메뉴 건너뛰기




Volumn 49, Issue 6, 2008, Pages 2322-2329

Local production of secretory IgA in the eye-associated lymphoid tissue (EALT) of the normal human ocular surface

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; SECRETORY IMMUNOGLOBULIN; IMMUNOGLOBULIN J CHAIN; SECRETORY COMPONENT;

EID: 47249103319     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-0691     Document Type: Article
Times cited : (55)

References (61)
  • 2
    • 0002628232 scopus 로고
    • Introduction: An overview of the mucosal immune system
    • Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee JR, Bienenstock J, eds. San Diego, CA: Academic Press
    • Tomasi TBJ. Introduction: an overview of the mucosal immune system. In: Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee JR, Bienenstock J, eds. Handbook of Mucosal Immunology. San Diego, CA: Academic Press; 1994;3-8.
    • (1994) Handbook of Mucosal Immunology , pp. 3-8
    • Tomasi, T.B.J.1
  • 3
    • 33947493325 scopus 로고    scopus 로고
    • Anatomy and immunology of the ocular surface
    • Niederkorn JY, Kaplan HJ, eds. Basel, Switzerland: Karger
    • Knop E, Knop N. Anatomy and immunology of the ocular surface. In: Niederkorn JY, Kaplan HJ, eds. Immune Response and the Eye. 2nd ed. Basel, Switzerland: Karger; 2007;36-49.
    • (2007) Immune Response and the Eye. 2nd Ed. , pp. 36-49
    • Knop, E.1    Knop, N.2
  • 4
    • 0035724878 scopus 로고    scopus 로고
    • Host-defense mechanism of the ocular surfaces
    • DOI 10.1023/A:1017943826684
    • Sack RA, Nunes I, Beaton A, Morris C. Host-defense mechanism of the ocular surfaces. Biosci Rep. 2001;21:463-480. (Pubitemid 34211830)
    • (2001) Bioscience Reports , vol.21 , Issue.4 , pp. 463-480
    • Sack, R.A.1    Nunes, I.2    Beaton, A.3    Morris, C.4
  • 5
    • 18244395597 scopus 로고    scopus 로고
    • Membrane array characterization of 80 chemokines, cytokines, and growth factors in open- And closed-eye tears: Angiogenin and other defense system constituents
    • DOI 10.1167/iovs.04-0760
    • Sack RA, Conradi L, Krumholz D, Beaton A, Sathe S, Morris C. Membrane array characterization of 80 chemokines, cytokines, and growth factors in open-and closed-eye tears: angiogenin and other defense system constituents. Invest Ophthalmol Vis Sci. 2005;46:1228-1238. (Pubitemid 41685857)
    • (2005) Investigative Ophthalmology and Visual Science , vol.46 , Issue.4 , pp. 1228-1238
    • Sack, R.A.1    Conradi, L.2    Krumholz, D.3    Beaton, A.4    Sathe, S.5    Morris, C.6
  • 6
    • 0001199522 scopus 로고
    • Immunohistologic studies of human lacrimal gland: Localization of immunoglobulins, secretory component and lactoferrin
    • Franklin RM, Kenyon KR, Tomasi TB Jr. Immunohistologic studies of human lacrimal gland: localization of immunoglobulins, secretory component and lactoferrin. J Immunol. 1973;110:984-992.
    • (1973) J Immunol , vol.110 , pp. 984-992
    • Franklin, R.M.1    Kenyon, K.R.2    Tomasi Jr., T.B.3
  • 7
  • 8
    • 0002387269 scopus 로고
    • An investigation into the presence of lymphatic tissue in the human conjunctiva, and its biological and clinical importance
    • Osterlind G. An investigation into the presence of lymphatic tissue in the human conjunctiva, and its biological and clinical importance. Acta Ophthalmol Copenh. 1944;23(suppl):1-79.
    • (1944) Acta Ophthalmol Copenh , vol.23 , Issue.SUPPL. , pp. 1-79
    • Osterlind, G.1
  • 9
    • 0002268979 scopus 로고
    • Mucous gland system of the conjunctiva: A quantitative normal anatomical study
    • Kessing SV. Mucous gland system of the conjunctiva: a quantitative normal anatomical study. Acta Ophthalmol Copenh. 1968;95(suppl):1-133.
