메뉴 건너뛰기




Volumn 8, Issue 2, 2010, Pages 113-127

An evidence-based systematic review of stevia by the Natural Standard Research Collaboration

Author keywords

Adverse effects; Analysis; Dosing; Evidence based; Interactions; Pharmacodynamics; Pharmacokinetics; Pharmacology; Review of the literature; Stevia (stevia rebaudiana); Systematic aggregation; Systematic review

Indexed keywords

ANTIDIABETIC AGENT; ATRACTYLOSIDE; DIURETIC AGENT; GLUCOSILSTEVIOL; ISOSTEVIOL; PLACEBO; PLANT GLYCOSIDE; PLANT MEDICINAL PRODUCT; REBAUDIOSIDE A; SODIUM MONOKETOCHOLATE; STEVIOSIDE; UNCLASSIFIED DRUG; VERAPAMIL;

EID: 77951562121     PISSN: 18715257     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152510791170960     Document Type: Review
Times cited : (37)

References (70)
  • 1
    • 4544319977 scopus 로고    scopus 로고
    • Rebaudioside a potently stimulates insulin secretion from isolated mouse islets: Studies on the dose-, glucose-, and calcium-dependency
    • DOI 10.1016/j.metabol.2004.04.014, PII S0026049504002100
    • Abudula, R.; Jeppesen, P.B.; Rolfsen, S.E.; Xiao, J.; Hermansen, K. Rebaudioside A potently stimulates insulin secretion from isolated mouse islets, studies on the dose-, glucose-, and calcium-dependency. Metabolism, 2004, 53(10), 1378-1381. (Pubitemid 39222103)
    • (2004) Metabolism: Clinical and Experimental , vol.53 , Issue.10 , pp. 1378-1381
    • Abudula, R.1    Jeppesen, P.B.2    Rolfsen, S.E.D.3    Xiao, J.4    Hermansen, K.5
  • 2
    • 0017408049 scopus 로고
    • Cytological effects of some medicinal plants used in the control of fertility
    • Schvartzman, J.B.; Krimer, D.B.; Moreno, A.R. Cytological effects of some medicinal plants used in the control of fertility. Experientia, 1977, 33(5), 663-665. (Pubitemid 8094290)
    • (1977) Experientia , vol.33 , Issue.5 , pp. 663-665
    • Schvartzman, J.B.1    Krimer, D.B.2    Moreno Azorero, R.3
  • 3
    • 0042051715 scopus 로고    scopus 로고
    • Metabolism of stevioside and rebaudioside a from Stevia rebaudiana extracts by human microflora
    • Gardana, C.; Simonetti, P.; Canzi, E.; Zanchi, R.; Pietta, P. Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. J. Agric. Food Chem., 2003, 51(22), 6618-6622.
    • (2003) J. Agric. Food Chem. , vol.51 , Issue.22 , pp. 6618-6622
    • Gardana, C.1    Simonetti, P.2    Canzi, E.3    Zanchi, R.4    Pietta, P.5
  • 6
    • 0022658261 scopus 로고
    • Characterization of bacterial mutagenicity mediated by 13-hydroxy-ent-kaurenoic acid (steviol) and several structurally-related derivatives and evaluation of potential to induce glutathione S-transferase in mice
    • Pezzuto, J.M.; Nanayakkara, N.P.; Compadre, C.M.; Swanson, S.M.; Kinghorn, A.D.; Guenthner, T.M.; Sparnins, V.L.; Lam, L.K. Characterization of bacterial mutagenicity mediated by 13-hydroxy-ent-kaurenoic acid (steviol) and several structurally-related derivatives and evaluation of potential to induce glutathione S-transferase in mice. Mutat. Res., 1986, 169(3), 93-103.
    • (1986) Mutat. Res. , vol.169 , Issue.3 , pp. 93-103
    • Pezzuto, J.M.1    Nanayakkara, N.P.2    Compadre, C.M.3    Swanson, S.M.4    Kinghorn, A.D.5    Guenthner, T.M.6    Sparnins, V.L.7    Lam, L.K.8
  • 7
    • 33244495699 scopus 로고    scopus 로고
    • Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells
    • Boonkaewwan, C.; Toskulkao, C.; and Vongsakul, M. Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells. J. Agric. Food Chem., 2006, 54(3), 785-789.
