Deletion of the gene encoding MyD88 protects from anorexia in a mouse tumor model

Brain, Behavior, and Immunity

Volumn 24, Issue 4, 2010, Pages 554-557

  Ruud, Johan ^a   Bäckhed, Fredrik ^b   Engblom, David ^a   Blomqvist, Anders ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Anorexia; Cachexia; Cancer; Innate immunity; Mice; MyD88

Indexed keywords

3 METHYLCHOLANTHRENE; INTERLEUKIN 1; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; MYD88 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; BODY WEIGHT; CACHEXIA; CONTROLLED STUDY; FEMALE; FOOD INTAKE; GENE DELETION; GENOTYPE; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR; TUMOR GROWTH; TUMOR VOLUME; WEIGHT REDUCTION; ANIMAL; APPETITE; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; EATING; GENETICS; IMMUNOLOGY; ISOGRAFT; KNOCKOUT MOUSE; NEOPLASM; PATHOPHYSIOLOGY; SYNDROME;

ANIMALS; ANOREXIA; APPETITE; BODY WEIGHT; CACHEXIA; DISEASE MODELS, ANIMAL; EATING; FEMALE; METHYLCHOLANTHRENE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; NEOPLASMS; SEQUENCE DELETION; SYNDROME; TRANSPLANTATION, ISOGENEIC; WEIGHT LOSS;

EID: 77951879242     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2010.01.006     Document Type: Article

References (31)

1. Adachi O., Kawai T., Takeda K., Matsumoto M., Tsutsui H., Sakagami M., Nakanishi K., Akira S. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 1998, 9:143-150.
2. Bosaeus I., Daneryd P., Svanberg E., Lundholm K. Dietary intake and resting energy expenditure in relation to weight loss in unselected cancer patients. Int. J. Cancer 2001, 93:380-383.
3. Colotta F., Allavena P., Sica A., Garlanda C., Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009, 30:1073-1081.
4. Durham W.J., Dillon E.L., Sheffield-Moore M. Inflammatory burden and amino acid metabolism in cancer cachexia. Curr. Opin. Clin. Nutr. Metab. Care 2009, 12:72-77.
5. Falandry C., Canney P.A., Freyer G., Dirix L.Y. Role of combination therapy with aromatase and cyclooxygenase-2 inhibitors in patients with metastatic breast cancer. Ann. Oncol. 2009, 20:615-620.
6. Gelin J., Andersson C., Lundholm K. Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. Cancer Res. 1991, 51:880-885.
7. Hardiman G., Jenkins N.A., Copeland N.G., Gilbert D.J., Garcia D.K., Naylor S.L., Kastelein R.A., Bazan J.F. Genetic structure and chromosomal mapping of MyD88. Genomics 1997, 45:332-339.
8. Iwasaki A., Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 2004, 5:987-995.
9. Kawai T., Akira S. TLR signaling. Cell Death Differ. 2006, 13:816-825.
10. Kleinridders A., Schenten D., Konner A.C., Belgardt B.F., Mauer J., Okamura T., Wunderlich F.T., Medzhitov R., Bruning J.C. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab. 2009, 10:249-259.
11. Koehne C.H., Dubois R.N. COX-2 inhibition and colorectal cancer. Semin. Oncol. 2004, 31:12-21.
12. Laflamme N., Soucy G., Rivest S. Circulating cell wall components derived from Gram-negative, not Gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS. J. Neurochem. 2001, 79:648-657.
13. Langhans W. Signals generating anorexia during acute illness. Proc. Nutr. Soc. 2007, 66:321-330.
14. Lundholm K., Edstrom S., Karlberg I., Ekman L., Schersten T. Relationship of food intake, body composition, and tumor growth to host metabolism in nongrowing mice with sarcoma. Cancer Res. 1980, 40:2516-2522.
15. Lundholm K., Karlberg I., Ekman L., Edstrom S., Schersten T. Evaluation of anorexia as the cause of altered protein synthesis in skeletal muscles from nongrowing mice with sarcoma. Cancer Res. 1981, 41:1989-1996.
16. Lundholm K., Daneryd P., Korner U., Hyltander A., Bosaeus I. Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia. Int. J. Oncol. 2004, 24:505-512.
17. Matthys P., Billiau A. Cytokines and cachexia. Nutrition 1997, 13:763-770.
18. Moldawer L.L., Rogy M.A., Lowry S.F. The role of cytokines in cancer cachexia. JPEN J. Parenter. Enteral Nutr. 1992, 16:43S-49S.
19. Molfino A., Rossi-Fanelli F., Laviano A. The interaction between pro-inflammatory cytokines and the nervous system. Nat. Rev. Cancer 2009, 9:224.
20. Morton G.J., Cummings D.E., Baskin D.G., Barsh G.S., Schwartz M.W. Central nervous system control of food intake and body weight. Nature 2006, 443:289-295.
21. Naugler W.E., Sakurai T., Kim S., Maeda S., Kim K., Elsharkawy A.M., Karin M. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007, 317:121-124.
22. Nelson K.A. The cancer anorexia-cachexia syndrome. Semin. Oncol. 2000, 27:64-68.
23. Ogimoto K., Harris M.K., Wisse B.E. MyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 beta. Endocrinology 2006, 147:4445-4453.
24. Rakoff-Nahoum S., Medzhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 2007, 317:124-127.
25. Rakoff-Nahoum S., Medzhitov R. Toll-like receptors and cancer. Nat. Rev. Cancer 2009, 9:57-63.
26. Ruud J., Blomqvist A. Identification of rat brainstem neuronal structures activated during cancer-induced anorexia. J. Comp. Neurol. 2007, 504:275-286.
27. Swann J.B., Vesely M.D., Silva A., Sharkey J., Akira S., Schreiber R.D., Smyth M.J. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc. Natl. Acad. Sci. USA 2008, 105:652-656.
28. Whiteside T.L. The tumor microenvironment and its role in promoting tumor growth. Oncogene 2008, 27:5904-5912.
29. Wisse B.E., Schwartz M.W. Does hypothalamic inflammation cause obesity?. Cell Metab. 2009, 10:241-242.
30. Wisse B.E., Ogimoto K., Tang J., Harris M.K., Raines E.W., Schwartz M.W. Evidence that lipopolysaccharide-induced anorexia depends upon central, rather than peripheral, inflammatory signals. Endocrinology 2007, 148:5230-5237.
31. Yamawaki, Y., Kimura, H., Hosoi, T., Ozawa, K., 2009. MyD88 plays a key role in LPS-induced STAT3 activation in the hypothalamus. Am. J. Physiol. Regul. Integr. Comp. Physiol. Dec. 2 (Epub ahead of print).