Matrix metalloproteinase 2 (MMP-2) and tissue transglutaminase (TG 2) are expressed in periglandular fibrosis in horse mares with endometrosis

Histology and Histopathology

Volumn 20, Issue 4, 2005, Pages 1105-1113

  Walter, Ingrid ^a   Handler, J ^a   Miller, I ^a   Aurich, C ^a  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

Endometrium; Endometrosis; Horse; MMP's; Transglutaminase

Indexed keywords

COLLAGEN TYPE 4; ENZYME PRECURSOR; GELATINASE A; LAMININ; MATRIX METALLOPROTEINASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; SCLEROPROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COLLAGEN DEGRADATION; CONTROLLED STUDY; ENDOMETRIOSIS; EXTRACELLULAR MATRIX; FEMALE; FIBROSIS; HOMEOSTASIS; HORSE DISEASE; IMMUNOHISTOCHEMISTRY; MYOFIBROBLAST; NONHUMAN; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UTERUS BIOPSY; ZYMOGRAPHY;

ANIMALS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOMETRIOSIS; ENDOMETRIUM; FEMALE; FIBROSIS; GTP-BINDING PROTEINS; HORSES; IMMUNOBLOTTING; MATRIX METALLOPROTEINASE 2; MICROSCOPY, CONFOCAL; TRANSGLUTAMINASES;

ANIMALIA; EQUUS CABALLUS;

