메뉴 건너뛰기




Volumn 31, Issue 2, 2010, Pages 179-193

Prognostic markers and putative therapeutic targets for hepatocellular carcinoma

Author keywords

Genetic predisposition; Hepatocarcinogenesis; Prognostic markers; Signal transduction; Therapeutic targets

Indexed keywords

5 (4 BROMO 2 CHLOROANILINO) 4 FLUORO 1 METHYL 1H BENZIMIDAZOLE 6 CARBOHYDROXAMIC ACID 2 HYDROXYETHYL ESTER; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BEVACIZUMAB; ERLOTINIB; FORKHEAD BOX M1; FORKHEAD TRANSCRIPTION FACTOR; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; IRINOTECAN; MAPATUMUMAB; MITOGEN ACTIVATED PROTEIN KINASE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; RAPAMYCIN; RAS PROTEIN; S ADENOSYLMETHIONINE; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG; UO 126;

EID: 77951429707     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mam.2010.02.007     Document Type: Review
Times cited : (66)

References (124)
  • 1
    • 33845450257 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: molecular biology and therapy
    • Abou-Alfa G.K. Hepatocellular carcinoma: molecular biology and therapy. Semin. Oncol. 2006, 33(Suppl. 11):S79-S83.
    • (2006) Semin. Oncol. , vol.33 , Issue.SUPPL. 11
    • Abou-Alfa, G.K.1
  • 2
    • 77951427164 scopus 로고    scopus 로고
    • Is sorafenib (S) safe and effective in patients (pts) with hepatocellular carcinoma (HCC) and child-pugh B (CPB) cirrhosis? J. Clin. Oncol. 26 (May 20 abstr. 4518).
    • Abou-Alfa, G.K., Amadori, D., Santoro, A., Figer, A., De Greve, J., Lathia, C., Voliotis, D., Anerson, S., Moscovici, M., Ricci, S., 2008. Is sorafenib (S) safe and effective in patients (pts) with hepatocellular carcinoma (HCC) and child-pugh B (CPB) cirrhosis? J. Clin. Oncol. 26 (May 20 Suppl. abstr. 4518).
    • (2008) , Issue.SUPPL.
    • Abou-Alfa, G.K.1    Amadori, D.2    Santoro, A.3    Figer, A.4    De Greve, J.5    Lathia, C.6    Voliotis, D.7    Anerson, S.8    Moscovici, M.9    Ricci, S.10
  • 3
    • 26444584958 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and liver carcinogenesis
    • Arsura M., Cavin L.G. Nuclear factor-kappaB and liver carcinogenesis. Cancer Lett. 2005, 229:157-169.
    • (2005) Cancer Lett. , vol.229 , pp. 157-169
    • Arsura, M.1    Cavin, L.G.2
  • 4
    • 33745547361 scopus 로고    scopus 로고
    • New therapies for hepatocellular carcinoma
    • Avila M.A., Berasain C., Sangro B., Prieto J. New therapies for hepatocellular carcinoma. Oncogene 2006, 25:3866-3884.
    • (2006) Oncogene , vol.25 , pp. 3866-3884
    • Avila, M.A.1    Berasain, C.2    Sangro, B.3    Prieto, J.4
  • 7
    • 33646562819 scopus 로고    scopus 로고
    • Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma
    • Branda M., Wands J.R. Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma. Hepatology 2006, 43:891-902.
    • (2006) Hepatology , vol.43 , pp. 891-902
    • Branda, M.1    Wands, J.R.2
  • 9
    • 0033867475 scopus 로고    scopus 로고
    • Genetics of hepatocellular carcinoma
    • Buendia M.A. Genetics of hepatocellular carcinoma. Semin. Cancer Biol. 2000, 10:185-200.
    • (2000) Semin. Cancer Biol. , vol.10 , pp. 185-200
    • Buendia, M.A.1
  • 10
    • 0038246249 scopus 로고    scopus 로고
    • Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a
    • Bulavin D.V., Kovalsky O., Hollander M.C., Fornace A.J. Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a. Mol. Cell. Biol. 2003, 23:3859-3871.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 3859-3871
    • Bulavin, D.V.1    Kovalsky, O.2    Hollander, M.C.3    Fornace, A.J.4
  • 11
    • 0345330223 scopus 로고    scopus 로고
    • Segregation analysis of hepatocellular carcinoma in a moderately high-incidence area of East China
    • Cai R.L., Meng W., Lu H.Y., Lin W.Y., Jiang F., Shen F.M. Segregation analysis of hepatocellular carcinoma in a moderately high-incidence area of East China. World J. Gastroenterol. 2003, 9:2428-2432.