    • (1968) Acta Ophthalmol Copenh , vol.95 , Issue.SUPPL. , pp. 1-133
    • Kessing, S.V.1
  • 10
    • 0017295799 scopus 로고
    • Tissue, tear, and serum IgE concentrations in vernal conjunctivitis
    • Allansmith MR, Hahn GS, Simon MA. Tissue, tear, and serum IgE concentrations in vernal conjunctivitis. Am J Ophthalmol. 1976;81:506-511.
    • (1976) Am J Ophthalmol , vol.81 , pp. 506-511
    • Allansmith, M.R.1    Hahn, G.S.2    Simon, M.A.3
  • 11
    • 0022480825 scopus 로고
    • Lymphocytic subpopulations in the normal human conjunctiva. a monoclonal antibody study
    • Sacks EH, Wieczorek R, Jakobiec FA, Knowles DM. Lymphocytic subpopulations in the normal human conjunctiva: a monoclonal antibody study. Ophthalmology. 1986;93:1276-1283. (Pubitemid 16008990)
    • (1986) Ophthalmology , vol.93 , Issue.10 , pp. 1276-1283
    • Sacks, E.H.1    Wieczorek, R.2    Jakobiec, F.A.3    Knowles II, D.M.4
  • 13
    • 0018836317 scopus 로고
    • Identification of T and B lymphocytes in the human conjunctiva and lacrimal gland in ocular diseases
    • Belfort R Jr, Mendes NF. Identification of T and B lymphocytes in the human conjunctiva and lacrimal gland in ocular diseases. Br J Ophthalmol. 1980;64:217-219. (Pubitemid 10082850)
    • (1980) British Journal of Ophthalmology , vol.64 , Issue.3 , pp. 217-219
    • Belfort Jr., R.1    Mendes, N.F.2
  • 14
    • 0019946555 scopus 로고
    • T-cell subsets and Langerhans cells in normal and diseased conjunctiva
    • Bhan AK, Fujikawa LS, Foster CS. T-cell subsets and Langerhans cells in normal and diseased conjunctiva. Am J Ophthalmol. 1982;94:205-212. (Pubitemid 12038553)
    • (1982) American Journal of Ophthalmology , vol.94 , Issue.2 , pp. 205-212
    • Bhan, A.K.1    Fujikawa, L.S.2    Foster, C.S.3
  • 16
    • 26944481070 scopus 로고    scopus 로고
    • Ultrastructural anatomy of CALT follicles in the rabbit reveal characteristics of M-cells, germinal centres and high endothelial venules
    • DOI 10.1111/j.1469-7580.2005.00470.x
    • Knop N, Knop E. Ultrastructural anatomy of CALT follicles in the rabbit reveals characteristics of M-cells, germinal centers and high endothelial venules. J Anat. 2005;207:409-426. (Pubitemid 41479544)
    • (2005) Journal of Anatomy , vol.207 , Issue.4 , pp. 409-426
    • Knop, N.1    Knop, E.2
  • 17
    • 0031769754 scopus 로고    scopus 로고
    • Comparative anatomy of mammalian conjunctival lymphoid tissue: A putative mucosal immune site
    • DOI 10.1016/S0145-305X(98)00022-6, PII S0145305X98000226
    • Chodosh J, Nordquist RE, Kennedy RC. Comparative anatomy of mammalian conjunctival lymphoid tissue: a putative mucosal immune site. Dev Comp Immunol. 1998;22:621-630. (Pubitemid 28541179)
    • (1998) Developmental and Comparative Immunology , vol.22 , Issue.5-6 , pp. 621-630
    • Chodosh, J.1    Nordquist, R.E.2    Kennedy, R.C.3
  • 18
    • 0031171913 scopus 로고    scopus 로고
    • Characterisation of the normal conjunctival leukocyte population
    • DOI 10.1006/exer.1996.0280
    • Hingorani M, Metz D, Lightman SL. Characterisation of the normal conjunctival leukocyte population. Exp Eye Res. 1997;64:905-912. (Pubitemid 27314765)
    • (1997) Experimental Eye Research , vol.64 , Issue.6 , pp. 905-912
    • Hingorani, M.1    Metz, D.2    Lightman, S.L.3
