Glial cell line-derived neurotrophic factor gene therapy ameliorates chronic hyperprolactinemia in senile rats

Neuroscience

Volumn 167, Issue 3, 2010, Pages 946-953

  Morel, G R ^a   Sosa, Y E ^a   Bellini, M J ^a   Carri, N G ^b   Rodriguez, S S ^a   Bohn, M C ^c   Goya, R G ^a  

^a INSTITUTO DE INVESTIGACIONES BIOQUÍMICAS DE LA PLATA INIBIOLP   (Argentina)

^b Instituto Multidisciplinario de Biologia Celular   (Argentina)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Aging; Chronic hyperprolactinemia; DA neurodegeneration; GDNF; Gene therapy; TIDA neurons

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NEURON SPECIFIC NUCLEAR PROTEIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GENE THERAPY; GENE TRANSFER; HYPERPROLACTINEMIA; HYPOTHALAMUS; IMAGE ANALYSIS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; TUBEROHYPOPHYSEAL TRACT;

ADENOVIRIDAE; AGING; ANIMALS; ANTIGENS, NUCLEAR; ARCUATE NUCLEUS; BETA-GALACTOSIDASE; CELL COUNT; CELLS, CULTURED; CHRONIC DISEASE; FEMALE; GENE THERAPY; GENES, REPORTER; GENETIC VECTORS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HYPERPROLACTINEMIA; LACTOTROPHS; MICROINJECTIONS; NERVE TISSUE PROTEINS; NEURONS; PROLACTIN; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; TREATMENT OUTCOME; TUBER CINEREUM; TYROSINE 3-MONOOXYGENASE;

EID: 77951268235     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.02.053     Document Type: Article

References (46)