    • (2003) World J. Gastroenterol. , vol.9 , pp. 2428-2432
    • Cai, R.L.1    Meng, W.2    Lu, H.Y.3    Lin, W.Y.4    Jiang, F.5    Shen, F.M.6
  • 12
    • 35248880645 scopus 로고    scopus 로고
    • Dissection of signal transduction pathways as a tool for the development of targeted therapies of hepatocellular carcinoma
    • Calvisi D.F., Pascale R.M., Feo F. Dissection of signal transduction pathways as a tool for the development of targeted therapies of hepatocellular carcinoma. Rev. Recent Clin. Trias 2007, 2:217-236.
    • (2007) Rev. Recent Clin. Trias , vol.2 , pp. 217-236
    • Calvisi, D.F.1    Pascale, R.M.2    Feo, F.3
  • 19
    • 74049095469 scopus 로고    scopus 로고
    • The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease
    • Calvisi D.F., Pinna F., Ladu S., Muroni M.R., Frau M., Demartis I., Tomasi M.L., Sini M., Simile M.M., Seddaiu M.A., Feo F., Pascale R.M. The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. Int. J. Cancer 2010, 126:1275-1281.
    • (2010) Int. J. Cancer , vol.126 , pp. 1275-1281
    • Calvisi, D.F.1    Pinna, F.2    Ladu, S.3    Muroni, M.R.4    Frau, M.5    Demartis, I.6    Tomasi, M.L.7    Sini, M.8    Simile, M.M.9    Seddaiu, M.A.10    Feo, F.11    Pascale, R.M.12
  • 20
    • 33748286796 scopus 로고    scopus 로고
    • A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
    • Carter S.L., Eklund A.C., Kohane I.S., Harris L.N., Szallasi Z. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat. Genet. 2006, 38:1043-1048.
    • (2006) Nat. Genet. , vol.38 , pp. 1043-1048
    • Carter, S.L.1    Eklund, A.C.2    Kohane, I.S.3    Harris, L.N.4    Szallasi, Z.5
  • 21
    • 22244467087 scopus 로고    scopus 로고
    • MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    • Chan J.A., Krichevsky A.M., Kosik K.S. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 2005, 65:6029-6033.
    • (2005) Cancer Res. , vol.65 , pp. 6029-6033
    • Chan, J.A.1    Krichevsky, A.M.2    Kosik, K.S.3
  • 23
    • 62849111990 scopus 로고    scopus 로고
    • A two-stage, multi-center, open label, dose escalation study of mapatumumab ([HGS1012], a fully-human monoclonal antibody to TRAIL-R1) in combination with sorafenib as a first line therapy in subjects with advanced hepatocellular carcinoma
    • ClinicalTrials.gov identifier: NCT00712855; 2008. A two-stage, multi-center, open label, dose escalation study of mapatumumab ([HGS1012], a fully-human monoclonal antibody to TRAIL-R1) in combination with sorafenib as a first line therapy in subjects with advanced hepatocellular carcinoma.
    • (2008) ClinicalTrials.gov identifier: NCT00712855
  • 25
    • 0035028474 scopus 로고    scopus 로고
    • Frequent loss of heterozygosity at the Hcr1 (hepatocarcinogenesis resistance) locus on chromosome 10 in primary hepatocellular carcinomas from LFF1 rat strain
    • De Mglio M.R., Muroni M.R., Simile M.M., Virdis P., Asara G., Frau M., Calvisi D.F., Seddaiu M.A., Pascale R.M., Feo F. Frequent loss of heterozygosity at the Hcr1 (hepatocarcinogenesis resistance) locus on chromosome 10 in primary hepatocellular carcinomas from LFF1 rat strain. Hepatology 2001, 33:1110-1117.
    • (2001) Hepatology , vol.33 , pp. 1110-1117
    • De Mglio, M.R.1    Muroni, M.R.2    Simile, M.M.3    Virdis, P.4    Asara, G.5    Frau, M.6    Calvisi, D.F.7    Seddaiu, M.A.8    Pascale, R.M.9    Feo, F.10
  • 30
    • 33846277262 scopus 로고    scopus 로고
    • Reversing hepatocellular carcinoma progression by using networked biological therapies
    • Epstein R.J., Leung T.W. Reversing hepatocellular carcinoma progression by using networked biological therapies. Clin. Cancer Res. 2007, 13:11-17.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 11-17
    • Epstein, R.J.1    Leung, T.W.2
  • 31
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi P.A., De Pinho R.A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. 2006, 6:674-687.
    • (2006) Nat. Rev. , vol.6 , pp. 674-687
    • Farazi, P.A.1    De Pinho, R.A.2
  • 32
    • 0023124846 scopus 로고
    • Hepatocarcinogenesis: a dynamic cellular perspective
    • Farber E., Sarma D.S.R. Hepatocarcinogenesis: a dynamic cellular perspective. Lab. Invest. 1987, 56:4-22.
