Immunohistochemical study of matrix metalloproteinases-2 and -9, macrophage inflammatory protein-2 and tissue inhibitors of matrix metalloproteinases-1 and -2 in normal, purulonecrotic and fungal infected equine corneas

Veterinary Ophthalmology

Volumn 13, Issue 2, 2010, Pages 81-90

  Boveland, Shannon D ^a   Moore, Phillip A ^a   Mysore, Jagannatha ^a   Krunkosky, Thomas M ^a   Dietrich, Ursula M ^a   Jarrett, Carla ^a   Paige Carmichael, K ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Equine fungal keratitis; Macrophage inflammatory protein 2; Matrix metalloproteinases; Neutrophil infiltration; Tissue inhibitor of matrix metalloproteinase

Indexed keywords

CXCL2 CHEMOKINE; GELATINASE A; GELATINASE B; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL; ANIMAL DISEASE; ARTICLE; FUNGAL EYE INFECTION; GENE EXPRESSION REGULATION; GENETICS; HORSE; HORSE DISEASE; KERATITIS; METABOLISM; MICROBIOLOGY; PHYSIOLOGY;

ANIMALS; CHEMOKINE CXCL2; EYE INFECTIONS, FUNGAL; GENE EXPRESSION REGULATION; HORSE DISEASES; HORSES; KERATITIS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EQUIDAE; FUNGI;

EID: 77951616689     PISSN: 14635216     EISSN: 14635224     Source Type: Journal    
DOI: 10.1111/j.1463-5224.2009.00757.x     Document Type: Article

References (52)

