Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans

Food and Chemical Toxicology

Volumn 41, Issue 6, 2003, Pages 875-883

  Koyama, Eriko ^a   Sakai, Norifumi ^a   Ohori, Yuji ^a   Kitazawa, Ken ^a   Izawa, Osamu ^a   Kakegawa, Kunio ^b   Fujino, Akiharu ^a   Ui, Michio ^c  

^a MITSUBISHI CHEMICAL CORPORATION   (Japan)

^b Maruzen Pharmaceuticals Co   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Hepatic metabolism; In vitro absorption; Rat everted sac method; Stevia mixture; Steviol

Indexed keywords

GLUCOSE DERIVATIVE; GLYCOSIDASE; SALICYLIC ACID; STEVIOL; SWEETENING AGENT;

AEROBIC METABOLISM; ARTICLE; BLOOD LEVEL; FEMALE; HUMAN; INTESTINE ABSORPTION; LIQUID CHROMATOGRAPHY; LIVER METABOLISM; LIVER MICROSOME; MALE; METABOLITE; NONHUMAN; NORMAL HUMAN; RAT;

STEVIA REBAUDIANA;

EID: 0038064401     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(03)00039-5     Document Type: Article

References (22)

1. Amidon G.L., Sinko P.J., Fleisher D. Estimating human oral fraction dose absorbed; a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds. Pharmaceutical Research. 5:1988;651-654.
2. Amidon G.L., Lennernas H., Shah V.P., Crison J.R. A theoretical basis for a biopharmaceutic drug classification. the correlation of in vitro drug product dissolution and in vivo bioabailability Pharmaceutical Research. 12:1995;413-420.
3. Aze Y., Toyoda K., Imaida K., Hayashi S., Imazawa T., Hayashi Y., Takahashi M. Subchronic oral toxicity study of stevioside in F344 rats. Bulletin of the National Institute Hygienic Sciences,(Tokyo, Japan). 1991;48-54.
4. 131I-stevioside and its metabolites. Nuclear and Medical Biology. 23:1996;97-100.
5. Chhabra R.S. Intestinal absorption and metabolism of xenobiotics. Environmental Health Perspectives. 33:1979;61-69.
6. Compadre C.M., Hussain R.A., Nanayakkara N.P.D., Pezzuto J.M., Kinghorn A.D. Mass spectral analysis of some derivatives and in vitro metabolites of steviol, the aglycone of the natural sweeteners, stevioside, rebaudioside A, and rubsoside. Biomedical and Environmental Mass Spectrometry. 15:1988;211-222.
7. Gobath F.A., MacCorquodale J.R., Haffner G.D. Intestinal absorption and biomagnification of organochlorines. Environmental Toxicology and Chemistry. 12:1993;567-576.
8. Hanson J.R., De Oliveira B.H. Stevioside and related sweet diterpenoid glycosides. Natural Products Reports. 10:1993;301-309.
9. Koyama E., Kitazawa K., Ohori Y., Izawa O., Kakegawa K., Fujino A., Ui M. In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora. Food and Chemical Toxicology. 41:2003;359-374.
10. Matsui M., Matsui K., Kawasaki Y., Oda T., Noguchi T., Kitagawa Y., Sawada M., Hayashi M., Nohmi T., Yoshihira K., Ishidate M., Sofuni T. Evaluation of the genotoxicity of stevioside and steviol using six in vitro and one in vivo mutagenicity assays. Mutagenesis. 11:1996;573-579.
11. Matsui M., Sofuni T., Nohmi T. Regionally-targeted mutagenesis by metabolically-activated steviol. DNA sequence analysis of steviol-induced mutants of guanine phophoribosyltransferase (gpt) gene of Salmonella typhimurium TM677 Mutagenesis. 11:1996;565-572.
12. Mori N., Sakanoue M., Takeuchi M., Shimpo K., Tanabe T. Effect of stevioside on fertility in rats. Journal of Food and Hygienic Society, (Tokyo, Japan). 22:1981;409-414.
13. Nakayama K., Kasahara D., Yamamoto F. Absorption, distribution, metablism and excretion of stevioside in rats. Journal of Food and Hygienic Society, (Tokyo, Japan). 27:1986;1-8.
14. Pezzuto J.M., Compadre C.M., Swanson S.M., Nanayakkara N.P.D., Kinghorn A.D. Metabolically activated steviol, the aglycone of stevioside, is mutagenic. Proceedings of the National Academy of Sciences, USA. 82:1985;2478-2482.
15. Soejarto D.D., Kinghorn A.D., Farnsworth N.R. Potential sweetening agents of plant origin. III. Organoleptic evaluation of Stevia leaf herbarium samples for sweetness. Journal of Natural Products. 45:1982;590-599.
16. Toskulkao C., Chaturat L., Temcharoen P., Glinsukon T. Acute toxicity of stevioside, a natural sweetener, and its metabolite, steviol, in several animal species. Drug and Chemical Toxicology. 20:1997;31-44.
17. Toyoda, K., Kawanishi, T., Ueyama, C., Takahashi, M. (1995) Re-evaluation of the safety of a food additive (reported in fiscal 1994). A chronic toxicity/carcinogenicity study of stevioside (a substance extracted from Stevia): Final report. Unpublished report from Division of Pathology, Biological Safety Research Center, National Institute of Health Sciences, Japan. Submitted to WHO by Ministry of Health and Welfare, Food Chemistry Division, Japan.
18. Toyoda K., Matsui H., Shoda T., Ueyama C., Takeda K., Takahashi M. Assessment of the carcinogenicity of stevioside in F344 rats. Food and Chemical Toxicology. 35:1997;597-603.
19. Wilson N.H., Wiseman G. The use of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface. Journal of Physiology. 123:1954;116-125.
20. Wingard R.E. Jr., Brown J.P., Enderlin F.E., Dale J.A., Seitz C.T. Intestinal degradation and absorption of the glycosidic sweeteners stevioside and rebaudioside A. Experientia. 36:1980;519-520.
21. Xili L., Chengjiany B., Eryi X., Reiming S., Yuengming W., Haodong S., Zhiyian H. Chronic oral toxicity and carcinogenicity study of stevioside in rats. Food and Chemical Toxicology. 30:1992;957-965.
22. Yamamoto A., Nakamura J., Takada S., Takeda M., Hashida M., Kimura T., Sezaki H. Drug absorption from the gastrointestinal tract and immunity. The mechanism of decreased absorption of salicylic acid during systemic anaphylaxis Journal of Pharmacobiodynamicss. 7:1984;728-736.