The role of the gut mucosal immunity in the development of tolerance against allergy to food

Current Opinion in Allergy and Clinical Immunology

Volumn 10, Issue 3, 2010, Pages 220-225

  Chahine, Bassem G ^a   Bahna, Sami L ^a  

^a Louisiana State University Health Sciences Center at Shreveport   (United States)

Author keywords

Food allergy; Food hypersensitivity; Food intolerance; Food tolerance; Gut immunity

Indexed keywords

FOOD ALLERGEN; PROBIOTIC AGENT; SECRETORY IMMUNOGLOBULIN;

ATOPIC DERMATITIS; DENDRITIC CELL; DIGESTION; FOOD ALLERGY; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; INTESTINE EPITHELIUM; INTESTINE FLORA; INTESTINE MUCOSA; INTESTINE MUCOSA PERMEABILITY; LYMPHOID TISSUE; MOUTH MUCOSA; MUCOSAL IMMUNITY; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; REVIEW; RISK FACTOR; TH2 CELL;

ALLERGENS; DENDRITIC CELLS; DIET; DIETARY PROTEINS; FOOD HYPERSENSITIVITY; HUMANS; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A, SECRETORY; INFANT;

EID: 77951850837     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0b013e32833982ab     Document Type: Review

References (71)

1. Cristofaro P, Opal SM. Role of Toll-like receptors in infection and immunity: clinical implications. Drugs 2006;66:15-29.
2. Kraus TA, Toy L, Chan L, et al. Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease. Gastroenterology 2004;126:1771-1778.
3. Chehade M, Mayer L. Oral tolerance and its relation to food hypersensitivities. J Allergy Clin Immunol 2005;115:3-12; quiz 13.
4. Braunstahl GJ. The unified immune system: respiratory tract-nasobronchial interaction mechanisms in allergic airway disease. J Allergy Clin Immunol 2005;115:142-148.
5. Rynda A, Maddaloni M, Mierzejewska D, et al. Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein sigma1. J Immunol 2008;180:5187-5200.
6. Thurau SR, Wildner G. Oral tolerance for treating uveitis: new hope for an old immunological mechanism. Prog Retin Eye Res 2002;21:577-589.
7. Sharkey KA, Kroese AB. Consequences of intestinal inflammation on the enteric nervous system: neuronal activation induced by inflammatory mediators. Anat Rec 2001;262:79-90.
8. Groschwitz KR, Hogan SP. Intestinal barrier function: molecular regulation • and disease pathogenesis. J Allergy Clin Immunol 2009;124:3-20. A study describing the role of the intestinal immune barrier in health and disease.
9. Bjarnason I, MacPherson A, Hollander D. Intestinal permeability: an overview. Gastroenterology 1995;108:1566-1581.
10. Falth-Magnusson K, Kjellman NI, Magnusson KE, Sundqvist T. Intestinal permeability in healthy and allergic children before and after sodium-cromoglycate treatment assessed with different-sized polyethyleneglycols (PEG 400 and PEG 1000). Clin Allergy 1984;14:277-286.
11. Schulzke JD, Bentzel CJ, Schulzke I, et al. Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue. Pediatr Res 1998;43:435-441.
12. Palosuo K, Alineus H, Varjonen E, et al. Update on wheat hypersensitivity. Curr Opin Allergy Clin Immunol 2003;3:205-209.
13. Oyefara BI, Bahna SL. Delayed food-dependent, exercise-induced anaphylaxis. Allergy Asthma Proc 2007;28:64-66.
14. Knop E, Knop N, Claus P. Local production of secretory IgA in the eyeassociated lymphoid tissue (EALT) of the normal human ocular surface. Invest Ophthalmol Vis Sci 2008;49:2322-2329.
15. Yu QH, Yang Q. Diversity of tight junctions (TJs) between gastrointestinal epithelial cells and their function in maintaining the mucosal barrier. Cell Biol Int 2009;33:78-82.
16. Neutra MR. Current concepts in mucosal immunity. V: Role of M cells in transepithelial transport of antigens and pathogens to the mucosal immune system. Am J Physiol 1998;274: G785-G791.
17. Rey J, Garin N, Spertini F, Corthesy B. Targeting of secretory IgA to Peyer's patch dendritic and T cells after transport by intestinal M cells. J Immunol 2004;172:3026-3033.
18. Jang MH, Kweon MN, Iwatani K, et al. Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci USA 2004;101:6110-6115.
19. Corthesy B. Roundtrip ticket for secretory IgA: role in mucosal homeostasis? J Immunol 2007;178:27-32.
