Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients

Journal of Immunology

Volumn 184, Issue 7, 2010, Pages 4025-4032

  Niland, Brian ^a   Miklossy, Gabriella ^a   Banki, Katalin ^a   Biddison, William E ^b   Casciola Rosen, Livia ^c   Rosen, Antony ^c   Martinvalet, Denis ^d   Lieberman, Judy ^d   Perl, Andras ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANZYME B; HLA A2 ANTIGEN; MYELIN BASIC PROTEIN; TRANSALDOLASE; AUTOANTIBODY; AUTOANTIGEN; GRANZYME;

AMINO TERMINAL SEQUENCE; ANTIGENICITY; ARTICLE; AUTOIMMUNITY; BINDING AFFINITY; CD8+ T LYMPHOCYTE; CELL DESTRUCTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MULTIPLE SCLEROSIS; NERVE CELL NECROSIS; OLIGODENDROGLIA; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; BLOOD; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; MONONUCLEAR CELL; WESTERN BLOTTING;

AMINO ACID SEQUENCE; AUTOANTIBODIES; AUTOANTIGENS; BLOTTING, WESTERN; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; GRANZYMES; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; MUTAGENESIS, SITE-DIRECTED; OLIGODENDROGLIA; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSALDOLASE;

EID: 77951643062     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0804174     Document Type: Article

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