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Volumn 38, Issue 2, 2010, Pages 373-386

Platycodon grandiflorum induces apoptosis in SKOV3 human ovarian cancer cells through mitochondrial-dependent pathway

Author keywords

Apoptosis; Caspase; Platycodon grandiflorum; SKOV3 Cells

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; LIPOCORTIN 5; PLATYCODON GRANDIFLORUM EXTRACT; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2;

EID: 77951689872     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X10007919     Document Type: Article
Times cited : (23)

References (28)
  • 1
    • 33646153996 scopus 로고    scopus 로고
    • Platycodin D-induced apoptosis through nuclear factor-kappaB activation in immortalized keratinocytes
    • Ahn, K.S., B.S. Hahn, K. Kwack, E.B. Lee and Y.S. Kim. Platycodin D-induced apoptosis through nuclear factor-kappaB activation in immortalized keratinocytes. Eur. J. Pharmacol. 537: 1-11, 2006.
    • (2006) Eur. J. Pharmacol. , vol.537 , pp. 1-11
    • Ahn, K.S.1    Hahn, B.S.2    Kwack, K.3    Lee, E.B.4    Kim, Y.S.5
  • 4
    • 33745919856 scopus 로고    scopus 로고
    • The fractionated Toona sinensis leaf extract induces apoptosis of human ovarian cancer cells and inhibits tumor growth in a murine xenograft model
    • Chang, H.L., H.K. Hsu, J.H. Su, P.H. Wang, Y.F. Chung, Y.C. Chia, L.Y. Tsai, Y.C. Wu and S.S. Yuan. The fractionated Toona sinensis leaf extract induces apoptosis of human ovarian cancer cells and inhibits tumor growth in a murine xenograft model. Gynecol. Oncol. 102: 309-314, 2006.
    • (2006) Gynecol. Oncol. , vol.102 , pp. 309-314
    • Chang, H.L.1    Hsu, H.K.2    Su, J.H.3    Wang, P.H.4    Chung, Y.F.5    Chia, Y.C.6    Tsai, L.Y.7    Wu, Y.C.8    Yuan, S.S.9
  • 5
    • 0036022407 scopus 로고    scopus 로고
    • Initiator caspase in apoptosis signaling pathways
    • Chen, M. and J. Wang. Initiator caspase in apoptosis signaling pathways. Apoptosis 7: 313-319, 2002.
    • (2002) Apoptosis , vol.7 , pp. 313-319
    • Chen, M.1    Wang, J.2
  • 6
    • 33847688864 scopus 로고    scopus 로고
    • Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer SK-OV-3 cells
    • Choi, E.J., T. Kim and M.S. Lee. Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer SK-OV-3 cells. Life Sci. 80: 1403-1408, 2007.
    • (2007) Life Sci. , vol.80 , pp. 1403-1408
    • Choi, E.J.1    Kim, T.2    Lee, M.S.3
  • 7
    • 0032968718 scopus 로고    scopus 로고
    • Discovery and development of antineoplastic agents from natural sources
    • Cragg, G.M. and D.J. Newman. Discovery and development of antineoplastic agents from natural sources. Cancer Invest. 17: 153-163, 1999.
    • (1999) Cancer Invest. , vol.17 , pp. 153-163
    • Cragg, G.M.1    Newman, D.J.2
  • 13
    • 33750375026 scopus 로고    scopus 로고
    • Qualitative and quantitative determination of ten major saponins in Platycodi Radix by high performance liquid chromatography with evaporative light scattering detection and mass spectrometry
    • Ha, Y.W., Y.C. Na, J.J. Seo, S.N. Kim, R.J. Linhardt and Y.S. Kim. Qualitative and quantitative determination of ten major saponins in Platycodi Radix by high performance liquid chromatography with evaporative light scattering detection and mass spectrometry. J. Chromatogr. A 1135(1): 27-35, 2006.