    • (2006) J. Agric. Food Chem. , vol.54 , Issue.3 , pp. 785-789
    • Boonkaewwan, C.1    Toskulkao, C.2    Vongsakul, M.3
  • 8
    • 57749106147 scopus 로고    scopus 로고
    • Stevioside and related compounds, therapeutic benefits beyond sweetness
    • Chatsudthipong, V.; Muanprasat, C. Stevioside and related compounds, therapeutic benefits beyond sweetness. Pharmacol. Ther., 2009, 121(1), 41-54.
    • (2009) Pharmacol. Ther. , vol.121 , Issue.1 , pp. 41-54
    • Chatsudthipong, V.1    Muanprasat, C.2
  • 9
    • 0030726091 scopus 로고    scopus 로고
    • Isolation, identification and antimicrobial activity of ombuoside from Stevia triflora
    • Amaro-Luis, J. M.; Adrian, M.; Diaz, C. Isolation, identification and antimicrobial activity of ombuoside from Stevia triflora. Ann. Pharm. Fr., 1997, 55(6), 262-268.
    • (1997) Ann. Pharm. Fr. , vol.55 , Issue.6 , pp. 262-268
    • Amaro-Luis, J.M.1    Adrian, M.2    Diaz, C.3
  • 13
    • 0033818478 scopus 로고    scopus 로고
    • A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension
    • Chan, P.; Tomlinson, B.; Chen, Y.J.; Liu, J.C.; Hsieh, M.H.; Cheng, J.T. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br. J. Clin. Pharmacol., 2000, 50(3), 215-220.
    • (2000) Br. J. Clin. Pharmacol. , vol.50 , Issue.3 , pp. 215-220
    • Chan, P.1    Tomlinson, B.2    Chen, Y.J.3    Liu, J.C.4    Hsieh, M.H.5    Cheng, J.T.6
  • 14
    • 0344664552 scopus 로고    scopus 로고
    • Efficacy and tolerability of oral stevioside in patients with mild essential hypertension, a two-year, randomized, placebo-controlled study
    • Hsieh, M.H.; Chan, P.; Sue, Y.M.; Liu, J.C.; Liang, T.H.; Huang, T.Y.; Tomlinson, B.; Chow, M.S.; Kao, P.F.; Chen, Y.J. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension, a two-year, randomized, placebo-controlled study. Clin. Ther., 2003, 25(11), 2797-2808.
    • (2003) Clin. Ther. , vol.25 , Issue.11 , pp. 2797-2808
    • Hsieh, M.H.1    Chan, P.2    Sue, Y.M.3    Liu, J.C.4    Liang, T.H.5    Huang, T.Y.6    Tomlinson, B.7    Chow, M.S.8    Kao, P.F.9    Chen, Y.J.10
  • 15
    • 0032476163 scopus 로고    scopus 로고
    • The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats
    • DOI 10.1016/S0024-3205(98)00439-1, PII S0024320598004391
    • Chan, P.; Xu, D.Y.; Liu, J.C.; Chen, Y.J.; Tomlinson, B.; Huang, W.P.; Cheng, J.T. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci., 1998, 63(19), 1679-1684. (Pubitemid 28494155)
    • (1998) Life Sciences , vol.63 , Issue.19 , pp. 1679-1684
    • Chan, P.1    Xu, D.-Y.2    Liu, J.-C.3    Chen, Y.-J.4    Tomlinson, B.5    Huang, W.-P.6    Cheng, J.-T.7
  • 16
    • 14944361919 scopus 로고    scopus 로고
    • Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana
    • Chen, T.H.; Chen, S.C.; Chan, P.; Chu, Y.L.; Yang, H.Y.; Cheng, J.T. Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. Planta Med., 2005, 71(2), 108-113.
    • (2005) Planta Med. , vol.71 , Issue.2 , pp. 108-113
    • Chen, T.H.1    Chen, S.C.2    Chan, P.3    Chu, Y.L.4    Yang, H.Y.5    Cheng, J.T.6
  • 18
    • 0025783380 scopus 로고
    • Effect of calcium and verapamil on renal function of rats during treatment with stevioside
    • Melis, M.S.; Sainati, A.R. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J. Ethnopharmacol., 1991, 33(3), 257-262.
