메뉴 건너뛰기




Volumn 36, Issue 6, 2010, Pages 1551-1561

Inhibition of MSP-RON signaling pathway in cancer cells by a novel soluble form of RON comprising the entire sema sequence

Author keywords

Antagonistic activity; Epithelial cancer; Receptor tyrosine kinase; Signal transduction; Truncated variant

Indexed keywords

COMPLEMENTARY DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; MACROPHAGE ACTIVATING FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PROTEIN RON RECEPTOR TYROSINE KINASE; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN; RON DELTA 85; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

EID: 77951548324     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000642     Document Type: Article
Times cited : (31)

References (38)
  • 1
    • 46749115181 scopus 로고    scopus 로고
    • Met-Related Receptor Tyrosine Kinase Ron in Tumor Growth and Metastasis
    • DOI 10.1016/S0065-230X(08)00001-8, PII S0065230X08000018
    • Wagh PK, Peace BE and Waltz SE: Met-related receptor tyrosine kinase Ron in tumor growth and metastasis. Adv Cancer Res 100: 1-33, 2008. (Pubitemid 351942429)
    • (2008) Advances in Cancer Research , vol.100 , pp. 1-33
    • Wagh, P.K.1    Peace, B.E.2    Waltz, S.E.3
  • 2
    • 18144422402 scopus 로고    scopus 로고
    • RON, a tyrosine kinase receptor involved in tumor progression and metastasis
    • DOI 10.1245/ASO.2005.08.013
    • Camp ER, Liu W, Fan F, Yang A, Somcio R and Ellis LM: RON, a tyrosine kinase receptor involved in tumor progression and metastasis. Ann Surg Oncol 12: 273-281, 2005. (Pubitemid 40616491)
    • (2005) Annals of Surgical Oncology , vol.12 , Issue.4 , pp. 273-281
    • Camp, E.R.1    Liu, W.2    Fan, F.3    Yang, A.4    Somcio, R.5    Ellis, L.M.6
  • 3
    • 36749041486 scopus 로고    scopus 로고
    • Altered expression of the RON receptor tyrosine kinase in various epithelial cancers and its contribution to tumourigenic phenotypes in thyroid cancer cells
    • DOI 10.1002/path.2245
    • Wang MH, Lee W, Luo YL, Weis MT and Yao HP: Altered expression of the RON receptor tyrosine kinase in various epithelial cancers and its contribution to tumourigenic phenotypes in thyroid cancer cells. J Pathol 213: 402-411, 2007. (Pubitemid 350206512)
    • (2007) Journal of Pathology , vol.213 , Issue.4 , pp. 402-411
    • Wang, M.-H.1    Lee, W.2    Luo, Y.-L.3    Weis, M.T.4    Yao, H.-P.5
  • 5
    • 33846260581 scopus 로고    scopus 로고
    • Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
    • DOI 10.1158/0008-5472.CAN-06-2473
    • Zinser GM, Leonis MA, Toney K, Pathrose P, Thobe M, Kader SA, Peace BE, Beauman SR, Collins MH and Waltz SE: Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation. Cancer Res 66: 11967-11974, 2006. (Pubitemid 46094210)
    • (2006) Cancer Research , vol.66 , Issue.24 , pp. 11967-11974
    • Zinser, G.M.1    Leonis, M.A.2    Toney, K.3    Pathrose, P.4    Thobe, M.5    Kader, S.A.6    Peace, B.E.7    Beauman, S.R.8    Collins, M.H.9    Waltz, S.E.10
  • 6
    • 0036848513 scopus 로고    scopus 로고
    • Recepteur d' origine nantais
    • Chen YQ, Zhou YQ, Fu LH, Wang D and Wang MH: Multiple pulmonary adenomas in the lung of transgenic mice over-expressing the RON receptor tyrosine kinase. Recepteur d' origine nantais. Carcinogenesis 23: 1811-1819, 2002.
    • (2002) Carcinogenesis , vol.23 , pp. 1811-1819
    • Chen, Y.Q.1    Zhou, Y.Q.2    Fu, L.H.3    Wang, D.4    Wang, M.H.5
  • 7
    • 33745427597 scopus 로고    scopus 로고
    • Oncogenesis of RON receptor tyrosine kinase: A molecular target for malignant epithelial cancers
    • Wang MH, Yao HP and Zhou YQ: Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers. Acta Pharmacol Sin 27: 641-650, 2006.
    • (2006) Acta Pharmacol Sin , vol.27 , pp. 641-650
    • Wang, M.H.1    Yao, H.P.2    Zhou, Y.Q.3
  • 9
    • 9144240012 scopus 로고    scopus 로고
    • RNA-mediated gene silencing of the RON receptor tyrosine kinase alters oncogenic phenotypes of human colorectal carcinoma cells
