The use of organotypic hippocampal slice cultures to evaluate protection by non-competitive NMDA receptor antagonists against excitotoxicity

Alternatives to Laboratory Animals

Volumn 38, Issue 1, 2010, Pages 71-82

  Ring, Avi ^a   Tanso, Rita ^a   Noraberg, Jens ^b  

^a NORWEGIAN DEFENCE RESEARCH ESTABLISHMENT FFI   (Norway)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Alzheimer's disease; Brain slices; Glutamate; In vitro models; Neuroprotection; Organophosphate; Parkinson's disease; Three Rs; Toxicity assays

Indexed keywords

GACYCLIDINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; ORGANOPHOSPHATE; PROCYCLIDINE; PROPIDIUM IODIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN SLICE; CLINICAL STUDY; COMPARATIVE STUDY; CONTROLLED STUDY; CULTURE TECHNIQUE; DENSITOMETRY; DRUG EFFICACY; DRUG INTOXICATION; EXCITOTOXICITY; HIPPOCAMPUS; IC 50; IMAGE ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; MODEL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RODENT; SCREENING;

ANIMALIA; RODENTIA;

EID: 77951663379     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119291003800108     Document Type: Article

References (48)

1. Choi, D.W. (1992). Excitotoxic cell death. Journal of Neurobiology 23, 1261-1276.
2. Chen, H.S. & Lipton, S.A. (2006). The chemical biology of clinically tolerated NMDA receptor antagonists. Journal of Neurochemistry 97, 1611-1626.
3. Braitman, D.J. & Sparenborg, S. (1989). MK-801 protects against seizures induced by the Cholin-esterase inhibitor soman. Brain Research Bulletin 23, 145-148.
4. Gill, R., Foster, A.C. & Woodruff, G.N. (1988). MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period. Neuroscience 25, 847-855.
5. Olney, J.W., Price, M.T., Labruyere, J., Salles, K.S., Frierdich, G., Mueller, M. & Silverman, E. (1987). Anti-parkinsonian agents are phencyclidine agonists and N-methyl-aspartate antagonists. European Journal of Pharmacology 142, 319-320. (Pubitemid 18045258)
6. + ketamine isomer in global forebrain ischemia. Brain Research 904, 245-251. (Pubitemid 32537648)
7. Dingledine, R., Borges, K., Bowie, D. & Traynelis, S.F. (1999). The glutamate receptor ion channels. Pharmacological Reviews 51, 7-61.
8. Fix, A.S., Horn, J.W., Wightman, K.A., Johnson, C.A., Long, G.G., Storts, R.W., Farber, N., Wozniak, D.F. & Olney, J.W. (1993). Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK(+) 801 (dizocilpine maleate): a light and electron microscopic evaluation of the rat retrosplenial cortex. Experimental Neurology 123, 204-215.
9. Ginsberg, M.D. (2008). Neuroprotection for ischemic stroke: Past, present and future. Neuropharmacology 55, 363-389.
10. Karanian, D.A., Baude, A.S., Brown, Q.B., Parsons, C.G. & Bahr, B.A. (2006). 3-Nitropropionic acid toxicity in hippocampus: protection through N-methyl-D-aspartate receptor antagonism. Hippocampus 16, 834-842.
11. Shimono, K., Baudry, M., Panchenko, V. & Taketani, M. (2002). Chronic multichannel recordings from organotypic hippocampal slice cultures: protection from excitotoxic effects of NMDA by non-competitive NMDA antagonists. Journal of Neuroscience Methods 120, 193-202. (Pubitemid 35248168)
12. Volbracht, C., van Beek, J., Zhu, C., Blomgren, K. & Leist, M. (2006). Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity. European Journal of Neuroscience 23, 2611-2622. (Pubitemid 43801453)
13. Wang, X.M. & Bausch, S.B. (2004). Effects of distinct classes of N-methyl-D-aspartate receptor antagonists on seizures, axonal sprouting and neuronal loss in vitro: suppression by NR2B-selective antagonists. Neuropharmacology 47, 1008-1020.
14. McDonough, J.H., Zoeffel, L.D., McMonagle, J., Copeland, T.L., Smith, C.D. & Shih, T.M. (2000). Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs. Epilepsy Research 38, 1-14. (Pubitemid 30055311)
15. Brocks, D.R. (1999). Anticholinergic drugs used in Parkinson's disease: An overlooked class of drugs from a pharmacokinetic perspective. Journal of Pharmacy & Pharmaceutical Sciences 2, 39-46.