    • (1991) J. Ethnopharmacol. , vol.33 , Issue.3 , pp. 257-262
    • Melis, M.S.1    Sainati, A.R.2
  • 19
    • 0029955183 scopus 로고    scopus 로고
    • A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats
    • Melis, M.S. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz. J. Med. Biol. Res., 1996, 29(5), 669-675.
    • (1996) Braz. J. Med. Biol. Res. , vol.29 , Issue.5 , pp. 669-675
    • Melis, M.S.1
  • 20
    • 0032852968 scopus 로고    scopus 로고
    • Effects of chronic administration of Stevia rebaudiana on fertility in rats
    • DOI 10.1016/S0378-8741(99)00081-1, PII S0378874199000811
    • Melis, M.S. Effects of chronic administration of Stevia rebaudiana on fertility in rats. J. Ethnopharmacol., 1999, 67(2), 157-161. (Pubitemid 29421670)
    • (1999) Journal of Ethnopharmacology , vol.67 , Issue.2 , pp. 157-161
    • Melis, M.S.1
  • 21
    • 33748762217 scopus 로고    scopus 로고
    • Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension
    • Ferri, L.A.; Alves-Do-Prado, W.; Yamada, S.S.; Gazola, S.; Batista, M.R.; Bazotte, R.B. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother. Res., 2006, 20(9), 732-736.
    • (2006) Phytother. Res. , vol.20 , Issue.9 , pp. 732-736
    • Ferri, L.A.1    Alves-Do-Prado, W.2    Yamada, S.S.3    Gazola, S.4    Batista, M.R.5    Bazotte, R.B.6
  • 22
    • 43749120034 scopus 로고    scopus 로고
    • Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. a pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics
    • Barriocanal, L.A.; Palacios, M.; Benitez, G.; Benitez, S.; Jimenez, J.T.; Jimenez, N.; Rojas, V. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics. Regul. Toxicol. Pharmacol., 2008, 51(1), 37-41.
    • (2008) Regul. Toxicol. Pharmacol. , vol.51 , Issue.1 , pp. 37-41
    • Barriocanal, L.A.1    Palacios, M.2    Benitez, G.3    Benitez, S.4    Jimenez, J.T.5    Jimenez, N.6    Rojas, V.7
  • 23
    • 45949100030 scopus 로고    scopus 로고
    • Overview, the history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages
    • Carakostas, M.C.; Curry, L.L.; Boileau, A.C.; Brusick, D.J. Overview, the history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages. Food Chem. Toxicol. 2008, 46(Suppl 7), S1-S10.
    • (2008) Food Chem. Toxicol. , vol.46 , Issue.SUPPL. 7
    • Carakostas, M.C.1    Curry, L.L.2    Boileau, A.C.3    Brusick, D.J.4
  • 25
    • 0026089997 scopus 로고
    • Effect of stevioside on growth and reproduction
    • Yodyingyuad, V.; Bunyawong, S. Effect of stevioside on growth and reproduction. Hum. Reprod. 1991, 6(1), 158-165.
    • (1991) Hum. Reprod. , vol.6 , Issue.1 , pp. 158-165
    • Yodyingyuad, V.1    Bunyawong, S.2
  • 27
    • 0027769643 scopus 로고
    • Mutagenicity and human chromosomal effect of stevioside, a sweetener from Stevia rebaudiana Bertoni
    • Suttajit, M.; Vinitketkaumnuen, U.; Meevatee, U.; Buddhasukh, D. Mutagenicity and human chromosomal effect of stevioside, a sweetener from Stevia rebaudiana Bertoni. Environ. Health Perspect. 1993, 101(Suppl 3), 53-56. (Pubitemid 24014753)
    • (1993) Environmental Health Perspectives , vol.101 , Issue.SUPPL. 3 , pp. 53-56
    • Suttajit, M.1    Vinitketkaumnuen, U.2    Meevatee, U.3    Buddhasukh, D.4
  • 28
    • 45949093346 scopus 로고    scopus 로고
    • A critical review of the genetic toxicity of steviol and steviol glycosides
    • Brusick, D.J. A critical review of the genetic toxicity of steviol and steviol glycosides. Food Chem.Toxicol., 2008, 46(Suppl 7), S83-S91.