    • DOI 10.1038/sj.onc.1207907
    • Xu XM, Wang D, Shen Q, Chen YQ and Wang MH: RNA-mediated gene silencing of the RON receptor tyrosine kinase alters oncogenic phenotypes of human colorectal carcinoma cells. Oncogene 23: 8464-8474, 2004. (Pubitemid 39540797)
    • (2004) Oncogene , vol.23 , Issue.52 , pp. 8464-8474
    • Xu, X.-M.1    Wang, D.2    Shen, Q.3    Chen, Y.-Q.4    Wang, M.-H.5
  • 11
    • 64049101039 scopus 로고    scopus 로고
    • From concept to reality: The long road to c-Met and RON receptor tyrosine kinase inhibitors for the treatment of cancer
    • Dussault I and Bellon SF: From concept to reality: the long road to c-Met and RON receptor tyrosine kinase inhibitors for the treatment of cancer. Anticancer Agents Med Chem 9: 221-229, 2009.
    • (2009) Anticancer Agents Med Chem , vol.9 , pp. 221-229
    • Dussault, I.1    Bellon, S.F.2
  • 13
    • 0033569877 scopus 로고    scopus 로고
    • Interaction of macrophage-stimulating protein with its receptor residues. Critical for beta chain binding and evidence for independent alpha chain binding
    • DOI 10.1074/jbc.274.42.29937
    • Danilkovitch A, Miller M and Leonard EJ: Interaction of macrophage-stimulating protein with its receptor. Residues critical for beta chain binding and evidence for independent alpha chain binding. J Biol Chem 274: 29937-29943, 1999. (Pubitemid 29483373)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.42 , pp. 29937-29943
    • Danilkovitch, A.1    Miller, M.2    Leonard, E.J.3
  • 14
    • 0027318311 scopus 로고
    • A novel putative receptor protein tyrosine kinase of the met family
    • Ronsin C, Muscatelli F, Mattei MG and Breathnach R: A novel putative receptor protein tyrosine kinase of the met family. Oncogene 8: 1195-1202, 1993. (Pubitemid 23129841)
    • (1993) Oncogene , vol.8 , Issue.5 , pp. 1195-1202
    • Ronsin, C.1    Muscatelli, F.2    Mattei, M.-G.3    Breathnach, R.4
  • 15
    • 3142595278 scopus 로고    scopus 로고
    • Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor
    • DOI 10.1038/sj.emboj.7600243
    • Stamos J, Lazarus RA, Yao X, Kirchhofer D and Wiesmann C: Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. EMBO J 23: 2325-2335, 2004. (Pubitemid 38954840)
    • (2004) EMBO Journal , vol.23 , Issue.12 , pp. 2325-2335
    • Stamos, J.1    Lazarus, R.A.2    Yao, X.3    Kirchhofer, D.4    Wiesmann, C.5
  • 16
    • 51049117095 scopus 로고    scopus 로고
    • A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met
    • Basilico C, Arnesano A, Galluzzo M, Comoglio PM and Michieli P: A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met. J Biol Chem 283: 21267-21277, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 21267-21277
    • Basilico, C.1    Arnesano, A.2    Galluzzo, M.3    Comoglio, P.M.4    Michieli, P.5
  • 17
    • 0942265513 scopus 로고    scopus 로고
    • The Soluble Sema Domain of the RON Receptor Inhibits Macrophage- stimulating Protein-induced Receptor Activation
    • DOI 10.1074/jbc.M309342200
    • Angeloni D, Danilkovitch-Miagkova A, Miagkov A, Leonard EJ and Lerman MI: The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation. J Biol Chem 279: 3726-3732, 2006. (Pubitemid 38140616)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.5 , pp. 3726-3732
    • Angeloni, D.1    Danilkovitch-Miagkova, A.2    Miagkov, A.3    Leonard, E.J.4    Lerman, M.I.5
  • 18
    • 35148819860 scopus 로고    scopus 로고
    • Multiple variants of the RON receptor tyrosine kinase: Biochemical properties, tumorigenic activities, and potential drug targets
    • DOI 10.1016/j.canlet.2007.08.007, PII S0304383507003667
    • Lu Y, Yao HP and Wang MH: Multiple variants of the RON receptor tyrosine kinase: biochemical properties, tumorigenic activities, and potential drug targets. Cancer Lett 257: 157-164, 2007. (Pubitemid 47538834)
    • (2007) Cancer Letters , vol.257 , Issue.2 , pp. 157-164
