Lessons from the inflammasome: a molecular sentry linking Candida and Crohn's disease

Trends in Immunology

Volumn 31, Issue 5, 2010, Pages 171-175

  Rehaume, Linda M ^a   Jouault, Thierry ^b   Chamaillard, Mathias ^c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b INSERM   (France)

^c INSERM U1019   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; INFLAMMASOME;

ARTICLE; AUTOINFLAMMATORY DISEASE; CANDIDA ALBICANS; CROHN DISEASE; FUNGAL COLONIZATION; FUNGUS HYPHAE; HUMAN; IMMUNOCOMPROMISED PATIENT; IMMUNOSURVEILLANCE; INFECTION RESISTANCE; INNATE IMMUNITY; INTESTINE MUCOSA; NONHUMAN; PATHOPHYSIOLOGY;

ANIMALS; CANDIDA; CANDIDIASIS; CROHN DISEASE; HUMANS; IMMUNITY, INNATE;

EID: 77951652390     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2010.01.007     Document Type: Article

References (49)

1. Arendorf T.M., and Walker D.M. Oral candidal populations in health and disease. Br. Dent. J. 147 (1979) 267-272
2. Cutler J.E. Putative virulence factors of Candida albicans. Annu. Rev. Microbiol. 45 (1991) 187-218
3. Lo H.J., et al. Nonfilamentous C. albicans mutants are avirulent. Cell 90 (1997) 939-949
4. Berman J., and Sudbery P.E. Candida albicans: a molecular revolution built on lessons from budding yeast. Nat. Rev. Genet. 3 (2002) 918-930
5. Leberer E., et al. Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans. Mol. Microbiol. 42 (2001) 673-687
6. Rocha C.R., et al. Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans. Mol. Biol. Cell 12 (2001) 3631-3643
7. Stoldt V.R., et al. Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J. 16 (1997) 1982-1991
8. Xu X.L., et al. Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p. Cell Host Microbe 4 (2008) 28-39
9. Netea M.G., et al. An integrated model of the recognition of Candida albicans by the innate immune system. Nat. Rev. Microbiol. 6 (2008) 67-78
10. Jouault T., et al. Host responses to a versatile commensal: PAMPs and PRRs interplay leading to tolerance or infection by Candida albicans. Cell Microbiol. 11 (2009) 1007-1115
11. Willment J.A., and Brown G.D. C-type lectin receptors in antifungal immunity. Trends Microbiol. 16 (2008) 27-32
12. Hise A.G., et al. An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe 5 (2009) 487-497
13. Taylor P.R., et al. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat. Immunol. 8 (2007) 31-38
14. Netea M.G., et al. Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J. Clin. Invest. 116 (2006) 1642-1650
15. Brown G.D., et al. Dectin-1 mediates the biological effects of beta-glucans. J. Exp. Med. 197 (2003) 1119-1124
16. Gantner B.N., et al. Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J. 24 (2005) 1277-1286
17. Wells C.A., et al. The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J. Immunol. 180 (2008) 7404-7413
18. Jouault T., et al. Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling. J. Immunol. 177 (2006) 4679-4687
19. Joly S., et al. Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome. J. Immunol. 183 (2009) 3578-3581
20. Sato K., et al. Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses. J. Biol. Chem. 281 (2006) 38854-38866
21. Robinson M.J., et al. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J. Exp. Med. 206 (2009) 2037-2051
22. Dinarello C.A. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27 (2009) 519-550
23. Conti H.R., et al. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. 206 (2009) 299-311
24. Vonk A.G., et al. Endogenous interleukin (IL)-1 alpha and IL-1 beta are crucial for host defense against disseminated candidiasis. J. Infect. Dis. 193 (2006) 1419-1426
25. Bellocchio S., et al. The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J. Immunol. 172 (2004) 3059-3069
26. Mencacci A., et al. Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice. Infect. Immun. 68 (2000) 5126-5131
27. Filler S.G., and Sheppard D.C. Fungal invasion of normally non-phagocytic host cells. PLoS Pathog. 2 (2006) e129
28. Heinsbroek S.E., et al. Dectin-1 escape by fungal dimorphism. Trends Immunol. 26 (2005) 352-354
29. Gross O., et al. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 459 (2009) 433-436
30. van de Veerdonk F.L., et al. The macrophage mannose receptor induces IL-17 in response to Candida albicans. Cell Host Microbe 5 (2009) 329-340
31. van der Graaf C.A., et al. Nucleotide oligomerization domain 2 (Nod2) is not involved in the pattern recognition of Candida albicans. Clin. Vaccine Immunol. 13 (2006) 423-425
32. Standaert-Vitse A., et al. Candida albicans is an immunogen for anti-Saccharomyces cerevisiae antibody markers of Crohn's disease. Gastroenterology 130 (2006) 1764-1775
33. Quinton J.F., et al. Anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut 42 (1998) 788-791
34. Israeli E., et al. Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of inflammatory bowel disease. Gut 54 (2005) 1232-1236
35. Devlin S.M., et al. NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives. Gastroenterology 132 (2006) 176-186
36. Standaert-Vitse A., et al. Candida albicans colonization and ASCA in familial Crohn's disease. Am. J. Gastroenterol. 104 (2009) 1745-1753
37. Peyrin-Biroulet L., et al. NODs in defence: from vulnerable antimicrobial peptides to chronic inflammation. Trends Microbiol. 14 (2006) 432-438
38. Valore E.V., et al. Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J. Clin. Invest. 101 (1998) 1633-1642
39. Jurevic R.J., et al. Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: high-throughput SNP assays and association with Candida carriage in type I diabetics and nondiabetic controls. J. Clin. Microbiol. 41 (2003) 90-96
40. Mpofu C.M., et al. Microbial mannan inhibits bacterial killing by macrophages: a possible pathogenic mechanism for Crohn's disease. Gastroenterology 133 (2007) 1487-1498
41. Cho J.H. The genetics and immunopathogenesis of inflammatory bowel disease. Nat. Rev. Immunol. 8 (2008) 458-466
42. Villani A.C., et al. Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat. Genet. 41 (2009) 71-76
43. McGovern D.P., et al. TUCAN (CARD8) genetic variants and inflammatory bowel disease. Gastroenterology 131 (2006) 1190-1196
44. Glocker E.O., et al. A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N. Engl. J. Med. 361 (2009) 1727-1735
45. Ferwerda B., et al. Human dectin-1 deficiency and mucocutaneous fungal infections. N. Engl. J. Med. 361 (2009) 1760-1767
46. Master S.S., et al. Mycobacterium tuberculosis prevents inflammasome activation. Cell Host Microbe 3 (2008) 224-232
47. Travassos L.H., et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat. Immunol. 11 (2009) 55-62
48. Cooney R., et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat. Med. 16 (2010) 90-97
49. Roetzer A., et al. Autophagy supports Candida glabrata survival during phagocytosis. Cell. Microbiol. 12 (2009) 199-216