16. Kim, W.S., Cho, Y., Kim, J.C., Huang, Z.Z., Park, S.H., Choi, E.K., Shin, S., Nam, S.Y., Kang, J.K., Hwang, S.Y. & Kim, Y.B. (2005). Protection by a transdermal patch containing physostigmine and procyclidine of soman poisoning in dogs. European Journal of Pharmacology 525, 135-142.
17. Kamenka, J.M., Chiche, B., Goudal, R., Geneste, P., Vignon, J., Vincent, J.P. & Lazdunski, M. (1982). Chemical synthesis and molecular pharmacology of hydroxylated 1-(1-phenylcyclohexyl) piperidine derivatives. Journal of Medicinal Chemistry 25, 431-435. (Pubitemid 12078648)
18. Vandame, D., Desmadryl, G., Becerril Ortega, J., Teigell, M., Crouzin, N., Buisson, A., Privat, A. & Hirbec, H. (2007). Comparison of the pharmacological properties of GK11 and MK801, two NMDA receptor antagonists: towards an explanation for the lack of intrinsic neurotoxicity of GK11. Journal of Neurochemistry 103, 1682-1696. (Pubitemid 47631834)
19. Lallement, G., Baubichon, D., Clarençon, D., Galonnier, M., Peoc'h, M. & Carpentier, P. (1999). Review of the value of gacyclidine (GK-11) as adjuvant medication to conventional treatments of organophosphate poisoning: primate experiments mimicking various scenarios of military or terrorist attack by soman. Neurotoxicology 20, 675-684.
20. Gaviria, M., Privat, A., D'Arbigny, P., Kamenka, J., Haton, H. & Ohanna, F. (2000). Neuroprotective effects of a novel NMDA antagonist, gacyclidine, after experimental contusive spinal cord injury in adult rats. Brain Research 874, 200-209.
21. Hirbec, H., Gaviria, M. & Vignon, J. (2001). Gacyclidine: a new neuroprotective agent acting at the N-methyl-D-aspartate receptor. CNS Drug Reviews 7, 172-198.
22. Sundstrom, L., Morrison, B., 3rd, Bradley, M. & Pringle, A. (2005). Organotypic cultures as tools for functional screening in the CNS. Drug Discovery Today 10, 993-1000.
23. Noraberg, J., Gramsbergen, J.B., Fonnum, F. & Zimmer, J. (1998). Trimethyltin (TMT) neurotoxicity in organotypic rat hippocampal slice cultures. Brain Research 783, 305-315.
24. Kristensen, B.W., Noer, H., Gramsbergen, J.B., Zimmer, J. & Noraberg, J. (2003). Colchicine induces apoptosis in organotypic hippocampal slice cultures. Brain Research 964, 264-278.
25. Noraberg, J., Jensen, C.V., Bonde, C., Montero, M., Nielsen, J.V., Jensen, N.A. & Zimmer, J. (2007). The developmental expression of fluorescent proteins in organotypic hippocampal slice cultures from transgenic mice and its use in the determination of excitotoxic neurodegeneration. ATLA 35, 61-70. (Pubitemid 46596006)
26. Cater, H.L., Gitterman, D., Davis, S.M., Benham, C.D., Morrison, B., III & Sundstrom, L.E. (2007). Stretch-induced injury in organotypic hippocampal slice cultures reproduces in vivo post-traumatic neurodegeneration: role of glutamate receptors and voltage-dependent calcium channels. Journal of Neurochemistry 101, 434-447. (Pubitemid 46525274)
27. Bonde, C., Noraberg, J. & Zimmer, J. (2002). Nuclear shrinkage and other markers of neuronal cell death after oxygen-glucose deprivation in rat hippocampal slice cultures. Neuroscience Letters 327, 49-52. (Pubitemid 34722440)
28. Bonde, C., Noraberg, J., Noer, H. & Zimmer, J. (2005). Ionotropic glutamate receptors and glutamate transporters are involved in necrotic neuronal cell death induced by oxygen-glucose deprivation of hippocampal slice cultures. Neuroscience 136, 779-794. (Pubitemid 41774724)
29. 2+ homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures. Neuroscience 128, 729-740.
30. Montero, M., Nielsen, M., Ronn, L.C., Moller, A., Noraberg, J. & Zimmer, J. (2007). Neuroprotective effects of the AMPA antagonist PNQX in oxygen-glucose deprivation in mouse hippocampal slice cultures and global cerebral ischemia in gerbils. Brain Research 1177, 124-135.