  • 20
    • 0035096271 scopus 로고    scopus 로고
    • Lacrimal drainage-associated lymphoid tissue (LDALT): A part of the human mucosal immune system
    • Knop E, Knop N. Lacrimal drainage associated lymphoid tissue (LDALT): a part of the human mucosal immune system. Invest Ophthalmol Vis Sci. 2001;43:566-574. (Pubitemid 32206893)
    • (2001) Investigative Ophthalmology and Visual Science , vol.42 , Issue.3 , pp. 566-574
    • Knop, E.1    Knop, N.2
  • 21
  • 22
    • 0032886323 scopus 로고    scopus 로고
    • Human conjunctiva contains high endothelial venules that express lymphocyte homing receptors
    • DOI 10.1006/exer.1999.0712
    • Haynes RJ, Tighe PJ, Scott RA, Singh DH. Human conjunctiva contains high endothelial venules that express lymphocyte homing receptors. Exp Eye Res. 1999;69:397-403. (Pubitemid 29469907)
    • (1999) Experimental Eye Research , vol.69 , Issue.4 , pp. 397-403
    • Haynes, R.J.1    Tighe, P.J.2    Scott, R.A.H.3    Singh Dua, H.4
  • 24
    • 0023928458 scopus 로고
    • The immunoarchitecture of the normal human lacrimal gland. Relevancy for understanding pathologic conditions
    • Wieczorek R, Jakobiec FA, Sacks EH, Knowles DM. The immunoarchitecture of the normal human lacrimal gland: relevancy for understanding pathologic conditions. Ophthalmology. 1988;95:100-109. (Pubitemid 18052409)
    • (1988) Ophthalmology , vol.95 , Issue.1 , pp. 100-109
    • Wieczorek, R.1    Jakobiec, F.A.2    Sacks, E.H.3    Knowles, D.M.4
  • 25
    • 0036931124 scopus 로고    scopus 로고
    • A functional unit for ocular surface immune defense formed by the lacrimal gland, conjunctivaand lacrimal drainage system
    • Knop E, Knop N. A functional unit for ocular surface immune defense formed by the lacrimal gland, conjunctiva and lacrimal drainage system. Adv Exp Med Biol. 2002;506:835-844. (Pubitemid 36308270)
    • (2002) Advances in Experimental Medicine and Biology , vol.506 B , pp. 835-844
    • Knop, E.1    Knop, N.2
  • 26
    • 15844363836 scopus 로고    scopus 로고
    • The role of eye-associated lymphoid tissue in corneal immune protection
    • DOI 10.1111/j.1469-7580.2005.00394.x
    • Knop E, Knop N. The role of eye-associated lymphoid tissue in corneal immune protection. J Anat. 2005;206:271-285. (Pubitemid 40424847)
    • (2005) Journal of Anatomy , vol.206 , Issue.3 , pp. 271-285
    • Knop, E.1    Knop, N.2
  • 27
    • 0002276108 scopus 로고    scopus 로고
    • Immunoglobulin transport and the polymeric immunoglobulin receptor
    • Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee JR, Bienenstock J, eds. San Diego, CA: Academic Press
    • Mostov K, Kaetzel CS. Immunoglobulin transport and the polymeric immunoglobulin receptor. In: Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee JR, Bienenstock J, eds. Handbook of Mucosal Immunology. 2nd ed. San Diego, CA: Academic Press; 1999;181-211.
    • (1999) Handbook of Mucosal Immunology. 2nd Ed. , pp. 181-211
    • Mostov, K.1    Kaetzel, C.S.2
  • 28
    • 76549182760 scopus 로고
    • Characteristics of an immune system common to certain external secretions
    • Tomasi TBJ, Tan EM, Solomon A, Prendergast RA. Characteristics of an immune system common to certain external secretions. J Exp Med. 1965;121:101-124.
