Xanthones as antimalarial agents: Stage specificity

American Journal of Tropical Medicine and Hygiene

Volumn 62, Issue 1, 2000, Pages 77-81

  Ignatushchenko, Marina V ^a   Winter, Rolf W ^b   Riscoe, Michael ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,4,5,6 PENTAHYDROXYXANTHONE; ANTIMALARIAL AGENT; ETHANOLAMINE; HEME; HEMOGLOBIN; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; BLOOD SMEAR; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ERYTHROCYTE; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERIZATION; STRUCTURE ACTIVITY RELATION; TROPHOZOITE;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0034026087     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2000.62.77     Document Type: Article

References (14)

1. Winter RW, Cornell KA, Johnson LL, Riscoe MK, 1995. Hydroxy-anthraquinones as antimalarial agents. Bioorg Med Chem Lett 5: 1927-1932.
2. Winter RW, Cornell KA, Johnson LL, Ignatushchenko M, Hinrichs DJ, Riscoe MK, 1996. Potentiation of the antimalarial agent rufigallol. Antimicrob Agents Chemother 40: 1408-1411.
3. Winter RW, Ignatushchenko M, Ogundahunsi OA, Cornell KA, Oduola AM, Hinrichs DJ, Riscoe MK, 1997. Potentiation of an antimalarial oxidant drug. Antimicrob Agents Chemother 41: 1449-1454.
4. Olliaro P, Goldberg D, 1995. The Plasmodium digestive vacuole: metabolic headquarters and choice drug target. Parasitol Today 11: 294-297.
5. Ignatushchenko MV, Winter RW, Bachinger HP, Hinrichs DJ, Riscoe MK, 1997. Xanthones as antimalarial agents: studies of a possible mode of action. FEBS Lett 409: 67-73.
6. Oduola AM, Milhous WK, Salako LA, Walker O, Desjardins RE, 1987. Reduced in-vitro susceptibility to mefloquine in West African isolates of Plasmodium falciparum. Lancet 2: 1304-1305.
7. Oduola AM, Weatherly NF, Bowdre JH, Desjardins RE, 1988. Plasmodium falciparum: cloning by single-erythrocyte micromanipulation and heterogeneity in vitro. Exp Parasitol 66: 86-95.
8. Lambros C, Vanderberg JP, 1979. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol 65: 418-420.
9. Elabbadi N, Ancelin ML, Vial HJ, 1992. Use of radioactive ethanolamine incorporation into phospholipids to assess in vitro antimalarial activity by the semiautomated microdilution technique. Antimicrob Agents Chemother 36: 50-55.
10. Sherman IW, 1979. Biochemistry of Plasmodium (malarial parasites). Microbiol Rev 43: 453-495.
11. Dorn A, Stoffel R, Matile H, Bubendorf A, Ridley RG, 1995. Malarial haemozoin/β-haematin supports haem polymerization in the absence of protein. Nature 374: 269-271.
12. Egan TJ, Ross DC, Adams PA, 1994. Quinoline anti-malarial drugs inhibit spontaneous formation of β-haematin (malaria pigment). FEBS Lett 352: 54-57.
13. Pandey AV, Tekwani BL, Pandey VC, 1995. Characterization of hemozoin from liver and spleen of mice infected with Plasmodium yoelii, a rodent malaria parasite. Biomed Res 16: 115-120.
14. Sullivan DJ Jr, Gluzman IY, Russell DG, Goldberg DE, 1996. On the molecular mechanism of chloroquine's antimalarial action. Proc Natl Acad Sci USA 93: 11865-11870.