Dose-rate effect on the induction of HPRT mutants in human G0 lymphocytes exposed in vitro to gamma radiation

Radiation Research

Volumn 165, Issue 1, 2006, Pages 43-50

  Kumar, P R Vivek ^a   Mohankumar, Mary N ^a   Hamza, V Zareena ^a   Jeevanram, R K ^a  

^a INDIRA GANDHI CENTRE FOR ATOMIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

ARTICLE; CELL CYCLE G0 PHASE; CELL SURVIVAL; CLONOGENIC ASSAY; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; GAMMA IRRADIATION; GENE; GENE EXPRESSION; GENE EXPRESSION TIME; GENE LOCUS; GENE MUTATION; HPRT GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; LINEAR ENERGY TRANSFER; LYMPHOCYTE; MALE; MUTATION RATE; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION PROTECTION; RADIATION RESPONSE; REGRESSION ANALYSIS; RISK ASSESSMENT; TIME;

CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENVIRONMENTAL EXPOSURE; G0 PHASE; GAMMA RAYS; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LYMPHOCYTES; MUTATION; RADIATION DOSAGE; RADIATION PROTECTION; RISK ASSESSMENT; RISK FACTORS;

EID: 29644441713     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR-3467.1     Document Type: Article

References (45)

1. United Nations Scientific Committee on the Effects of Atomic Radiation, Sources and Effects of Ionizing Radiation, report to the General Assembly, with scientific annexes. United Nations, New York, 2000.
2. ICRR 1990 Recommendations of the International Commission of Radiological Protection. Publication 60. Annals of the ICRP, Vol. 21, Nos. 1-3, Pergamon Press, Oxford, 1991.
3. A. B. Miller, G. R. Howe, G. J. Sherman, J. P. Lindsay, M. Y. Yaffe, P. J. Dinner, H. A. Risch and D. L. Preston, Mortality from breast cancer after irradiation during fluoroscopic examinations in patients being treated for tuberculosis. N. Engl. J. Med. 321, 1285-1289 (1989).
4. D. H. Moore, II, J. D. Tucker, I. M. Jones, R. G. Langlois, P. Pleshanov, I. Vorobtsova and R. Jensen, A study of the effects of exposure on cleanup workers at the Chernobyl nuclear reactor accident using multiple end points. Radiat. Res. 148, 463-475 (1997).
5. J. D. Tucker, E. J. Tawn, D. Holdsworth, S. Morris, R. Langlois, M. J. Ramsey, P. Kato, J. D. Boice, Jr., R. E. Tarone and R. H. Jensen, Biological dosimetry of radiation workers at the Sellafield nuclear facility. Radiat. Res. 148, 216-226 (1997).
6. K. J. Sorensen, L. A. Zetterberg, D. O. Nelson, J. Grawe and J. D. Tucker, The in vivo dose rate effect of chronic gamma radiation in mice: Translocation and micronucleus analyses. Mutat. Res. 457, 125-136 (2000).
7. 0 lymphocytes irradiated in vitro: A test for a possible population bias in the cohort of atomic bomb survivors exposed to high doses. Radiat. Res. 134, 316-322 (1993).
8. R. J. Albertini, L. S. Clark, J. A. Nicklas, J. P. O'Neill, T. E. Hui and R. Jostes, Radiation quality affects the efficiency of induction and the molecular spectrum of HPRT mutations in human T cells. Radiat. Res. 148 (Suppl.), S76-S86 (1997).
9. K. Messing, J. Ferraris, W. E. Bradley, J. Swartz and A. M. Seifert, Mutant frequency of radiotherapy technicians appears to be associated with recent dose of ionizing radiation. Health Phys. 57, 537-544 (1989).
10. J. Cao, Y. Liu, H. Sun, G. Cheng, X. Pang and Z. Zhou, Chromosomal aberrations, DNA strand breaks and gene mutations in nasopharyngeal cancer patients undergoing radiation therapy. Mutat. Res. 504, 85-90 (2002).