    • (1987) Lab. Invest. , vol.56 , pp. 4-22
    • Farber, E.1    Sarma, D.S.R.2
  • 35
    • 77951465721 scopus 로고    scopus 로고
    • Models for liver cancer
    • In: Alison, M.R. (Ed.), The Cancer Handbook, second ed., John Wiley and Sons, Ltd., Chichester, UK
    • Feo, F., Pascale, R.M., Calvisi, D.F., 2007. Models for liver cancer. In: Alison, M.R. (Ed.), The Cancer Handbook, vol. 2. second ed., John Wiley and Sons, Ltd., Chichester, UK, pp. 1118-1133.
    • (2007) , vol.2 , pp. 1118-1133
    • Feo, F.1    Pascale, R.M.2    Calvisi, D.F.3
  • 36
    • 63449112698 scopus 로고    scopus 로고
    • Interaction of major genes predisposing to hepatocellular carcinoma with genes encoding signal transduction pathways influences tumor phenotype and prognosis
    • Feo F., Frau M., Pascale R.M. Interaction of major genes predisposing to hepatocellular carcinoma with genes encoding signal transduction pathways influences tumor phenotype and prognosis. World J. Gastroenterol. 2008, 14:6601-6615.
    • (2008) World J. Gastroenterol. , vol.14 , pp. 6601-6615
    • Feo, F.1    Frau, M.2    Pascale, R.M.3
  • 39
    • 0034471496 scopus 로고    scopus 로고
    • Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia
    • Fosslien E. Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. Crit. Rev. Clin. Lab. Sci. 2000, 3:431-502.
    • (2000) Crit. Rev. Clin. Lab. Sci. , vol.3 , pp. 431-502
    • Fosslien, E.1
  • 40
    • 0032790551 scopus 로고    scopus 로고
    • Analysis of loss of heterozygosity in neoplastic nodules induced by diethylnitrosamine in the resistant BFF1 rat strain
    • Gariboldi M., Pascale R.M., Manenti G., De Miglio M.R., Calvisi D., Carru A., Dragani T.A., Feo F. Analysis of loss of heterozygosity in neoplastic nodules induced by diethylnitrosamine in the resistant BFF1 rat strain. Carcinogenesis 1999, 20:1363-1368.
    • (1999) Carcinogenesis , vol.20 , pp. 1363-1368
    • Gariboldi, M.1    Pascale, R.M.2    Manenti, G.3    De Miglio, M.R.4    Calvisi, D.5    Carru, A.6    Dragani, T.A.7    Feo, F.8
  • 42
    • 0344654862 scopus 로고    scopus 로고
    • Mutational analysis of three tumor suppressor genes in two models of rat hepatocarcinogenesis
    • Gómez-Angelats M., Teeguarden J.G., Dragan Y.P., Pitot H.C. Mutational analysis of three tumor suppressor genes in two models of rat hepatocarcinogenesis. Mol. Carcinogen. 1999, 25:157-163.
    • (1999) Mol. Carcinogen. , vol.25 , pp. 157-163
    • Gómez-Angelats, M.1    Teeguarden, J.G.2    Dragan, Y.P.3    Pitot, H.C.4
  • 44
    • 1542328234 scopus 로고    scopus 로고
    • The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer
    • Greten F.R., Karin M. The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Lett. 2004, 206:193-199.
    • (2004) Cancer Lett. , vol.206 , pp. 193-199
    • Greten, F.R.1    Karin, M.2
  • 45
    • 2342650027 scopus 로고    scopus 로고
    • Familial risks of cancer as a guide to gene identification and mode of inheritance
    • Hemminki K., Li X. Familial risks of cancer as a guide to gene identification and mode of inheritance. Int. J. Cancer 2004, 110:291-294.
    • (2004) Int. J. Cancer , vol.110 , pp. 291-294
    • Hemminki, K.1    Li, X.2
  • 46
    • 33646185479 scopus 로고    scopus 로고
    • Identification of p122RhoGAP (deleted in liver cancer-1) serine-322 as a substrate for protein kinase B and RSK in insulin-stimulated cells
    • Hers I., Wherlock M., Homma Y., Yagisawa H., Tavare J.M. Identification of p122RhoGAP (deleted in liver cancer-1) serine-322 as a substrate for protein kinase B and RSK in insulin-stimulated cells. J. Biol. Chem. 2006, 281:4762-4770.
    • (2006) J. Biol. Chem. , vol.281 , pp. 4762-4770
    • Hers, I.1    Wherlock, M.2    Homma, Y.3    Yagisawa, H.4    Tavare, J.M.5
  • 47
    • 63649086487 scopus 로고    scopus 로고
    • Targeting the ubiquitin system in cancer therapy
    • Hoeller D., Dikic I. Targeting the ubiquitin system in cancer therapy. Nature 2009, 458:438-454.