EID: 27144443081     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Aeschlimann D. and Paulsson M. (1991). Cross-linking of laminin-nidogen complexes by tissue transglutaminase. J. Biol. Chem. 266, 15308-15317.
2. Alcolado R., Arthur M.J. and Iredale J.P. (1997). Pathogenesis of liver fibrosis. Clin. Sci. 92, 103-112.
3. Allen W.R. (1993). Proceedings of the John P. Hughes International Workshop on Equine Endometritis. Equine Vet. J. 25, 184-193.
4. Aupperle H., Hasenbein I., Ellenberger C., Ludwig S., Schoon D. and Schoon H.A. (2003). Histopathological findings in ovarian vessels in comparison to the alterations in extraovarian, extrauterine and uterine vessels in the mare. Pferdeheilkunde 19, 589-594.
5. Belkin A.M., Zemskov E.A., Hang J., Akimov S.S., Sikora S. and Strongin A. (2004). Cell-surface-associated tissue transglutaminase is a target of MMP-2 proteolysis. Biochemistry 43, 11760-11769.
6. Benyon R.C., Iredale J.P., Goddard S., Winwood P.J. and Arthur M.J. (1996). Expression of tissue inhibitor of metal loproteinases 1 and 2 is increased in fibrotic liver. Gasterenterology 110, 821-831.
7. Blazejewski S., Preaux A.M., Mallat A., Brocheriou I., Mavier P., Dhumeaux D., Hartmann D., Schuppan D. and Rosenbaum D. (1995). Human myofibroblastlike cells obtained by outgrowth are representative of the fibrogenic cells in the liver. Hepatology 22, 788-797.
8. Bradford M.M. (1976). A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
9. Butler G.S., Butler M.J., Atkinson S.J., Will H., Tamura T., van Westrum S.S, Crabbe T., Clements J., d'Ortho M.P. and Murphy G. (1998). The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A - a kinetic study. J. Biol. Chem. 273, 871-880.
10. Di Nezza L.A., Jobling T. and Salamonsen L.A. (2003). Progestin suppresses matrix metalloproteinase production in endometrial cancer. Gynecol. Oncol. 89, 325-333.
11. Freitas S., Meduri G., Le Nestour E., Bausero P. and Perro-Applanat M. (1999). Expression of metalloproteinases and their inhibitors in blood vessels in human endometrium. Biol. Reprod. 61, 1070-1082.
12. Greenberg C.S., Birckbichler P.J. and Rice R.H. (1991). Transglutaminases: Multifunctional cross-linking enzymes that stabilize tissues. FASEB J. 5, 3071-3077.
13. Grüninger B., Schoon H.A., Schoon D., Menger S. and Klug E. (1998). Incidence and morphology of endometrial angiopathies in mares in relationship to age and parity. J. Comp. Pathol. 119, 293-309.
14. Hayashi T., Stetler-Stevenson W.G., Fleming M.V., Fischback N., Koss M.N., Liotta L.A., Ferrans V.J. and Travis W.D. (1996). Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis. Am. J. Pathol. 149, 1241-1256.
15. Hoffmann C., Bazer F.W., Klug J., Allen W.R., Aupperle H. and Ellenberger C. (2003). Morpho-functional studies regarding the pathogenesis of the equine endometrosis with special emphasis on uterine secretions - preliminary results. Pferdeheilkunde 19, 666-669.
16. Iredale J.P. (1997). Tissue inhibitors of metalloproteinases in liver fibrosis. Int. J. Biochem. Cell Biol. 29, 43-54.
17. Kenney R.M. and Doig P.A. (1986). Equine endometrial biopsy. In: Current Therapy in Theriogenology. 2nd ed. Morrow D.A. (ed). W.B. Saunders Company. Philadelphia. pp 723-729.
18. Laemmli U.K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
19. Marbaix E., Donnez J., Courtoy P.J. and Eeckhout Y. (1992). Progesterone regulates the activity of collagenase and related gelatinases A and B in human endometrial explants. Proc. Nat. Acad. Sci. USA 15, 89, 11789-11793.
20. Martinez J., Chalupowicz D.G., Roush R.K., Sheth A. and Barsigian C. (1994). Transglutaminase-mediated processing of fibronectin by endothelial cell monolayers. Biochemistry 33, 2538-2545.
21. Murphy G., Ward R., Hembry R.M., Reynolds J.J., Kühn K. and Tryggvason K. (1989). Characterization of gelatinase from pig monomorphonuclear leucocytes. Biochem. J. 258, 463-472.
22. Norusis M.J. (1988). SPSS/PC+ for the IBM PC/XT/AT and PC2. SPSS Inc. Chicago.
23. Osteen K.G., Keller N.R., Feltus F.A. and Melner M.H. (1999). Paracrine regulation of matrix metalloproteinase expression in the normal human endometrium. Gynecol. Obstet. Invest. 48, Suppl. 2-13.
24. Park D.W., Ryu H.S., Choi D.S., Park Y.H., Chang K.H. and Min C.K. (2001). Localization of matrix metalloproteinases on endometrial cancer cell invasion in vitro. Gynecol. Oncol. 82, 442-449.
25. Phan S.H. (2002) The myofibroblast in pulmonary fibrosis. Chest 122 (6 suppl.), 286-289.
26. Rodgers W.H., Matrisian L.M., Giudice L.C., Dsupin B., Cannon P., Svitek C., Gorstein F. and Osteen K.G. (1994). Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones. J. Clin. Invest. 94, 946-953.
27. Salamonsen L.A., Butt A.R., Hammond,F.R., Garcia S. and Zhang J. (1997). Production of endometrial matrix metalloproteinases, but not their tissue inhibitors, is modulated by progesterone withdrawal in an in vitro model for menstruation. J. Clin. Endocrinol. Metabol. 82, 1409-1415.
28. Schittny J.C., Paulsson M., Vallan C., Burri P.H., Kedei N. and Aeschlimann D. (1997). Protein cross-linking mediated by tissue transglutaminase correlated with the maturation of extracellular matrices during lung development. Am. J. Respir. Cell Mol. Biol. 17, 334-343.
29. Schmitt-Graff A., Chakroun G. and Gabbiani G. (1993) Modulation of perisinusoidal cell cytoskeletal features during experimental hepatic fibrosis. Virchows Arch. (A) 422, 99-107.
30. Schoon D., Schoon H.A and Klug E. (1999). Angioses in the equine endometrium - Pathogenesis and clinical correlations. Pferdeheilkunde 15, 541-546.
31. Skill N.J., Johnson T.S., Coutts I.G., Saint R.E., Fisher M., Huang L., El Nahas A.M., Collighan R.J. and Griffin M. (2004). Inhibition of transglutaminase, activity reduces extracellular matrix accumulation induced by high glucose levels in proximal tubular epithelial cells. J. Biol. Chem. 12, 47754-47762.
32. Stetler-Stevenson W.G., Krutzsch H.C. and Liotta L.A. (1989). Tissue inhibitor of metalloproteinase (TIMP-2). A new member of metalloproteinase inhibitor family. J. Biol. Chem. 264, 17374-17378.
33. Takahara T., Furui K., Funaki J., Nakayama Y., Itoh H., Miyabayashi C., Sato H., Seiki M., Ooshima A. and Watanabe A. (1995). Increased expression of matrix metalloproteinase-II in experimental liver fibrosis in rats. Hepatology 21, 787-795.
34. Walter I., Handler J., Reifinger M. and Aurich C. (2001). Association of endometrosis in horses with differentiation of periglandular myofibroblasts and changes of extracellular matrix proteins. Reproduction 121, 581-586.
35. Will H.S., Atkinson S.J., Butler G.S, Smith B. and Murphy G. (1996). The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. J. Biol. Chem. 271, 17119-17123.
36. Woessner J.F. jr. (1991). Matrix metalloproteinases and their inhibitors in connective tissue remodelling. FASEB J. 5, 2145-2154.
37. Woessner J.F. and Nagase H. (2000). Matrix Metalloproteinases. In: Protein profile. Sheterline P. (ed). Oxford University Press. England.
38. Zhang J., Hampton A.L., Nie G. and Salamonsen L.A. (2000). Progesterone inhibits activation of latent matrix metalloproteinase (MMP)-2 by membrane-type 1 MMP: enzymes coordinately expressed in human endometrium. Biol. Reprod. 62, 85-94.