A futile cycle, formed between two ATP-dependant γ-glutamyl cycle enzymes, γ-glutamyl cysteine synthetase and 5-oxoprolinase: The cause of cellular ATP depletion in nephrotic cystinosis?

Journal of Biosciences

Volumn 35, Issue 1, 2010, Pages 21-25

  Kumar, Akhilesh ^a   Bachhawat, Anand Kumar ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

Author keywords

glutamyl cycle; glutamyl glutathione; 5 oxoproline; ATP depletion; Cysteine synthetase; Cystinosis

Indexed keywords

5 OXOPROLINASE; ADENOSINE TRIPHOSPHATE; CYSTEINE; GAMMA GLUTAMYLCYSTEINE; GLUTAMATE CYSTEINE LIGASE; GLUTAMIC ACID; GLUTATHIONE; PYROGLUTAMIC ACID;

CELL ORGANELLE; DISEASE TRANSMISSION; ENZYME; MODELING; OBSERVATIONAL METHOD; PATHOLOGY;

BIOLOGICAL MODEL; CYSTINOSIS; GLUTATHIONE METABOLISM; HUMAN; HYPOTHESIS; NONHUMAN; PHENOTYPE; REVIEW;

ADENOSINE TRIPHOSPHATE; AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; ANIMALS; CYSTEINE; CYSTINOSIS; DISEASE MODELS, ANIMAL; GLUTAMATE-CYSTEINE LIGASE; GLUTAMIC ACID; HUMANS; MICE; MODELS, BIOLOGICAL; PYROGLUTAMATE HYDROLASE; PYRROLIDONECARBOXYLIC ACID;

EID: 77951750549     PISSN: 02505991     EISSN: 02505991     Source Type: Journal    
DOI: 10.1007/s12038-010-0004-8     Document Type: Review

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