    • (2008) Food Chem.Toxicol. , vol.46 , Issue.SUPPL. 7
    • Brusick, D.J.1
  • 29
    • 0036953051 scopus 로고    scopus 로고
    • Genotoxicity studies of stevia extract and steviol by the comet assay
    • Sekihashi, K.; Saitoh, H.; Sasaki, Y. [Genotoxicity studies of stevia extract and steviol by the comet assay]. J. Toxicol. Sci., 2002, 27(Suppl 1),1-8.
    • (2002) J. Toxicol. Sci. , vol.27 , Issue.SUPPL. 1 , pp. 1-8
    • Sekihashi, K.1    Saitoh, H.2    Sasaki, Y.3
  • 31
    • 0036634168 scopus 로고    scopus 로고
    • Mutagenicity of steviol and its oxidative derivatives in Salmonella typhimurium TM677
    • DOI 10.1248/cpb.50.1007
    • Terai, T.; Ren, H.; Mori, G.; Yamaguchi, Y.; Hayashi, T. Mutagenicity of steviol and its oxidative derivatives in Salmonella typhimurium TM677. Chem. Pharm. Bull. (Tokyo), 2002, 50(7), 1007-1010. (Pubitemid 41694885)
    • (2002) Chemical and Pharmaceutical Bulletin , vol.50 , Issue.7 , pp. 1007-1010
    • Terai, T.1    Ren, H.2    Mori, G.3    Yamaguchi, Y.4    Hayashi, T.5
  • 32
    • 23744439067 scopus 로고    scopus 로고
    • Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors
    • DOI 10.1016/j.lfs.2005.03.022, PII S0024320505004182
    • Mizushina, Y.; Akihisa, T.; Ukiya, M.; Hamasaki, Y.; Murakami-Nakai, C.; Kuriyama, I.; Takeuchi, T.; Sugawara, F.; Yoshida, H. Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors. Life Sci., 2005, 77(17), 2127-2140. (Pubitemid 41140453)
    • (2005) Life Sciences , vol.77 , Issue.17 , pp. 2127-2140
    • Mizushina, Y.1    Akihisa, T.2    Ukiya, M.3    Hamasaki, Y.4    Murakami-Nakai, C.5    Kuriyama, I.6    Takeuchi, T.7    Sugawara, F.8    Yoshida, H.9
  • 33
    • 0035672675 scopus 로고    scopus 로고
    • Inhibitory effect of stevioside on calcium influx to produce antihypertension
    • DOI 10.1055/s-2001-18841
    • Lee, C.N.; Wong, K.L.; Liu, J.C.; Chen, Y.J.; Cheng, J.T.; Chan, P. Inhibitory effect of stevioside on calcium influx to produce antihypertension. Planta. Med., 2001, 67(9), 796-799. (Pubitemid 34015540)
    • (2001) Planta Medica , vol.67 , Issue.9 , pp. 796-799
    • Lee, C.-N.1    Wong, K.-L.2    Liu, J.-C.3    Chen, Y.-J.4    Cheng, J.-T.5    Chan, P.6
  • 35
    • 0027024527 scopus 로고
    • Evaluation of the cariogenic potential of the intense natural sweeteners stevioside and rebaudioside A
    • Das, S.; Das, A.K.; Murphy, R.A.; Punwani, I.C.; Nasution, M.P.; Kinghorn, A.D. Evaluation of the cariogenic potential of the intense natural sweeteners stevioside and rebaudioside A. Caries Res., 1992, 26(5), 363-366.
    • (1992) Caries Res. , vol.26 , Issue.5 , pp. 363-366
    • Das, S.1    Das, A.K.2    Murphy, R.A.3    Punwani, I.C.4    Nasution, M.P.5    Kinghorn, A.D.6
  • 36
    • 1442348378 scopus 로고    scopus 로고
    • Isosteviol acts on potassium channels to relax isolated aortic strips of Wistar rat
    • Wong, K.L.; Chan, P.; Yang, H.Y.; Hsu, F.L.; Liu, I.M.; Cheng, Y.W.; Cheng, J.T. Isosteviol acts on potassium channels to relax isolated aortic strips of Wistar rat. Life Sci., 2004, 74(19), 2379-2387.