    • (2009) Nature , vol.458 , pp. 438-454
    • Hoeller, D.1    Dikic, I.2
  • 49
    • 0036014815 scopus 로고    scopus 로고
    • Rationale and feasibility of chemoprovention of hepatocellular carcinoma by cyclooxygenase-2 inhibitors
    • Hu K.-Q. Rationale and feasibility of chemoprovention of hepatocellular carcinoma by cyclooxygenase-2 inhibitors. J. Lab. Clin. Med. 2002, 139:234-243.
    • (2002) J. Lab. Clin. Med. , vol.139 , pp. 234-243
    • Hu, K.-Q.1
  • 50
    • 35848938280 scopus 로고    scopus 로고
    • P38alpha: a suppressor of cell proliferation and tumorigenesis
    • Hui L., Bakiri L., Stepniak E., Wagner E.F. P38alpha: a suppressor of cell proliferation and tumorigenesis. Cell Cycle 2007, 6:2429-2433.
    • (2007) Cell Cycle , vol.6 , pp. 2429-2433
    • Hui, L.1    Bakiri, L.2    Stepniak, E.3    Wagner, E.F.4
  • 51
    • 35648983903 scopus 로고    scopus 로고
    • Inflammation and cancer: an ancient link with novel potentials
    • Hussain S.P., Harris C.C. Inflammation and cancer: an ancient link with novel potentials. Int. J. Cancer 2007, 121:2373-2380.
    • (2007) Int. J. Cancer , vol.121 , pp. 2373-2380
    • Hussain, S.P.1    Harris, C.C.2
  • 52
    • 33846781365 scopus 로고    scopus 로고
    • Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma
    • Huynh H., Soo K.C., Chow P.K., Tran E. Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma. Mol. Cancer Ther. 2007, 6:138-146.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 138-146
    • Huynh, H.1    Soo, K.C.2    Chow, P.K.3    Tran, E.4
  • 54
    • 34248530332 scopus 로고    scopus 로고
    • Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression
    • Ieta K., Ojima E., Tanaka F., Nakamura Y., Haraguchi N., Mimori K., Inoue H., Kuwano H., Mori M. Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression. Int. J. Cancer 2007, 121:33-38.
    • (2007) Int. J. Cancer , vol.121 , pp. 33-38
    • Ieta, K.1    Ojima, E.2    Tanaka, F.3    Nakamura, Y.4    Haraguchi, N.5    Mimori, K.6    Inoue, H.7    Kuwano, H.8    Mori, M.9
  • 55
    • 0036793871 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase and survivin messenger RNA expression in hepatocellular carcinoma
    • Ikeguchi M., Ueta T., Yamane Y., Hirooka Y., Kaibara N. Inducible nitric oxide synthase and survivin messenger RNA expression in hepatocellular carcinoma. Clin. Cancer Res. 2002, 8:3131-3136.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3131-3136
    • Ikeguchi, M.1    Ueta, T.2    Yamane, Y.3    Hirooka, Y.4    Kaibara, N.5
  • 59
    • 33745489431 scopus 로고    scopus 로고
    • Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis
    • Kawanishi S., Hiraku Y., Pinlaor S., Ma N. Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol. Chem. 2006, 387:365-372.
    • (2006) Biol. Chem. , vol.387 , pp. 365-372
    • Kawanishi, S.1    Hiraku, Y.2    Pinlaor, S.3    Ma, N.4
  • 60
    • 0036384160 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • Kern M.A., Breuhahn K., Schirmacher P. Molecular pathogenesis of human hepatocellular carcinoma. Adv. Cancer Res. 2002, 86:67-112.
    • (2002) Adv. Cancer Res. , vol.86 , pp. 67-112
    • Kern, M.A.1    Breuhahn, K.2    Schirmacher, P.3
  • 62
    • 0042889191 scopus 로고    scopus 로고
    • Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis
    • Kimura H., Esumi H. Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis. Acta Biochim. Pol. 2003, 50:49-59.
    • (2003) Acta Biochim. Pol. , vol.50 , pp. 49-59
    • Kimura, H.1    Esumi, H.2
  • 63
    • 0037150228 scopus 로고    scopus 로고
    • Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kB signaling
    • Kuo M.T., Liu Z., Wei Y., Lin-Lee Y.C., Tatebe S., Mills G.B., Unate H. Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kB signaling. Oncogene 2002, 21:1945-1954.
