Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an α- or β-myosin heavy chain backbone

Journal of Biological Chemistry

Volumn 283, Issue 29, 2008, Pages 20579-20589

  Lowey, Susan ^a   Lesko, Leanne M ^a   Rovner, Arthur S ^a   Hodges, Alex R ^a   White, Sheryl L ^a   Low, Robert B ^a   Rincon, Mercedes ^b   Gulick, James ^c   Robbins, Jeffrey ^c  

^a UNIVERSITY OF VERMONT   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; MAMMALS; MOTORS;

ACTIN FILAMENTS; ENZYMATIC ACTIVITIES; FAMILIAL HYPERTROPHIC CARDIOMYOPATHIES; FUNCTIONAL EFFECTS; HEART MUSCLES; HYPERTROPHIC CARDIOMYOPATHIES; IN VITRO MOTILITY ASSAYS; ISOFORM; MGATPASE ACTIVITIES; MOTOR FUNCTIONS; MOUSE MODELS; MYOSIN HEAVY CHAINS; MYOSIN MOTORS; N TERMINUSES; PROTEIN ISOLATIONS; TRANSGENIC MOUSE MODELS; WILD TYPES;

PLANTS (BOTANY);

ADENOSINE TRIPHOSPHATASE (MAGNESIUM); MYOSIN; MYOSIN HEAVY CHAIN ALPHA; MYOSIN HEAVY CHAIN BETA; MYOSIN SUBFRAGMENT 1; NICKEL COMPLEX; POLYHISTIDINE TAG; ADENOSINE TRIPHOSPHATASE (CALCIUM MAGNESIUM); ARGININE; ISOPROTEIN; MYOSIN HEAVY CHAIN; PROPYLTHIOURACIL; VENTRICULAR MYOSIN;

ACTIN FILAMENT; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; GENETIC VARIABILITY; HEAVY CHAIN; HYPERTROPHIC CARDIOMYOPATHY; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN ISOLATION; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; CHEMICAL STRUCTURE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MUTATION; PROTEIN QUATERNARY STRUCTURE;

MAMMALIA; MUS MUSCULUS;

ANIMALS; ARGININE; CA(2+) MG(2+)-ATPASE; CARDIOMYOPATHY, HYPERTROPHIC; GENE EXPRESSION REGULATION; MICE; MICE, TRANSGENIC; MODELS, MOLECULAR; MUTATION; MYOSIN HEAVY CHAINS; PROPYLTHIOURACIL; PROTEIN ISOFORMS; PROTEIN STRUCTURE, QUATERNARY; VENTRICULAR MYOSINS;

EID: 50649083738     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800554200     Document Type: Article

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