    • (1965) J Exp Med , vol.121 , pp. 101-124
    • Tomasi, T.B.J.1    Tan, E.M.2    Solomon, A.3    Prendergast, R.A.4
  • 31
    • 33845956481 scopus 로고    scopus 로고
    • Roundtrip ticket for secretory IgA: Role in mucosal homeostasis?
    • Corthesy B. Roundtrip ticket for secretory IgA: role in mucosal homeostasis? J Immunol. 2007;178:27-32. (Pubitemid 46033584)
    • (2007) Journal of Immunology , vol.178 , Issue.1 , pp. 27-32
    • Corthesy, B.1
  • 32
    • 23344433145 scopus 로고    scopus 로고
    • The polymeric immunoglobulin receptor: Bridging innate and adaptive immune responses at mucosal surfaces
    • DOI 10.1111/j.0105-2896.2005.00278.x
    • Kaetzel CS. The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces. Immunol Rev. 2005;206:83-99. (Pubitemid 41105164)
    • (2005) Immunological Reviews , vol.206 , pp. 83-99
    • Kaetzel, C.S.1
  • 33
    • 0019456476 scopus 로고
    • Fixation techniques for secretory component in human lacrimal gland and conjunctiva
    • Cohen EJ, Allansmith MR. Fixation techniques for secretory component in human lacrimal gland and conjunctiva. Am J Ophthalmol. 1981;91:789-793. (Pubitemid 11078534)
    • (1981) American Journal of Ophthalmology , vol.91 , Issue.6 , pp. 789-793
    • Cohen, E.J.1    Allansmith, M.R.2
  • 34
    • 0001241974 scopus 로고    scopus 로고
    • Ocular mucosal immunity
    • Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee J, Bienenstock J, eds. San Diego, CA: Academic Press
    • Sullivan DA. Ocular mucosal immunity. In: Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee J, Bienenstock J, eds. Handbook of Mucosal Immunology. 2nd ed. San Diego, CA: Academic Press; 1999;1241-1281.
    • (1999) Handbook of Mucosal Immunology. 2nd Ed. , pp. 1241-1281
    • Sullivan, D.A.1
  • 36
    • 0019423594 scopus 로고
    • Use of Avidin-Biotin-Peroxidase Complex (ABC) in Immunoperoxidase Techniques: A comparison between ABC and unlabeled antibody (PAP) procedures
    • Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981;29:577-580. (Pubitemid 11147380)
    • (1981) Journal of Histochemistry and Cytochemistry , vol.29 , Issue.4 , pp. 577-580
    • Hsu, S.M.1    Raine, L.2    Fanger, H.3
  • 37
    • 0030405040 scopus 로고    scopus 로고
    • High mobility group proteins cHMG1a, cHMG1b, and cHMGI are distinctly distributed in chromosomes and differentially expressed during ecdysone dependent cell differentiation
    • Ghidelli S, Claus P, Thies G, Wisniewski JR. High mobility group proteins cHMG1a, cHMG1b, and cHMGI are distinctly distributed in chromosomes and differentially expressed during ecdysone dependent cell differentiation. Chromosoma. 1997;105:369-379. (Pubitemid 127789466)
    • (1997) Chromosoma , vol.105 , Issue.6 , pp. 369-379
    • Ghidelli, S.1    Claus, P.2    Thies, G.3    Wisniewski, J.R.4
  • 39
    • 0022577040 scopus 로고
    • Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues
    • Kett K, Brandtzaeg P, Radl J, Haaijman JJ. Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues. J Immunol. 1986;136:3631-3635. (Pubitemid 16122056)
    • (1986) Journal of Immunology , vol.136 , Issue.10 , pp. 3631-3635
    • Kett, K.1    Brandtzaeg, P.2    Radl, J.3    Haaijman, J.J.4
  • 40
    • 0020638190 scopus 로고
    • Immunohistochemical characterization of intracellular J-chain and binding site for secretory component (SC) in human immunoglobulin (Ig)-producing cells
    • Brandtzaeg P. Immunohistochemical characterization of intracellular J-chain and binding site for secretory component (SC) in human immunoglobulin (Ig)-producing cells. Mol Immunology. 1983;20:941-966.
