A Nod toward understanding Crohn's disease

CMAJ. Canadian Medical Association Journal

Volumn 172, Issue 6, 2005, Pages 738-739

  Secko, David ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; ANTIBIOTIC AGENT; ANTIINFLAMMATORY AGENT; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CRYPTDIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; MURAMYL DIPEPTIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

BONE MARROW; CLINICAL FEATURE; CROHN DISEASE; DISEASE PREDISPOSITION; GENE MUTATION; HEREDITY; HUMAN; IMMUNE RESPONSE; INTESTINE INFECTION; MACROPHAGE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SHORT SURVEY;

EID: 15244356849     PISSN: 08203946     EISSN: 14882329     Source Type: Journal    
DOI: 10.1503/cmaj.050181     Document Type: Short Survey

References (6)

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3. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001;411(6837):603-6.
4. Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, et al. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 2005;307 (5710):734-8.
5. Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nunez G, et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005;307(5710):731-4.
6. Wehkamp J, Harder J, Weichenthal M, Schwab M, Schaffeler E, Schlee M, et al. Nod2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 2004;53(11):1658-64.