Phase behaviour analysis of solid dispersions of loperamide and two structurally related compounds with the polymers PVP-K30 and PVP-VA64

European Journal of Pharmaceutical Sciences

Volumn 22, Issue 5, 2004, Pages 375-385

  Weuts, Ilse ^a   Kempen, Dieter ^a   Decorte, Annelies ^b   Verreck, Geert ^b   Peeters, Jef ^b   Brewster, Marcus ^b   Van Den Mooter, Guy ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Crystallinity; Differential scanning calorimetry; Loperamide; Phase behaviour; Solid dispersions

Indexed keywords

4 (4 CHLOROPHENYL) 4 PIPERIDINOL; 4 DIMETHYLAMINO N,N DIMETHYL 2,2 DIPHENYLBUTYRAMIDE; ARYLBUTYRIC ACID DERIVATIVE; LOPERAMIDE; PIPERIDINE DERIVATIVE; POLYMER; POVIDONE K30; PVP VA64; SOLVENT; UNCLASSIFIED DRUG; WATER;

ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; EVALUATION; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; INFRARED SPECTROSCOPY; MODEL; MOLECULAR INTERACTION; MOLECULE; PRIORITY JOURNAL; SAMPLE; SOLID; SOLID STATE; SPRAY DRYING; STRUCTURE ANALYSIS; THERMOGRAVIMETRY; WATER CONTENT; X RAY DIFFRACTION;

LOPERAMIDE; MOLECULAR STRUCTURE; POLYMERS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3242706588     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2004.04.002     Document Type: Article

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