    • Lu, Y.1    Yao, H.-P.2    Wang, M.-H.3
  • 19
    • 40949129114 scopus 로고    scopus 로고
    • Activation of RON differentially regulates claudin expression and localization: Role of claudin-1 in RON-mediated epithelial cell motility
    • DOI 10.1093/carcin/bgn003
    • Zhang K, Yao HP and Wang MH: Activation of RON differentially regulates claudin expression and localization: role of claudin-1 in RON-mediated epithelial cell motility. Carcinogenesis 29: 552-559, 2008. (Pubitemid 351404871)
    • (2008) Carcinogenesis , vol.29 , Issue.3 , pp. 552-559
    • Zhang, K.1    Yao, H.-P.2    Wang, M.-H.3
  • 20
    • 33751081244 scopus 로고    scopus 로고
    • Agonistic monoclonal antibodies potentiate tumorigenic and invasive activities of splicing variant of the RON receptor tyrosine kinase
    • Yao HP, Luo YL, Feng L, Cheng LF, Lu Y, Li W and Wang MH: Agonistic monoclonal antibodies potentiate tumorigenic and invasive activities of splicing variant of the RON receptor tyrosine kinase. Cancer Biol Ther 5: 1179-1186, 2006. (Pubitemid 44772234)
    • (2006) Cancer Biology and Therapy , vol.5 , Issue.9 , pp. 1179-1186
    • Yao, H.-P.1    Luo, Y.-L.2    Feng, L.3    Cheng, L.-F.4    Lu, Y.5    Li, W.6    Wang, M.-H.7
  • 21
    • 0037448657 scopus 로고    scopus 로고
    • Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: Generation of different splicing RON variants and their oncogenic potential
    • DOI 10.1038/sj.onc.1206075
    • Zhou YQ, He C, Chen YQ, Wang D and Wang MH: Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: Generation of different splicing variants and their oncogenic potential. Oncogene 22: 186-197, 2003. (Pubitemid 36174176)
    • (2003) Oncogene , vol.22 , Issue.2 , pp. 186-197
    • Zhou, Y.-Q.1    He, C.2    Chen, Y.-Q.3    Wang, D.4    Wang, M.-H.5
  • 22
    • 35148842564 scopus 로고    scopus 로고
    • Blocking tumorigenic activities of colorectal cancer cells by a splicing RON receptor variant defective in the tyrosine kinase domain
    • Wang MH, Lao WF, Wang D, Luo YL and Yao HP: Blocking tumorigenic activities of colorectal cancer cells by a splicing RON receptor variant defective in the tyrosine kinase domain. Cancer Biol Ther 6: 1121-1129, 2007. (Pubitemid 351574966)
    • (2007) Cancer Biology and Therapy , vol.6 , Issue.7 , pp. 1121-1129
    • Wang, M.-H.1    Lao, W.-F.2    Wang, D.3    Luo, Y.-L.4    Yao, H.-P.5
  • 25
    • 0141565232 scopus 로고    scopus 로고
    • Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor
    • DOI 10.1016/S0014-4827(03)00280-5
    • Peace BE, Hill KJ, Degen SJ and Waltz SE: Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor. Exp Cell Res 289: 317-325, 2003. (Pubitemid 37117417)
    • (2003) Experimental Cell Research , vol.289 , Issue.2 , pp. 317-325
    • Peace, B.E.1    Hill, K.J.2    Degen, S.J.F.3    Waltz, S.E.4
  • 27
  • 28
    • 65649137768 scopus 로고    scopus 로고
    • RON receptor tyrosine kinase in human gliomas: Expression, function, and identification of a novel soluble splice variant
    • Eckerich C, Schulte A, Martens T, Zapf S, Westphal M and Lamszus K: RON receptor tyrosine kinase in human gliomas: expression, function, and identification of a novel soluble splice variant. J Neurochem 109: 969-980, 2009.
    • (2009) J Neurochem , vol.109 , pp. 969-980
    • Eckerich, C.1    Schulte, A.2    Martens, T.3    Zapf, S.4    Westphal, M.5    Lamszus, K.6
  • 29
    • 3142512610 scopus 로고    scopus 로고
    • Targeting the tumor and its microenvironment by a dual-function decoy Met receptor
    • DOI 10.1016/j.ccr.2004.05.032, PII S1535610804001448
    • Michieli P, Mazzone M, Basilico C, Cavassa S, Sottile A, Naldini L and Comoglio PM: Targeting the tumor and its microenvironment by a dual-function decoy Met receptor. Cancer Cell 6: 61-73, 2004. (Pubitemid 38903162)
    • (2004) Cancer Cell , vol.6 , Issue.1 , pp. 61-73
    • Michieli, P.1    Mazzone, M.2    Basilico, C.3    Cavassa, S.4    Sottile, A.5    Naldini, L.6    Comoglio, P.M.7