1. Andrew SE, Willis AM. Diseases of the cornea and sclera. Equine Ophthalmology 2005, 192-199. Gilger BC, In, ed, Elsevier Saunders, St Louis
2. Martin CL. Cornea and sclera. Ophthalmic Disease in Veterinary Medicine 2005, 273-274. Martin CL. In, ed, Manson Publishing, London
3. Itoi M, Gnädinger MC, Slansky HH. Collagenase in the cornea. Experimental Eye Research 1969, 8:369-373.
4. Fini ME, Girard MT. Expression of collagenolytic/gelatinolytic metalloproteinases by normal cornea. Investigative Ophthalmology and Visual Science 1990, 31:1779-1788.
5. Berman MB. Collagenase and corneal ulceration. Collagenase in Normal and Pathological Connective Tissues 1980, 140-174. Wooley DEEvanson JM. In, eds, John Wiley & Sons Ltd., New York
6. Fini ME, Yue BY, Sugar J. Collagenolytic/gelatinolytic metalloproteinases in normal and keratoconus corneas. Current Eye Research 1992, 11:849-862.
7. Matsubara M, Girard MT, Kublin CL. Differential roles for two gelatinolytic enzymes of the matrix metalloproteinase family in the remodeling cornea. Developmental Biology 1991, 147:425-439.
8. Walter I, Handler J, Miller I. Matrix metalloproteinase 2 (MMP-2) and tissue transglutamase (TG 2) are expressed in periglandular fibrosis in horse mares with endometriosis. Histology and Histopathology 2005, 20:1105-1113.
9. Matsubara M, Zieske JD, Fini ME. Mechanism of basement membrane dissolution preceding corneal ulceration. Investigative Ophthalmology and Visual Science 2005, 32:3221-3237.
10. Lan J, Kumar RK, Di Girolamo N. Expression and distribution of matrix metalloproteinases and their inhibitors in the human iris and ciliary body. British Journal of Ophthalmology 2003, 87:208-211.
11. Gopinathan U, Ramakrishna T, Wilcox M. Enzymatic, clinical and histologic evaluation of corneal tissues in experimental fungal keratitis in rabbits. Experimental Eye Research 2001, 72:433-442.
12. Strubbe DT, Brooks DE, Schultz GS. Evaluation of tear film proteinases in horses with ulcerative keratitis. Veterinary Ophthalmology 2000, 3:111-119.
13. Ollivier EJ, Brooks DE, Van Setten GB. Profiles of matrix metalloproteinase activity in equine tear fluid during corneal healing in 10 horses with ulcerative keratitis. Veterinary Ophthalmology 2004, 7:397-405.
14. Kernacki KA, Barrett RP, Hobden JA. Macrophage inflammatory protein-2 is a mediator of polymorphonuclear neutrophil influx in ocular bacterial infection. Journal of Immunology 2000, 164:1037-1045.
15. Mandal M, Mandal A, Das S. Clinical implications of matrix metalloproteinases. Molecular Cell Biochemistry 2003, 252:305-329.
16. Tumpey TM, Cheng H. Chemokine synthesis in the HSV-1 infected cornea and its suppression by IL-10. Journal of Leukocyte Biology 1998, 63:486.
17. Yan XT, Tumpey TM, Kunkel SL. Role of MIP-2 in neutrophil migration and tissue injury in the herpes simplex virus-1-infected cornea. Investigative Ophthalmology and Visual Science 1998, 39:1854.
18. Krunkosky TM, Maruo K, Potempa S. Inhibition of tumor necrosis factor-α- induced RANTES secretion by alkaline protease in A549 cells. American Journal of Respiratory Cell and Molecular Biology 2005, 33:483-489.
19. Xue ML, Thakur A, Willcox MDP. Role and regulation of CXC-chemokines in acute experimental keratitis. Experimental Eye Research 2003, 76:221-231.
20. Matsuno K, Adachi Y, Yamamoto H. The expression of matrix metalloproteinase matrilysin indicates the degree of inflammation in ulcerative colitis. Journal of Gastroenterology 2002, 38:348-354.
21. Ollivier FJ, Gilger BC, Barrie KP. Proteinases of the cornea and preocular tear film. Veterinary Ophthalmology 2007, 10:199-206.
22. Ollivier F. Matrix metalloproteinase 2, matrix metalloproteinase 9, connective tissue growth factor in the equine tear fluid: possible implications in corneal wound healing 2004, PhD Dissertation, University of Florida, Gainesville, May
23. Tekamp-Olson P, Gallegos C, Bauer D. Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. Journal of Experimental Medicine 1990, 172:911.
24. Xue ML, Wakefield D, Willcox MDP. Regulation of MMPs and TIMPs by IL-1β during corneal ulceration and infection. Investigative Ophthalmology and Visual Science 2005, 44:2020-2025.
25. Kernacki KA, Chunta JL, Barrett RP. TIMP-1 role in protection against Pseudomonas aeruginosa corneal destruction. Experimental Eye Research 2004, 78:1155-1162.
26. Yang YN, Bauer D, Wasmuth S. Matrix metalloproteinases (MMP-2 and 9) and tissue inhibitors of matrix metalloproteinases (TIMP-1 and 2) during the course of experimental necrotizing herpetic keratitis. Experimental Eye Research 2003, 77:227-237.