20. Pabst O, Bernhardt G, Forster R. The impact of cell-bound antigen transport on mucosal tolerance induction. J Leukoc Biol 2007;82:795-800.
21. Cebra JJ, Logan AC, Weinstein PD. The preference for switching to expression of the IgA isotype of antibody exhibited by B lymphocytes in Peyer's patches is likely due to intrinsic properties of their microenvironment. Immunol Res 1991;10:393-395.
22. Salim SY, Silva MA, Keita AV, et al. CD83+CCR7-dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer's patches of ileal Crohn's disease. Am J Pathol 2009;174:82-90.
23. Foti M, Ricciardi-Castagnoli P. Antigen sampling by mucosal dendritic cells. Trends Mol Med 2005;11:394-396.
24. Heyman M, Desjeux JF. Cytokine-induced alteration of the epithelial barrier to food antigens in disease. Ann N Y Acad Sci 2000;915:304-311.
25. Marcucci F, Incorvaia C, Sensi L, et al. Lack of inflammatory cells in the oral mucosa of subjects undergoing sublingual immunotherapy. Int J Immunopathol Pharmacol 2008;21:609-613.
26. Moingeon P, Batard T, Fadel R, et al. Immune mechanisms of allergen-specific sublingual immunotherapy. Allergy 2006;61:151-165.
27. Akdis CA, Barlan IB, Bahceciler N, Akdis M. Immunological mechanisms of sublingual immunotherapy. Allergy 2006;61(Suppl 81):11-14.
28. Bai Z, Hayasaka H, Kobayashi M, et al. CXC chemokine ligand 12 promotes CCR7-dependent naive T cell trafficking to lymph nodes and Peyer's patches. J Immunol 2009;182:1287-1295.
29. Battaglia M, Gianfrani C, Gregori S, Roncarolo MG. IL-10-producing T regulatory type 1 cells and oral tolerance. Ann N Y Acad Sci 2004;1029:142-153.
30. Elphick DA, Mahida YR. Paneth cells: their role in innate immunity and inflammatory disease. Gut 2005;54:1802-1809.
31. Secko D. A Nod toward understanding Crohn's disease. CMAJ 2005;172:738-739.
32. Rosenzweig HL, Kawaguchi T, Martin TM, et al. Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma. Invest Ophthalmol Vis Sci 2009;50:1739-1745.
33. Garrett WS, Lord GM, Punit S, et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 2007;131:33-45.
34. Targan SR, Karp LC. Defects in mucosal immunity leading to ulcerative colitis. Immunol Rev 2005;206:296-305.
35. Medina M, De Palma G, Ribes-Koninckx C, et al. Bifidobacterium strains suppress in vitro the pro-inflammatory milieu triggered by the large intestinal microbiota of coeliac patients. J Inflamm (Lond) 2008;5:19.
36. Blumberg RS, Lencer WI, Zhu X, et al. Antigen presentation by intestinal epithelial cells. Immunol Lett 1999;69:7-11.
37. Yio XY, Mayer L. Characterization of a 180-kDa intestinal epithelial cell membrane glycoprotein, gp180: a candidate molecule mediating t cellepithelial cell interactions. J Biol Chem 1997;272:12786-12792.
38. Hershberg RM, Mayer LF. Antigen processing and presentation by intestinal epithelial cells: polarity and complexity. Immunol Today 2000;21:123-128.
39. Fukata M, Breglio K, Chen A, et al. The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease. J Immunol 2008;180:1886-1894.
40. Kelly D, Conway S, Aminov R. Commensal gut bacteria: mechanisms of immune modulation. Trends Immunol 2005;26:326-333.
41. Untersmayr E, Scholl I, Swoboda I, et al. Antacid medication inhibits digestion of dietary proteins and causes food allergy: a fish allergy model in BALB/c mice. J Allergy Clin Immunol 2003;112:616-623.
42. Untersmayr E, Poulsen LK, Platzer MH, et al. The effects of gastric digestion on codfish allergenicity. J Allergy Clin Immunol 2005;115:377-382.
43. Prioult G, Fliss I, Pecquet S. Effect of probiotic bacteria on induction and maintenance of oral tolerance to beta-lactoglobulin in gnotobiotic mice. Clin Diagn Lab Immunol 2003;10:787-792.
44. Adel-Patient K, Ah-Leung S, Creminon C, et al. Oral administration of recombinant Lactococcus lactis expressing bovine beta-lactoglobulin partially prevents mice from sensitization. Clin Exp Allergy 2005;35:539-546.
45. Sudo N, Sawamura S, Tanaka K, et al. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 1997;159:1739-1745.