  • 30
    • 34047253613 scopus 로고    scopus 로고
    • Identification of a fibroblast growth factor receptor 1 splice variant that inhibits pancreatic cancer cell growth
    • DOI 10.1158/0008-5472.CAN-06-3843
    • Liu Z, Neiss N, Zhou S, Henne-Bruns D, Korc M, Bachem M and Kornmann M: Identification of a fibroblast growth factor receptor 1 splice variant that inhibits pancreatic cancer cell growth. Cancer Res 67: 2712-2719, 2007. (Pubitemid 46548959)
    • (2007) Cancer Research , vol.67 , Issue.6 , pp. 2712-2719
    • Liu, Z.1    Neiss, N.2    Zhou, S.3    Henne-Bruns, D.4    Korc, M.5    Bachem, M.6    Kornmann, M.7
  • 32
    • 3142619403 scopus 로고    scopus 로고
    • The Sema domain of Met is necessary for receptor dimerization and activation
    • DOI 10.1016/j.ccr.2004.06.013, PII S1535610804001801
    • Kong-Beltran M, Stamos J and Wickramasinghe D: The Sema domain of Met is necessary for receptor dimerization and activation. Cancer Cell 6: 75-84, 2004. (Pubitemid 38903163)
    • (2004) Cancer Cell , vol.6 , Issue.1 , pp. 75-84
    • Kong-Beltran, M.1    Stamos, J.2    Wickramasinghe, D.3
  • 33
    • 33746504571 scopus 로고    scopus 로고
    • Invasive growth: A MET-driven genetic programme for cancer and stem cells
    • DOI 10.1038/nrc1912, PII NRC1912
    • Boccaccio C and Comoglio PM: Invasive growth: a MET-driven genetic programme for cancer and stem cells. Nat Rev Cancer 6: 637-645, 2006. (Pubitemid 44140861)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.8 , pp. 637-645
    • Boccaccio, C.1    Comoglio, P.M.2
  • 34
    • 0034685025 scopus 로고    scopus 로고
    • Requirement of both tyrosine residues 1330 and 1337 in the C-terminal tail of the RON receptor tyrosine kinase for epithelial cell scattering and migration
    • Xiao ZQ, Chen YQ and Wang MH: Requirement of both tyrosine residues 1330 and 1337 in the C-terminal tail of the RON receptor tyrosine kinase for epithelial cell scattering and migration. Biochem Biophys Res Commun 267: 669-675, 2000.
    • (2000) Biochem Biophys Res Commun , vol.267 , pp. 669-675
    • Xiao, Z.Q.1    Chen, Y.Q.2    Wang, M.H.3
  • 35
    • 21644472065 scopus 로고    scopus 로고
    • Mechanisms of cytoplasmic {beta}-catenin accumulation and its involvement in tumorigenic activities mediated by oncogenic splicing variant of the receptor originated from Nantes tyrosine kinase
    • Xu XM, Zhou YQ and Wang MH: Mechanisms of cytoplasmic {beta}-catenin accumulation and its involvement in tumorigenic activities mediated by oncogenic splicing variant of the receptor originated from Nantes tyrosine kinase. J Biol Chem 280: 25087-25094, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 25087-25094
    • Xu, X.M.1    Zhou, Y.Q.2    Wang, M.H.3
  • 36
    • 67649774148 scopus 로고    scopus 로고
    • Recepteur d'origine nantais tyrosine kinase is a direct target of hypoxia-inducible factor-1alpha-mediated invasion of breast carcinoma cells
    • Thangasamy A, Rogge J and Ammanamanchi S: Recepteur d'origine nantais tyrosine kinase is a direct target of hypoxia-inducible factor-1alpha-mediated invasion of breast carcinoma cells. J Biol Chem 284: 14001-14010, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 14001-14010
    • Thangasamy, A.1    Rogge, J.2    Ammanamanchi, S.3
  • 38
    • 0027444577 scopus 로고
    • Antibodies to macrophage stimulating protein (MSP): Specificity, epitope interactions, and immunoassay of MSP in human serum
    • Wang MH, Skeel A, Yoshimura T, Copeland TD, Sakaguchi K and Leonard EJ: Antibodies to macrophage stimulating protein (MSP): specificity, epitope interactions, and immunoassay of MSP in human serum. J Leukoc Biol 54: 289-295, 1993. (Pubitemid 23317695)
    • (1993) Journal of Leukocyte Biology , vol.54 , Issue.4 , pp. 289-295
    • Wang, M.-H.1    Skeel, A.2    Yoshimura, T.3    Copeland, T.D.4    Sakaguchi, K.5    Leonard, E.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.