Brief antiepileptic drug withdrawal prolongs interval to next seizure

Neurology

Volumn 53, Issue 8, 1999, Pages 1736-1741

  Laowattana, Somchai ^a   Abou Khalil, Bassel ^a,b   Fakhoury, Toufic ^a   Ashmead, Dan ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Antiepileptic drug withdrawal; EEG video monitoring; Seizure frequency; Tachyphylaxis

Indexed keywords

ANTICONVULSIVE AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; CARBAMAZEPINE; GABAPENTIN; LAMOTRIGINE; PHENYTOIN; TOPIRAMATE; VALPROIC ACID;

ANTICONVULSANT THERAPY; ARTICLE; DISEASE SEVERITY; DRUG RESPONSE; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAM; FEMALE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; INTRACTABLE EPILEPSY; MAJOR CLINICAL STUDY; MALE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; SEIZURE; TACHYPHYLAXIS;

EID: 0033544407     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.53.8.1736     Document Type: Article

References (19)

1. Sutula TP, Sackellares JC, Miller JQ, Dreifuss FE. Intensive monitoring in refractory epilepsy. Neurology 1981;31:243-247.
2. Boon P, De Reuck J, Drieghe C, De Bruycker K, Aers I, Pengel J. Long-term video-EEG monitoring revisited: the value of interictal and ictal video-EEG recording, a follow-up study. Eur Neurol 1994;34(suppl 1):3-39.
3. Doyle WK, Devinsky O, Luciano D, Perrine K, Dogali M. Decreased seizure frequency after withdrawal and reinstitution of antiepileptic drug therapy. Seizure 1994;3:61-65.
4. Weiss SR, Clark M, Rosen JB, Smith MA, Post RM. Contingent tolerance to the anticonvulsant effects of carbamazepine: relationship to loss of endogenous adaptive mechanisms. Brain Res Rev 1995;20:305-325.
5. Sato S, Malow BA. Benzodiazepines: clonazepam. In: Levy RH, Mattson RH, Meldrum BS, eds. Antiepileptic drugs. 4th ed. New York: Raven Press, 1995:725-734.
6. Post RM, Leverich GS, Rosoff AS, Altshuler LL. Carbamazepine prophylaxis in refractory affective disorders: a focus on long-term follow-up. J Clin Psychopharmacol 1990;10:318-327.
7. Marciani MG, Gotman J, Andermann F, Oliver A. Patterns of seizure activation after withdrawal of antiepileptic medication. Neurology 1985;35:1537-1543.
8. Duncan JS, Shorvon SD, Trimble MR. Discontinuation of phenytoin, carbamazepine and valproate in patients with active epilepsy. Epilepsia 1990;31:324-333.
9. Direnfeld LK, Feldman RG, Alexander MP, Kelly-Hayes M. Is L-dopa drug holiday useful? Neurology 1980;30:785-788.
10. Weiner WJ, Koller WC, Perlik S, Nausieda PA, Klawans HL. Drug holiday and management of Parkinson's disease. Neurology 1980;30:1257-1261.
11. Kaye JA, Feldman RG. The role of L-dopa holiday in the long-term management of Parkinson's disease. Clin Neuropharmacol 1986;9:1-13.
12. Goetz CG, Tanner CM, Nausieda PA. Weekly drug holiday in Parkinson disease. Neurology 1981;31:1460-1462.
13. Mayeux R, Stern Y, Mulvey K, Cote L. Reappraisal of temporary levodopa withdrawal ("drug holiday") in Parkinson's disease. N Engl J Med 1985;313:724-728.
14. Pledger GW, Kramer LD. Clinical trials of investigational antiepileptic drugs: monotherapy designs. Epilepsia 1991;32: 716-721.
15. Bourgeois B, Leppik IE, Sackellares JC, et al. Felbamate: a double-blind controlled trial in patients undergoing presurgical evaluation of partial seizures. Neurology 1993;43:693-696.
16. Devinsky O, Faught RE, Wilder BJ, et al. Efficacy of felbamate monotherapy in patients undergoing presurgical evaluation of partial seizures. Epilepsy Res 1995;20:241-246.
17. Bergey GK, Morris HH, Rosenfeld W, et al. Gabapentin monotherapy: I. An 8-day, double-blind, dose-controlled, multi-center study in hospitalized patients with refractory complex partial or secondarily generalized seizures. Neurology 1997; 49:739-745.
18. Beydoun A, Fischer J, Labar DR, et al. Gabapentin monotherapy: II. A 26-week, double-blind, dose-controlled, multi-center study of conversion from polytherapy in outpatients with refractory complex partial or secondarily generalized seizures. Neurology 1997;49:746-752.
19. Theodore WH, Raubertas RF, Porter RJ, et al. Felbamate: a clinical trial for complex partial seizures. Epilepsia 1991;32: 392-397.