    • (2002) Oncogene , vol.21 , pp. 1945-1954
    • Kuo, M.T.1    Liu, Z.2    Wei, Y.3    Lin-Lee, Y.C.4    Tatebe, S.5    Mills, G.B.6    Unate, H.7
  • 65
    • 0029786329 scopus 로고    scopus 로고
    • Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway
    • Lavoie J.N., L'Allemain G., Brunet A., Müller R., Pouysségur J. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 1996, 271:20608-20616.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20608-20616
    • Lavoie, J.N.1    L'Allemain, G.2    Brunet, A.3    Müller, R.4    Pouysségur, J.5
  • 66
    • 33745577640 scopus 로고    scopus 로고
    • Comparative and integrative functional genomics of HCC
    • Lee J.S., Thorgeirsson S.S. Comparative and integrative functional genomics of HCC. Oncogene 2006, 25:3801-3809.
    • (2006) Oncogene , vol.25 , pp. 3801-3809
    • Lee, J.S.1    Thorgeirsson, S.S.2
  • 67
    • 18944381315 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase, nitrotyrosine and apoptosis in gastric adenocarcinomas and their correlation with a poor survival
    • Li L.G., Xu H.H. Inducible nitric oxide synthase, nitrotyrosine and apoptosis in gastric adenocarcinomas and their correlation with a poor survival. World J. Gastroenterol. 2005, 11:2539-2544.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 2539-2544
    • Li, L.G.1    Xu, H.H.2
  • 68
    • 33644863486 scopus 로고    scopus 로고
    • Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling
    • Lin Y.W., Yang J.L. Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling. J. Biol. Chem. 2006, 281:915-926.
    • (2006) J. Biol. Chem. , vol.281 , pp. 915-926
    • Lin, Y.W.1    Yang, J.L.2
  • 70
    • 74149085153 scopus 로고    scopus 로고
    • Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis
    • Liu R.M., Gaston Pravia K.A. Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis. Free Radic. Biol. Med. 2010, 48:1-15.
    • (2010) Free Radic. Biol. Med. , vol.48 , pp. 1-15
    • Liu, R.M.1    Gaston Pravia, K.A.2
  • 71
    • 17744368500 scopus 로고    scopus 로고
    • Role of resistant Drh1 locus in chemical carcinogen-induced hepatocarcinogenesis in rats: analysis with a speed congenic strain
    • Liu H., Higashi K., Hiai H.P. Role of resistant Drh1 locus in chemical carcinogen-induced hepatocarcinogenesis in rats: analysis with a speed congenic strain. Cancer Sci. 2005, 96:164-169.
    • (2005) Cancer Sci. , vol.96 , pp. 164-169
    • Liu, H.1    Higashi, K.2    Hiai, H.P.3
  • 72
    • 54449083925 scopus 로고    scopus 로고
    • Molecular targeted therapies in hepatocellular carcinoma
    • Llovet J.M., Bruix J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology 2008, 48:1312-1327.
    • (2008) Hepatology , vol.48 , pp. 1312-1327
    • Llovet, J.M.1    Bruix, J.2
  • 73
    • 56149100880 scopus 로고    scopus 로고
    • Antioxidants in the treatment of chronic liver diseases: why is the efficacy evidence so weak in humans?
    • Lu S.C. Antioxidants in the treatment of chronic liver diseases: why is the efficacy evidence so weak in humans?. Hepatology 2008, 48:1359-1361.
    • (2008) Hepatology , vol.48 , pp. 1359-1361
    • Lu, S.C.1
  • 75
    • 0032750043 scopus 로고    scopus 로고
    • How do small GTPase signal transduction pathways regulate cell cycle entry?
    • Marshall C. How do small GTPase signal transduction pathways regulate cell cycle entry?. Curr. Opin. Cell Biol. 1999, 11:732-736.
    • (1999) Curr. Opin. Cell Biol. , vol.11 , pp. 732-736
    • Marshall, C.1
  • 76
    • 34248653254 scopus 로고    scopus 로고
    • Role of S-adenosyl-l-methionine in liver health and injury
    • Mato J.M., Lu S.C. Role of S-adenosyl-l-methionine in liver health and injury. Hepatology 2007, 45:1306-1312.
    • (2007) Hepatology , vol.45 , pp. 1306-1312
    • Mato, J.M.1    Lu, S.C.2
  • 78
    • 0027502534 scopus 로고
    • A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis
    • Melhem M.F., Kunz H.W., Gill T.J. A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis. Proc. Natl. Acad. Sci. USA 1993, 90:1967-1971.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1967-1971
    • Melhem, M.F.1    Kunz, H.W.2    Gill, T.J.3
  • 86
    • 0027423088 scopus 로고
    • Genomic abnormalities in hepatocarcinogenesis. Implications for a chemopreventive strategy
    • Pascale R.M., Simile M.M., Feo F. Genomic abnormalities in hepatocarcinogenesis. Implications for a chemopreventive strategy. Anticancer Res. 1993, 13:1341-1356.