46. Bashir ME, Louie S, Shi HN, Nagler-Anderson C. Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. J Immunol 2004;172:6978-6987.
47. Ly NP, Ruiz-Perez B, Onderdonk AB, et al. Mode of delivery and cord blood cytokines: a birth cohort study. Clin Mol Allergy 2006;4:13.
48. Kalliomaki M, Salminen S, Arvilommi H, et al. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001;357:1076-1079.
49. Favre L, Spertini F, Corthesy B. Secretory IgA possesses intrinsic modulatory properties stimulating mucosal and systemic immune responses. J Immunol 2005;175:2793-2800.
50. Kelsall BL, Strober W. Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch. J Exp Med 1996;183:237-247.
51. Fujihashi K, Dohi T, Rennert PD, et al. Peyer's patches are required for oral tolerance to proteins. Proc Natl Acad Sci U S A 2001;98:3310-3315.
52. Warner RH, Stevens FM, McCarthy CF. Salivary SIgA and SIgA 1 in coeliac disease, inflammatory bowel disease and controls. Ir J Med Sci 1999;168:33-35.
53. Field CJ. The immunological components of human milk and their effect on immune development in infants. J Nutr 2005;135:1-4.
54. Zeiger RS, Heller S. The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. J Allergy Clin Immunol 1995;95:1179-1190.
55. Spahn TW, Fontana A, Faria AM, et al. Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches. Eur J Immunol 2001;31:1278-1287.
56. Chambers SJ, Bertelli E, Winterbone MS, et al. Adoptive transfer of dendritic cells from allergic mice induces specific immunoglobulin E antibody in naive recipients in absence of antigen challenge without altering the T helper 1/T helper 2 balance. Immunology 2004;112:72-79.
57. Burks AW, Laubach S, Jones SM. Oral tolerance, food allergy, and immunotherapy: implications for future treatment. J Allergy Clin Immunol 2008;121:1344-1350.
58. Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell 2001;106:255-258.
59. Akbari O, Faul JL, Hoyte EG, et al. CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N Engl J Med 2006;354:1117-1129.
60. Deniz G, Erten G, Kucuksezer UC, et al. Regulatory NK cells suppress antigen-specific T cell responses. J Immunol 2008;180:850-857.
61. Yoshino S, Hayashi H, Taneda S, et al. Effect of diesel exhaust particle extracts on induction of oral tolerance in mice. Toxicol Sci 2002;66:293-297.
62. Menezes JS, Mucida DS, Cara DC, et al. Stimulation by food proteins plays a critical role in the maturation of the immune system. Int Immunol 2003;15:447-455.
63. Hsieh KY, Tsai CC, Wu CH, Lin RH. Epicutaneous exposure to protein antigen and food allergy. Clin Exp Allergy 2003;33:1067-1075.
64. Strid J, Hourihane J, Kimber I, et al. Disruption of the stratum corneum allows potent epicutaneous sensitization with protein antigens resulting in a dominant H2 response. Eur J Immunol 2004;34:2100-2109.
65. Sicherer SH. The genetics of food allergy. Immunol Allergy Clin America 2002;22:211-212.
66. Strobel S, Ferguson A. Immune responses to fed protein antigens in mice. 3: Systemic tolerance or priming is related to age at which antigen is first encountered. Pediatr Res 1984;18:588-594.
67. Eastham EJ, Lichauco T, Grady MI, Walker WA. Antigenicity of infant formulas: role of immature intestine on protein permeability. J Pediatr 1978;93:561-564.
68. Andersson Y, Hammarstrom ML, Lonnerdal B, et al. Formula feeding skews •• immune cell composition toward adaptive immunity compared to breastfeeding. J Immunol 2009;183:4322-4328. This study addresses the effect of formula feeding on the innate and adaptive immunity in infants.
69. Janzi M, Kull I, Sjoberg R, et al. Selective IgA deficiency in early life: association • to infections and allergic diseases during childhood. Clin Immunol 2009;133:78-85. This study discusses the predisposing effect of IgA deficiency to increased infections and allergy.
70. Sanchez-Valverde F, Gil F, Martinez D, et al. The impact of caesarean delivery and type of feeding on cow's milk allergy in infants and subsequent development of allergic march in childhood. Allergy 2009;64:884-889.
71. Osborn DA, Sinn JK. Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev 2007: CD006475.