Azides derived from colchicine and their use in library synthesis: A practical entry to new bioactive derivatives of an old natural drug

ChemMedChem

Volumn 5, Issue 5, 2010, Pages 661-665

  Nicolaus, Norman ^a   Zapke, Janet ^b   Riesterer, Philipp ^c   Neudörfl, Jörg Martin ^a   Prokop, Aram ^c   Oschkinat, Hartmut ^b   Schmalz, Hans Günther ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^c UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

1,3 dipolar cycloaddition; Antitumor agents; Click chemistry; Diversity oriented synthesis; Natural products

Indexed keywords

ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; AZIDE; COLCHICINE; COLCHICINE DERIVATIVE; PACLITAXEL; TRIAZOLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BURKITT LYMPHOMA; CONJUGATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; LYMPHOMA CELL; MICROTUBULE ASSEMBLY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; UTERINE CERVIX CARCINOMA;

ANTINEOPLASTIC AGENTS; AZIDES; COLCHICINE; CRYSTALLOGRAPHY, X-RAY; HELA CELLS; HUMANS; MOLECULAR CONFORMATION; TRIAZOLES; TUBULIN MODULATORS;

EID: 77951694589     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000063     Document Type: Article

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