Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase

Carcinogenesis

Volumn 23, Issue 11, 2002, Pages 1811-1819

  Chen, Yi Qing ^a   Zhou, Yong Qing ^b   Fu, Lu Hong ^c   Wang, Dong ^a   Wang, Ming Hai ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Jinhua Guangfu Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; PROTEIN RON; PROTEIN TYROSINE KINASE; RAS PROTEIN; SURFACTANT PROTEIN C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CELL GROWTH; CELL TYPE; CONTROLLED STUDY; EPITHELIUM CELL; GENE ACTIVATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC STABILITY; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG ADENOMA; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS WALL; LUNG CARCINOGENESIS; LUNG NODULE; MALIGNANT TRANSFORMATION; MOUSE; MULTIPLE CANCER; NONHUMAN; ONCOGENE K RAS; PHENOTYPE; PRECANCER; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENE; TRANSGENIC MOUSE; WESTERN BLOTTING;

EID: 0036848513     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/23.11.1811     Document Type: Article

References (44)

1. Travis,W.D., Linder,J. and Mackay,B. (2000). Classification, histology, cytology and electron microscopy. In Pass,H.I., Mitchell,J.B., Johnson,D.H., Turrisi,A.T. and Minna,J.D. (eds) Lung Cancer: Principles and Practice. Lippincott Williams & Wilkins. Philadelphia, pp. 453-495.
2. Hammer,S.P. (1995) Common neoplasms. In Dail,D.H., Hammer,S.P. and Colby,T.V. (eds) Pulmonary Pathology and Tumors. Spriner-Verlag, New York, pp. 1-156.
3. Nelkin,B.D., Mabry,M. and Baylin,S.B. (1998). Lung cancer. In Vogelstein,B. and Kinzler,K.W. (eds) The Genetic Basis of Human Cancer. McGraw-Hill, Baltimore, pp. 671-680.
4. Ronsin,C., Muscatelli,F., Mattei,M.G. and Breathnach,R. (1994) A novel putative receptor protein tyrosine kinase of the met family. Oncogene, 8, 1195-1202.
5. Iwama,A., Okano,K., Sudo,T., Matsuda,Y. and Suda,T. (1994) Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells. Blood, 83, 3160-3169.
6. Rubin,J.S., Bottaro,D.P. and Aaronson,S.A. (1993) Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product. Biochem. Biophys. Acta, 1155, 357-364.
7. Sekido,Y., Fong,K.M. and Minna,J.D. (1998) Progress in understanding the molecular pathogenesis of human lung cancer. Biochem. Biophys. Acta, 1378, F21-59.
8. Wang,M.-H., Ronsin,C., Gesnel,M.C., Coupeym,L., Skeel,A., Leonard,E.J. and Breathnach,R. (1994). Identification of the Ron gene product as the receptor for the human macrophage stimulating protein. Science, 266, 117-119.
9. Gaudino,G., Follenzi,A., Naldini,L., Collesi,C., Santoro,M., Gallo,K.A., Godowski,P.J. and Comoglio,P.M. (1994) RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J., 13, 3524-3532.
10. Skeel,A., Yoshimura,T., Showalter,S.D., Tanaka,S., Appella,E. and Leonard,E.J. (1991). Macrophage stimulating protein, partial amino acid sequence and cellular activity. J. Exp. Med., 173, 1227-1234.
11. Han,S., Stuart,L.A. and Degen,S.J.F. (1991) Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. Biochemistry, 30, 9768-9780.
12. Wang,M.-H., Montero-Julian,F.A. and Leonard,E.J. (1996) Requirement of PI-3 kinase for epithelial cell migration activated by human macrophage stimulating protein. Oncogene, 13, 2167-2175.