    • (2004) Life Sci. , vol.74 , Issue.19 , pp. 2379-2387
    • Wong, K.L.1    Chan, P.2    Yang, H.Y.3    Hsu, F.L.4    Liu, I.M.5    Cheng, Y.W.6    Cheng, J.T.7
  • 38
    • 0043053467 scopus 로고    scopus 로고
    • Inhibitory effect of stevioside on tumor promotion by 12-O- Tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin
    • DOI 10.1248/bpb.25.1488
    • Yasukawa, K.; Kitanaka, S.; Seo, S. Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Biol. Pharm. Bull., 2002, 25(11), 1488-1490. (Pubitemid 39663173)
    • (2002) Biological and Pharmaceutical Bulletin , vol.25 , Issue.11 , pp. 1488-1490
    • Yasukawa, K.1    Kitanaka, S.2    Seo, S.3
  • 39
    • 0026633949 scopus 로고
    • Renal excretion of stevioside in rats
    • Melis, M.S. Renal excretion of stevioside in rats. J. Nat. Prod., 1992, 55(5), 688-690.
    • (1992) J. Nat. Prod. , vol.55 , Issue.5 , pp. 688-690
    • Melis, M.S.1
  • 42
    • 0037333120 scopus 로고    scopus 로고
    • In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora
    • DOI 10.1016/S0278-6915(02)00235-1, PII S0278691502002351
    • Koyama, E.; Kitazawa, K.; Ohori, Y.; Izawa, O.; Kakegawa, K.; Fujino, A.; Ui, M. In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora. Food Chem. Toxicol. 2003, 41(3), 359-374. (Pubitemid 36015773)
    • (2003) Food and Chemical Toxicology , vol.41 , Issue.3 , pp. 359-374
    • Koyama, E.1    Kitazawa, K.2    Ohori, Y.3    Izawa, O.4    Kakegawa, K.5    Fujino, A.6    Ui, M.7
  • 44
    • 0028978210 scopus 로고
    • Steviol and steviol-glycoside, glucosyltransferase activities in Stevia rebaudiana Bertoni - Purification and partial characterization
    • Shibata, H.; Sawa, Y.; Oka, T.; Sonoke, S.; Kim, K.K.; Yoshioka, M. Steviol and steviol-glycoside, glucosyltransferase activities in Stevia rebaudiana Bertoni - purification and partial characterization. Arch. Biochem. Biophys., 1995, 321(2), 390-396.
    • (1995) Arch. Biochem. Biophys. , vol.321 , Issue.2 , pp. 390-396
    • Shibata, H.1    Sawa, Y.2    Oka, T.3    Sonoke, S.4    Kim, K.K.5    Yoshioka, M.6
  • 45
    • 0036836919 scopus 로고    scopus 로고
    • Leaf Ests from Stevia rebaudiana, a resource for gene discovery in diterpene synthesis
    • Brandle, J.E.; Richman, A.; Swanson, A.K.; Chapman, B.P. Leaf Ests from Stevia rebaudiana, a resource for gene discovery in diterpene synthesis. Plant Mol. Biol., 2002, 50(4-5), 613-622.
    • (2002) Plant Mol. Biol. , vol.50 , Issue.4-5 , pp. 613-622
    • Brandle, J.E.1    Richman, A.2    Swanson, A.K.3    Chapman, B.P.4
  • 46
    • 12744278046 scopus 로고    scopus 로고
    • Functional genomics uncovers three glucosyltransferases involved in the synthesis of the major sweet glucosides of Stevia rebaudiana
    • Richman, A.; Swanson, A.; Humphrey, T.; Chapman, R.; McGarvey, B.; Pocs, R.; Brandle, J. Functional genomics uncovers three glucosyltransferases involved in the synthesis of the major sweet glucosides of Stevia rebaudiana. Plant J., 2005, 41(1), 56-67.