    • (1983) Mol Immunology , vol.20 , pp. 941-966
    • Brandtzaeg, P.1
  • 41
    • 0033961056 scopus 로고    scopus 로고
    • Tear production after unilateral removal of the main lacrimal gland in squirrel monkeys
    • Maitchouk DY, Beuerman RW, Ohta T, Stern M, Varnell RJ. Tear production after unilateral removal of the main lacrimal gland in squirrel monkeys. Arch Ophthalmol. 2000;118:246-252. (Pubitemid 30086211)
    • (2000) Archives of Ophthalmology , vol.118 , Issue.2 , pp. 246-252
    • Maitchouk, D.Y.1    Beuerman, R.W.2    Ohta, T.3    Stern, M.4    Varnell, R.J.5
  • 43
    • 0032974175 scopus 로고    scopus 로고
    • Reduced amount of secretory component of IgA secretion in tears of patients with atopic dermatitis
    • DOI 10.1016/S0923-1811(98)00056-5, PII S0923181198000565
    • Toshitani A, Imayama S, Shimozono Y, Yoshinaga T, Furue M, Hori Y. Reduced amount of secretory component of IgA secretion in tears of patients with atopic dermatitis. J Dermatol Sci. 1999;19:134-138. (Pubitemid 29096444)
    • (1999) Journal of Dermatological Science , vol.19 , Issue.2 , pp. 134-138
    • Toshitani, A.1    Imayama, S.2    Shimozono, Y.3    Yoshinaga, T.4    Furue, M.5    Hori, Y.6
  • 44
    • 0025921056 scopus 로고
    • Sjögren syndrome: Comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA
    • Wehmeyer A, Das PK, Swaak T, Gebhart W, Kijlstra A. Sjögren syndrome: comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA. Int Ophthalmol. 1991;15:147-151.
    • (1991) Int Ophthalmol , vol.15 , pp. 147-151
    • Wehmeyer, A.1    Das, P.K.2    Swaak, T.3    Gebhart, W.4    Kijlstra, A.5
  • 45
    • 0021752664 scopus 로고
    • Evaluation of nine different fixatives.1. Preservation of immunoglobulin isotypes, J chain, and secretory component in human tissues
    • Brandtzaeg P, Rognum TO. Evaluation of nine different fixatives. 1. Preservation of immunoglobulin isotypes, J chain, and secretory component in human tissues. Pathol Res Pract. 1984;179:250-266. (Pubitemid 15184590)
    • (1984) Pathology Research and Practice , vol.179 , Issue.2 , pp. 250-266
    • Brandtzaeg, P.1    Rognum, T.O.2
  • 49
    • 0015883046 scopus 로고
    • In vitro synthesis of immunoglobulins, secretory component and complement in normal and pathological skin and the adjacent mucous membranes
    • Lai a Fat RF, Suurmond D, Furth RV. In vitro synthesis of immunoglobulins, secretory component and complement in normal and pathological skin and the adjacent mucous membranes. Clin Exp Immunol. 1973;14:377-395.
    • (1973) Clin Exp Immunol , vol.14 , pp. 377-395
    • Lai A Fat, R.F.1    Suurmond, D.2    Furth, R.V.3
  • 50
    • 0017106188 scopus 로고
    • Studies on translocation of immunoglobulins across intestinal epithelium. II. Immunoelectronmicroscopic localization of immunoglobulins and secretory component in human intestinal mucosa
    • Brown WR, Isobe Y, Nakane PK. Studies on translocation of immunoglobulins across intestinal epithelium. II. Immunoelectronmicroscopic localization of immunoglobulins and secretory component in human intestinal mucosa. Gastroenterology. 1976;71:985-995.
