Transient improvement after brief antiepileptic drug withdrawal in the epilepsy monitoring unit - possible relationship to AED tolerance

Epilepsia

Volumn 51, Issue 5, 2010, Pages 811-817

  Azar, Nabil J ^a   Lagrange, Andre H ^a   Wang, Lily ^a   Song, Yanna ^a   Abou Khalil, Bassel W ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antiepileptic drug withdrawal; Drug holiday; Drug tolerance; Epilepsy monitoring; Seizure interval

Indexed keywords

ETIRACETAM; LAMOTRIGINE; OXCARBAZEPINE;

ADULT; ARTICLE; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG TOLERANCE; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; GENERALIZED EPILEPSY; HOSPITAL DISCHARGE; HOSPITAL MANAGEMENT; HOSPITALIZATION; HUMAN; MALE; MONOTHERAPY; PATIENT MONITORING; PRIORITY JOURNAL; TONIC CLONIC SEIZURE; TREATMENT RESPONSE;

ADULT; ANTICONVULSANTS; CARBAMAZEPINE; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE; DRUG TOLERANCE; ELECTROENCEPHALOGRAPHY; EPILEPSY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; PIRACETAM; SEVERITY OF ILLNESS INDEX; SUBSTANCE WITHDRAWAL SYNDROME; TREATMENT OUTCOME; TRIAZINES;

EID: 77951557264     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2009.02494.x     Document Type: Article

References (33)