31. Montero, M., Poulsen, F.R., Noraberg, J., Kirkeby, A., van Beek, J., Leist, M. & Zimmer, J. (2007). Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen-glucose deprivation (OGD) and NMDA excitotoxicity in mouse hippocampal slice cultures. Experimental Neurology 204, 106-117.
32. Runden-Pran, E., Tanso, R., Haug, F.M., Ottersen, O.P. & Ring, A. (2005). Neuroprotective effects of inhibiting N-methyl-D-aspartate receptors, P2X receptors and the mitogen-activated protein kinase cascade: a quantitative analysis in organotypical hippocampal slice cultures subjected to oxygen and glucose deprivation. Neuroscience 136, 795-810.
33. Kristensen, B.W., Noraberg, J. & Zimmer, J. (2001). Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures. Brain Research 917, 21-44.
34. Noraberg, J. (2004). Organotypic brain slice cultures: an efficient and reliable method for neurotoxicological screening and mechanistic studies. ATLA 32, 329-337.
35. Zimmer, J., Kristensen, B.W., Jakobsen, B. & Noraberg, J. (2000). Excitatory amino acid neurotoxicity and modulation of glutamate receptor expression in organotypic brain slice cultures. Amino Acids 19, 7-21.
36. Noraberg, J., Poulsen, F.R., Blaabjerg, M., Kristensen, B.W., Bonde, C., Montero, M., Meyer, M., Gramsbergen, J.B. & Zimmer, J. (2005). Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair. Current Drug Targets - CNS & Neurological Disorders 4, 435-452.
37. Noraberg, J., Kristensen, B.W. & Zimmer, J. (1999). Markers for neuronal degeneration in organotypic slice cultures. Brain Research, Brain Research Protocols 3, 278-290.
38. Ring, A. & Tanso, R. (2007). Measurements with fluorescent probes in primary neural cultures; improved multiwell techniques. Journal of Pharmacological & Toxicological Methods 56, 300-307.
39. Clemedson, C., Kolman, A. & Forsby, A. (2007). The integrated acute systemic toxicity project (ACuteTox) for the optimisation and validation of alternative in vitro tests. ATLA 35, 33-38.
40. Pfaller, W., Balls, M., Clothier, R., Coecke, S., Dierickx, P., Ekwall, B., Hanley, B.A., Hartung, T., Prieto, P., Ryan, M.P., Schmuck, G., Sladowski, D., Vericat, J.A., Wendel, A., Wolf, A. & Zimmer, J. (2001). Novel advanced in vitro methods for long-term toxicity testing. The report and recommendations of ECVAM Workshop 45. ATLA 29, 393-426.
41. Prieto, P., Baird, A.W., Blaauboer, B.J., Castell Ripoll, J.V., Corvi, R., Dekant, W., Dietl, P., Gennari, A., Gribaldo, L., Griffin, J.L., Hartung, T., Heindel, J.J., Hoet, P., Jennings, P., Marocchio, L., Noraberg, J., Pazos, P., Westmoreland, C., Wolf, A., Wright, J. & Pfaller, W. (2006). The assessment of repeated dose toxicity in vitro: a proposed approach. The report and recommendations of ECVAM Workshop 56. ATLA 34, 315-341.
42. Litchfield, M.H. (2005). Estimates of acute pesticide poisoning in agricultural workers in less developed countries. Toxicological Reviews 24, 271-278.
43. Lepeintre, J.F., D'Arbigny, P., Mathe, J.F., Vigue, B., Loubert, G., Delcour, J., Kempf, C. & Tadie, M. (2004). Neuroprotective effect of gacyclidine. A multicenter double-blind pilot trial in patients with acute traumatic brain injury. Neurochirurgie 50, 83-95.
44. Koplovitz, I., Schulz, S., Shutz, M., Railer, R., Macalalag, R., Schons, M. & McDonough, J. (2001). Combination anticonvulsant treatment of soman-induced seizures. Journal of Applied Toxicology 21, Suppl. 1, S53-S55.
45. Lim, D.K., Hoskins, B. & Ho, I.K. (1991). Tri-hexyphenidyl enhances physostigmine prophylaxis against soman poisoning in guinea pigs. Fundamental & Applied Toxicology 16, 482-489.
46. Chen, H.S. & Lipton, S.A. (2005). Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartategated channels. Journal of Pharmacology & Experimental Therapeutics 314, 961-971.
47. Rogawski, M.A. & Wenk, G.L. (2003). The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. CNS Drug Reviews 9, 275-308.
48. Shih, T., McDonough, J.H. & Koplovitz, I. (1999). Anticonvulsants for soman-induced seizure activity. Journal of Biomedical Science 6, 86-96.