    • (2005) Plant J. , vol.41 , Issue.1 , pp. 56-67
    • Richman, A.1    Swanson, A.2    Humphrey, T.3    Chapman, R.4    McGarvey, B.5    Pocs, R.6    Brandle, J.7
  • 49
    • 0026276095 scopus 로고
    • Sensitivity of ketogenesis and citric acid cycle to stevioside inhibition of palmitate transport across the cell membrane
    • Constantin, J.; Ishii-Iwamoto, E.L.; Ferraresi-Filho, O.; Kelmer-Bracht, A.M.; Bracht, A. Sensitivity of ketogenesis and citric acid cycle to stevioside inhibition of palmitate transport across the cell membrane. Braz. J. Med. Biol. Res., 1991, 24(8), 767-771.
    • (1991) Braz. J. Med. Biol. Res. , vol.24 , Issue.8 , pp. 767-771
    • Constantin, J.1    Ishii-Iwamoto, E.L.2    Ferraresi-Filho, O.3    Kelmer-Bracht, A.M.4    Bracht, A.5
  • 50
    • 0021949181 scopus 로고
    • Effects of Stevia rebaudiana natural products on rat liver mitochondria
    • DOI 10.1016/0006-2952(85)90769-5
    • Kelmer, Bracht A.; Alvarez, M.; Bracht, A. Effects of Stevia rebaudiana natural products on rat liver mitochondria. Biochem. Pharmacol., 1985, 34(6), 873-882. (Pubitemid 15107182)
    • (1985) Biochemical Pharmacology , vol.34 , Issue.6 , pp. 873-882
    • Bracht, A.K.1    Alvarez, M.2    Bracht, A.3
  • 51
    • 4944226696 scopus 로고    scopus 로고
    • Molecular cloning and characterization of Stevia rebaudiana UDP-glucosyltransferase
    • Ma, L.B.; Zhang, da B.; Chen, L.; Chen, M.C. Molecular cloning and characterization of Stevia rebaudiana UDP-glucosyltransferase. Shi Yan. Sheng Wu Xue. Bao., 2003, 36(2), 123-129.
    • (2003) Shi Yan. Sheng Wu Xue. Bao. , vol.36 , Issue.2 , pp. 123-129
    • Ma, L.B.1    Zhang, D.B.2    Chen, L.3    Chen, M.C.4
  • 52
    • 0030586753 scopus 로고    scopus 로고
    • Hydroxylation of ent-kaurenoic acid to steviol in Stevia rebaudiana Bertoni - Purification and partial characterization of the enzyme
    • DOI 10.1006/abbi.1996.0336
    • Kim, K.K.; Sawa, Y.; Shibata, H. Hydroxylation of ent-kaurenoic acid to steviol in Stevia rebaudiana Bertoni - purification and partial characterization of the enzyme. Arch. Biochem. Biophys., 1996, 332(2), 223-230. (Pubitemid 26260383)
    • (1996) Archives of Biochemistry and Biophysics , vol.332 , Issue.2 , pp. 223-230
    • Kim, K.K.1    Sawa, Y.2    Shibata, H.3
  • 53
    • 0033180217 scopus 로고    scopus 로고
    • Diterpene synthesis in Stevia rebaudiana: Recruitment and up-regulation of key enzymes from the gibberellin biosynthetic pathway
    • DOI 10.1046/j.1365-313X.1999.00531.x
    • Richman, A.S.; Gijzen, M.; Starratt, A.N.; Yang, Z.; Brandle, J.E. Diterpene synthesis in Stevia rebaudiana, recruitment and upregulation of key enzymes from the gibberellin biosynthetic pathway. Plant J. 1999, 19(4), 411-421. (Pubitemid 29452036)
    • (1999) Plant Journal , vol.19 , Issue.4 , pp. 411-421
    • Richman, A.S.1    Gijzen, M.2    Starratt, A.N.3    Yang, Z.4    Brandle, J.E.5
  • 54
    • 0020365090 scopus 로고
    • Potential sweetening agents of plant origin. III. Organoleptic evaluation of Stevia leaf herbarium samples for sweetness
    • Soejarto, D.D.; Kinghorn, A.D.; Farnsworth, N.R. Potential sweetening agents of plant origin. III. Organoleptic evaluation of Stevia leaf herbarium samples for sweetness. J. Nat. Prod. 1982, 45(5), 590-599.
