Cardiac myosin heavy chain isoform exchange alters the phenotype of cTnT-related cardiomyopathies in mouse hearts

Journal of Molecular and Cellular Cardiology

Volumn 48, Issue 5, 2010, Pages 979-988

  Rice, Ron ^a   Guinto, Pia ^a   Dowell Martino, Candice ^a,d   He, Huamei ^b,e   Hoyer, Kirsten ^b   Krenz, Maike ^c   Robbins, Jeffrey ^c   Ingwall, Joanne S ^b   Tardiff, Jil C ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e NONE

Author keywords

Ca2+ kinetics; Cardiac relaxation; Cardiac Troponin T; Contractile performance; Familial Hypertrophic Cardiomyopathy; Myosin heavy chain Isoforms

Indexed keywords

CALCIUM ION; ISOPROTEIN; MYOSIN HEAVY CHAIN; MYOSIN HEAVY CHAIN BETA; PEPTIDE; PHOSPHOLAMBAN; TROPONIN T;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CALCIUM HOMEOSTASIS; CALCIUM MOBILIZATION; CARDIOMYOPATHY; CELL MUTANT; CONTROLLED STUDY; DIASTOLE; DIASTOLIC DYSFUNCTION; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; HEART CONTRACTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE RELAXATION; MOUSE; MYOFILAMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SARCOPLASMIC RETICULUM; SYSTOLIC DYSFUNCTION; THIN FILAMENT; TRANSGENIC MOUSE;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CARDIOMYOPATHY, HYPERTROPHIC, FAMILIAL; HEART VENTRICLES; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOFIBRILS; MYOSIN HEAVY CHAINS; PHOSPHORYLATION; PROTEIN ISOFORMS; SARCOMERES; TROPONIN T;

MURINAE; MUS;

EID: 77951623550     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.11.018     Document Type: Article

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