1. Ben-Jonathan N., Arbogast L.A., Hyde J.F. Neuroendocrine regulation of prolactin release. Prog Neurobiol 1989, 33:399-477.
2. Bilang-Bleuel A., Revah F., Colin P., Locquet I., Robert J.J., Mallet J., Horellou P. Intrastriatal injection of an adenoviral vector expressing glial cell line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease. Proc Natl Acad Sci USA 1997, 94:8818-8823.
3. Bjorklund A., Rosenblud C., Winkler C., Kirik D. Studies of neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease. Neurobiol Dis 1997, 4:186-200.
4. Bowenkamp K.E., Hoffman A.F., Gerhardt G.A., Henry M.A., Biddle P.T., Hoffer B.J., Granholm A.C.E. Glial cell line-derived neurotrophic factor supports survival of injured midbraindopaminergic neurons. J Comp Neurol 1995, 355:479-489.
5. Burazin T.C.D., Gundlach A.L. Localization of GDNF/neurturin receptor (c-ret, GFRα-1and α-2) mRNAs in postnatal rat brain: differential regional and temporal expression in hippocampus, cortex and cerebellum. Brain Res Mol Brain Res 1999, 73:151-171.
6. Carri N.G., Bengtsson H., Charette M.F., Ebendal T. BMPR-II expression and OP-1 effects indeveloping chicken retinal explants. Neuroreport 1998, 9:1097-1101.
7. Choi-Lundberg D.L., Lin Q., Chang Y.N., Chiang Y.L., Hay C.M., Mohajeri H., Davidson B.L., Bohn M.C. Dopaminergic neurons protected from degeneration by GDNF genetherapy. Science 1997, 275:838-841.
8. Connor B., Kozlowski D.A., Schallert T., Tillerson J.L., Davidson B.L., Bohn M.C. Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat. Gene Ther 1999, 6:1936-1951.
9. Cónsole G., Gómez Dumm C.L.A., Brown O.A., Goya R.G. Sexual dimorphism in the age changes of the pituitary lactotrophs in rats. Mech Ageing Dev 1997, 95:157-166.
10. Cusimano G., Capriani C., Bonifati V., Meco G. Hypothalamo-pituitary function and dopamine dependence in untreated parkinsonian patients. Acta Neurol Scand 1991, 83:145-150.
11. Dahlström A., Fuxe K. Evidence for the existence of monoamine containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol Scand 1964, 62:1-55.
12. de Rijk M.C., Breteler M.M., Graveland G.A., Ott A., Grobbee D.E., van der Meche F., Hofman A. Prevalence of Parkinson's disease in the elderly: the Rotterdam study. Neurology 1995, 45:2143-2146.
13. Ebendal T. Use of collagen gels to bioassay nerve growth factor activity. Nerve growth factors. IBRO handbook series. Methods in the Neurosciences, Vol. 12 1989, 81-93. John Wiley and Sons Ltd, Chichesterl. R.A. Rush (Ed.).
14. Ebendal T., Tomac A., Hoffer B.J., Olson L. Glial cell line-derived neurotrophic factor stimulates fiber formation and survival in cultured neurons from peripheral autonomic ganglia. J Neurosci Res 1995, 40:276-284.
15. Elsdale T., Bard J. Collagen substrata for studies on cell behavior. J Cell Biol 1972, 54:626-637.
16. Emborg M.E., Ma S.Y., Mufson E.J., Levey A.I., Taylor M.D., Brown W.D., Holden J.E., Kordower J.H. Age-related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys. J Comp Neurol 1998, 401:253-265.
17. Gash D.M., Zhang Z., Ovadia A., Cass W.A., Yi A., Simmerman L., Russell D., Martin D., Lapchak P.A., Collins F., Hoffer B.J., Gerhardt G.A. Functional recovery in parkinsonian monkeys treated with GDNF. Nature 1996, 380:252-255.
18. Geddes B.J., Harding T.C., Lightman S.L., Uney J.B. Long-term gene therapy in the CNS: reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin. Nat Med 1997, 3:402-1404.
19. Goudreau J.L., Lindley S.E., Lookingland K.J., Moore K.E. Evidence that hypothalamic periventricular dopamine neurons innervate the intermediate lobe of the rat pituitary. Neuroendocrinology 1992, 40:145-151.
20. Goya R.G., Lu J.K.H., Meites J. Gonadal function and pituitary and mammary pathology in the aging rat. Mech Ageing Dev 1990, 56:77-88.
21. Gudelsky G.A., Nansel D.D., Porter J.C. Dopaminergic control of prolactin secretion in the aging male rat. Brain Res 1981, 204:446-450.
22. Hereñú C.B., Cristina C., Rimoldi O.J., Becú-Villalobos D., Cambiaggi V., Portiansky E.L., Goya R.G. Restorative effect of insulin-like growth factor I gene therapy in the hypothalamus of senile rats with dopaminergic dysfunction. Gene Ther 2007, 14:237-245.
23. Hoffer B.J., Hoffman A., Bowenkamp K., Huettl P., Hudson J., Martin D., Lin L.F.H., Gerhardt G.A. Glial cell line-derived neurotrophic factor reverses toxin-induced injured to midbrain dopaminergic neurons in vivo. Neurosci Lett 1994, 182:107-111.