    • (1982) J. Nat. Prod. , vol.45 , Issue.5 , pp. 590-599
    • Soejarto, D.D.1    Kinghorn, A.D.2    Farnsworth, N.R.3
  • 55
    • 0031446371 scopus 로고    scopus 로고
    • Bactericidal activity of a fermented hot-water extract from Stevia rebaudiana Bertoni towards enterohemorrhagic Escherichia coli O157:H7 and other food-borne pathogenic bacteria
    • Tomita, T.; Sato, N.; Arai, T.; Shiraishi, H.; Sato, M.; Takeuchi, M.; Kamio, Y. Bactericidal activity of a fermented hot-water extract from Stevia rebaudiana Bertoni towards enterohemorrhagic Escherichia coli O157,H7 and other food-borne pathogenic bacteria. Microbiol. Immunol. 1997, 41(12), 1005-1009. (Pubitemid 28030695)
    • (1997) Microbiology and Immunology , vol.41 , Issue.12 , pp. 1005-1009
    • Tomita, T.1    Sato, N.2    Arai, T.3    Shiraishi, H.4    Sato, M.5    Takeuchi, M.6    Kamio, Y.7
  • 56
    • 1542284229 scopus 로고    scopus 로고
    • Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells
    • DOI 10.1055/s-2004-815485
    • Wong, K.L.; Yang, H.Y.; Chan, P.; Cheng, T.H.; Liu, J.C.; Hsu, F.L.; Liu, I.M.; Cheng, Y.W.; Cheng, J.T. Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells. Planta Med., 2004, 70(2), 108-112. (Pubitemid 38299770)
    • (2004) Planta Medica , vol.70 , Issue.2 , pp. 108-112
    • Wong, K.-L.1    Yang, H.-Y.2    Chan, P.3    Cheng, T.-H.4    Liu, J.-C.5    Hsu, F.-L.6    Liu, I.-M.7    Cheng, Y.-W.8    Cheng, J.-T.9
  • 58
    • 0347316396 scopus 로고    scopus 로고
    • Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle
    • Lailerd, N.; Saengsirisuwan, V.; Sloniger, J.A.; Toskulkao, C.; Henriksen, E.J. Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle. Metabolism, 2004, 53(1), 101-107.
    • (2004) Metabolism , vol.53 , Issue.1 , pp. 101-107
    • Lailerd, N.1    Saengsirisuwan, V.2    Sloniger, J.A.3    Toskulkao, C.4    Henriksen, E.J.5
  • 60
    • 0036190439 scopus 로고    scopus 로고
    • Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: Studies in the diabetic Goto-Kakizaki (GK) rats
    • Jeppesen, P.B.; Gregersen, S.; Alstrup, K.K.; Hermansen, K. Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo, studies in the diabetic Goto-Kakizaki (GK) rats. Phytomedicine, 2002, 9(1), 9-14. (Pubitemid 34184204)
    • (2002) Phytomedicine , vol.9 , Issue.1 , pp. 9-14
    • Jeppesen, P.B.1    Gregersen, S.2    Alstrup, K.K.3    Hermansen, K.4
  • 61
    • 3042668731 scopus 로고    scopus 로고
    • Glucose concentration in the blood of intact and alloxan-treated mice after pretreatment with commercial preparations of Stevia rebaudiana (Bertoni)
    • Raskovic, A.; Gavrilovic, M.; Jakovljevic, V.; Sabo, J. Glucose concentration in the blood of intact and alloxan-treated mice after pretreatment with commercial preparations of Stevia rebaudiana (Bertoni). Eur. J. Drug Metab. Pharmacokinet., 2004, 29(2), 87-90. (Pubitemid 38828620)
    • (2004) European Journal of Drug Metabolism and Pharmacokinetics , vol.29 , Issue.2 , pp. 87-90
    • Raskovic, A.1    Gavrilovic, M.2    Jakovljevic, V.3    Sabo, J.4
  • 62
    • 0022001583 scopus 로고
    • Effect of steviol and its structural analogues on glucose production and oxygen uptake in rat renal tubules
    • DOI 10.1007/BF02005871
    • Yamamoto, N.S.; Kelmer Bracht, A.M.; Ishii, E.L.; Kemmelmeier, F.S.; Alvarez, M.; Bracht, A. Effect of steviol and its structural analogues on glucose production and oxygen uptake in rat renal tubules. Experientia, 1985, 41(1), 55-57. (Pubitemid 15163760)
    • (1985) Experientia , vol.41 , Issue.1 , pp. 55-57
    • Yamamoto, N.S.1    Kelmer Bracht, A.M.2    Ishii, E.L.3
  • 63
    • 0022481532 scopus 로고
    • Stevioside, the sweet glycoside of Stevia rebaudiana, inhibits the action of atractyloside in the isolated perfused rat liver
    • Ishii, E.L.; Bracht, A. Stevioside, the sweet glycoside of Stevia rebaudiana, inhibits the action of atractyloside in the isolated perfused rat liver. Res. Commun. Chem, Pathol, Pharmacol., 1986, 53(1), 79-91.