13. Santoro,M.M., Collesi,C., Grisendi,S., Gaudino,G. and Comoglio,P.M. (1996) Constitutive activation of the RON gene promotes invasive growth but not transformation. Mol. Cell. Biol., 16, 7072-7083.
14. Li,B., Wang,M.-H., Kung,H.-F., Ronsin,C., Breathnach,R., Leonard,E.J. and Kamata,T. (1995) Macrophage stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor. Biochem. Biophy. Res. Commun., 216, 110-118.
15. Danilkovitch,A., Donley,S., Skeel,A. and Leonard,E.J. (2000). Two independent signaling pathways mediate the antiapoptotic action of macrophage stimulating protein on epithelial cells. Mol. Cell. Biol., 20, 2218-2227.
16. Sakamoto,O., Iwama,A., Amitani,R., Takehara,T., Yamaguchi,N., Yamamoto,T., Masuyama,K., Yamanaka,T., Ando,M. and Suda,T. (1997) Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility. J. Clin. Invest., 99, 701-709.
17. Peace,B.E., Hughes,M.J., Degen,S.J.F. and Waltz,S.E. (2001) Point mutations and overexpression of Ron induce transformation, tumor formation and metastasis. Oncogene, 20, 6142-6151.
18. Santoro,M.M., Penengo,L., Minetto,M., Orecchia,S., Cilli,M. and Gadino,G. (1998). Point mutations in the kinase domain release the oncogenic and metastatic potential of the RON receptor. Oncogene, 17, 741-749.
19. PRC mutations in the RON receptor result in upregulation of tyrosine kinase activity and acquisition of oncogenic potential. J. Cell. Physiol., 181, 507-514.
20. Maggiora,P., Marchio,S., Stella,M.C., Giai,M., Belfiore,A., De Bortoli,M., Di Renzo,M.F., Costantino,A., Sismondi,P. and Comoglio,P.M. (1998) Overexpression of the RON gene in human breast carcinoma. Oncogene, 16, 2927-2933.
21. Chen,Y.-Q., Zhou,Y.-Q., Angeloni,D., Kurtz,A.L., Qiang,X.-Z. and Wang,M.-H. (2000) Overexpression and activation of the RON receptor tyrosine kinase in a panel of human colorectal carcinoma cell lines. Exp. Cell Res., 261, 229-238.
22. Willett,C.G., Smith D.I., Shridhar,V., Wang,M.-H., Emanuel,R., Patidar,K., Graham,S.A., Zhang,F, Hatch,V., Sugarbaker,J.D. and Sunday,M.E. (1997) Differential screening of a human chromosome-3 library identifies hepatocyte growth factor-like/macrophage stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival. J. Clin. Invest., 99, 2979-2991.
23. Willett,C., Wang,M.-H., Emanuel,R.L., Graham,S.A., Smith,D.I., Shridhar,V., Sugarbaker,D.J. and Sunday,M. (1998) Macrophage stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration. Am. J. Respir. Cell Mol. Biol., 18, 489-496.
24. Angeloni,D., Danilkovitch-Miagkova,A., Ivanov,S.V., Breathnach,R., Johnson,B.E., Leonard,E.J. and Lerman,M.I. (2000) Gene structure of the human receptor tyrosine kinase RON and mutation analysis in lung cancer samples. Genes Chrom. Cancer, 29, 147-156.
25. Glasser,S.W., Korfhagen,T.R., Wert,S.E., Bruno,M.D., McWilliams,K.M., Vorbroker,D.K. and Whitsett,J.A. (1991) Genetic element from human surfactant protein (SP)-C gene confers bronchiolar alveolar cell specificity in transgenic mice. Am. J. Physiol., 261, L349-356.
26. Singh,G. and Katyal,S. (1998) Clara cells and Clara cell 10 kD protein (CC10). Am. J. Respir. Cell Mol., 17, 141-143.
27. Hogan,B.F., Constantiti,F. and Lacy,E. (1996) Manipulating the Mouse Embryo. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY.