    • (1976) Gastroenterology , vol.71 , pp. 985-995
    • Brown, W.R.1    Isobe, Y.2    Nakane, P.K.3
  • 52
    • 0030730308 scopus 로고    scopus 로고
    • Polymeric immunoglobulin a receptor in the rodent female reproductive tract: Influence of estradiol in the vagina and differential expression of messenger ribonucleic acid during estrous cycle
    • DOI 10.1095/biolreprod57.5.958
    • Kaushic C, Frauendorf E, Wira CR. Polymeric immunoglobulin A receptor in the rodent female reproductive tract: influence of estradiol in the vagina and differential expression of messenger ribonucleic acid during estrous cycle. Biol Reprod. 1997;57:958-966. (Pubitemid 27461185)
    • (1997) Biology of Reproduction , vol.57 , Issue.5 , pp. 958-966
    • Kaushic, C.1    Frauendorf, E.2    Wira, C.R.3
  • 53
    • 0019490765 scopus 로고
    • Secretory component of IgA: A marker for differentiation of ocular epithelium
    • Liu SH, Tagawa Y, Prendergast RA, Franklin RM, Silverstein AM. Secretory component of IgA: a marker for differentiation of ocular epithelium. Invest Ophthalmol Vis Sci. 1981;20:100-109. (Pubitemid 11062156)
    • (1981) Investigative Ophthalmology and Visual Science , vol.20 , Issue.1 , pp. 100-109
    • Liu, S.H.1    Tagawa, Y.2    Prendergast, R.A.3
  • 55
    • 0023000402 scopus 로고
    • Naturally occurring IgA antibodies to ocular and oral microorganisms in tears, saliva and colostrum: Evidence for a common mucosal immune system and local response
    • DOI 10.1016/S0014-4835(86)80005-7
    • Gregory RL, Allansmith MR. Naturally occurring IgA antibodies to ocular and oral microorganisms in tears saliva and colostrum: evidence for a common mucosal immune system and local immune response. Exp Eye Res. 1986;43:739-749. (Pubitemid 17209073)
    • (1986) Experimental Eye Research , vol.43 , Issue.5 , pp. 739-749
    • Gregory, R.L.1    Allansmith, M.R.2
  • 58
    • 0036337774 scopus 로고    scopus 로고
    • Secretory component: A new role in secretory IgA-mediated immune exclusion in vivo
    • DOI 10.1016/S1074-7613(02)00341-2
    • Phalipon A, Cardona A, Kraehenbuhl JP, Edelman L, Sansonetti PJ, Corthesy B. Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo. Immunity. 2002;17:107-115. (Pubitemid 34874623)
    • (2002) Immunity , vol.17 , Issue.1 , pp. 107-115
    • Phalipon, A.1    Cardona, A.2    Kraehenbuhl, J.-P.3    Edelman, L.4    Sansonetti, P.J.5    Corthesy, B.6
  • 59
    • 0034776339 scopus 로고    scopus 로고
    • Epithelial mucins of the ocular surface: Structure, biosynthesis and function
    • DOI 10.1006/exer.2001.1045
    • Argueso P, Gipson IK. Epithelial mucins of the ocular surface: structure, biosynthesis and function. Exp Eye Res. 2001;73:281-289. (Pubitemid 32977194)
    • (2001) Experimental Eye Research , vol.73 , Issue.3 , pp. 281-289
    • Argueso, P.1    Gipson, I.K.2
  • 60
    • 0024307282 scopus 로고
    • Ultrastructure of the conjunctival epithelium
    • Steuhl KP. Ultrastructure of the conjunctival epithelium. Dev Ophthalmol. 1989;19:1-104.
    • (1989) Dev Ophthalmol , vol.19 , pp. 1-104
    • Steuhl, K.P.1
  • 61
    • 37349003869 scopus 로고    scopus 로고
    • New techniques in lacrimal gland research: The magic juice and how to drill for it
    • DOI 10.1159/000111695
    • Knop E, Knop N. New techniques in lacrimal gland research: the magic juice and how to drill for it. Ophthalmic Res. 2008;40:2-4. (Pubitemid 350308295)
    • (2008) Ophthalmic Research , vol.40 , Issue.1 , pp. 2-4
    • Knop, E.1    Knop, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.