    • (2006) J. Chromatogr. A , vol.1135 , Issue.1 , pp. 27-35
    • Ha, Y.W.1    Na, Y.C.2    Seo, J.J.3    Kim, S.N.4    Linhardt, R.J.5    Kim, Y.S.6
  • 14
    • 33745848859 scopus 로고    scopus 로고
    • Effect of Platycodon grandiflorum on lipopolysaccharide-stimulated production pf prostaglandin E2, nitric oxide, and interleukin-8 in mouse microglial BV2 cells
    • Jang, M.H., C.J. Kim, E.H. Kim, M.G. Kim, K.H. Leem and J. Kim. Effect of Platycodon grandiflorum on lipopolysaccharide-stimulated production pf prostaglandin E2, nitric oxide, and interleukin-8 in mouse microglial BV2 cells. J. Med. Food 9: 169-174, 2006.
    • (2006) J. Med. Food , vol.9 , pp. 169-174
    • Jang, M.H.1    Kim, C.J.2    Kim, E.H.3    Kim, M.G.4    Leem, K.H.5    Kim, J.6
  • 15
    • 29044450102 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor-alpha-induced expression of adhesion molecules in human endothelial cells by the saponins derived from roots of Platycodon grandiflorum
    • Kim, J.Y., D.H. Kim, H.G. Kim, G.Y. Song, Y.C. Chung, S.H. Roh and H.G. Jeong. Inhibition of tumor necrosis factor-alpha-induced expression of adhesion molecules in human endothelial cells by the saponins derived from roots of Platycodon grandiflorum. Toxicol. Appl. Pharmacol. 210: 150-156, 2006.
    • (2006) Toxicol. Appl. Pharmacol. , vol.210 , pp. 150-156
    • Kim, J.Y.1    Kim, D.H.2    Kim, H.G.3    Song, G.Y.4    Chung, Y.C.5    Roh, S.H.6    Jeong, H.G.7
  • 16
    • 21344449760 scopus 로고    scopus 로고
    • Isolation of a new saponin and cytotoxic effect of saponins from the root of Platycodon grandiflorum on human tumor cell lines
    • Kim, Y.S., J.S. Kim, S.U. Choi, J.S. Kim, H.S. Lee, S.H. Roh, Y.C. Jeong, Y.K. Kim and S.Y. Ryu. Isolation of a new saponin and cytotoxic effect of saponins from the root of Platycodon grandiflorum on human tumor cell lines. Planta Med. 71: 566-568, 2005.
    • (2005) Planta Med. , vol.71 , pp. 566-568
    • Kim, Y.S.1    Kim, J.S.2    Choi, S.U.3    Kim, J.S.4    Lee, H.S.5    Roh, S.H.6    Jeong, Y.C.7    Kim, Y.K.8    Ryu, S.Y.9
  • 17
    • 1442286330 scopus 로고    scopus 로고
    • The role of Bcl-2 family member in tumorigenesis
    • Kirkin, V., S. Joos and M. Zornig. The role of Bcl-2 family member in tumorigenesis. Biochim. Biophys. Acta 1644: 229-249, 2004.
    • (2004) Biochim. Biophys. Acta , vol.1644 , pp. 229-249
    • Kirkin, V.1    Joos, S.2    Zornig, M.3
  • 18
    • 33748351414 scopus 로고    scopus 로고
    • Chemopreventive effect of saponins derived from roots of Platycodon grandiflorum on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice
    • Lee, K.J., D.W. Shin, Y.C. Chung and H.G. Jeong. Chemopreventive effect of saponins derived from roots of Platycodon grandiflorum on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. Arch. Pharm. Res. 29: 651-656, 2006.
    • (2006) Arch. Pharm. Res. , vol.29 , pp. 651-656
    • Lee, K.J.1    Shin, D.W.2    Chung, Y.C.3    Jeong, H.G.4
  • 19
    • 33750688244 scopus 로고    scopus 로고
    • Inhibition of tumor invasion and metastasis by aqueous extract of the radix of Platycodon grandiflorum
    • Lee, K.J., J.Y. Kim, J.H. Choi, H.G. Kim, Y.C. Chung, S.H. Roh and H.G. Jeong. Inhibition of tumor invasion and metastasis by aqueous extract of the radix of Platycodon grandiflorum. Food Chem. Toxicol. 44: 1890-1896, 2006.
