Induction of human β-defensin-2 in pulmonary epithelial cells by Legionella pneumophila: Involvement of TLR2 and TLR5, p38 MAPK, JNK, NF-κB, and AP-1

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 298, Issue 5, 2010, Pages

  Scharf, Stefanie ^a   Hippenstiel, Stefan ^a   Flieger, Antje ^b   Suttorp, Norbert ^a   N'Guessan, Philippe Dje ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b ROBERT KOCH INSTITUTE   (Germany)

Author keywords

A549 cells; Pneumonia

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BETA DEFENSIN 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 5; TRANSCRIPTION FACTOR AP 1;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; LUNG ALVEOLUS EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; RESPIRATORY EPITHELIUM;

BASE SEQUENCE; BETA-DEFENSINS; CELL LINE; CELLS, CULTURED; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNITY, INNATE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PNEUMOCYTES; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 5; TRANSCRIPTION FACTOR AP-1;

EID: 77951601179     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00365.2009     Document Type: Article

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