27. Barro CD, Romanet J-P, Fdili A. Gelatinase concentration in tears of corneal-grafted patients. Current Eye Research 1998, 17:174-182.
28. Kumagai N, Yamamoto K, Fukuda K. Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis. Journal of Allergy and Clinical Immunology 2002, 110:489-491.
29. Carter RT, Kambampati R, Murphy CJ. Expression of matrix metalloproteinase 2 and 9 in experimentally wounded canine corneas and spontaneous chronic corneal epithelial defects. Cornea 2007, 26:1213-1219.
30. Niimi Y, Pawankar R, Kawana S. Increased expression of matrix metalloproteinase-2, -9 and -13 in lesional skin and bullous pemphigoid. International Archives of Allergy and Immunology 2006, 139:104-113.
31. Wong TT, Sethi C, Daniels JT. Matrix metalloproteinases in disease and repair processes in the anterior segment. Survey of Ophthalmology 2002, 47:239-256.
32. Paterson C, Wells JG, Koklitis PA. Recombinant tissue inhibitor of metalloproteinases type 1 suppresses alkali-burn-induced corneal ulceration in rabbits. Investigative Ophthalmology and Visual Science 1994, 35:677-684.
33. Heiligenhaus A, Li HF, Yang Y. Transplantation of amniotic membrane in murine herpes stromal keratitis modulates matrix metalloproteinases in the cornea. Investigative Ophthalmology and Visual Science 2005, 46:4079.
34. Shoshani Y, Pe'er J, Doviner V. Increased expression of inflammatory cytokines and matrix metalloproteinases in pseudophakic corneal edema. Investigative Ophthalmology and Visual Science 2005, 46:1940-1947.
35. Chandler HL, Kusewitt DF. Enhanced protease production in refractory corneal ulcers. Association for Research in Vision and Ophthalmology 2003, 37. (abstract 914)
36. Gabison EE, Mourah S, Steinfels E. Differential expression of extracellular matrix metalloproteinase inducer (CD 147) in normal and ulcerated corneas. American Journal of Pathology 2005, 166:209-219.
37. Kozák I, Klisenbauer D, Juhás T. UV-B induced production of MMP-2 and MMP-9 in human corneal cells. Physiological Research 2003, 52:229-234.
38. Dong X, Shi W, Zeng Q. Roles of adherence and matrix metalloproteinases in growth patterns of fungal pathogens in cornea. Current Eye Research 2005, 30:613-620.
39. Chandler HL, Kusewitt DF, Colitz CMH. Modulation of matrix metalloproteinases by ultraviolet radiation in the canine cornea. Veterinary Ophthalmology 2008, 11:135-144.
40. Parsons SL, Watson SA, Brown PD. Matrix metalloproteinases. British Journal of Surgery 1997, 84:160-166.
41. Dahlen B, Shute J, Howarth P. Immunohistochemical localization of the matrix metalloproteinases MMP-3 and MMP-9 within the airways in asthma. Thorax 1999, 54:590-596.
42. Stähle-Bäckdahl M, Inoue M, Giudice GJ. 92-kD gelatinase is produced by eosinophils at the site of blister formation in bullous pemphigoid and cleaves the extracellular domain of recombinant 180-kD bullous pemphigoid autoantigen. Journal of Clinical Investigation 1994, 93:2022-2030.
43. Murayama T, Amitani R, Ikegami Y. Suppressive effects of Aspergillus fumigatus culture filtrates on human alveolar macrophages and polymorphonuclear leukocytes. European Respiratory Journal 1996, 9:293-300.
44. Lin TC, Li CY, Tsai CS. Neutrophil-mediated secretion and activation of matrix metalloproteinase-9 during cardiac surgery with cardiopulmonary bypass. Anesthesia Analgesia 2005, 100:1554-1560.
45. Twining SS. Regulation of proteolytic activity in tissues. Critical review of biochemistry and molecular biology 1994, 29:315-383.
46. Slansky HH, Gnädinger MC, Itoi M. Collagenase in corneal ulcerations. Archives of Ophthalmology 1969, 82:108-111.
47. Hibbetts K, Hines B, Williams D. An overview of proteinase inhibitors. Journal of Veterinary International Medicine 1999, 13:302-308.
48. Fini ME, Parks WC, Rinehart WB. Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury. American Journal Pathology 1996, 149:1287-1302.
49. Brooks DE, Ollivier FJ, Lassaline ME. MMP production by microbial isolates from equine corneal ulcers. 34th Annual Meeting of the American College of Veterinary Ophthalmologist 2003, 6:354. (Abstract No. 17)
50. Li D-Q, Lokeshwar BL, Solomon A. Regulation of MMP-9 production by human corneal epithelial cells. Experimental Eye Research 2001, 73:449-459.
51. Sotozono C. Second injury in the cornea. The role of inflammatory cytokines in corneal damage and repair. Cornea 2001, 19:S155-S159.
52. Cole N, Hume E, Khan S. Contribution of the cornea to cytokine levels in the whole eye induced during the early phase of Pseudomonas aeruginosa challenge. Immunology and Cell Biology 2005, 83:301-306.