24. Johnston L.C., Eberling J., Pivirotto P., Hadaczek P., Federoff H.J., Forsayeth J. Clinically relevant effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys. Hum Gene Ther 2009, 20:497-510.
25. Kawano H., Daikoku S. Functional topography of the rat hypothalamic dopamine neuron systems: retrograde tracing and immunohistochemical study. J Comp Neurol 1997, 265:242-253.
26. Kordower J.H., Emborg M.E., Bloch J., Ma S.Y., Chu Y., Leventhal L., McBride J., Chen E.Y., Palfi S., Roitberg B.Z., Brown W.D., Holden J.E., Pyzalski R., Taylor M.D., Carvey P., Ling Z., Trono D., Hantraye P., Deglon N., Aebischer P. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 2000, 290:767-773.
27. Lapchak P.A., Araujo D.M., Hilt D.C., Sheng J., Jiao S. Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease. Brain Res 1997, 777:153-160.
28. Lapchak P.A., Miller P.J., Jiao S. Glial cell line- derived neurotrophic factor induces the dopaminergic and cholinergic phenotype and increases locomotor activity in aged Fischer 344 rats. Neuroscience 1997, 77:745-752.
29. Mandel R.J., Spratt S.K., Snyder R.O., Leff S.E. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc Natl Acad Sci U S A 1997, 94:14083-14088.
30. Manfredsson F.P., Tumer N., Erdos B., Landa T., Broxson C.S., Sullivan L.F., Rising A.C., Foust K.D., Zhang Y., Muzyczka N., Gorbatyuk O.S., Scarpace P.J., Mandel R.J. Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity. Mol Ther 2009, 17:980-991.
31. Mayeux R., Marder K., Cote L.J., Denaro J., Hemenegildo N., Mejia H., Tang M.X., Lantigua R., Wilder D., Gurland B. The frequency of idiopathic Parkinson's disease by age, ethnic group and sex in northern Manhattan, 1988-1993. Am J Epidemiol 1995, 142:820-827.
32. Nutt J.G., Burchiel K.J., Comella C.L., Jankovic J., Lang A.E., Laws E.R., Lozano A.M., Penn R.D., Simpson R.K., Stacy M., Wooten G.F. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology 2003, 60:69-73.
33. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1998, Academic Press, San Diego, CA.
34. Porter J.C., Aguila-Mansilla N., Ramin S.M., Kedzierski W. Secretion by hypothalamic dopaminergic neurons of the aged brain. Neurobiol Aging 1994, 15:535-539.
35. Porter J.C., Nansel D.D., Guselsky G.A., Reymond M.J., Pilotte N.S., Foreman M.M., Tilders F.J.H. Some aspects of hypothalamic and hypophysial secretion in aging rats. Peptides 1980, 1:135-139.
36. Reymond M.J., Porter J.C. Secretion of hypothalamic dopamine into pituitary stalk blood of aged female rats. Brain Res Bull 1981, 7:69-73.
37. Sanchez H.L., Silva L.B., Portiansky E.L., Goya R.G., Zuccolilli G.O. Impact of very old age on hypothalamic dopaminergic neurons in the female rat: a morphometric study. J Comp Neurol 2003, 458:319-325.
38. Sanchez H.L., Silva L.B., Portiansky E.L., Hereñu C.B., Goya R.G., Zuccolilli G.O. Dopaminergic mesencephalic systems and motor performance in very old rats. Neuroscience 2008, 154:1598-1606.
39. Shimohama S., Sawada H., Kitamura Y., Taniguchi T. Disease model: Parkinson's disease. Trends Mol Med 2003, 9:360-365.
40. Tillet Y., Kitahama K. Distribution of central catecholaminergic neurons: a comparison between ungulates, humans and other species. Histol Histopathol 1998, 13:1163-1177.
41. Tomac A., Lindqvist E., Lin L.F.H., Ögrenn S.O., Young D., Hoffer B.J., Olson L. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 1995, 373:335-339.
42. Trupp M., Belluardo N., Funakoshi H., Ibanez C.F. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-a indicates multiple mechanisms of trophic actions in the adult Rat CNS. J Neurosci 1997, 17:3554-3567.
43. Tumer N., Scarpace P.J., Dogan M.D., Broxson C.S., Matheny M., Yurek D.M., Peden C.S., Burger C., Muzyczka N., Mandel R.J. Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity. Neurobiol Aging 2006, 27:459-470.
44. Valtin H. Genetic models of diabetes insipidus. Handbook of physiology 1992, 1281-1316. Oxford University Press, New York, NY. E.E. Windhager (Ed.).
45. West M.J., Slomianka L., Gundersen H.J. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 1991, 231:482-497.
46. Zhang Z., Miyoshi Y., Lapchak P.A., Collins F., Hilt D., Lebel C., Kryscio R., Gash D.M. Dose response to intraventricular glial cell line-derived neurotrophic factor administration in parkinsonian monkeys. J Pharmacol Exp Ther 1997, 282:1396-1401.