    • (1993) Anticancer Res. , vol.13 , pp. 1341-1356
    • Pascale, R.M.1    Simile, M.M.2    Feo, F.3
  • 88
    • 0029044729 scopus 로고
    • Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase activity and gene expression by dehydrocpiandrosterone in preneoplastic liver nodules
    • Pascale R.M., Simile M.M., De Miglio M.R., Nufris A., Seddaiu M.A., Muroni M.R., Danni O., Rao K.N., Feo F. Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase activity and gene expression by dehydrocpiandrosterone in preneoplastic liver nodules. Carcinogenesis 1995, 16:1537-1542.
    • (1995) Carcinogenesis , vol.16 , pp. 1537-1542
    • Pascale, R.M.1    Simile, M.M.2    De Miglio, M.R.3    Nufris, A.4    Seddaiu, M.A.5    Muroni, M.R.6    Danni, O.7    Rao, K.N.8    Feo, F.9
  • 92
    • 0037056002 scopus 로고    scopus 로고
    • Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention
    • Pedersen P.L., Mathupala S., Rempel A., Geschwind J.F., Ko Y.H. Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention. Biochim. Biophys. Acta 2002, 1555:14-20.
    • (2002) Biochim. Biophys. Acta , vol.1555 , pp. 14-20
    • Pedersen, P.L.1    Mathupala, S.2    Rempel, A.3    Geschwind, J.F.4    Ko, Y.H.5
  • 93
    • 0030876720 scopus 로고    scopus 로고
    • Relationship between loss of heterozygosity of tumor suppressor genes and histologic differentiation in hepatocellular carcinoma
    • Piao Z., Kim H., Jeon B.K., Lee W.J., Park C. Relationship between loss of heterozygosity of tumor suppressor genes and histologic differentiation in hepatocellular carcinoma. Cancer 1997, 80:865-872.
    • (1997) Cancer , vol.80 , pp. 865-872
    • Piao, Z.1    Kim, H.2    Jeon, B.K.3    Lee, W.J.4    Park, C.5
  • 94
    • 0034745390 scopus 로고    scopus 로고
    • P16INK4a and beta-catenin alterations in rat liver tumors induced by NNK
    • Pulling L.C., Klinge D.M., Belinsky S.A. P16INK4a and beta-catenin alterations in rat liver tumors induced by NNK. Carcinogenesis 2001, 22:461-466.
    • (2001) Carcinogenesis , vol.22 , pp. 461-466
    • Pulling, L.C.1    Klinge, D.M.2    Belinsky, S.A.3
  • 95
    • 40149098824 scopus 로고    scopus 로고
    • Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer
    • Rizell M., Andersson M., Cahlin C., Hafström L., Olausson M., Lindnér P. Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer. Int. J. Clin. Oncol. 2008, 13:66-70.
    • (2008) Int. J. Clin. Oncol. , vol.13 , pp. 66-70
    • Rizell, M.1    Andersson, M.2    Cahlin, C.3    Hafström, L.4    Olausson, M.5    Lindnér, P.6
  • 96
    • 0031963692 scopus 로고    scopus 로고
    • Disruption of pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-Myc and Transforming Growth Factor-α
    • Santoni-Rugiu E., Jensen M.R., Thorgeirsson S.S. Disruption of pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-Myc and Transforming Growth Factor-α. Cancer Res. 1998, 58:123-134.
    • (1998) Cancer Res. , vol.58 , pp. 123-134
    • Santoni-Rugiu, E.1    Jensen, M.R.2    Thorgeirsson, S.S.3
  • 97
    • 0030761976 scopus 로고    scopus 로고
    • Specific chromosomal changes in albumin simian virus 40 T antigen transgenic rat liver neoplasms
    • Sargent L.M., Dragan Y.P., Sattle G., Xu Y.H., Wiley J., Pitot H.C. Specific chromosomal changes in albumin simian virus 40 T antigen transgenic rat liver neoplasms. Cancer Res. 1997, 57:3451-3456.
    • (1997) Cancer Res. , vol.57 , pp. 3451-3456
    • Sargent, L.M.1    Dragan, Y.P.2    Sattle, G.3    Xu, Y.H.4    Wiley, J.5    Pitot, H.C.6
  • 98
    • 0032899817 scopus 로고    scopus 로고
    • Nonrandom cytogenetic alterations in hepatocellular carcinoma from transgenic mice overexpressing c-Myc and transforming growth factor-alpha in the liver
    • Sargent L.M., Zhou X., Keck C.L., Sanderson N.D., Zimonjic D.B., Popescu N.C., Thorgeirsson S.S. Nonrandom cytogenetic alterations in hepatocellular carcinoma from transgenic mice overexpressing c-Myc and transforming growth factor-alpha in the liver. Am. J. Pathol. 1999, 154:1047-1055.
