Longdan Xiegan Tang has immunomodulatory effects on CD4 +CD25+ T cells and attenuates pathological signs in MRL/lpr mice

International Journal of Molecular Medicine

Volumn 25, Issue 5, 2010, Pages 677-685

  Lee, Tzung Yan ^a   Chang, Hen Hong ^a,b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Longdan Xiegan Tang; MRL lpr

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYCLOOXYGENASE 2; CYTOKINE; DNA ANTIBODY; ENOLASE; FERRITIN; GAMMA INTERFERON; GLUTATHIONE; HERBACEOUS AGENT; IMMUNOGLOBULIN G; IMMUNOMODULATING AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; LONGDAN XIEGAN TANG; PHOSPHOGLYCERATE KINASE; PROTEOME; SELENIUM BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISTRESS SYNDROME; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFICACY; FEMALE; GLOMERULUS; IMMUNE COMPLEX DEPOSITION; IMMUNOMODULATION; LIGHT CHAIN; LPR MOUSE; MOUSE; MOUSE STRAIN; MOUSE STRAIN MRL; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; SPLENOMEGALY; SYSTEMIC LUPUS ERYTHEMATOSUS; TH1 CELL; TH2 CELL; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DRUGS, CHINESE HERBAL; FEMALE; FLOW CYTOMETRY; GLUTATHIONE; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; KIDNEY; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED MRL LPR; PROTEOME; RANDOM ALLOCATION; T-LYMPHOCYTE SUBSETS;

EID: 77951700075     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm-00000391     Document Type: Article

References (34)

1. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA and Nagata S: Lymphoproliferative disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356: 314-317, 1992.
2. Ravirajan CT, Sarraf CE, Anilkumar TV, Golding MC, Alison MR and Isenberg DA: An analysis of apoptosis in lymphoid organs and lupus disease in murine systemic lupus erythematosus (SLE). Clin Exp Immunol 105: 306-312, 1996.
3. Piredda L, Amendola A, Colizzi V, Davies PJ, Farrace MG, Fraziano M, Gentile V, et al: Lack of 'tissue' transglutaminase protein cross-linking leads to leakage of macromolecules from dying cells: relationship to development of autoimmunity in MRL lpr/lpr mice. Cell Death Differ 4: 463-472, 1997.
4. Theofilopoulos AN and Lawson BR: Tumour necrosis factor and other cytokines in murine lupus. Ann Rheum Dis 58: 49-55, 1999.
5. Kono DH and Theofilopoulos AN: Genetics of systemic autoimmunity in mouse models of lupus. Int Rev Immunol 19: 367-387, 2000.
6. Benihoud K, Bonardelle D, Soual-Hoebeke E, Durand-Gasselin I, Emilie D, Kiger N and Bobé P: Unusual expression of LINE-1 transposable element in the MRL autoimmune lymphoproliferative syndrome-prone strain. Oncogene 21: 5593-5600, 2002. (Pubitemid 34983549)
7. La Cava A: T-regulatory cells in systemic lupus erythematosus. Lupus 17: 421-425, 2008. (Pubitemid 351798720)
8. +CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 178: 2579-2588, 2007.
9. Morgan PE, Sturgess AD and Davies MJ: Increased levels of serum protein oxidation and correlation with disease activity in systemic lupus erythematosus. Arthritis Rheum 52: 2069-2079, 2005. (Pubitemid 41001420)
10. Giustarini D, Lorenzini S, Rossi R, Chindamo D, Di Simplicio P and Marcolongo R: Altered thiol pattern in plasma of subjects affected by rheumatoid arthritis. Clin Exp Rheumatol 23: 205-212, 2005. (Pubitemid 40663001)
11. Sukkar SG and Rossi E: Oxidative stress and nutritional prevention in autoimmune rheumatic diseases. Autoimmun Rev 3: 199-206, 2004.
12. Chen FP, Kung YY, Chen YC, Jong MS, Chen TJ, Chen FJ and Hwang SJ: Frequency and pattern of Chinese herbal medicine prescriptions for chronic hepatitis in Taiwan. J Ethnopharmacol 117: 84-91, 2008.
13. Wang CH, Cheng XM, Bligh SW, White KN, Branford-White CJ and Wang ZT: Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats - Comparison with gentiopicroside alone. J Pharm Biomed Anal 44: 1113-1117, 2007.
14. Reed DJ, Babson JR, Beatty PW, Brodie AE, Ellis WW and Potter DW: High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Anal Biochem 106: 55-62, 1980.
15. Lee TY, Chang HH, Kuo JJ and Shen JJ: Changes of hepatic proteome in bile duct ligated rats with hepatic fibrosis following treatment with Yin-Chen-Hao-Tang. Int J Mol Med 23: 477-484, 2009.
16. Wu HY and Staines NA: A deficiency of CD4+CD25+ T cells permits the development of spontaneous lupus-like disease in mice, and can be reversed by induction of mucosal tolerance to histone peptide autoantigen. Lupus 13: 192-200, 2004.
17. De la Torre A, Debiton E, Durand D, Chardigny JM, Berdeaux O, Loreau O, Barthomeuf C, et al: Conjugated linoleic acid isomers and their conjugated derivatives inhibit growth of human cancer cell lines. Anticancer Res 25: 3943-3949, 2005. (Pubitemid 41665167)
18. Haddad JJ and Harb HL: L-gamma-Glutamyl-L-cysteinylglycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)? Mol Immunol 42: 987-1014, 2005. (Pubitemid 40501835)
19. Venkatraman JT, Chandrasekar B, Kim JD and Fernandes G: Genotype effects on the antioxidant enzyme activity and mRNA expression in liver and kidney tissues of autoimmune-prone MRL/MpJ-lpr/lpr mice. Biochim Biophys Acta 1213: 167-175, 1994. (Pubitemid 24222807)
20. Fujita T: Senescence marker protein-30 (SMP30): structure and biological function. Biochem Biophys Res Commun 254: 1-4, 1999.
21. Fujita T, Shirasawa T, Uchida K and Maruyama N: Gene regulation of senescence marker protein-30 (SMP30): coordinated up-regulation with tissue maturation and gradual down-regulation with aging. Mech Ageing Dev 87: 219-229, 1996. (Pubitemid 26179139)
22. Pancholi V: Multifunctional alpha-enolase: its role in diseases. Cell Mol Life Sci 58: 902-920, 2001. (Pubitemid 32652817)
23. Sabbatini A, Dolcher MP, Marchini B, Chimenti D, Moscato S, Pratesi F, Bombardieri S and Migliorini P: Alpha-enolase is a renal-specific antigen associated with kidney involvement in mixed cryoglobulinemia. Clin Exp Rheumatol 15: 655-658, 1997. (Pubitemid 27501652)
24. Migliorini P, Pratesi F, Bongiorni F, Moscato S, Scavuzzo M and Bombardieri S: The targets of nephritogenic antibodies in systemic autoimmune disorders. Autoimmun Rev 1: 168-173, 2002. (Pubitemid 38340268)
25. Mattow J, Demuth I, Haeselbarth G, Jungblut PR and Klose J: Selenium-binding protein 2, the major hepatic target for acetaminophen, shows sex differences in protein abundance. Electrophoresis 27: 1683-1691, 2006.
26. Pumford NR, Hinson JA, Benson RW and Roberts DW: Immunoblot analysis of protein containing 3-(cystein-S-yl) acetaminophen adducts in serum and subcellular liver fractions from acetaminophen-treated mice. Toxicol Appl Pharmacol 104: 521-532, 1990.
27. Le NT and Richardson DR: The role of iron in cell cycle progression and the proliferation of neoplastic cells. Biochim Biophys Acta 1603: 31-46, 2002. (Pubitemid 35257983)
28. Torti FM and Torti SV: Regulation of ferritin genes and protein. Blood 99: 3505-3516, 2002.
29. Megli FM and Sabatini K: EPR studies of phospholipid bilayers after lipoperoxidation. 1. Inner molecular order and fluidity gradient. Chem Phys Lipids 125: 161-172, 2003.
30. Shetty S, Ganachari M, Liu MC, Azghani A, Muniyappa H and Idell S: Regulation of urokinase receptor expression by phosphoglycerate kinase is independent of its catalytic activity. Am J Physiol Lung Cell Mol Physiol 289: L591-L598, 2005. (Pubitemid 41361669)
31. Rosa R, George C, Fardeau M, Calvin MC, Rapin M and Rosa J: A new case of phosphoglycerate kinase deficiency: PGK Creteil associated with rhabdomyolysis and lacking hemolytic anemia. Blood 60: 84-91, 1982. (Pubitemid 12085924)
32. Turner G, Fletcher J, Elber J, Yanagawa Y, Davé V and Yoshida A: Molecular defect of a phosphoglycerate kinase variant associated with haemolytic anaemia and neurological disorders in a large kindred. Br J Haematol 91: 60-65, 1995.
33. Luan HY, Tang SJ, Yang W, Tsai CY, Sun GH and Sun KH: Monoclonal anti-double-stranded DNA antibodies cross-react with phosphoglycerate kinase 1 and inhibit the expression and production of IL-2 in activated Jurkat T cell line. Clin Immunol 120: 326-334, 2006. (Pubitemid 44202601)
34. Rekvig OP and Nossent JC: Anti-double-stranded DNA antibodies, nucleosomes, and systemic lupus erythematosus: a time for new paradigms? Arthritis Rheum 48: 300-312, 2003.