11. V. Saddi, J. Curry, A. Nohturfft, W. Kusser and B. W. Glickman, Increased hprt mutant frequencies in Brazilian children accidentally exposed to ionizing radiation. Environ. Mol. Mutagen. 28, 267-275 (1996).
12. C. B. Thomas, D. O. Nelson, P. Pleshanov, I. Vorobtsova, L. Tureva, R. Jensen and I. M. Jones, Elevated frequencies of hypoxanthine phosphoribosyl transferase lymphocyte mutants are detected in Russian liquidators 6 to 10 years after exposure to radiation from the Chernobyl nuclear power plant accident. Mutat. Res. 439, 105-119 (1999).
13. I. M. Jones, C. B. Thomas, K. Haag, P. Pleshanov, I. Vorobtsova, L. Tureva and D. O. Nelson, Total gene deletions and mutant frequency of the HPRT gene as indicators of radiation exposure in Chernobyl liquidators. Mutat. Res. 431, 233-246 (1999).
14. - mutations in individuals exposed to ionizing radiation in Goiânia, Brazil. Environ. Mol. Mutagen. 29, 107-116 (1997).
15. I. M. Jones, H. Galick, P. Kato, R. G. Langlois, M. L. Mendelsohn, G. A. Murphy. P. Pleshanov, M. J. Ramsey, C. B. Thomas and D. O. Nelson, Three somatic genetic biomarkers and covariates in radiation-exposed Russian cleanup workers of the Chernobyl nuclear reactor 6-13 years after exposure. Radiat. Res. 158, 424-442 (2002).
16. 137Cs γ-irradiated mouse. Int. J. Radiat. Biol. 66, 319-326 (1994).
17. I. Furuno-Fukushi, K. Tatsumi, M. Takahagi and A. Tachibana, Quantitative and qualitative effect of γ-ray dose-rate on mutagenesis in human lymphoblastoid cells. Int. J. Radiat. Biol. 70, 209-217 (1996).
18. F. Konig and J. Kiefer, Lack of dose rate effect for mutation induction by γ-rays in human TK6 cells. Int. J. Radiat. Biol. 54. 891-897 (1988).
19. S. A. Amundson and D. J. Chen, Inverse dose-rate effect for mutation induction by γ-rays in human lymphoblasts. Int. J. Radiat. Biol. 69, 555-563 (1996).
20. J. P. O'Neill, L. M. Sullivan and R. J. Albertini, In vitro induction, expression and selection of thioguanine-resistant mutants with human T-lymphocytes. Mutat. Res. 240, 135-142 (1990).
21. 0 phase lymphocytes irradiated in vitro with γ rays. Mutat. Res. 474, 147-158 (2001).
22. 0 lymphocytes with low-energy protons (28 keV/μm): HPRT mutations and chromosome aberrations. Radiat. Res. 160, 52-60 (2003).
23. S-M. Hou, F. J. Van Dam, F. deZwart, C. Warnock, M. Mognato, J. Turner, N. Podlutskaja, A. Podlutsky, R. Becker and A. D. Tales, Validation of the human T-lymphocyte cloning assay-ring test report from the EU concerted action on HPRT mutation (EUCAHM). Mutat. Res. 431, 211-221 (1999).
24. P. R. V. Kumar, V. Z. Hamza, M. N. Mohankumar and R. K. Jeevanram, Studies on the HPRT mutant frequency in T lymphocytes from healthy Indian male population as a function of age and smoking. Mutat. Res. 556, 107-116 (2004).
25. J. P. O'Neill, L. M. Sullivan, T. C. Hunter and J. A. Nicklas, Cytosine arabinoside enhancement of gamma irradiation induced mutations in human T-lymphocytes. Environ. Mol. Mutagen. 17, 231-237 (1991).
26. A. Podlutsky, T. Bastlová and B. Lambert, Reduced proliferation rate of hypoxanthine phosphoribosyl transferase mutant human T-lymphocytes in vitro. Environ. Mol. Mutagen. 28, 13-18 (1996).
27. E. J. Hall, Radiation dose-rate: A factor of importance in radiobiology and radiotherapy. Br. J. Radiol. 45, 81-97 (1972).
28. H. P. Leenhouts and K. H. Chadwick, The influence of dose-rate on the dose-effect relationship. J. Radiol. Prot. 10, 95-102 (1990).