    • (1999) Am. J. Pathol. , vol.154 , pp. 1047-1055
    • Sargent, L.M.1    Zhou, X.2    Keck, C.L.3    Sanderson, N.D.4    Zimonjic, D.B.5    Popescu, N.C.6    Thorgeirsson, S.S.7
  • 102
    • 0029987613 scopus 로고    scopus 로고
    • Persistent chemopreventive effect of S-adenosyl-l-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats
    • Simile, M.M., Saviozzi, M., De Miglio, M.R., Muroni, M.R., Nufris, A., Pascale, R.M., Malvaldi, G., Feo, F., 1996. Persistent chemopreventive effect of S-adenosyl-l-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats. Carcinogenesis 17, 1533-1537.
    • (1996) Carcinogenesis , vol.17 , pp. 1533-1537
    • Simile, M.M.1    Saviozzi, M.2    De Miglio, M.R.3    Muroni, M.R.4    Nufris, A.5    Pascale, R.M.6    Malvaldi, G.7    Feo, F.8
  • 103
    • 0034745043 scopus 로고    scopus 로고
    • 5′-Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication
    • Simile M.M., Banni S., Angioni E., Carta G., De Miglio M.R., Muroni M.R., Calvisi D.F., Carru A., Pascale R.M., Feo F. 5′-Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication. J. Hepatol. 2001, 34:386-394.
    • (2001) J. Hepatol. , vol.34 , pp. 386-394
    • Simile, M.M.1    Banni, S.2    Angioni, E.3    Carta, G.4    De Miglio, M.R.5    Muroni, M.R.6    Calvisi, D.F.7    Carru, A.8    Pascale, R.M.9    Feo, F.10
  • 104
    • 12144291647 scopus 로고    scopus 로고
    • Down-regulation of c-myc and Cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cells
    • Simile M.M., De Miglio M.R., Muroni M.R., Frau M., Asara G., Serra S., Muntoni M.D., Seddaiu M.A., Daino L., Feo F., Pascale R.M. Down-regulation of c-myc and Cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cells. Carcinogenesis 2004, 25:333-341.
    • (2004) Carcinogenesis , vol.25 , pp. 333-341
    • Simile, M.M.1    De Miglio, M.R.2    Muroni, M.R.3    Frau, M.4    Asara, G.5    Serra, S.6    Muntoni, M.D.7    Seddaiu, M.A.8    Daino, L.9    Feo, F.10    Pascale, R.M.11
  • 106
    • 0029665779 scopus 로고    scopus 로고
    • Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4
    • Stepanova L., Leng X., Parker S.B., Harper J.W. Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Genes Dev. 1996, 10:1491-1502.
    • (1996) Genes Dev. , vol.10 , pp. 1491-1502
    • Stepanova, L.1    Leng, X.2    Parker, S.B.3    Harper, J.W.4
  • 107
    • 0037261429 scopus 로고    scopus 로고
    • Relevance of hepatic preneoplasia for human hepatocarcinogenesis
    • Su Q., Bannasch P. Relevance of hepatic preneoplasia for human hepatocarcinogenesis. Toxicol. Pathol. 2003, 31:126-133.
    • (2003) Toxicol. Pathol. , vol.31 , pp. 126-133
    • Su, Q.1    Bannasch, P.2
  • 108
    • 0024341181 scopus 로고
    • Amplification, rearrangements, and enhanced expression of c-myc in chemically induced rat liver tumors in vivo and in vitro
    • Suchy B.K., Sarafoff M., Kerler R., Rabes H.M. Amplification, rearrangements, and enhanced expression of c-myc in chemically induced rat liver tumors in vivo and in vitro. Cancer Res. 1989, 49:6781-6787.
    • (1989) Cancer Res. , vol.49 , pp. 6781-6787
    • Suchy, B.K.1    Sarafoff, M.2    Kerler, R.3    Rabes, H.M.4
  • 109
    • 28644433990 scopus 로고    scopus 로고
    • Expressions of inducible nitric oxide synthase and matrix metalloproteinase-9 and their effects on angiogenesis and progression of hepatocellular carcinoma
    • Sun M.H., Han X.C., Jia M.K., Jiang W.D., Wang M., Zhang H., Han G., Jiang Y. Expressions of inducible nitric oxide synthase and matrix metalloproteinase-9 and their effects on angiogenesis and progression of hepatocellular carcinoma. World J. Gastroenterol. 2005, 11:5931-5937.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 5931-5937
    • Sun, M.H.1    Han, X.C.2    Jia, M.K.3    Jiang, W.D.4    Wang, M.5    Zhang, H.6    Han, G.7    Jiang, Y.8
  • 110
    • 34250800462 scopus 로고    scopus 로고
    • Amplification of c-myc and cyclin D1 genes in primary and metastatic carcinomas of the liver
    • Takahashi Y., Kawate S., Watanabe M., Fukushima J., Mori S., Fukusato T. Amplification of c-myc and cyclin D1 genes in primary and metastatic carcinomas of the liver. Pathol. Int. 2007, 57:437-442.
