H., Wang P. Gut-derived norepinephrine plays a critical role in producing hepatocellular dysfunction during early sepsis. American Journal of Physiology. Gastrointestinal and Liver Physiology 2000, 279(6):G1274-G1281.
37. Zhou M., Das P., Simms H.H., Wang P. Gut-derived norepinephrine plays an important role in up-regulating IL-1beta and IL-10. Biochimica et Biophysica Acta 2005, 1740(3):446-452.
38. Zhou M., Yang S., Koo D.J., Ornan D.A., Chaudry I.H., Wang P. The role of Kupffer cell alpha(2)-adrenoceptors in norepinephrine-induced TNF-alpha production. Biochimica et Biophysica Acta 2001, 1537(1):49-57.
39. Zhou M, Wu, R. Dong, W. Leong, J. Wang, P. Accelerated apoptosis contributes to aging-related hyperinflammation in endotoxemia. International Journal of Molecular Medicine, in press.