28. Ho,Y.-S., Vincent,R., Dey,M.S., Slot,J.W. and Crapo,J.D. (1998) Transgenic models for the study of lung antioxidant defense: enhanced manganese-containing superoxide dismutase activity five partial protection to B6C3 hybrid mice exposed to hyperoxis. Am. J. Respir. Cell. Mol. Biol., 18, 538-547.
29. Allred,D.C., Harvey,J., Berardo,M. and Clark,G.M. (1998). Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Modern Pathol., 11, 155-168.
30. George,D.L., Scott,A.F., Trusko,S., Glick,B., Ford,E. and Dorney,D.J. (1985) Structure and expression of amplified cKi-ras gene sequences in Y1 mouse adrenal tumor cells. EMBO J., 4, 1199-1203.
31. Bienz,B., Zakut-Houri,R., Givol,D. and Oren,M. (1984) Analysis of the gene coding for the murine cellular tumor antigen p53. EMBO J., 3, 2179-2183.
32. Zietkiewicz,E., Rafalski,A. and Labuda,D. (1994) Genome fingerprinting by simple sequence repeat (SSR)-anchored polymerase chain reaction amplification. Genomics, 20, 176-183.
33. Stoler,D.L., Chen,N., Basik,M., Kahlenberg,M.S., Rodriguez-Bigas,M.A., Petrelli,N.J. and Anderson,G.R. (1999) The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc. Natl Acad. Sci. USA, 96, 15121-15126.
34. Wikenheiser,K.A., Clark,J.C., Linnoila,I., Stahlman,M.T. and Whitsett,J.A. (1992) Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice. Cancer Res., 52, 5342-5352.
35. Lavigueur,A., Maltby,V., Mock,D., Rossant,J., Pawson,T. and Bernstein,A. (1989) High incidence of lung bone and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol. Cell. Biol., 9, 3982-3991.
36. Kalina,M., Mason,R.J. and Shannon,J.M. (1992) Surfactant protein C is expressed in alveolar type II cells but not in Clara cells of rat lung. Am. J. Respir. Cell. Mol. Biol., 6, 594-600.
37. Mason,R.J., Kalina,M., Nielsen,L.D., Malkinson,A.M. and Shannon,J.M. (2000) Surfactant protein C expression in urethane-induced murine pulmonary tumors. Am. J. Pathol., 156, 175-182.
38. Malkinson,A.M. (1998) Molecular comparison of human and mouse pulmonary adenocarcinomass. Exp. Lung Res., 24, 541-555.
39. Kerkhoff,E., Fedorov,L.M., Siefken,R., Walter,A.O., Papadopoulos,T. and Rapp,U.R. (2000) Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein. Cell Growth. Differ., 11, 185-190.
40. Clark,J.C., Tichelaar,J.W., Wert,S.E., Itoh,N., Perl,A.-K.T., Stahlman,M.T. and Whitsett,J.A. (2001) FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo. Am. J. Physiol. Lung Cell Mol. Physiol., 280, L705-715.
41. Lebel,M., Webster,M., Muller,W., Royal,A., Gauthier,J. and Mes-Masson,A.-M. (1995) Transgenic mice bearing the polyomavirus large T antigen directed by 2.1 kb of the keratin 19 promoter develop bronchiolar papillary tumors with progression to lung adenocarcinomas. Cell Growth Differen., 6, 1591-1600.
42. Dixon,D., Horton,D., Haseman,J.K., Talley,F., Greenwell,A., Nettesheim,P., Hook,G.E. and Maronpot,R.R. (1991) Histomorphology and ultrastructure of spontaneous pulmonary neoplasms in strain A mice. Exp. Lung Res., 17, 131-155.
43. Thaete,L.G., Gunning,W.T., Stoner,G.D. and Malkinson,A.M. (1987) Cellular derivation of lung tumors in sensitive and resistant strains of mice: results at 28 and 56 weeks after urethane treatment. J. Natl Cancer Inst., 78, 743-749.
44. Sandmoeller,A., Halter,R., Suske,G., Paul,D. and Beato,M. (1995) A transgenic mouse model for lung adenocarcinoma. Cell Growth Differen., 6, 97-1103.