1. Abou-Khalil B, Lazenby B. (2003) Long-term experience with levetiracetam. Epileptic Disord 5(suppl 1):S33-S37.
2. Azar NJ, Wang L, Song Y, Abou-Khalil BW. (2008a) Temporal pattern of oxcarbazepine and phenytoin withdrawal seizures during epilepsy monitoring. Epilepsy Res 79:78-83.
3. Azar NJ, Wright AT, Wang L, Song Y, Abou-Khalil BW. (2008b) Generalized tonic-clonic seizures after acute oxcarbazepine withdrawal. Neurology 70:2187-2188.
4. Berg AT, Langfitt J, Shinnar S, Vickrey BG, Sperling MR, Walczak T, Bazil C, Pacia SV, Spencer SS. (2003) How long does it take for partial epilepsy to become intractable? Neurology 60:186-190.
5. Berg AT, Vickrey BG, Testa FM, Levy SR, Shinnar S, DiMario F, Smith S. (2006) How long does it take for epilepsy to become intractable? A prospective investigation. Ann Neurol 60:73-79.
6. Boon P, De Reuck J, Drieghe C, De Bruycker K, Aers I, Pengel J. (1994) Long-term video-EEG monitoring revisited. The value of interictal and ictal video-EEG recording, a follow-up study. Eur Neurol 34(suppl 1): 33-39.
7. Busto U, Sellers EM. (1991) Pharmacologic aspects of benzodiazepine tolerance and dependence. J Subst Abuse Treat 8:29-33.
8. Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P. (2007) Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways. Drug Metab Dispos 35:1032-1041. (Pubitemid 46956421)
9. Doyle WK, Devinsky O, Luciano D, Perrine K, Dogali M. (1994) Decreased seizure frequency after withdrawal and reinstitution of antiepileptic drug therapy. Seizure 3:61-65. (Pubitemid 24184293)
10. Frison L, Pocock SJ. (1992) Repeated measures in clinical trials: analysis using mean summary statistics and its implications for design. Stat Med 11:1685-1704.
11. Higgitt A, Fonagy P, Lader M. (1988) The natural history of tolerance to the benzodiazepines. Psychol Med Monogr Suppl 13:1-55.
12. Kwan P, Brodie MJ. (2005) Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia 46:224-235. (Pubitemid 40194666)
13. Laowattana S, Abou-Khalil B, Fakhoury T, Ashmead D. (1999) Brief antiepileptic drug withdrawal prolongs interval to next seizure. Neurology 53:1736-1741. (Pubitemid 29530348)
14. Loscher W, Potschka H. (2005) Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci 6:591-602. (Pubitemid 41059334)
15. Luna-Tortos C, Fedrowitz M, Loscher W. (2008) Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology 55:1364-1375.
16. Malow BA, Blaxton TA, Stertz B, Theodore WH. (1993) Carbamazepine withdrawal: effects of taper rate on seizure frequency. Neurology 43:2280-2284. (Pubitemid 23346962)
17. Malow BA, Lynch B, Blaxton TA, Mikati MA. (1994) Relationship of carbamazepine reduction rate to seizure frequency during inpatient telemetry. Epilepsia 35:1160-1164. (Pubitemid 24379426)
18. Marciani MG, Gotman J, Andermann F, Olivier A. (1985) Patterns of seizure activation after withdrawal of antiepileptic medication. Neurology 35:1537-1543. (Pubitemid 16248659)
19. Post RM, Leverich GS, Rosoff AS, Altshuler LL. (1990) Carbamazepine prophylaxis in refractory affective disorders: a focus on long-term follow-up. J Clin Psychopharmacol 10:318-327.
20. Remy S, Gabriel S, Urban BW, Dietrich D, Lehmann TN, Elger CE, Heinemann U, Beck H. (2003) A novel mechanismunderlying drug resistance in chronic epilepsy. Ann Neurol 53:469-479. (Pubitemid 36373258)
21. Riley TL, Porter RJ, White BG, Penry JK. (1981) The hospital experience and seizure control. Neurology 31:912-915.
22. Sato S, Malow B. (1995) Benzodiazepines: clonazepam. In Levy RH, Mattson R, Meldrum BS (Eds) Antiepileptic drugs. Raven Press, New York, pp. 725-734.
23. Schaffler L, Bourgeois BF, Luders HO. (1994) Rapid reversibility of autoinduction of carbamazepine metabolism after temporary discontinuation. Epilepsia 35:195-198. (Pubitemid 24074486)
24. Schmidt D, Kupferberg HJ, Yonekawa W, Penry JK. (1980) The development of tolerance to the anticonvulsant effect of phenobarbital in mice. Epilepsia 21:141-147. (Pubitemid 10125583)
25. Singh A, Guberman AH, Boisvert D. (1995) Clobazam in long-term epilepsy treatment: sustained responders versus those developing tolerance. Epilepsia 36:798-803.
26. Sun GC, Werkman TR, Wadman WJ. (2006) Kinetic changes and modulation by carbamazepine on voltage-gated sodium channels in rat CA1 neurons after epilepsy. Acta Pharmacol Sin 27:1537-1546.
27. Sutula TP, Sackellares JC, Miller JQ, Dreifuss FE. (1981) Intensive monitoring in refractory epilepsy. Neurology 31:243-247.
28. Tate SK, Sisodiya SM. (2007) Multidrug resistance in epilepsy: a pharmacogenomic update. Expert Opin Pharmacother 8:1441-1449.
29. van Vliet EA, van Schaik R, Edelbroek PM, Voskuyl RA, Redeker S, Aronica E, Wadman WJ, Gorter JA. (2007) Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats. J Pharmacol Exp Ther 322:141-147. (Pubitemid 46956371)
30. Weiss SR, Clark M, Rosen JB, Smith MA, Post RM. (1995) Contingent tolerance to the anticonvulsant effects of carbamazepine: relationship to loss of endogenous adaptive mechanisms. Brain Res Brain Res Rev 20:305-325.
31. Wen T, Liu YC, Yang HW, Liu HY, Liu XD, Wang GJ, Xie L. (2008) Effect of 21-day exposure of phenobarbital, carbamazepine and phenytoin on P-glycoprotein expression and activity in the rat brain. J Neurol Sci 270:99-106.
32. Yang HW, Liu HY, Liu X, Zhang DM, Liu YC, Liu XD, Wang GJ, Xie L. (2008) Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro. Neurosci Lett 434:299-303.
33. Zhang ZJ, Xing GQ, Russell S, Obeng K, Post RM. (2003) Unidirectional cross-tolerance from levetiracetam to carbamazepine in amygdala-kindled seizures. Epilepsia 44:1487-1493. (Pubitemid 38020181)