    • (2007) Pathol. Int. , vol.57 , pp. 437-442
    • Takahashi, Y.1    Kawate, S.2    Watanabe, M.3    Fukushima, J.4    Mori, S.5    Fukusato, T.6
  • 111
    • 0037180344 scopus 로고    scopus 로고
    • Inaugural article: a comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades
    • Tanaka Y., Hanada K., Mizokami M., Yeo A.E., Shih J.W., Gojobori T., Alter H.J. Inaugural article: a comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades. Proc. Natl. Acad. Sci. USA 2002, 99:15584-15589.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 15584-15589
    • Tanaka, Y.1    Hanada, K.2    Mizokami, M.3    Yeo, A.E.4    Shih, J.W.5    Gojobori, T.6    Alter, H.J.7
  • 112
    • 0034106254 scopus 로고    scopus 로고
    • Genome-wide los of heterozygosity analysis of chemically induced rat hepatocellular carcinomas reveals elevated frequency of allelic imbalances on chromosomes 1, 6, 8, 11. 17, and 20
    • Teeguarden J.G., Newton M.A., Dragan Y., Pitot H.C. Genome-wide los of heterozygosity analysis of chemically induced rat hepatocellular carcinomas reveals elevated frequency of allelic imbalances on chromosomes 1, 6, 8, 11. 17, and 20. Mol. Carcinogen. 2000, 28:51-61.
    • (2000) Mol. Carcinogen. , vol.28 , pp. 51-61
    • Teeguarden, J.G.1    Newton, M.A.2    Dragan, Y.3    Pitot, H.C.4
  • 114
    • 0036240015 scopus 로고    scopus 로고
    • Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats
    • Tsujiuchi T., Sasaki Y., Kubozoe T., Tsutsumi M., Konishi Y., Nakae D. Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats. Mol. Carcinogen. 2002, 34:19-24.
    • (2002) Mol. Carcinogen. , vol.34 , pp. 19-24
    • Tsujiuchi, T.1    Sasaki, Y.2    Kubozoe, T.3    Tsutsumi, M.4    Konishi, Y.5    Nakae, D.6
  • 116
    • 28544449224 scopus 로고    scopus 로고
    • Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase
    • Wang I.C., Chen Y.J., Hughes D., Petrovic V., Major M.L., Park H.J., Tan Y., Ackerson T., Costa R.H. Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol. Cell Biol. 2005, 25:10875-10894.
    • (2005) Mol. Cell Biol. , vol.25 , pp. 10875-10894
    • Wang, I.C.1    Chen, Y.J.2    Hughes, D.3    Petrovic, V.4    Major, M.L.5    Park, H.J.6    Tan, Y.7    Ackerson, T.8    Costa, R.H.9
  • 117
    • 36248990364 scopus 로고    scopus 로고
    • FOXM1, a typical proliferation-associated transcription factor
    • Wierstra I., Alves J. FOXM1, a typical proliferation-associated transcription factor. Biol. Chem. 2007, 388:1257-1274.
    • (2007) Biol. Chem. , vol.388 , pp. 1257-1274
    • Wierstra, I.1    Alves, J.2
  • 118
    • 0035395236 scopus 로고    scopus 로고
    • Beta-catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance
    • Wong C.M., Fan S.T., Ng I.O. Beta-catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance. Cancer 2001, 92:136-145.
    • (2001) Cancer , vol.92 , pp. 136-145
    • Wong, C.M.1    Fan, S.T.2    Ng, I.O.3
  • 119
    • 57749203825 scopus 로고    scopus 로고
    • Management of advanced hepatocellular carcinoma in the era of targeted therapy
    • Yau T., Chan P., Epstein R., Poo R.T.P. Management of advanced hepatocellular carcinoma in the era of targeted therapy. Liver Int. 2009, 29:10-17.
    • (2009) Liver Int. , vol.29 , pp. 10-17
    • Yau, T.1    Chan, P.2    Epstein, R.3    Poo, R.T.P.4
  • 124
    • 27144477363 scopus 로고    scopus 로고
    • Expressions of nuclear factor kappaB, inducible nitric oxide synthase, and vascular endothelial growth factor in adenoid cystic carcinoma of salivary glands: correlations with the angiogenesis and clinical outcome
    • Zhang J., Peng B., Chen X. Expressions of nuclear factor kappaB, inducible nitric oxide synthase, and vascular endothelial growth factor in adenoid cystic carcinoma of salivary glands: correlations with the angiogenesis and clinical outcome. Clin. Cancer Res. 2005, 11:7334-7343.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 7334-7343
    • Zhang, J.1    Peng, B.2    Chen, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.