    • (1986) Res. Commun. Chem, Pathol, Pharmacol. , vol.53 , Issue.1 , pp. 79-91
    • Ishii, E.L.1    Bracht, A.2
  • 64
    • 0033952852 scopus 로고    scopus 로고
    • +-channel activity
    • Jeppesen, P.B.; Gregersen, S.; Poulsen, C.R.; Hermansen, K. Stevioside acts directly on pancreatic beta cells to secrete insulin, actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. Metabolism, 2000, 49(2), 208-214. (Pubitemid 30090885)
    • (2000) Metabolism: Clinical and Experimental , vol.49 , Issue.2 , pp. 208-214
    • Jeppesen, P.B.1    Gregersen, S.2    Poulsen, C.R.3    Hermansen, K.4
  • 65
    • 0024545549 scopus 로고
    • Chronic administration of aqueous extract of Stevia rebaudiana (Bert.) Bertoni in rats, endocrine effects
    • Oliveira-Filho, R.M.; Uehara, O.A.; Minetti, C.A.; Valle, L.B. Chronic administration of aqueous extract of Stevia rebaudiana (Bert.) Bertoni in rats, endocrine effects. Gen. Pharmacol., 1989, 20(2) 187-191.
    • (1989) Gen. Pharmacol. , vol.20 , Issue.2 , pp. 187-191
    • Oliveira-Filho, R.M.1    Uehara, O.A.2    Minetti, C.A.3    Valle, L.B.4
  • 66
    • 0029008328 scopus 로고
    • Chronic administration of aqueous extract of Stevia rebaudiana in rats, renal effects
    • Melis, M.S. Chronic administration of aqueous extract of Stevia rebaudiana in rats, renal effects. J. Ethnopharmacol. 1995, 47(3), 129-134.
    • (1995) J. Ethnopharmacol. , vol.47 , Issue.3 , pp. 129-134
    • Melis, M.S.1
  • 67
    • 0026650515 scopus 로고
    • Stevioside effect on renal function of normal and hypertensive rats
    • Melis, M.S. Stevioside effect on renal function of normal and hypertensive rats. J. Ethnopharmacol., 1992, 36(3), 213-217.
    • (1992) J. Ethnopharmacol. , vol.36 , Issue.3 , pp. 213-217
    • Melis, M.S.1
  • 68
    • 0038064401 scopus 로고    scopus 로고
    • Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans
    • Koyama, E.; Sakai, N.; Ohori, Y.; Kitazawa, K.; Izawa, O.; Kakegawa, K.; Fujino, A.; Ui, M. Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans. Food Chem. Toxicol., 2003, 41(6), 875-883.
    • (2003) Food Chem. Toxicol. , vol.41 , Issue.6 , pp. 875-883
    • Koyama, E.1    Sakai, N.2    Ohori, Y.3    Kitazawa, K.4    Izawa, O.5    Kakegawa, K.6    Fujino, A.7    Ui, M.8
  • 69
    • 0028897821 scopus 로고
    • Stevioside is not metabolized in the isolated perfused rat liver
    • Ishii-Iwamoto, E.L.; Bracht, A. Stevioside is not metabolized in the isolated perfused rat liver. Res. Commun. Mol. Pathol. Pharmacol., 1995, 87(2), 167-175.
    • (1995) Res. Commun. Mol. Pathol. Pharmacol. , vol.87 , Issue.2 , pp. 167-175
    • Ishii-Iwamoto, E.L.1    Bracht, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.