    • (2006) Food Chem. Toxicol. , vol.44 , pp. 1890-1896
    • Lee, K.J.1    Kim, J.Y.2    Choi, J.H.3    Kim, H.G.4    Chung, Y.C.5    Roh, S.H.6    Jeong, H.G.7
  • 20
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine, A.J. P53, The cellular gatekeeper for growth and division. Cell 88: 323-331, 1997.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 21
    • 0344142396 scopus 로고    scopus 로고
    • Emerging roles of caspase-3 in apoptosis
    • Porter, A.G. and R.U. Janicke. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 6: 99-104, 1999.
    • (1999) Cell Death Differ. , vol.6 , pp. 99-104
    • Porter, A.G.1    Janicke, R.U.2
  • 23
    • 0036515075 scopus 로고    scopus 로고
    • Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters
    • Shin, C.Y., W.J. Lee, E.B. Lee, E.Y. Choi and K.H. Ko. Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters. Planta Med. 68: 221-225, 2002.
    • (2002) Planta Med. , vol.68 , pp. 221-225
    • Shin, C.Y.1    Lee, W.J.2    Lee, E.B.3    Choi, E.Y.4    Ko, K.H.5
  • 24
    • 0016572224 scopus 로고
    • Studies on the saponins of the root of Platycodon grandiflorum A. De Candolle. I. Isolation and the structure of platycodin-D
    • Tada, A., Y. Kaineiwa, J. Shoji and S. Shibata. Studies on the saponins of the root of Platycodon grandiflorum A. De Candolle. I. Isolation and the structure of platycodin-D. Chem. Pharm. Bull. (Tokyo) 23: 2965-2972, 1975.
    • (1975) Chem. Pharm. Bull. (Tokyo) , vol.23 , pp. 2965-2972
    • Tada, A.1    Kaineiwa, Y.2    Shoji, J.3    Shibata, S.4
  • 25
    • 32644473650 scopus 로고    scopus 로고
    • How the Bcl-2 family of proteins interact to regulate apoptosis
    • van Delft, M.F. and D.C. Huang. How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res. 16: 203-213, 2006.
    • (2006) Cell Res. , vol.16 , pp. 203-213
    • Van Delft, M.F.1    Huang, D.C.2
  • 26
    • 0031985647 scopus 로고    scopus 로고
    • Annexin v-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure
    • van Engeland, M., L.J. Nieland, F.C. Ramaekers, B. Schutte and C.P. Reutelingsperqer. Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31: 1-9, 1998.
    • (1998) Cytometry , vol.31 , pp. 1-9
    • Van Engeland, M.1    Nieland, L.J.2    Ramaekers, F.C.3    Schutte, B.4    Reutelingsperqer, C.P.5
  • 27
    • 0029043888 scopus 로고
    • A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V
    • Vermes, I., C. Haanen, H. Steffens-Nakken and C. Reutelingsperger. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V. J. Immunol. Methods 184: 39-51, 1995.
    • (1995) J. Immunol. Methods , vol.184 , pp. 39-51
    • Vermes, I.1    Haanen, C.2    Steffens-Nakken, H.3    Reutelingsperger, C.4
  • 28
    • 21844471043 scopus 로고    scopus 로고
    • In vitro inhibitory effect of triter-penoidal saponins from Platycodi Radix on pancreatic lipase
    • Xu, B.J., L.K. Han, Y.N. Zheng, J.H. Lee and C.K. Sung. in vitro inhibitory effect of triter-penoidal saponins from Platycodi Radix on pancreatic lipase. Arch. Pharm. Res. 28: 180-185, 2005.
    • (2005) Arch. Pharm. Res. , vol.28 , pp. 180-185
    • Xu, B.J.1    Han, L.K.2    Zheng, Y.N.3    Lee, J.H.4    Sung, C.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.