Effects of Platycodon grandiflorum on lipopolysaccharide-stimulated production of prostaglandin E 2, nitric oxide, and interleukin-8 in mouse microglial BV2 cells

Journal of Medicinal Food

Volumn 9, Issue 2, 2006, Pages 169-174

  Jang, Mi Hyeon ^a   Kim, Chang Ju ^a   Kim, Ee Hwa ^b   Kim, Myung Gyou ^b   Leem, Kang Hyun ^b   Kim, Jeongseon ^c  

^a Kyung Hee University Hospital   (South Korea)

^b Kyung Hee University   (South Korea)

^c Semyung University   (South Korea)

Author keywords

Interleukin 8; Microglia; Nitric oxide; Platycodon grandiflorum; Prostaglandin E 2

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; PLATYCODON GRANDIFLORUM EXTRACT; PROSTAGLANDIN E2;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CAMPANULACEAE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; IMMUNOASSAY; INFLAMMATION; MICROGLIA; MOUSE; NONHUMAN; ORIENTAL MEDICINE; PLANT ROOT; PLATYCODON; PLATYCODON GRANDIFLORUM; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; GENE EXPRESSION; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; PLANT ROOTS; PLATYCODON;

CAMPANULACEAE; PLATYCODON GRANDIFLORUM;

EID: 33745848859     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2006.9.169     Document Type: Article

References (27)

1. Gonzalez-Scarano F, Baltuch G: Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 1999;22:219-240.
2. Mitchell JA, Larkin S, Williams TJ: Cyclooxygenase-2: regulation and relevance in inflammation. Biochem Pharmacol 1995;50: 1535-1542.
3. Fiebich BL, Lieb K, Hüll M, Aicher B, van Ryn J, Pairet M, Engelhardt G: Effects of caffeine and paracetamol alone or in combination with acetylsalicylic acid on prostaglandin E2 synthesis in rat microglial cells. Neuropharmacology 2000;39:2205-2213.
4. Korhonen R, Lahti A, Hamalainen M, Kankaanranta H, Moilanen E: Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages. Mol Pharmacol 2002;62:698-704.
5. Vegeto E, Bonincontro C, Pollio G, Sala A, Viappiani S, Nardi F, Brusadelli A, Viviani B, Ciana P, Maggi A: Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia. J Neurosci 2001;21:1809-1818.
6. Bacon KB, Harrison JK: Chemokines and their receptors in neurobiology: perspectives in physiology and homeostasis. J Neuroimmunol 2000;104:92-97.
7. Ehrlich LC, Hu S, Sheng WS, Sutton RL, Rockswold GL, Peterson PK, Chao CC: Cytokine regulation of human microglial cell IL-8 production. J Immunol 1998;160:1944-1948.
8. Kim KS, Ezaki O, Ikemoto S, Itakura H: Effects of Platycodon grandiflorum feeding on serum and liver lipid concentration in rats with diet-induced hyperlipidemia. J Nutr Sci Vitaminol 1995;41:485-491.
9. Kim KS, Seo EK, Lee YC, Lee TK, Cho YW, Ezaki O, Kim CH: Effects of dietary Platycodon grandiflorum on the improvement of insulin resistance in obese Zucker rats. J Nutr Biochem 2000;11:420-424.
10. Lee JH, Choi YH, Kang HS, Choi BT: An aqueous extract of Platycodi radix inhibits NF-kappaB nuclear translocation in human cultured airway epithelial cells. Int J Mol Med 2004;13: 843-847.
11. Yoon YD, Kang JS, Han SB, Park SK, Lee HS, Kang JS, Kim HM: Activation of mitogen-activated protein kinases and AP-1 by polysaccharide isolated from the radix of Platycodon grandiflorum in RAW 264.7 cells. Int Immunopharmacol 2004;4:1477-1487.
12. Wang C, Levis GBS, Lee EB, Levis WR, Lee DW, Kim BS, Park SY, Park E: Platycodon D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells. Int Immunopharmacol 2004;4:1039-1049.
13. Jang MH, Shin MC, Kim YL, Kim CJ, Kim Y, Kim EH: Atractylodes japonica suppresses lipopolysaccharide-stimulated expressions of inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 macrophages. Biol Pharm Bull 2004;27: 324-327.
14. Schmidt HH, Walter U: NO at work. Cell 1994;78:919-925.
15. Crofford LJ, Lipsky PE, Brooks P, Abramson SB, Simon LS, Van de Putte LB: Basic biology and clinical application of specific cyclooxygenase-2 inhibitors. Arthritis Rheum 2000;43:4-13.
16. Shao J, Sheng H, Inoue H, Morrow JD, DuBois RN: Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells. J Biol Chem 2000;275:33951-33956.
17. Nakashima MN, Ajiki K, Nakashima K, Takahashi M: Possible role of nitric oxide in anxiety following transient cerebral ischemia in mice. J Pharmacol Sci 2003;91:47-52.
18. Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P: Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci USA 1993;90:7240-7244.
19. Amin AR, Vyas P, Attur M, Leszczynska-Piziak J, Patel IR, Weissmann G, Abramson SB: The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase. Proc Natl Acad Sci USA 1995;92:7926-7930.
20. Lawrence T, Gilroy DW, Colville-Nash PR, Willoughby DA: Possible new role for NF-kappaB in the resolution of inflammation. Nat Med 2001;7:1291-1297.
21. Suk K, Lee H, Kang SS, Cho GJ, Choi WS: Flavonoid baicalein attenuates activation-induced cell death of brain microglia. J Pharmacol Exp Ther 2003;305:638-645.
22. Dodel R, Du Y, Bales KR, Gao F, Paul S: Sodium salicylate and 17beta-estradiol attenuate nuclear transcription factor NF-kappaB translocation in cultured rat astroglial cultures following exposure to amyloid beta(1-40) and lipopolysaccharides. J Neurochem 1999;73:1453-1460.
23. Glabinski AR, Tani M, Aras S, Stoler MH, Tuohy VK, Ransohoff RM: Regulation and function of central nervous system chemokines. Int J Dev Neurosci 1995;13:153-165.
24. Meda L, Bonaiuto C, Szendrei GL, Ceska M, Rossi F, Cassatella MA: Beta-amyloid(25-35) induces the production of interleukin-8 from human monocytes. J Neuroimmunol 1995;59:29-33.
25. Gitter BD, Cox LM, Rydel RE, May PC: Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells. Proc Natl Acad Sci USA 1995;92: 10738-10741.
26. Choi CY, Kim JY, Kim YS, Chung YC, Seo JK, Jeong HG: Aqueous extract isolated from Platycodon grandiflorum elicits the release of nitric oxide and tumor necrosis factor-alpha from murine macrophages. Int Immunopharmacol 2001;1:1141-1151.
27. Ahn KS, Noh EJ, Zhao HL, Jung SH, Kang SS, Kim YS: Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells. Life Sci 2005;76: 2315-2328.