Discovery and development of antineoplastic agents from natural sources

Cancer Investigation

Volumn 17, Issue 2, 1999, Pages 153-163

  Cragg, Gordon M ^a   Newman, David J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer; Drugs; Natural products

Indexed keywords

ASPARAGINASE MACROGOL; BICALUTAMIDE; BISANTRENE; BLEOMYCIN; CYTARABINE; DACTINOMYCIN; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; FLUDARABINE; FORMESTANE; GAMMA INTERFERON; GEMCITABINE; IDARUBICIN; IRINOTECAN; MILTEFOSINE; NATURAL PRODUCT; PACLITAXEL; PENTOSTATIN; PHOTOFRIN; RALTITREXED; SOBUZOXANE; TOPOTECAN; VINBLASTINE; ZINOSTATIN;

ANTINEOPLASTIC ACTIVITY; BIODIVERSITY; DRUG ISOLATION; ENVIRONMENTAL EXPOSURE; GENETIC ENGINEERING; GENETIC MANIPULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEIC ACID ANALYSIS; PRIORITY JOURNAL; REVIEW;

EID: 0032968718     PISSN: 07357907     EISSN: None     Source Type: Journal    
DOI: 10.1080/07357909909011730     Document Type: Review

References (32)

1. Chang H-M, But PP-H, eds: Pharmacology and Applications of Chinese Materia Medica, Vol. 1 and 2, Singapore, World Scientific Publishing, 1986.
2. Kapoor LD: CRC Handbook of Ayurvedic Medicinal Plants. Boca Raton, FL, CRC Press, 1990.
3. Farnsworth NR, Akerele O, Bingel AS, et al: Medicinal plants in therapy. Bull WHO 63:965-981, 1985.
4. Kinghorn AD: The discovery of drugs from higher plants. In: The Discovery of Natural Products with Therapeutic Potential, edited by VP Gullo, Boston, Butterworth-Heinemann, 1994, pp 81-108.
5. McConnell O, Longley RE, Koehn FE: The discovery of marine natural products with therapeutic potential. In: The Discovery of Natural Products with Therapeutic Potential, edited by VP Gullo, Boston, MA, Butterworth-Heinemann, 1994, pp 109-174.
6. Cragg GM, Newman DJ, Snader KM: Natural products in drug discovery and development. J Nat Prod 60:52-60, 1997.
7. Hartwell JL: Plants Used Against Cancer. Lawrence, MA, Quarterman, 1982.
8. Cragg GM, Boyd MR, Cardellina II JH, et al: Ethnobotany and drug discovery: the experience of the US National Cancer Institute. In: Ethnobotany and the Search for New Drugs. Ciba Foundation Symposium 185, edited by DJ Chadwick, J Marsh, Chichester, U.K., Wiley & Sons, 1994, pp 178-196.
9. Cragg GM, Schepartz SA, Suffness M, et al: The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents. J Nat Prod 56:1657-1668, 1993.
10. Cortes JE, Pazdur R: Docetaxel. J Clin Oncol 13:2643-2655, 1995.
11. Potmeisel M, Pinedo H, eds: Camptothecins: New Anticancer Agents. Boca Raton, FL, CRC Press, 1995.
12. Cragg GM, Boyd MR, Cardellina II JH, et al: Role of plants in the National Cancer Institute drug discovery and development program. In: Human Medicinal Agents from Plants. Am Chem Soc Symposium Series 534, edited by AD Kinghorn, MF Balandrin, Washington, DC, Amer Chem Soc, 1993, pp 80-95.
13. Christian MC, Pluda JM, Ho TC, et al: Promising new agents under development by the Division of Cancer Treatment, Diagno-sis, and Centers of the National Cancer Institute. Semin Oncol 24:219-240, 1997.
14. Naik RG, Kattige SL, Bhat SV, et al: An antiflammatory cum immunomodulatory piperidinylbenzopyranone from Dysoxylum binectariferum: Isolation, structure, and total synthesis. Tetrahedron 44:2081-2086, 1988.
15. Carté BK: Biomedicinal potential of marine natural products. Bio-Science 46:271-286, 1996.
16. Philip PA, Rea D, Thavasu P, et al: Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. J Natl Cancer Inst 85:1812-1818, 1993.
17. Cragg GM, Newman DJ, Weiss RB: Coral reefs, forests, and thermal vents: the worldwide exploration of nature for novel antitumor agents. Semin Oncol 24:156-163, 1997.
18. Foye WO, ed: Cancer Chemotherapeutic Agents. ACS Professional Reference Book. Washington, DC, Amer Chem Soc, 1995.
19. Bollag DM, McQueney PA, Zhu J, et al: Epothilones, a new class of microtubule- stabilizing agents with a taxol-like mechanism of action. Cancer Res 55:2325-2333, 1995.
20. Newman DJ: Mother nature's pharmacy. A source of novel chemical structures. SIM News 44:277-283, 1994
21. Boyd MR, Paull KD: Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen. Drug Dev Res 34:91-109, 1995.
22. Mays TD, Mazan KD, Cragg G, et al: "Triangular privity" - a working paradigm for the equitable sharing of benefits from biodiversity research and development. In: Global Genetic Resources: Access, Ownership, and Intellectual Property Rights, edited by KE Hoagland, AY Rossman, Washington DC, Association of Systematics Collections, 1997, pp 279-298.
23. Sufffness M, Cragg GM, Grever MR, et al: The National Cooperative Natural Products Drug discovery Group (NCNPDDG) and International Cooperative Biodiversity Group (ICBG) Programs. Int J Pharmacogn 33(Suppl):5-16, 1995.
24. Rosenthal J, OECD Proceedings: Investing in Biological Diversity. The Cairns Conference, Australia, 25-28 March, 1996, Paris, OECD Publications, 1997, pp 253.
25. Baker JT, Borris RP, Carte B, et al: Natural product drug discovery and development: new perspectives on international collaboration. J Nat Prod 58:1325-1357, 1995.
26. Lutz RA, Shank TM, Fornari DJ, et al: Rapid growth at deep-sea vents. Nature 371:663-664, 1994.
27. Lutz RA, Kennish MJ: Ecology of deep-sea hydrothermal vent communities: a review. Rev Geophys 31:211-242, 1993.
28. Balandrin MF, Kinghorn AD, Farnsworth NR: Plant-derived natural products in drug discovery and development. An overview. In: Human Medicinal Agents from Plants. Am Chem Soc Symposium Series 534, edited by AD Kinghorn, MF Balandrin, Washington, DC, Amer Chem Soc, 1993, pp 2-12.
29. Young P: Major microbial diversity initiative recommended. ASM News 63:417-421, 1997.
30. Melton RG, Sherwood RF. Antibody-enzyme conjugates for cancer therapy. J Natl Cancer Inst 88:153-165, 1996
31. McDaniel R, Ebert-Khosla S, Hopwood DA, et al: Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic units. Nature 375:549-554, 1995.
32. Horan AC: Actinomycetes: a continuous source of novel natural products. In: The Discovery of Natural Products with Therapeutic Potential, edited by VP Gullo, Boston, Butterworth-Heinemann, 1994, pp 3-30.