29. C. S. Potten, Hair medullary cell counts following low-dose-rate γ- and high energy neutron irradiation. Int. J. Radiat. Biol. 63, 97-104 (1993).
30. J. D. Chapman, Single-hit mechanism of tumour cell killing by radiation. Int. J. Radiat. Biol. 79, 71-81 (2003).
31. H. H. Rossi, Microdosimetry and radiobiology. Radiat. Prot. Dosim. 13, 259-265 (1985).
32. J. K. Wickliffe, A. M. Bickham, B. E. Rodgers, R. K. Chesser, C. J. Philips, S. P. Gaschak, J. A. Goryanaya, I. Chizevsky and R. J. Baker, Exposure to chronic, low-dose rate γ-radiation at Chornobyl does not induce point mutations in Big Blue® mice. Environ. Mol. Mutagen. 42, 11-18 (2003).
33. J. Magae, Y. Hoshi, C. Furakawa, Y. Kawakami and H. Ogata, Quantitative analysis of biological responses to ionizing radiation, including dose, irradiation time, and dose rate. Radiat. Res. 160, 543-548 (2003).
34. I. Furuno-Fukushi, A. M. Ueno and H. Matsudaira, Mutation induction by very low dose rate γ rays in cultured mouse leukemia cells L5178Y Radiat. Res. 115, 273-280 (1988).
35. M. S. Park, T. Hanks, A. Jaberaboansari and D. J. Chen, Molecular-analysis of gamma-ray-induced mutations at the hprt locus in primary human skin fibroblasts by multiplex polymerase chain reaction. Radiat. Res. 141, 11-18 (1995).
36. J. L. Schwartz, R. Jordan, J. Sun, H. Ma and A. W. Hsie, Dose-dependent changes in the spectrum of mutations induced by ionizing radiation. Radiat. Res. 153, 312-317 (2000).
37. S. L. Nelson, I. M. Jones, J. C. Fuscoe, K. B. Schultz and A. J. Grosovsky, Mapping the end points of large deletions affecting the HPRT locus in human peripheral blood cells and cell lines. Radiat. Res. 141, 2-10 (1995).
38. D. R. Robinson, K. Goodall, R. J. Albertini, J. P. O'Neill, B. Finnette, M. Sala-Trepat, E. Moustacchi, A. D. Tates, D. M. Beare and J. Cole, An analysis of in vivo hprt mutant frequency in circulating T-lymphocytes in the normal human population: A comparison of four datasets. Mutat. Res. 313, 227-247 (1994).
39. N. Nakamura, S. Umeki, Y. Hirai, S. Kyoizumi, Kushiro, Y. Kusoniki and M. Akiyama, Evaluation of four somatic mutation assays for biological dosimetry of radiation-exposed people including atomic bomb survivors. Prog. Clin. Biol. Res. 372, 341-350 (1991).
40. M. L. Mendelsohn, New approaches for biological monitoring of radiation workers. Health Phys. 59, 23-28 (1990).
41. Y. Hirai, Y. Kusunoki, S. Kyoizumi, A. A. Awa, D. J. Pawel, N. Nakamura and M. Akiyama, Mutant frequency at the HPRT locus in peripheral blood T-lymphocytes of atomic bomb survivors. Mutat. Res. 329, 183-196 (1995).
42. R. F. Branda, L. M. Sullivan, J. P. O'Neill, M. T. Falta, J. A. Nicklas, B. Hirsch, P. M. Vacek and R. J. Albertini, Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations. Mutat. Res. 285, 267-279 (1993).
43. R. Lorenz, K. Leuner, W. Deubel, T. Göllner and K. Hempel, Normal and reverse dose-rate effect for the induction of mutants in somatic cells by ionizing radiation. Toxicol. Lett. 67, 353-363 (1993).
44. W. L. Russell and E. M. Kelly, Mutation frequencies in male mice and the estimation of genetic hazards of radiation in men. Proc. Natl. Acad. Sci. USA 79, 542-544 (1982).
45. Y. Ina, H. Tanooka, T. Yaraada and K. Sakai, Suppression of thymic lymphoma by life-long low-dose-rate irradiation accompanied by immune activation in C57BL/6 mice. Radiat. Res. 163, 153-158 (2005).