Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers

Journal of Investigative Dermatology

Volumn 106, Issue 5, 1996, Pages 1119-1124

  Weckroth, Miina ^a   Vaheri, Antti ^a   Lauharanta, Jorma ^d   Sorsa, Timo ^c   Konttinen, Yrjö T ^b,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Exudate; Proteinase; Wound fluid

Indexed keywords

CATHEPSIN G; COLLAGENASE; DOXYCYCLINE; ELASTASE; GELATINASE; MATRIX METALLOPROTEINASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; LEG ULCER; PRIORITY JOURNAL; ULCER; WOUND HEALING;

EID: 0029972104     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12340167     Document Type: Article

References (42)

1. Agren MS, Taplin CJ, Woessner JF Jr, Eaglstein WH, Mertz PM: Collagenase in wound healing: effect of wound age and type. J Invest Dermatol 99:709-714, 1992
2. Bedi GS, Williams T: Purification and characterization of a collagen degrading protease from Porphyromonas gingivalis. J Biol Chem 269:599-606, 1994
3. Bieth J, Spiess B, Wermuth G: The synthesis and analytical use of a highly sensitive and convenient substrate of elastase. Biochem Med 11:350-357, 1974
4. Birkedal-Hansen H, Taylor RE, Zambon JJ, Harva PK, Neiders ME: Characterization of collagenolytic activity from strains of Bacteroides gingivalis. J Periodontal Res 23:258-264, 1988
5. Bodden MK, Harber GJ, Birkedal-Hansen B, Windsor LJ, Caterina NC, Engler JA, Birkedal-Hansen H: Functional domains of human TIMP-1 (tissue inhibitor of metalloproteinases). J Biol Chem 269:18943-52, 1994
6. Bullen EC, Longaker MT, Updike DL, Benton R, Ladin D, Hou Z, Howard EW: Tissue inhibitor of metalloproteinases-1 is decreased and activated gelatinases are increased in chronic wounds. J Invest Dermatol 104:236-240, 1995
7. Cheatle TR, Sarin S, Coleridge-Smith PD, Scurr JH: The pathogenesis of skin damage in venous disease: a review. Eur J Vasc Surg 5:115-123, 1991
8. Clowes AW, Clowes MM: Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery. Circ Res 67:61-67, 1990
9. Goldberg GI, Wilhelm SM, Kronberger A, Bauer EA, Grant GA, Eisen AZ: Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein. J Biol Chem 261:6600-5, 1986
10. Golub LM, Sorsa T, Lee HM, Ciancio S, Sorbi D, Ramamurthy NS, Gruber B, Salo T, Konttinen YT: Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J Clin Periodontol 22:100-109, 1995
11. Greenwald R, Golub LM, Lavietes B, Ramamurthy NS, Gruber B, Laskin R, McNamara TF: Tetracyclines inhibit human synovial collagenase in vivo and in vitro. J Rheumatol 14:28-32, 1987
12. Grenier D, Chao G, McBride BC: Characterization of sodium dodecyl sulphate-stable Bacteroides gingivalis proteases by polyacrylamide gel electrophoresis. Infect Immun 57:95-99, 1989
13. Grinnell F, Ho C-H, Wysocki A: Degradation of fibronectin and vitronectin in chronic wound fluid: analysis by cell blotting, immunoblotting, and cell adhesion assays. J Invest Dermatol 98:410-416, 1992
14. Falanga V: Chronic wounds: pathophysiologic and experimental considerations. J Invest Dermatol 100:721-725, 1993
15. Konttinen YT, Lindy O, Suomalainen K, Ritchlin C, Saari H, Vauhkonen M, Lauhio A, Santavirta S, Sorsa T: Substrate specificity and activation mechanisms of collagenase from human rheumatoid synovium. Matrix 11:395-403, 1991
16. Lauhio A, Salo T, Ding Y, Konttinen YT, Nordström D, Tschesche H, Lähdevirta J, Golub LM, Sorsa T: In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and NSAID in acute reactive arthritis. Clin Exp Immunol 98:21-28, 1994
17. Lin HY, Wells BR, Taylor RE, Birkedal-Hansen H: Degradation of type I collagen by rat mucosal keratinocytes. J Biol Chem 262:6823-6831, 1987
18. Liotta LA, Goldfarb RH, Brundale R, Siegal GP, Terranova V, Garbiza S: Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane. Cancer Res 41:4629-4636, 1981
19. Mainardi CL, Hibbs MS, Hasty KA, Seyer JM: Purification of a type V collagen degrading metalloproteinase from rabbit alveolar macrophages. Collagen Rel Res 4:479-492, 1984
20. Michaelis J, Vissers MC, Winterbourn CC: Human neutrophil collagenase cleaves alpha 1-antitrypsin. Biochem J 270:809-14, 1990
21. 2-terminal portion of the smaller fragment released from both collagens. Biochemistry 15:787-792, 1976
22. Morioka SM, Lazarus GS, Baird JL, Jensen PJ: Migrating keratinocytes express urokinase-type plasminogen activator. J Invest Dermatol 88:418-423, 1987
23. Moscatelli D, Ritkin DB: Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis. Biochem Biophys Acta 948:67-85, 1988
24. Murphy G, Hembry RM, Hughes CE, Fosang AJ, Hardingham TE: Role and regulation of metalloproteinases in connective tissue turnover. Biochem Soc Trans 18:812-815, 1990
25. Murphy G, McAlpine CG, Poll CT, Reynolds JJ: Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen. Biochim Biophys Acta 831:49-58;, 1985
26. O'Grady RL, Upfold LI, Stephens RW: Rat mammary carcinoma cells secrete active collagenase and activate latent enzyme in the stroma via plasminogen activator. Int J Cancer 28:509-515, 1981
27. Palolahti M, Lanharanta L, Stephens RW, Kuusela P, Vaheri A: Proteolytic activity in leg ulcer exudate. Exp Dermatol 2:29-37, 1993
28. Rømer J, Lund LR, Eriksen J, Raltkiær, Zeheb R, Gelehrter TD, Danø K, Kristensen P: Differential expression of urokinase-type plasminogen activator and its type-1 inhibitor during healing of mouse skin wounds. J Invest Dermatol 97:803-811, 1991
29. Saarialho-Kere UK, Kovacs SO, Pentland AP, Olerud JE, Welgus HG, Parks WC: Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing. J Clin Invest 92:2858-2866, 1993
30. Salo T, Lyons JG, Ramemtulla F, Birkedal-Hansen H, Larjava H: Transforming growth factor-b1 up-regulates type IV collagenase expression in cultured human keratinocytes. J Biol Chem 266:11436-11441, 1991
31. Sorsa T, Ding Y, Salo T, Lauhio A, Teronen O, Ingman T, Ohtani H, Andoh N, Takeha S, Konttinen YT: Effects of terracyclines on neutrophil, gingival, and salivary collagenases. A functional and Western-blot assessment with special reference to their cellular sources in periodomal diseases. Ann NY Acad Sci 732:112-131, 1994
32. Sorsa T, Uitto V-J, Suomalainen K, Turto H, Lindy S: A trypsin-like protease from Bacteroides gingivalis: partial purification and characterization. J Peridont Res 22:375-380, 1987
33. Stetler-Stevenson WJ, Krutzsch HC, Liotta LA: Tissue inhibitor of metalloproteinase (TIMP-2), a new member of the metalloproteinase family. J Biol Chem 264: 17374-17378, 1989
34. Stricklin GP, Jeffrey JJ, Roswit WT, Eisen AZ: Human skin procollagenase: mechanisms of activation by organomercurials and trypsin. Biochemistry 22:61-68, 1983
35. Suomalainen K, Sorsa T, Golub LM, Ramamurthy N, Lee H-M, Uitto V-J, Saari H, Konttinen YT: Specificity of the anti-collagenase action of tetracyclines: relevance to their anti-inflammatory potential. Antimicrobiol Agents Chemother 36:227-229, 1992
36. Tryggvason K, Höyhtyä M, Salo T: Proteolytic degradation of extracellular matrix in tumor invasion. Biochim Biophys Acta 907:191-217, 1987
37. Turto H, Lindy S, Uitto V-J, Wegelius O, Uitto J: Human leukocyte collagenase: characterization of enzyme kinetics by a new method. Anal Biochem 83:557-569, 1977
38. Vaheri A, Stephens RW, Salonen E-M, Pöllänen J, Tapiovaara H: Plasminogen activation at the cell surface -matrix interface. Cell Differ Dev 32:255-262, 1990
39. Werb Z, Gordon S: Secretion of a specific collagenase by stimulated macrophages. J Exp Med 142:346-360, 1975
40. Wysocki AB, Staiano-Coico L, Grinnell F: Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9. J Invest Dermatol 101:64-68, 1993
41. Young PK, Grinnell F: Metalloproteinase activation cascade after burn injury: a longitudinal analysis ot the human wound environment. J Invest Dermatol 103:660-664, 1994
42. Yu LP Jr, Smith GN Jr, Hasty KA, Brandt KD: Doxycycline inhibits type XI collagenolytic activity of extracts from human osteoarthritic cartilage and of golatinase. J Rheumatol 18:1450-1452, 1991